Lista de obras - Wolfgang Sadee - Dominio Público Uruguay

5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).

artículo científico publicado en 2006

6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study

artículo científico publicado en 2011

A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent TB Infection

artículo científico publicado en 2017

A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas

artículo científico publicado en 2009

A pharmacoproteomics study of the cancer cell line EKVX using capillary-LC/MS/MS.

artículo científico publicado en 2006

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma

artículo científico publicado en 2005

Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms

artículo científico publicado en 2015

Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues

artículo científico publicado en 2008

Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile

artículo científico publicado en 2017

Analyzing allele specific RNA expression using mixture models

artículo científico publicado en 2015

Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents

artículo científico publicado en 2012

Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder

artículo científico publicado en 2014

Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study

artículo científico publicado en 2013

Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management

scientific article published on 11 September 2020

Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

artículo científico publicado en 2018

Bridging material and biological sciences: the legacy of Hans Peter Merkle.

artículo científico publicado en 2013

CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response

artículo científico publicado en 2009

CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure

artículo científico publicado en 2017

CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing

artículo científico publicado en 2015

CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control

artículo científico publicado en 2013

Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-.

artículo científico publicado en 2007

Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines

artículo científico publicado en 2005

Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk

artículo científico publicado en 2012

Cladograms with Path to Event (ClaPTE): a novel algorithm to detect associations between genotypes or phenotypes using phylogenies

artículo científico publicado en 2014

Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence

article

Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity

artículo científico publicado en 2013

Conditional entropy in variation-adjusted windows detects selection signatures associated with expression quantitative trait loci (eQTLs).

artículo científico publicado en 2015

DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory

artículo científico publicado en 2014

Design and implementation of a randomized controlled trial of genomic counseling for patients with chronic disease

artículo científico publicado en 2014

Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment

artículo científico publicado en 2007

Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction

artículo científico publicado en 2013

Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder

artículo científico publicado en 2011

Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.

artículo científico publicado en 2005

Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis

artículo científico publicado en 2017

Erratum to: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

artículo científico publicado en 2016

Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq

artículo científico publicado en 2017

Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver

artículo científico publicado en 2013

Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder

artículo científico publicado en 2014

Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene

artículo científico publicado en 2009

Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition

artículo científico publicado en 2010

Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans

artículo científico publicado en 2009

Gene expression profiling of brain samples from patients with Lewy body dementia

artículo científico publicado en 2016

Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example

artículo científico publicado en 2013

Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein

artículo científico publicado en 2014

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance

artículo científico publicado en 2010

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response

artículo científico

Genomic architecture of pharmacological efficacy and adverse events

artículo científico publicado en 2014

Genotyping panel for assessing response to cancer chemotherapy

artículo científico publicado en 2008

Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia

artículo científico publicado en 2006

Human N-acetyltransferase 1 10 and 11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity ⬇️

artículo científico publicado el 1 de octubre de 2011

Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations

artículo científico publicado en 2015

Institutional Profile: Program in Pharmacogenomics at the Ohio State University Medical Center ⬇️

artículo científico publicado el 1 de mayo de 2012

Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression

scientific article published on 01 October 2018

Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor

artículo científico publicado en 2003

Intronic Polymorphisms Affecting Alternative Splicing of Human Dopamine D2 Receptor Are Associated with Cocaine Abuse ⬇️

artículo científico publicado el 8 de diciembre de 2010

Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits ⬇️

artículo científico publicado en 2017

KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)

scientific article published on September 2007

Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility

artículo científico publicado en 2009

MicroRNA expression profiles for the NCI-60 cancer cell panel

artículo científico publicado en 2007

MicroRNAs modulate the chemosensitivity of tumor cells

artículo científico publicado en 2008

Missing heritability of common diseases and treatments outside the protein-coding exome

artículo científico publicado en 2014

Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex

artículo científico publicado en 2012

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms

artículo científico publicado en 2010

Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

artículo científico publicado en 2016

Personalized Therapeutics and Pharmacogenomics: Integral to Personalized Health Care

artículo científico publicado en 2017

Pharmacogenomic Biomarkers: Validation Needed for both the Molecular Genetic Mechanism and Clinical Effect ⬇️

artículo científico publicado el 1 de mayo de 2011

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others

artículo científico publicado en 2011

Pharmacogenomics of the RNA World: Structural RNA Polymorphisms in Drug Therapy ⬇️

artículo científico publicado el 2 de febrero de 2011

Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics

artículo científico publicado en 2004

Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice

artículo científico publicado en 2016

Profiling solute carrier transporters in the human blood-brain barrier

artículo científico publicado en 2013

Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension

artículo científico publicado en 2008

Protein therapeutics: new applications for pharmacogenetics

artículo científico publicado en 2006

RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles

artículo científico publicado en 2015

Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616

artículo científico publicado en 2015

Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart

artículo científico publicado en 2017

Regulatory polymorphisms in CYP2C19 affecting hepatic expression

artículo científico publicado en 2013

Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity

artículo científico publicado en 2014

Response to paper by Kelly et al "The opioid receptor pharmacology of GSK1521498 compared to other ligands with different effects on compulsive reward-related behaviors" published in Psychopharmacology 232, 305-314, 2014.

artículo científico publicado en 2015

Strategies and methods for research on sex differences in brain and behavior

artículo científico publicado en 2004

Synaptic Signaling and Aberrant RNA Splicing in Autism Spectrum Disorders ⬇️

artículo científico publicado el 26 de enero de 2011

The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations

artículo científico publicado en 2016

The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy

artículo científico publicado en 2012

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.

artículo científico publicado en 2017

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

artículo científico publicado en 2013

The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics

artículo científico publicado en 2015

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

artículo científico publicado en 2008

Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies

artículo científico publicado en 2004

Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research

artículo científico publicado en 2017

Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics

artículo científico publicado en 2017

Whole transcriptome RNA-Seq allelic expression in human brain

artículo científico publicado en 2013

mRNA Transcript Diversity Creates New Opportunities for Pharmacological Intervention ⬇️

artículo científico publicado el 7 de febrero de 2012

Lista de obras de Wolfgang Sadee

5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).

6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study

A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent TB Infection

A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas

A pharmacoproteomics study of the cancer cell line EKVX using capillary-LC/MS/MS.

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma

Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms

Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues

Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile

Analyzing allele specific RNA expression using mixture models

Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents

Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder

Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study

Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management

Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

Bridging material and biological sciences: the legacy of Hans Peter Merkle.

CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response

CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure

CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing

CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control

Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-.

Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines

Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk

Cladograms with Path to Event (ClaPTE): a novel algorithm to detect associations between genotypes or phenotypes using phylogenies

Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence

Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity

Conditional entropy in variation-adjusted windows detects selection signatures associated with expression quantitative trait loci (eQTLs).

DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory

Design and implementation of a randomized controlled trial of genomic counseling for patients with chronic disease

Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment

Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction

Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder

Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.

Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis

Erratum to: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq

Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver

Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder

Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene

Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition

Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans

Gene expression profiling of brain samples from patients with Lewy body dementia

Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example

Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response

Genomic architecture of pharmacological efficacy and adverse events

Genotyping panel for assessing response to cancer chemotherapy

Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia

Human N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity ⬇️

Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations

Institutional Profile: Program in Pharmacogenomics at the Ohio State University Medical Center ⬇️

Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression

Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor

Intronic Polymorphisms Affecting Alternative Splicing of Human Dopamine D2 Receptor Are Associated with Cocaine Abuse ⬇️

Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits ⬇️

KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)

Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility

MicroRNA expression profiles for the NCI-60 cancer cell panel

MicroRNAs modulate the chemosensitivity of tumor cells

Missing heritability of common diseases and treatments outside the protein-coding exome

Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms

Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

Personalized Therapeutics and Pharmacogenomics: Integral to Personalized Health Care

Pharmacogenomic Biomarkers: Validation Needed for both the Molecular Genetic Mechanism and Clinical Effect ⬇️

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others

Pharmacogenomics of the RNA World: Structural RNA Polymorphisms in Drug Therapy ⬇️

Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics

Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice

Profiling solute carrier transporters in the human blood-brain barrier

Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension

Protein therapeutics: new applications for pharmacogenetics

RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles

Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616

Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart

Regulatory polymorphisms in CYP2C19 affecting hepatic expression

Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity

Response to paper by Kelly et al "The opioid receptor pharmacology of GSK1521498 compared to other ligands with different effects on compulsive reward-related behaviors" published in Psychopharmacology 232, 305-314, 2014.

Human N-acetyltransferase 1 10 and 11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity ⬇️