Lista de obras - Ludwig Dubois - Dominio Público Uruguay

A longitudinal evaluation of partial lung irradiation in mice by using a dedicated image-guided small animal irradiator

artículo científico publicado en 2014

Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape

artículo científico publicado en 2020

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

artículo científico publicado en 2011

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

scientific article published on 01 December 2020

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

article

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

artículo científico publicado en 2018

Epigenetics in radiotherapy: where are we heading?

artículo científico publicado en 2014

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

artículo científico publicado en 2019

How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models

artículo científico publicado en 2015

Hypoxia PET Imaging with [18F]-HX4-A Promising Next-Generation Tracer

scientific article published on 22 May 2020

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

scientific article published on 18 May 2020

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

artículo científico publicado en 2019

Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response

artículo científico publicado en 2009

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

artículo científico publicado en 2009

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

artículo científico publicado en 2007

Immunotherapy as sensitizer for local radiotherapy

artículo científico publicado en 2020

Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance

artículo científico publicado en 2009

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

scientific article published on 01 December 2018

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

artículo científico publicado en 2013

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

artículo científico publicado en 2016

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

artículo científico publicado en 2021

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

artículo científico publicado en 2011

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

artículo científico publicado en 2009

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer ⬇️

artículo científico publicado en 2023

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

artículo científico publicado en 2014

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

artículo científico publicado en 2009

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses.

artículo científico publicado en 2018

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

artículo científico publicado en 2009

Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide

artículo científico publicado en 2020

Lista de obras de Ludwig Dubois

A longitudinal evaluation of partial lung irradiation in mice by using a dedicated image-guided small animal irradiator

Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Epigenetics in radiotherapy: where are we heading?

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models

Hypoxia PET Imaging with [18F]-HX4-A Promising Next-Generation Tracer

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

Immunotherapy as sensitizer for local radiotherapy

Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer ⬇️

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses.

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide