Lista de obras - Patrick Dansette - Dominio Público Uruguay

A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties

artículo científico publicado en 2017

A new intermediate in naphthoquinone and menaquinone biosynthesis

article

Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression

scientific article published on 16 October 2019

Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.

artículo científico publicado en 1996

Assay and partial purification of epoxide hydrase from rat liver microsomes

article

Automated multiple analysis of protein structures: application to homology modeling of cytochromes P450.

artículo científico publicado en 1997

Bioactivation of clopidogrel and prasugrel: factors determining the stereochemistry of the thiol metabolite double bond.

artículo científico publicado en 2015

Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin ⬇️

artículo científico publicado el 1 de enero de 1976

Comparison of the Substrate Specificities of Human Liver Cytochrome P450s 2C9 and 2C18: Application to the Design of a Specific Substrate of CYP 2C18

artículo científico publicado en 1999

Continuous fluorometric assay of epoxide hydrase activity

article

Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.

artículo científico publicado en 2011

Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions

artículo científico publicado en 2008

Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID

artículo científico publicado en 2008

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

artículo científico publicado en 1999

Effect of purified epoxide hydrolase on metabolic activa-tion and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway

artículo científico publicado en 1980

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography ⬇️

artículo científico publicado el 1 de noviembre de 1974

Endogenous induction of epoxide hydrolase, benzo(a)pyrene hydroxylase and glutathione-S-transferase in “responsive” C57B16 mice and in “nonresponsive” DBA2 mice during pregnancy

artículo científico publicado en 1983

Enzymatic characterization of the polynuclear aromatic hydrocarbons activating rat-liver preparations used in the mutagenicity test of Ames ⬇️

artículo científico publicado el 1 de febrero de 1984

Epoxide hydrase and glutathione S-transferase activities with selected alkene and arene oxides in several marine species ⬇️

artículo científico publicado el 1 de mayo de 1979

Evaluation of Deuterium Labeled and Unlabeled Bis-methyl Glutathione Combined with Nanoliquid Chromatography−Mass Spectrometry to Screen and Characterize Reactive Drug Metabolites

scientific article published on 04 March 2011

Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid

artículo científico publicado el 14 de agosto de 1992

Facile synthesis of arene oxides at the K regions of polycyclic hydrocarbons ⬇️

artículo científico publicado el 20 de febrero de 1974

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation

artículo científico publicado en 2016

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

artículo científico publicado en 2009

First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives.

artículo científico publicado en 2005

Human Anti-Mitochondria Autoantibodies Appearing in Iproniazid-Induced Immunoallergic Hepatitis Recognize Human Liver Monoamine Oxidase B

artículo científico publicado en 1996

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

artículo científico publicado en 1987

Hydroxylation of the thiophene ring by hepatic monooxygenases

artículo científico publicado en 1990

In vitro metabolism of isaxonine phosphate: formation of two metabolites, 5-hydroxyisaxonine and 2-aminopyrimidine, and covalent binding to microsomal proteins.

artículo científico publicado en 1992

In vivo administration of hydroxylated phenobarbital metabolites: effect on rat hepatic cytochromes P-450, epoxide hydrolase and udp-glucuronosyltransferase

artículo científico publicado en 1980

Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.

artículo científico publicado en 2001

Induction of drug metabolizing enzymes in the liver of diabetic mice.

artículo científico publicado en 1982

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

artículo científico publicado en 2017

Iron-porphyrin catalysis of the oxidative dealkylation of para-nitro-anisole and 7-ethoxycoumarin by cumylhydroperoxide: a possible model for the corresponding cytochrome P 450-dependent reactions

article

Lack of effect of trichloropropene oxide on benzo(a)pyrene tumor-initiating activity on mouse skin

artículo científico publicado el 1 de enero de 1979

Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes

artículo científico publicado en 2019

Mechanism of catalysis for the hydration of substituted styrene oxides by hepatic epoxide hydrase

artículo científico publicado en 1978

Membrane fluidity and drug metabolism in liver microsomes of lean, ob/ob and db/db mice.

artículo científico publicado en 1980

Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring

scientific article published on 18 April 2012

Metabolic hydroxylation of the thiophene ring: Isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat

scientific article published on 01 May 1984

Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways

scientific article published on 17 July 2018

Metabolism of benzo[a]pyrene by brain microsomes of fetal and adult rats and mice. Induction by 5,6 benzoflavone, comparison with liver and lung microsomal activities

article

Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols ⬇️

artículo científico publicado el 1 de agosto de 1975

Opposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two Compounds

Oxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9

article

Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.

artículo científico publicado en 1990

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

artículo científico publicado en 2015

Partial purification of human liver cytochrome P 450 ⬇️

artículo científico publicado el 13 de junio de 1979

Presence of benzo[a]pyrene metabolizing activities in isolated rat liver nucleoli

artículo científico publicado en 1981

Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2

scholarly article by Pierre Lafite published in July 2018

Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.

artículo científico publicado en 2007

Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.

artículo científico publicado en 2003

Sulfenic acids as reactive intermediates in xenobiotic metabolism ⬇️

artículo científico publicado el 1 de marzo de 2011

Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.

artículo científico publicado en 2001

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

article

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study†

artículo científico publicado en 1997

The effect of some mixed function oxidase inducers on aryl hẏdrocarbon hydroxylase and epoxide hydrase in nuclei and microsomes from rat liver and lung. The effect of cigarette smoke ⬇️

artículo científico publicado el 1 de junio de 1979

The end product of transglutaminase crosslinking: simultaneous quantitation of [Nepsilon-(gamma-glutamyl) lysine] and lysine by HPLC-MS3.

artículo científico publicado en 2008

The shikimate pathway : II. Stereospecificity of hydrogen transfer catalyzed by NADPH-dehydroshikimate reductase of E. coli.

artículo científico publicado en 1974

The shikimate pathway. I. Preparation of 3-3H, 4-3H and 2,4-3H2 D-shikimic acid.

artículo científico publicado en 1973

UPD-glucuronosyltransferase, epoxide hydrolase and gultathione S-transferase

artículo científico publicado en 1981

Unusual regioselectivity and active site topology of human cytochrome P450 2J2

artículo científico publicado en 2007

Lista de obras de Patrick Dansette

A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties

A new intermediate in naphthoquinone and menaquinone biosynthesis

Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression

Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.

Assay and partial purification of epoxide hydrase from rat liver microsomes

Automated multiple analysis of protein structures: application to homology modeling of cytochromes P450.

Bioactivation of clopidogrel and prasugrel: factors determining the stereochemistry of the thiol metabolite double bond.

Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin ⬇️

Comparison of the Substrate Specificities of Human Liver Cytochrome P450s 2C9 and 2C18: Application to the Design of a Specific Substrate of CYP 2C18

Continuous fluorometric assay of epoxide hydrase activity

Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.

Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions

Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

Effect of purified epoxide hydrolase on metabolic activa-tion and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography ⬇️

Endogenous induction of epoxide hydrolase, benzo(a)pyrene hydroxylase and glutathione-S-transferase in “responsive” C57B16 mice and in “nonresponsive” DBA2 mice during pregnancy

Enzymatic characterization of the polynuclear aromatic hydrocarbons activating rat-liver preparations used in the mutagenicity test of Ames ⬇️

Epoxide hydrase and glutathione S-transferase activities with selected alkene and arene oxides in several marine species ⬇️

Evaluation of Deuterium Labeled and Unlabeled Bis-methyl Glutathione Combined with Nanoliquid Chromatography−Mass Spectrometry to Screen and Characterize Reactive Drug Metabolites

Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid

Facile synthesis of arene oxides at the K regions of polycyclic hydrocarbons ⬇️

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives.

Human Anti-Mitochondria Autoantibodies Appearing in Iproniazid-Induced Immunoallergic Hepatitis Recognize Human Liver Monoamine Oxidase B

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

Hydroxylation of the thiophene ring by hepatic monooxygenases

In vitro metabolism of isaxonine phosphate: formation of two metabolites, 5-hydroxyisaxonine and 2-aminopyrimidine, and covalent binding to microsomal proteins.

In vivo administration of hydroxylated phenobarbital metabolites: effect on rat hepatic cytochromes P-450, epoxide hydrolase and udp-glucuronosyltransferase

Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.

Induction of drug metabolizing enzymes in the liver of diabetic mice.

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

Iron-porphyrin catalysis of the oxidative dealkylation of para-nitro-anisole and 7-ethoxycoumarin by cumylhydroperoxide: a possible model for the corresponding cytochrome P 450-dependent reactions

Lack of effect of trichloropropene oxide on benzo(a)pyrene tumor-initiating activity on mouse skin

Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes

Mechanism of catalysis for the hydration of substituted styrene oxides by hepatic epoxide hydrase

Membrane fluidity and drug metabolism in liver microsomes of lean, ob/ob and db/db mice.

Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring

Metabolic hydroxylation of the thiophene ring: Isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat

Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways

Metabolism of benzo[a]pyrene by brain microsomes of fetal and adult rats and mice. Induction by 5,6 benzoflavone, comparison with liver and lung microsomal activities

Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols ⬇️

Opposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two Compounds

Oxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9

Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

Partial purification of human liver cytochrome P 450 ⬇️

Presence of benzo[a]pyrene metabolizing activities in isolated rat liver nucleoli

Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2

Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.

Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.

Sulfenic acids as reactive intermediates in xenobiotic metabolism ⬇️

Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study†

The effect of some mixed function oxidase inducers on aryl hẏdrocarbon hydroxylase and epoxide hydrase in nuclei and microsomes from rat liver and lung. The effect of cigarette smoke ⬇️

The end product of transglutaminase crosslinking: simultaneous quantitation of [Nepsilon-(gamma-glutamyl) lysine] and lysine by HPLC-MS3.

The shikimate pathway : II. Stereospecificity of hydrogen transfer catalyzed by NADPH-dehydroshikimate reductase of E. coli.

The shikimate pathway. I. Preparation of 3-3H, 4-3H and 2,4-3H2 D-shikimic acid.

UPD-glucuronosyltransferase, epoxide hydrolase and gultathione S-transferase

Unusual regioselectivity and active site topology of human cytochrome P450 2J2