Lista de obras - Giuseppe Pappalardo - Dominio Público Uruguay

A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity

A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator.

artículo científico publicado en 2008

Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity.

artículo científico publicado en 2016

Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: a comparative study with two PEG-conjugated variants of the human sequence

artículo científico publicado en 2010

An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution

article

Antioxidant effect of copper(II) on photosensitized lipid peroxidation

scientific article published on 01 February 1995

Beta-amyloid monomers are neuroprotective.

artículo científico publicado en 2009

Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein

artículo científico publicado en 2011

Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.

artículo científico publicado en 2011

Copper(II) Interaction with Unstructured Prion Domain Outside the Octarepeat Region: Speciation, Stability, and Binding Details of Copper(II) Complexes with PrP106−126 Peptides

artículo científico publicado en 2005

Copper(II) binding modes in the prion octapeptide PHGGGWGQ: a spectroscopic and voltammetric study

scientific article published on 01 November 2000

Copper(II) binding to two novel histidine-containing model hexapeptides: evidence for a metal ion driven turn conformation.

artículo científico publicado en 2008

Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region

artículo científico publicado en 2004

Copper(II) complexes of rat amylin fragments.

artículo científico publicado en 2011

Copper(II) complexes with chicken prion repeats: influence of proline and tyrosine residues on the coordination features.

artículo científico publicado en 2005

Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new β-cyclodextrin conjugates

artículo científico publicado en 2012

Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details

scientific article published on 01 January 2007

Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

artículo científico publicado en 2016

Corrigendum: Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity

artículo científico publicado en 2016

Cross-talk between the octarepeat domain and the fifth binding site of prion protein driven by the interaction of copper(II) with the N-terminus

artículo científico publicado en 2015

Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy

artículo científico publicado en 2018

Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Abeta(1-42) fibrillogenesis and toxicity.

artículo científico publicado en 2009

Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore

artículo científico publicado en 2007

Environmental Effects on a Prion's Helix II Domain: Copper(II) and Membrane Interactions with PrP180–193 and Its Analogues

Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.

artículo científico publicado en 2016

Interaction of copper(II) with the prion peptide fragment HuPrP(76-114) encompassing four histidyl residues within and outside the octarepeat domain.

artículo científico publicado en 2009

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on Aβ1-40 peptide early assembly

artículo científico publicado en 2019

Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: the role of copper(II) ions, pH, and membrane mimicking environments.

artículo científico publicado en 2010

Metal ions affect insulin-degrading enzyme activity.

artículo científico publicado en 2012

Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein.

artículo científico publicado en 2012

Molecular and cytotoxic properties of hIAPP17–29 and rIAPP17–29 fragments: A comparative study with the respective full-length parent polypeptides

artículo científico publicado en 2014

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

artículo científico publicado en 2015

Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity.

artículo científico publicado en 2015

New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity

artículo científico publicado en 2016

New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway.

artículo científico publicado en 2017

Nickel(II) complexes of the multihistidine peptide fragments of human prion protein.

artículo científico publicado en 2010

Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region

scientific article published on 20 February 2007

On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides

artículo científico publicado en 2015

Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes

scientific article published on 31 May 2019

Prion proteins leading to neurodegeneration.

artículo científico publicado en 2008

Probing the residual structure in avian prion hexarepeats by CD, NMR and MD techniques.

artículo científico publicado en 2013

Repurposing of Copper(II)-chelating drugs for the treatment of neurodegenerative diseases.

artículo científico publicado en 2017

Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity.

artículo científico publicado en 2014

Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments

artículo científico publicado en 2008

Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films--effects on fibroblast spreading.

artículo científico publicado en 2009

The Metal Loading Ability of β-Amyloid N-Terminus: A Combined Potentiometric and Spectroscopic Study of Copper(II) Complexes with β-Amyloid(1−16), Its Short or Mutated Peptide Fragments, and Its Polyethylene Glycol (PEG)-ylated Analogue

artículo científico publicado en 2008

The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities

artículo científico publicado en 2015

The ability of the NiSOD binding loop to chelate zinc(ii): the role of the terminal amino group in the enzymatic functions

scientific article published on 01 May 2019

The interaction of a peptide with a scrambled hydrophobic/hydrophilic sequence (Pro-Asp-Ala-Asp-Ala-His-Ala-His-Ala-His-Ala-Ala-Ala-His-Gly) (PADH) with DPPC model membranes: a DSC study

Transition metal complexes of terminally protected peptides containing histidyl residues

artículo científico publicado en 2006

Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain

artículo científico publicado en 2008

Weak forces in the thermodynamic stereoselectivity of proton and copper(II) complexes with diastereoisomeric dipeptides containing aromatic side chains

Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of Aβ(1-16)-polyethylenglycol-ylated peptide: implications in Alzheimer's disease

artículo científico publicado en 2011

Lista de obras de Giuseppe Pappalardo

A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity

A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator.

Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity.

Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: a comparative study with two PEG-conjugated variants of the human sequence

An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution

Antioxidant effect of copper(II) on photosensitized lipid peroxidation

Beta-amyloid monomers are neuroprotective.

Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein

Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.

Copper(II) Interaction with Unstructured Prion Domain Outside the Octarepeat Region: Speciation, Stability, and Binding Details of Copper(II) Complexes with PrP106−126 Peptides

Copper(II) binding modes in the prion octapeptide PHGGGWGQ: a spectroscopic and voltammetric study

Copper(II) binding to two novel histidine-containing model hexapeptides: evidence for a metal ion driven turn conformation.

Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region

Copper(II) complexes of rat amylin fragments.

Copper(II) complexes with chicken prion repeats: influence of proline and tyrosine residues on the coordination features.

Copper(II) coordination properties of the integrin ligand sequence PHSRN and its new β-cyclodextrin conjugates

Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details

Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

Corrigendum: Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity

Cross-talk between the octarepeat domain and the fifth binding site of prion protein driven by the interaction of copper(II) with the N-terminus

Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy

Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Abeta(1-42) fibrillogenesis and toxicity.

Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore

Environmental Effects on a Prion's Helix II Domain: Copper(II) and Membrane Interactions with PrP180–193 and Its Analogues

Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.

Interaction of copper(II) with the prion peptide fragment HuPrP(76-114) encompassing four histidyl residues within and outside the octarepeat domain.

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on Aβ1-40 peptide early assembly

Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: the role of copper(II) ions, pH, and membrane mimicking environments.

Metal ions affect insulin-degrading enzyme activity.

Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein.

Molecular and cytotoxic properties of hIAPP17–29 and rIAPP17–29 fragments: A comparative study with the respective full-length parent polypeptides

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity.

New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity

New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway.

Nickel(II) complexes of the multihistidine peptide fragments of human prion protein.

Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region

On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides

Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes

Prion proteins leading to neurodegeneration.

Probing the residual structure in avian prion hexarepeats by CD, NMR and MD techniques.

Repurposing of Copper(II)-chelating drugs for the treatment of neurodegenerative diseases.

Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity.

Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments

Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films--effects on fibroblast spreading.

The Metal Loading Ability of β-Amyloid N-Terminus: A Combined Potentiometric and Spectroscopic Study of Copper(II) Complexes with β-Amyloid(1−16), Its Short or Mutated Peptide Fragments, and Its Polyethylene Glycol (PEG)-ylated Analogue

The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities

The ability of the NiSOD binding loop to chelate zinc(ii): the role of the terminal amino group in the enzymatic functions

The interaction of a peptide with a scrambled hydrophobic/hydrophilic sequence (Pro-Asp-Ala-Asp-Ala-His-Ala-His-Ala-His-Ala-Ala-Ala-His-Gly) (PADH) with DPPC model membranes: a DSC study

Transition metal complexes of terminally protected peptides containing histidyl residues

Unveiling the role of histidine and tyrosine residues on the conformation of the avian prion hexarepeat domain

Weak forces in the thermodynamic stereoselectivity of proton and copper(II) complexes with diastereoisomeric dipeptides containing aromatic side chains

Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of Aβ(1-16)-polyethylenglycol-ylated peptide: implications in Alzheimer's disease