Lista de obras - Bernard Le Bonniec - Dominio Público Uruguay

A motif within the N-terminal domain of TSP-1 specifically promotes the proangiogenic activity of endothelial colony-forming cells

artículo científico publicado en 2012

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

artículo científico publicado en 2015

Characterization of the P2' and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis

artículo científico publicado en 1996

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes

artículo científico publicado en 2003

Contribution of interactions with the core domain of hirudin to the stability of its complex with thrombin.

artículo científico publicado en 1994

Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans

artículo científico publicado en 2005

Determination of the P1', P2' and P3' subsite-specificity of factor Xa.

artículo científico publicado en 2003

Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I

scientific article published on 01 April 2001

Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model.

artículo científico publicado en 2012

Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis.

artículo científico publicado en 2013

Functional identification of t-PA in crude and purified systems

artículo científico publicado en 1988

Gestational age-related patterns of AMOT methylation are revealed in preterm infant endothelial progenitors

artículo científico publicado en 2017

Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.

artículo científico publicado en 1994

Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin

artículo científico publicado en 1995

Inherited factor VII deficiency: identification of two novel mutations (A191V and T239P) in the catalytic domain.

artículo científico publicado en 2004

Inhibitory mechanism of serpins. Identification of steps involving the active-site serine residue of the protease

scientific article published on 01 January 1997

Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin ⬇️

artículo científico publicado el 25 de septiembre de 1992

Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I

scientific article published on 01 June 1997

Large-Scale Chromatin Immunoprecipitation with Promoter Sequence Microarray Analysis of the Interaction of the NSs Protein of Rift Valley Fever Virus with Regulatory DNA Regions of the Host Genome ⬇️

artículo científico publicado el 15 de agosto de 2012

Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of factor X and prothrombin

artículo científico publicado el 1 de marzo de 1998

Low molecular weight fucoidan and heparin enhance the basic fibroblast growth factor-induced tube formation of endothelial cells through heparan sulfate-dependent alpha6 overexpression.

artículo científico publicado en 2003

Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates.

artículo científico publicado en 2002

Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis

artículo científico publicado en 1994

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

artículo científico publicado en 2002

Multimodal assessment of non-specific hemostatic agents for apixaban reversal

artículo científico publicado en 2015

Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin.

artículo científico publicado en 2006

Protein C activation.

artículo científico publicado en 1993

Proteolytic derivatives of thrombin

artículo científico publicado en 1986

Pulsed cavitational therapy using high-frequency ultrasound for the treatment of deep vein thrombosis in an in vitro model of human blood clot

artículo científico publicado en 2017

Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit

artículo científico publicado en 2012

Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel

artículo científico publicado en 2010

Role of the P2 residue in determining the specificity of serpins

artículo científico publicado en 1996

The VKOR target for warfarin identified

artículo científico publicado en 2004

The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1

artículo científico publicado en 2001

The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions.

artículo científico publicado en 2003

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

artículo científico publicado en 2004

The response to thrombin of human neutrophils: evidence for two novel receptors

scientific article published on 01 September 1995

The role of Glu(192) in the allosteric control of the S(2)' and S(3)' subsites of thrombin

artículo científico publicado en 2000

The role of calcium ions in factor X activation by thrombin E192Q

scientific article published on 01 April 1992

The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors

artículo científico publicado en 1993

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

artículo científico publicado en 1997

Thrombin Glu-39 restricts the P'3 specificity to nonacidic residues

artículo científico publicado en 1991

Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells

artículo científico publicado en 2008

Thrombin generation test: A reliable tool to evaluate the pharmacodynamics of vitamin K antagonist rodenticides in rats

artículo científico publicado en 2018

Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas.

artículo científico publicado en 2005

Thrombomodulin modulates the mitogenic response to thrombin of human umbilical vein endothelial cells

scientific article published on 01 April 1998

Ticagrelor reversal: in vitro assessment of four haemostatic agents

artículo científico publicado en 2017

Topology of the stable serpin-protease complexes revealed by an autoantibody that fails to react with the monomeric conformers of antithrombin

artículo científico publicado en 1999

Lista de obras de Bernard Le Bonniec

A motif within the N-terminal domain of TSP-1 specifically promotes the proangiogenic activity of endothelial colony-forming cells

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

Characterization of the P2' and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes

Contribution of interactions with the core domain of hirudin to the stability of its complex with thrombin.

Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans

Determination of the P1', P2' and P3' subsite-specificity of factor Xa.

Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I

Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model.

Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis.

Functional identification of t-PA in crude and purified systems

Gestational age-related patterns of AMOT methylation are revealed in preterm infant endothelial progenitors

Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.

Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin

Inherited factor VII deficiency: identification of two novel mutations (A191V and T239P) in the catalytic domain.

Inhibitory mechanism of serpins. Identification of steps involving the active-site serine residue of the protease

Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin ⬇️

Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I

Large-Scale Chromatin Immunoprecipitation with Promoter Sequence Microarray Analysis of the Interaction of the NSs Protein of Rift Valley Fever Virus with Regulatory DNA Regions of the Host Genome ⬇️

Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of factor X and prothrombin

Low molecular weight fucoidan and heparin enhance the basic fibroblast growth factor-induced tube formation of endothelial cells through heparan sulfate-dependent alpha6 overexpression.

Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates.

Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

Multimodal assessment of non-specific hemostatic agents for apixaban reversal

Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin.

Protein C activation.

Proteolytic derivatives of thrombin

Pulsed cavitational therapy using high-frequency ultrasound for the treatment of deep vein thrombosis in an in vitro model of human blood clot

Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit

Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel

Role of the P2 residue in determining the specificity of serpins

The VKOR target for warfarin identified

The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1

The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions.

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

The response to thrombin of human neutrophils: evidence for two novel receptors

The role of Glu(192) in the allosteric control of the S(2)' and S(3)' subsites of thrombin

The role of calcium ions in factor X activation by thrombin E192Q

The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

Thrombin Glu-39 restricts the P'3 specificity to nonacidic residues

Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells

Thrombin generation test: A reliable tool to evaluate the pharmacodynamics of vitamin K antagonist rodenticides in rats

Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas.

Thrombomodulin modulates the mitogenic response to thrombin of human umbilical vein endothelial cells

Ticagrelor reversal: in vitro assessment of four haemostatic agents

Topology of the stable serpin-protease complexes revealed by an autoantibody that fails to react with the monomeric conformers of antithrombin