Lista de obras -

A conserved splicing mechanism of the LMNA gene controls premature aging.

artículo científico publicado en 2011

A functional link between the tumour suppressors ARF and p33ING1.

artículo científico publicado en 2006

A gene homologous to topoisomerase II in African swine fever virus.

artículo científico publicado en 1992

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

artículo científico publicado en 2005

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

artículo científico publicado en 2011

An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.

artículo científico publicado en 2000

AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.

artículo científico publicado en 2003

Autophagy is essential for mouse sense of balance

artículo científico publicado en 2010

Cell autonomous and systemic factors in progeria development

artículo científico publicado en 2011

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

artículo científico publicado en 2008

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

artículo científico publicado en 2009

Detection of nuclear envelope alterations in senescence

artículo científico publicado en 2013

Deubiquitinases in cancer: new functions and therapeutic options.

artículo científico

Deubiquitination in cancer stem cells.

artículo científico publicado en 2017

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

scientific article published on 18 February 2019

Evaluation of some newer matrix metalloproteinases

artículo científico publicado en 1999

Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome

artículo científico publicado en 2011

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

artículo científico publicado en 2011

From immature lamin to premature aging: molecular pathways and therapeutic opportunities.

artículo científico publicado en 2005

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

artículo científico publicado en 2013

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

artículo científico publicado en 2011

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

artículo científico publicado en 2019

High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus.

artículo científico publicado en 1993

Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues

artículo científico publicado en 1991

Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes

artículo científico publicado en 1993

Identification of compounds with preferential inhibitory activity against low-Nm23-expressing human breast carcinoma and melanoma cell lines

artículo científico publicado en 1997

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

artículo científico publicado en 2003

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

artículo científico publicado en 2010

Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

artículo científico publicado en 2016

Lamins, guardians of the soma and the genome

artículo científico publicado en 2011

Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization.

artículo científico publicado en 1993

Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.

artículo científico publicado en 2015

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

artículo científico publicado en 2005

Loss of the Deubiquitinase USP36 Destabilizes the RNA Helicase DHX33 and Causes Preimplantation Lethality in Mice

artículo científico publicado en 2017

Mapping and sequence of the gene coding for protein p72, the major capsid protein of African swine fever virus.

artículo científico publicado en 1990

Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses

scientific article published on 01 July 2018

Metabolic Control of Longevity.

artículo científico publicado en 2016

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

scientific article published on 01 August 2018

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.

artículo científico publicado en 2008

Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain) ⬇️

artículo científico publicado el 17 de mayo de 2013

NF-κB signaling as a driver of ageing.

artículo científico publicado en 2016

Nm23/PuF does not directly stimulate transcription through the CT element in vivo

artículo científico publicado en 1997

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.

artículo científico publicado en 2014

Predict7, a program for protein structure prediction.

artículo científico publicado en 1989

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

scientific article published on January 2013

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

artículo científico publicado en 2008

Protease Silencing to Explore the Molecular Mechanisms of Cancer and Aging.

artículo científico publicado en 2018

Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.

artículo científico publicado en 2004

Reprogramming aging and progeria.

artículo científico

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

article

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis.

artículo científico publicado en 2016

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function

scientific article published on 22 October 2018

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

artículo científico publicado en 2017

Lista de obras de

A conserved splicing mechanism of the LMNA gene controls premature aging.

A functional link between the tumour suppressors ARF and p33ING1.

A gene homologous to topoisomerase II in African swine fever virus.

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.

AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.

Autophagy is essential for mouse sense of balance

Cell autonomous and systemic factors in progeria development

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

Detection of nuclear envelope alterations in senescence

Deubiquitinases in cancer: new functions and therapeutic options.

Deubiquitination in cancer stem cells.

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

Evaluation of some newer matrix metalloproteinases

Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

From immature lamin to premature aging: molecular pathways and therapeutic opportunities.

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus.

Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues

Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes

Identification of compounds with preferential inhibitory activity against low-Nm23-expressing human breast carcinoma and melanoma cell lines

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

Lamins, guardians of the soma and the genome

Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization.

Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

Loss of the Deubiquitinase USP36 Destabilizes the RNA Helicase DHX33 and Causes Preimplantation Lethality in Mice

Mapping and sequence of the gene coding for protein p72, the major capsid protein of African swine fever virus.

Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses

Metabolic Control of Longevity.

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.

Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain) ⬇️

NF-κB signaling as a driver of ageing.

Nm23/PuF does not directly stimulate transcription through the CT element in vivo

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.

Predict7, a program for protein structure prediction.

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

Protease Silencing to Explore the Molecular Mechanisms of Cancer and Aging.

Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.

Reprogramming aging and progeria.

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis.

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.