Lista de obras - Raphaël Frédérick - Dominio Público Uruguay

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio

artículo científico publicado en 2018

31ièmes Journées Franco-Belges de Pharmacochimie: Meeting Report

artículo científico publicado en 2017

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

artículo científico publicado en 2019

Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities

artículo científico publicado en 2017

Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy

artículo científico publicado en 2016

Computational tools for in silico fragment-based drug design.

artículo científico publicado en 2012

Coumarin and isocoumarin as serine protease inhibitors.

artículo científico publicado en 2004

Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review

scientific article published on 16 January 2019

Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.

artículo científico publicado en 2010

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors ⬇️

artículo científico publicado el 26 de febrero de 2011

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.

artículo científico publicado en 2011

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.

artículo científico publicado en 2010

Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008 - 2012).

artículo científico

Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.

artículo científico publicado en 2012

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides

scientific article published on 06 April 2020

Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics

artículo científico publicado en 2016

Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket.

artículo científico publicado en 2006

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

scientific journal article

Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors

artículo científico publicado en 2008

Mechanism-based thrombin inhibitors: design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative

artículo científico publicado en 2007

Modulators of the coagulation cascade: focus and recent advances in inhibitors of tissue factor, factor VIIa and their complex.

artículo científico publicado en 2005

NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening.

artículo científico publicado en 2010

New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.

artículo científico publicado en 2012

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR ⬇️

artículo científico publicado el 25 de noviembre de 2011

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

artículo científico publicado en 2012

Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells

artículo científico publicado en 2021

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

artículo científico publicado en 2009

Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation

artículo científico publicado en 2010

Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors

artículo científico publicado en 2017

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

artículo científico publicado en 2012

Synthesis and In Vitro Evaluation of Polyethylene Glycol-Paclitaxel Conjugates for Lung Cancer Therapy

artículo científico publicado en 2016

Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors.

artículo científico publicado en 2015

Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

artículo científico publicado en 2011

Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors

scientific article published on 25 November 2010

Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives

scientific article published on 08 October 2011

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

artículo científico publicado en 2007

Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles ⬇️

artículo científico publicado el 3 de mayo de 2012

Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

artículo científico publicado en 2016

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core

artículo científico publicado en 2006

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties

artículo científico publicado en 2014

Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors.

artículo científico publicado en 2004

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators ⬇️

artículo científico publicado el 18 de julio de 2011

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).

artículo científico publicado en 2017

Lista de obras de Raphaël Frédérick

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio

31ièmes Journées Franco-Belges de Pharmacochimie: Meeting Report

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities

Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy

Computational tools for in silico fragment-based drug design.

Coumarin and isocoumarin as serine protease inhibitors.

Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review

Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors ⬇️

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.

Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008 - 2012).

Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides

Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics

Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket.

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors

Mechanism-based thrombin inhibitors: design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative

Modulators of the coagulation cascade: focus and recent advances in inhibitors of tissue factor, factor VIIa and their complex.

NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening.

New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR ⬇️

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation

Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Synthesis and In Vitro Evaluation of Polyethylene Glycol-Paclitaxel Conjugates for Lung Cancer Therapy

Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors.

Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors

Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles ⬇️

Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties

Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors.

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators ⬇️

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).