Lista de obras - Lorella Pasquinucci - Dominio Público Uruguay

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects

artículo científico publicado en 2016

(+)-cis-N-Ethyleneamino-N-normetazocine Derivatives. Novel and Selective σ Ligands with Antagonist Properties ⬇️

artículo científico publicado el 7 de mayo de 1998

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

scientific article published on 18 February 2019

An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain.

artículo científico publicado en 2016

Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand

artículo científico publicado en 2012

Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.

artículo científico publicado en 2010

Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review

artículo científico publicado en 2018

Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review

artículo científico publicado en 2018

Bivalent opioid peptides synthesized from μ selective monomers display preferential selectivity for δ receptors

CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.

artículo científico publicado en 1995

Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity.

artículo científico publicado en 2013

Development of novel LP1-based analogues with enhanced delta opioid receptor profile.

artículo científico publicado en 2017

Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model.

artículo científico publicado en 2014

Evaluation of N-substituent structural variations in opioid receptor profile of LP1.

artículo científico publicado en 2016

Evaluation of N-substitution in 6,7-benzomorphan compounds.

artículo científico publicado en 2010

Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist

artículo científico publicado en 2020

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.

artículo científico publicado en 2018

In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations

artículo científico publicado en 2018

Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management

artículo científico publicado en 2016

Multitarget opioid ligands in pain relief: New players in an old game

artículo científico publicado en 2015

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

artículo científico publicado en 2016

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties

artículo científico publicado en 2011

Progress in the development of more effective and safer analgesics for pain management

artículo científico publicado en 2019

Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.

artículo científico publicado en 2017

Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles

artículo científico publicado en 2017

Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation

scientific article published on 25 January 2019

Specific kappa opioid receptor agonists.

artículo científico publicado en 2001

Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites

artículo científico publicado en 2000

Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

artículo científico publicado en 2018

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

artículo científico publicado en 2018

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.

artículo científico publicado en 2013

The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment

artículo científico publicado en 2011

The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures ⬇️

artículo científico publicado el 27 de marzo de 2013

Lista de obras de Lorella Pasquinucci

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects

(+)-cis-N-Ethyleneamino-N-normetazocine Derivatives. Novel and Selective σ Ligands with Antagonist Properties ⬇️

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain.

Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand

Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.

Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review

Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review

Bivalent opioid peptides synthesized from μ selective monomers display preferential selectivity for δ receptors

CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.

Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity.

Development of novel LP1-based analogues with enhanced delta opioid receptor profile.

Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model.

Evaluation of N-substituent structural variations in opioid receptor profile of LP1.

Evaluation of N-substitution in 6,7-benzomorphan compounds.

Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.

In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations

Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management

Multitarget opioid ligands in pain relief: New players in an old game

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties

Progress in the development of more effective and safer analgesics for pain management

Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.

Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles

Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation

Specific kappa opioid receptor agonists.

Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites

Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.

The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment

The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures ⬇️