Lista de obras - Helen C Hailes - Dominio Público Uruguay

'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile

artículo científico publicado en 2015

A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/ω-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol

A bicyclic -adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks

artículo científico publicado en 2021

A colorimetric assay for screening transketolase activity.

artículo científico publicado en 2006

A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase.

artículo científico publicado en 2015

A toolbox approach for the rapid evaluation of multi-step enzymatic syntheses comprising a ‘mix and match’E. coliexpression system with microscale experimentation

Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

scientific article published on 15 April 2008

Aminopolyols from Carbohydrates: Amination of Sugars and Sugar-Derived Tetrahydrofurans with Transaminases

artículo científico publicado el 14 de febrero de 2019

An automated microscale platform for evaluation and optimization of oxidative bioconversion processes

artículo científico publicado en 2012

An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates

artículo científico publicado en 2017

Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo.

artículo científico publicado en 2006

Antimycobacterial calixarenes enhance innate defense mechanisms in murine macrophages and induce control of Mycobacterium tuberculosis infection in mice.

artículo científico publicado en 2004

Applications of tailored ferrocenyl molecules as electrochemical probes of biochemical interactions

artículo científico publicado en 2007

Asymmetric synthesis of dialkyloxy-3-alkylammonium cationic lipids.

artículo científico publicado en 2004

Biomimetic Phosphate-Catalyzed Pictet-Spengler Reaction for the Synthesis of 1,1'-Disubstituted and Spiro-Tetrahydroisoquinoline Alkaloids

artículo científico publicado en 2019

Biophysical Characterization of an Integrin-Targeted Lipopolyplex Gene Delivery Vector†

article

Catalytic direct amidations in tert-butyl acetate using B(OCH2CF3)3

artículo científico publicado en 2019

Chemoenzymatic approaches to plant natural product inspired compounds

artículo científico publicado en 2022

Competition between photodetachment and autodetachment of the 2(1)ππ* state of the green fluorescent protein chromophore anion

artículo científico publicado en 2014

Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy.

artículo científico publicado en 2012

Data on a thermostable enzymatic one-pot reaction for the production of a high-value compound from l-arabinose

artículo científico publicado en 2018

Delivery of siRNA using ternary complexes containing branched cationic peptides: the role of peptide sequence, branching and targeting

artículo científico publicado en 2016

Design and Use of de novo Cascades for the Biosynthesis of New Benzylisoquinoline Alkaloids

artículo científico publicado en 2019

Design and synthesis of ferrocene probe molecules for detection by electrochemical methods

scientific article published on 01 September 2006

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

artículo científico publicado en 2017

Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes

artículo científico publicado en 2018

Directed evolution of biocatalytic processes

artículo científico publicado en 2005

Directed evolution of transketolase activity on non-phosphorylated substrates.

artículo científico publicado en 2007

Directed evolution to re-adapt a co-evolved network within an enzyme.

artículo científico publicado en 2011

Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents

scientific article published on 26 August 2019

Engineering stereoselectivity of ThDP-dependent enzymes

artículo científico

Enzymatic and Chemoenzymatic Three-Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines

artículo científico publicado en 2017

Enzymatic synthesis of chiral amino-alcohols by coupling transketolase and transaminase-catalyzed reactions in a cascading continuous-flow microreactor system.

artículo científico publicado en 2017

Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines.

artículo científico publicado en 2017

Functionalised tetrahydrofuran fragments from carbohydrates or sugar beet pulp biomass

article by Laure Benhamou et al published 2019 in Green Chemistry

Gene delivery using ternary lipopolyplexes incorporating branched cationic peptides: the role of Peptide sequence and branching.

artículo científico publicado en 2012

Gold catalysed synthesis of 3-alkoxyfurans at room temperature

artículo científico publicado en 2014

Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations.

artículo científico publicado en 2013

Highly stable cyclic dimers based on non-covalent interactions

scientific article published on 20 April 2006

Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging

artículo científico publicado en 2012

Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules.

artículo científico publicado en 2008

Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration ⬇️

artículo científico publicado el 12 de noviembre de 2010

Investigating the reaction mechanism and organocatalytic synthesis of α,α'-dihydroxy ketones

artículo científico publicado en 2012

Irreversible endo-selective diels-alder reactions of substituted alkoxyfurans: a general synthesis of endo-cantharimides

artículo científico publicado en 2015

Library of Norcoclaurine Synthases and Their Immobilization for Biocatalytic Transformations.

artículo científico publicado en 2017

Lipid chain geometry of C14 glycerol-based lipids: effect on lipoplex structure and transfection

artículo científico publicado en 2010

Lipopolyplex ternary delivery systems incorporating C14 glycerol-based lipids

artículo científico publicado en 2011

Mechanism of resonant electron emission from the deprotonated GFP chromophore and its biomimetics

artículo científico publicado en 2017

Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems.

artículo científico publicado en 2008

Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours

artículo científico publicado en 2020

Multi-step biocatalytic strategies for chiral amino alcohol synthesis

artículo científico publicado en 2015

Multifunctional receptor-targeted nanocomplexes for magnetic resonance imaging and transfection of tumours

artículo científico publicado en 2012

Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the brain

artículo científico publicado en 2013

Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.

artículo científico publicado en 2011

Non-α-hydroxylated aldehydes with evolved transketolase enzymes

artículo científico publicado en 2010

One-Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors

artículo científico publicado en 2017

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues

artículo científico publicado en 2018

One-pot synthesis of amino-alcohols using a de-novo transketolase and beta-alanine: pyruvate transaminase pathway in Escherichia coli.

artículo científico publicado en 2007

One-pot, two-step transaminase and transketolase synthesis of l-gluco-heptulose from l-arabinose

artículo científico publicado en 2018

Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids

artículo científico publicado en 2011

Prediction of size distribution of lipid-peptide-DNA vector particles using Monte Carlo simulation techniques.

artículo científico publicado en 2003

Quadruply hydrogen bonded cytosine modules for supramolecular applications

scientific article published on 01 May 2006

Rational substrate and enzyme engineering of transketolase for aromatics.

artículo científico publicado en 2012

Resonantly Enhanced Multiphoton Ionization Spectrum of the Neutral Green Fluorescent Protein Chromophore.

artículo científico publicado en 2014

Royal Society of Chemistry and The Biochemical Society's international symposium on functional genomics: from gene to commercial reality? September 19-22, 1999, Ambleside, UK.

artículo científico publicado en 2000

Second generation engineering of transketolase for polar aromatic aldehyde substrates.

artículo científico publicado en 2015

Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase

artículo científico publicado en 2015

Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell

artículo científico publicado en 2009

Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.

artículo científico publicado en 2016

Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase

artículo científico publicado en 2017

Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acid

artículo científico publicado en 2008

Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses.

artículo científico publicado en 2015

Synthesis and Characterization of Optically Active Surfactants Derived from Phenylalanine and Leucine

artículo científico publicado en 2001

Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

artículo científico publicado en 2014

TTC-based screening assay for ω-transaminases: a rapid method to detect reduction of 2-hydroxy ketones

artículo científico publicado en 2012

Targeted gene delivery to human airway epithelial cells with synthetic vectors incorporating novel targeting peptides selected by phage display

artículo científico publicado en 2004

Targeting lipopolyplexes using bifunctional peptides incorporating hydrophobic spacer amino acids: synthesis, transfection, and biophysical studies

artículo científico publicado en 2007

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.

artículo científico publicado en 2015

The Effect of Conjugation on the Competition between Internal Conversion and Electron Detachment: A Comparison between Green Fluorescent and Red Kaede Protein Chromophores.

artículo científico publicado en 2017

The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems

scientific article published on 01 January 2019

The fractal structure of polycation-DNA complexes.

artículo científico publicado en 2005

The identification and use of robust transaminases from a domestic drain metagenome

artículo científico publicado en 2018

The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells

artículo científico publicado en 2009

The selective functionalisation and difunctionalisation of p-substituted calix[6]arene and calix[8]arenes using hydrophilic moieties

scientific article published on 01 January 2003

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca

artículo científico publicado en 2014

Trichain cationic lipids: the potential of their lipoplexes for gene delivery

article

Tumor-specific gene transfer with receptor-mediated nanocomplexes modified by polyethylene glycol shielding and endosomally cleavable lipid and peptide linkers.

artículo científico publicado en 2010

Tunable Semiconducting Polymer Nanoparticles with INDT-Based Conjugated Polymers for Photoacoustic Molecular Imaging.

artículo científico publicado en 2017

Two steps in one pot: enzyme cascade for the synthesis of nor(pseudo)ephedrine from inexpensive starting materials

artículo científico publicado en 2013

ortho and para chromophores of green fluorescent protein: controlling electron emission and internal conversion.

artículo científico publicado en 2016

pET expression vector customized for efficient seamless cloning

artículo científico publicado en 2020

α, α -Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies Using Biocatalysts

α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes ⬇️

artículo científico publicado el 10 de septiembre de 2010

ω-Transaminases for the amination of functionalised cyclic ketones

artículo científico publicado en 2015

Lista de obras de Helen C Hailes

'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile

A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/ω-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol

A bicyclic -adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks

A colorimetric assay for screening transketolase activity.

A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase.

A toolbox approach for the rapid evaluation of multi-step enzymatic syntheses comprising a ‘mix and match’E. coliexpression system with microscale experimentation

Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

Aminopolyols from Carbohydrates: Amination of Sugars and Sugar-Derived Tetrahydrofurans with Transaminases

An automated microscale platform for evaluation and optimization of oxidative bioconversion processes

An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates

Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo.

Antimycobacterial calixarenes enhance innate defense mechanisms in murine macrophages and induce control of Mycobacterium tuberculosis infection in mice.

Applications of tailored ferrocenyl molecules as electrochemical probes of biochemical interactions

Asymmetric synthesis of dialkyloxy-3-alkylammonium cationic lipids.

Biomimetic Phosphate-Catalyzed Pictet-Spengler Reaction for the Synthesis of 1,1'-Disubstituted and Spiro-Tetrahydroisoquinoline Alkaloids

Biophysical Characterization of an Integrin-Targeted Lipopolyplex Gene Delivery Vector†

Catalytic direct amidations in tert-butyl acetate using B(OCH2CF3)3

Chemoenzymatic approaches to plant natural product inspired compounds

Competition between photodetachment and autodetachment of the 2(1)ππ* state of the green fluorescent protein chromophore anion

Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy.

Data on a thermostable enzymatic one-pot reaction for the production of a high-value compound from l-arabinose

Delivery of siRNA using ternary complexes containing branched cationic peptides: the role of peptide sequence, branching and targeting

Design and Use of de novo Cascades for the Biosynthesis of New Benzylisoquinoline Alkaloids

Design and synthesis of ferrocene probe molecules for detection by electrochemical methods

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes

Directed evolution of biocatalytic processes

Directed evolution of transketolase activity on non-phosphorylated substrates.

Directed evolution to re-adapt a co-evolved network within an enzyme.

Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents

Engineering stereoselectivity of ThDP-dependent enzymes

Enzymatic and Chemoenzymatic Three-Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines

Enzymatic synthesis of chiral amino-alcohols by coupling transketolase and transaminase-catalyzed reactions in a cascading continuous-flow microreactor system.

Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines.

Functionalised tetrahydrofuran fragments from carbohydrates or sugar beet pulp biomass

Gene delivery using ternary lipopolyplexes incorporating branched cationic peptides: the role of Peptide sequence and branching.

Gold catalysed synthesis of 3-alkoxyfurans at room temperature

Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations.

Highly stable cyclic dimers based on non-covalent interactions

Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging

Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules.

Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration ⬇️

Investigating the reaction mechanism and organocatalytic synthesis of α,α'-dihydroxy ketones

Irreversible endo-selective diels-alder reactions of substituted alkoxyfurans: a general synthesis of endo-cantharimides

Library of Norcoclaurine Synthases and Their Immobilization for Biocatalytic Transformations.

Lipid chain geometry of C14 glycerol-based lipids: effect on lipoplex structure and transfection

Lipopolyplex ternary delivery systems incorporating C14 glycerol-based lipids

Mechanism of resonant electron emission from the deprotonated GFP chromophore and its biomimetics

Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems.

Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours

Multi-step biocatalytic strategies for chiral amino alcohol synthesis

Multifunctional receptor-targeted nanocomplexes for magnetic resonance imaging and transfection of tumours

Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the brain

Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.

Non-α-hydroxylated aldehydes with evolved transketolase enzymes

One-Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues

One-pot synthesis of amino-alcohols using a de-novo transketolase and beta-alanine: pyruvate transaminase pathway in Escherichia coli.

One-pot, two-step transaminase and transketolase synthesis of l-gluco-heptulose from l-arabinose

Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids

Prediction of size distribution of lipid-peptide-DNA vector particles using Monte Carlo simulation techniques.

Quadruply hydrogen bonded cytosine modules for supramolecular applications

Rational substrate and enzyme engineering of transketolase for aromatics.

Resonantly Enhanced Multiphoton Ionization Spectrum of the Neutral Green Fluorescent Protein Chromophore.

Royal Society of Chemistry and The Biochemical Society's international symposium on functional genomics: from gene to commercial reality? September 19-22, 1999, Ambleside, UK.

Second generation engineering of transketolase for polar aromatic aldehyde substrates.

Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase

Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell

Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.

Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase

Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acid

Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses.

Synthesis and Characterization of Optically Active Surfactants Derived from Phenylalanine and Leucine

Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

TTC-based screening assay for ω-transaminases: a rapid method to detect reduction of 2-hydroxy ketones

Targeted gene delivery to human airway epithelial cells with synthetic vectors incorporating novel targeting peptides selected by phage display

Targeting lipopolyplexes using bifunctional peptides incorporating hydrophobic spacer amino acids: synthesis, transfection, and biophysical studies

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.

The Effect of Conjugation on the Competition between Internal Conversion and Electron Detachment: A Comparison between Green Fluorescent and Red Kaede Protein Chromophores.