Lista de obras - Danyel G.J. Jennen - Dominio Público Uruguay

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

artículo científico publicado en 2012

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure

artículo científico publicado en 2016

A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo ⬇️

artículo científico publicado el 23 de mayo de 2012

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

artículo científico publicado en 2016

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

artículo científico publicado en 2011

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

artículo científico publicado en 2017

Assessing compound carcinogenicity in vitro using connectivity mapping

artículo científico publicado en 2013

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes

artículo científico publicado en 2009

Association of the FADS2 gene with omega-6 and omega-3 PUFA Concentration in the egg yolk of Japanese quail

artículo científico publicado en 2007

Bayesian Network Inference Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans

artículo científico publicado en 2015

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes

artículo científico publicado en 2010

Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?

artículo científico publicado en 2014

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

artículo científico publicado en 2010

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells ⬇️

artículo científico publicado el 1 de junio de 2011

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds

artículo científico publicado en 2016

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time

artículo científico publicado en 2009

Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens

artículo científico publicado en 2015

Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks

artículo científico publicado en 2017

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

scientific article published on 27 June 2019

ELIXIR and Toxicology: a community in development

artículo científico publicado en 2023

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury

article

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

artículo científico publicado en 2014

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity

artículo científico publicado en 2016

Expression of the prion protein gene (PRNP) and cellular prion protein (PrPc) in cattle and sheep fetuses and maternal tissues during pregnancy.

artículo científico publicado en 2007

Gender-specific transcriptomic response to environmental exposure in Flemish adults

artículo científico publicado en 2013

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

scientific article published on 27 August 2019

Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics

artículo científico publicado en 2017

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

artículo científico publicado en 2015

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

artículo científico publicado en 2015

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

artículo científico publicado en 2011

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

artículo científico publicado en 2016

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

artículo científico publicado en 2017

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

artículo científico publicado en 2015

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis

artículo científico

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis

artículo científico publicado en 2016

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids

artículo científico publicado en 2021

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate

artículo científico publicado en 2021

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking ⬇️

artículo científico publicado en 2016

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study

artículo científico publicado en 2015

Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity

artículo científico publicado en 2012

Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study

artículo científico publicado en 2016

QTL for the heritable inverted teat defect in pigs.

artículo científico publicado en 2008

ROS networks: designs, aging, Parkinson's disease and precision therapies

artículo científico publicado en 2020

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

artículo científico publicado en 2015

Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women.

artículo científico publicado en 2016

Time series analysis of oxidative stress response patterns in HepG2: A toxicogenomics approach ⬇️

artículo científico publicado el 11 de febrero de 2013

Transcriptomic and metabolomic data integration

artículo científico publicado en 2015

Translational Proteomics Analysis of Anthracycline-Induced Cardiotoxicity From Cardiac Microtissues to Human Heart Biopsies

artículo científico publicado en 2021

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

scientific article published on 11 August 2020

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.

artículo científico

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.

artículo científico publicado en 2011

Xenobiotic metabolism in differentiated human bronchial epithelial cells

artículo científico publicado en 2016

diXa: a data infrastructure for chemical safety assessment

artículo científico publicado en 2014

Lista de obras de Danyel G.J. Jennen

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure

A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo ⬇️

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

Assessing compound carcinogenicity in vitro using connectivity mapping

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes

Association of the FADS2 gene with omega-6 and omega-3 PUFA Concentration in the egg yolk of Japanese quail

Bayesian Network Inference Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes

Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells ⬇️

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time

Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens

Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

ELIXIR and Toxicology: a community in development

ELIXIR and Toxicology: a community in development

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity

Expression of the prion protein gene (PRNP) and cellular prion protein (PrPc) in cattle and sheep fetuses and maternal tissues during pregnancy.

Gender-specific transcriptomic response to environmental exposure in Flemish adults

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids

Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking ⬇️

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study

Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity

Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study

QTL for the heritable inverted teat defect in pigs.

ROS networks: designs, aging, Parkinson's disease and precision therapies

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women.

Time series analysis of oxidative stress response patterns in HepG2: A toxicogenomics approach ⬇️

Transcriptomic and metabolomic data integration

Translational Proteomics Analysis of Anthracycline-Induced Cardiotoxicity From Cardiac Microtissues to Human Heart Biopsies

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.

Xenobiotic metabolism in differentiated human bronchial epithelial cells

diXa: a data infrastructure for chemical safety assessment