Lista de obras - René de Waal Malefyt - Dominio Público Uruguay

A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.

artículo científico publicado en 2006

A clinical biomarker assay to quantitate thymic stromal lymphopoietin in human plasma at sub-pg/ml level.

artículo científico publicado en 2015

Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice

artículo científico publicado en 2014

Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys

artículo científico publicado en 1995

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

artículo científico publicado en 1993

Biological properties of interleukin 10

scientific article published on 01 July 1992

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease

artículo científico publicado en 2012

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Non-Human Primates of the Anti-PD-1 Antibody Pembrolizumab

artículo científico publicado en 2020

CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes.

artículo científico publicado en 1993

Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells

artículo científico publicado en 2001

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

artículo científico publicado en 2009

Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3

artículo científico publicado en 1991

Co-stimulation of T cells results in distinct IL-10 and TNF-α cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3

artículo científico publicado en 1999

Correction: Defining the Roles of IFN-γ and IL-17A in Inflammation and Protection against Helicobacter pylori Infection

artículo científico publicado en 2015

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

artículo científico publicado en 2007

Development and function of TH17 cells in health and disease

artículo científico publicado en 2009

Development, cytokine profile and function of human interleukin 17-producing helper T cells

artículo científico publicado en 2007

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis ⬇️

artículo científico publicado el 11 de febrero de 2011

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

artículo científico publicado en 2006

Do human TH1 and TH2 CD4+ clones exist? ⬇️

artículo científico publicado el 1 de enero de 1991

Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen-induced late phase cutaneous responses in atopic subjects

article

Effects of interleukin 4 on monocyte functions: comparison to interleukin 13.

artículo científico publicado en 1993

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.

artículo científico

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis.

artículo científico publicado en 2013

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction

artículo científico publicado en 2018

Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization.

artículo científico publicado en 2004

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

artículo científico publicado en 2008

Functional characterization of human IL-10.

artículo científico publicado en 1992

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells

artículo científico publicado en 2010

Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells

scientific article published on 03 February 2014

Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine

scientific journal article

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

artículo científico publicado en 1994

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

artículo científico publicado en 2004

Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage

artículo científico publicado en 2010

Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells

artículo científico publicado en 2003

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

artículo científico publicado en 2002

Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

artículo científico publicado en 2004

IL-12 and IL-23: master regulators of innate and adaptive immunity.

artículo científico publicado en 2004

IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones

artículo científico publicado en 1994

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand ⬇️

artículo científico publicado el 1 de junio de 1993

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

artículo científico publicado en 2017

IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis

artículo científico publicado en 2014

IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

artículo científico publicado en 2000

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

artículo científico publicado en 2016

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

artículo científico publicado en 2006

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells ⬇️

artículo científico publicado el 1 de septiembre de 2003

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

artículo científico publicado en 2009

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

artículo científico publicado en 2002

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

artículo científico publicado en 2015

In contrast to their murine counterparts, normal human keratinocytes and human epidermoid cell lines A431 and HaCaT fail to express IL-10 mRNA and protein

scientific article published on 01 January 1997

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

artículo científico publicado en 2002

Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13

artículo científico publicado en 2004

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

artículo científico publicado en 1992

Interleukin 10 inhibits transforming growth factor-beta (TGF-beta) synthesis required for osteogenic commitment of mouse bone marrow cells.

artículo científico publicado en 1994

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

artículo científico publicado en 1993

Interleukin-10

artículo científico publicado en 1993

Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.

artículo científico publicado en 1997

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice

artículo científico publicado en 2008

Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

artículo científico publicado en 1998

Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products

artículo científico publicado en 2011

Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells.

artículo científico publicado en 2004

Modelling asthma in macaques: longitudinal changes in cellular and molecular markers

artículo científico publicado en 2010

Molecular regulation of Th2 immunity by dendritic cells.

artículo científico publicado en 2004

Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells

scientific article published on 01 December 1994

Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice.

artículo científico publicado en 2014

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

artículo científico publicado en 2009

Pulmonary arterial remodeling induced by a Th2 immune response

artículo científico publicado en 2008

Reciprocal control of T helper cell and dendritic cell differentiation

scientific article published on 01 February 1999

Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10

scientific article published on 01 July 2001

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

artículo científico publicado en 2010

The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains

artículo científico publicado en 2004

The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).

artículo científico publicado en 2002

Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.

artículo científico publicado en 2013

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

artículo científico publicado en 2004

Lista de obras de René de Waal Malefyt

A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.

A clinical biomarker assay to quantitate thymic stromal lymphopoietin in human plasma at sub-pg/ml level.

Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice

Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

Biological properties of interleukin 10

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Non-Human Primates of the Anti-PD-1 Antibody Pembrolizumab

CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes.

Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3

Co-stimulation of T cells results in distinct IL-10 and TNF-α cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3

Correction: Defining the Roles of IFN-γ and IL-17A in Inflammation and Protection against Helicobacter pylori Infection

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

Development and function of TH17 cells in health and disease

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis ⬇️

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

Do human TH1 and TH2 CD4+ clones exist? ⬇️

Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen-induced late phase cutaneous responses in atopic subjects

Effects of interleukin 4 on monocyte functions: comparison to interleukin 13.

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis.

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction

Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization.

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

Functional characterization of human IL-10.

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells

Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells

Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage

Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

IL-12 and IL-23: master regulators of innate and adaptive immunity.

IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand ⬇️

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis

IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells ⬇️

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

In contrast to their murine counterparts, normal human keratinocytes and human epidermoid cell lines A431 and HaCaT fail to express IL-10 mRNA and protein

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

Interleukin 10 inhibits transforming growth factor-beta (TGF-beta) synthesis required for osteogenic commitment of mouse bone marrow cells.

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

Interleukin-10

Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice

Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products

Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells.

Modelling asthma in macaques: longitudinal changes in cellular and molecular markers

Molecular regulation of Th2 immunity by dendritic cells.

Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells

Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice.

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

Pulmonary arterial remodeling induced by a Th2 immune response

Reciprocal control of T helper cell and dendritic cell differentiation

Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains

The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).

Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27