Lista de obras - Fatima Bosch - Dominio Público Uruguay

AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance

artículo científico publicado en 2016

AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice.

artículo científico publicado en 2017

AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.

artículo científico publicado en 2014

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.

artículo científico publicado en 2016

Activation by vanadate of glycolysis in hepatocytes from diabetic rats.

artículo científico publicado en 1991

Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity

artículo científico publicado en 2006

Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance.

artículo científico publicado en 2012

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

artículo científico publicado en 2013

Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism

artículo científico publicado en 2011

Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.

artículo científico publicado en 2008

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

artículo científico publicado en 2017

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

artículo científico publicado en 2019

BMP7 overexpression in adipose tissue induces white adipogenesis and improves insulin sensitivity in ob/ob mice

artículo científico publicado en 2020

Beta cell expression of IGF-I leads to recovery from type 1 diabetes.

artículo científico publicado en 2002

Biochemical, histological and functional correction of mucopolysaccharidosis type IIIB by intra-cerebrospinal fluid gene therapy

artículo científico publicado en 2014

CDK4 is an essential insulin effector in adipocytes

scientific journal article

CNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome)

artículo científico publicado en 2016

Calcium-mobilizing effectors inhibit P-enolpyruvate carboxykinase gene expression in cultured rat hepatocytes.

artículo científico publicado en 1993

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material

artículo científico publicado en 2010

Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion

artículo científico publicado en 2015

Control of glycogen synthase and phosphorylase in hepatocytes from diabetic rats. Effects of glucagon, vasopressin, and vanadate.

artículo científico publicado en 1989

Correction of diabetic alterations by glucokinase.

artículo científico publicado en 1996

Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer

artículo científico publicado en 2012

Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice.

artículo científico publicado en 2002

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.

artículo científico publicado en 2010

Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice

artículo científico publicado en 2018

Diabetic neuropathy: electrophysiological and morphological study of peripheral nerve degeneration and regeneration in transgenic mice that express IFNbeta in beta cells.

artículo científico publicado en 2010

Different effects of glucagon and epinephrine on the kinetic properties of liver glycogen synthase

scientific article published on 01 January 1983

Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID.

artículo científico publicado en 2017

Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes

artículo científico publicado en 1986

Effects of vanadate on protein kinases in rat hepatocytes.

artículo científico publicado en 1989

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

scientific article published on April 2010

Erratum to: Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

scholarly article by Francisco J. Ortega et al published 8 March 2013 in Journal of Molecular Medicine

Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes Mellitus

artículo científico publicado en 1998

Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

scientific article published on 01 August 1996

Evidence from transgenic mice that myc regulates hepatic glycolysis

artículo científico publicado en 1995

Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes

artículo científico publicado en 1994

Expression of Glucokinase in Skeletal Muscle: A New Approach to Counteract Diabetic Hyperglycemia

artículo científico publicado en 2000

Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes

artículo científico publicado en 2006

Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.

artículo científico publicado en 1994

FGF21 gene therapy as treatment for obesity and insulin resistance

article

Gene and cellular therapy in Spain: moving forward

artículo científico publicado en 2009

Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone gene

scientific article published on 01 June 1993

Glucose-regulated glucose uptake by transplanted muscle cells expressing glucokinase counteracts diabetic hyperglycemia

artículo científico publicado en 2002

Glycogen synthase activation by sugars in isolated hepatocytes

scientific article published on 01 July 1988

Good news on the clinical gene transfer front

artículo científico publicado en 2008

HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance.

artículo científico publicado en 2015

Hormonal effects on the phosphorylation of glycogen synthase in rat hepatocytes

artículo científico publicado en 1984

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

artículo científico publicado en 2010

IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.

artículo científico publicado en 2004

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

artículo científico publicado en 2008

Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells

artículo científico publicado en 2015

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

scientific article published on 17 January 2017

In vivo adeno-associated viral vector-mediated genetic engineering of white and brown adipose tissue in adult mice

artículo científico publicado en 2013

In vivo gene transfer to healthy and diabetic canine pancreas.

artículo científico publicado en 2005

In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9.

artículo científico publicado en 2011

Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

artículo científico publicado en 1986

Increased Atherosclerotic Lesion Calcification in a Novel Mouse Model Combining Insulin Resistance, Hyperglycemia, and Hypercholesterolemia

artículo científico publicado en 2007

Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance

artículo científico publicado en 2002

Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown

artículo científico publicado en 2009

Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

artículo científico publicado en 2004

Insulin activation of basal hepatic glycogen synthase

artículo científico publicado en 1981

Insulin inhibits liver expression of the CCAAT/enhancer-binding protein beta

scientific article published on 01 March 1995

Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage

artículo científico publicado en 2015

Insulin-like growth factor I (IGF-I)-induced chronic gliosis and retinal stress lead to neurodegeneration in a mouse model of retinopathy

artículo científico publicado en 2013

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

artículo científico publicado en 2012

Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression.

artículo científico publicado en 2015

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

artículo científico publicado en 2011

Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression ⬇️

artículo científico publicado el 15 de febrero de 1992

Lithium restores glycogen synthesis from glucose in hepatocytes from diabetic rats

artículo científico publicado en 1993

Liver production of sulfamidase reverses peripheral and ameliorates CNS pathology in mucopolysaccharidosis IIIA mice

artículo científico publicado en 2011

Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs

artículo científico publicado en 2017

Long-Term Retinal PEDF Overexpression Prevents Neovascularization in a Murine Adult Model of Retinopathy ⬇️

artículo científico publicado el 20 de julio de 2012

Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

artículo científico publicado en 2003

Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.

artículo científico publicado en 2014

Molecular signature of the immune and tissue response to non-coding plasmid DNA in skeletal muscle after electrotransfer ⬇️

artículo científico publicado el 15 de diciembre de 2011

Morphofunctional changes underlying intestinal dysmotility in diabetic RIP-I/hIFNβ transgenic mice.

artículo científico publicado en 2011

New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance.

artículo científico publicado en 2013

Nonviral-mediated hepatic expression of IGF-I increases Treg levels and suppresses autoimmune diabetes in mice

artículo científico publicado en 2012

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

artículo científico

Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit.

artículo científico publicado en 2012

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

artículo científico publicado en 2017

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.

artículo científico publicado en 2008

Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism

artículo científico publicado en 2002

Overexpression of c-myc in the liver prevents obesity and insulin resistance.

artículo científico publicado en 2003

Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction

artículo científico publicado en 2009

Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis

artículo científico publicado en 1994

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells

artículo científico publicado en 2007

Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery.

artículo científico publicado en 2014

Phosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosis

scientific journal article

Prevention of diabetic alterations in transgenic mice overexpressing Myc in the liver.

artículo científico publicado en 1996

Prevention of obesity and insulin resistance by glucokinase expression in skeletal muscle of transgenic mice.

artículo científico publicado en 2003

Production, purification and characterization of adeno-associated vectors.

artículo científico publicado en 2010

Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC.

artículo científico publicado en 2016

Proinsulin protects against age-related cognitive loss through anti-inflammatory convergent pathways.

artículo científico publicado en 2017

Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosa

artículo científico publicado en 2012

Proliferative retinopathies: animal models and therapeutic opportunities

artículo científico publicado en 2015

Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.

artículo científico publicado en 2011

Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3ζ.

artículo científico publicado en 2015

Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations.

artículo científico publicado en 1994

Regulated production of mature insulin by non-beta-cells.

artículo científico publicado en 1997

Relevance of an academic GMP Pan-European vector infra-structure (PEVI).

artículo científico

Response to Comment on: Elias et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 2012;61:1801-1813.

artículo científico publicado en 2013

Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.

artículo científico publicado en 2006

Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood-retinal barrier.

artículo científico publicado en 2009

Skeletal muscle metabolism in the pathology and treatment of type 1 diabetes.

artículo científico publicado en 2010

Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer

artículo científico publicado en 2014

Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

artículo científico publicado en 2012

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

artículo científico publicado en 2014

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

artículo científico publicado en 2012

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

artículo científico publicado en 2016

The Deep Genome Project

scientific article published on 03 February 2020

The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.

artículo científico publicado en 2010

Tissue-specific expression and dietary regulation of chimeric mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase/human growth hormone gene in transgenic mice.

artículo científico publicado en 1996

Toward a gene therapy for neurological and somatic MPSIIIA

artículo científico publicado en 2013

Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.

artículo científico publicado en 2008

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

artículo científico publicado en 2000

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

artículo científico publicado en 1994

Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy.

artículo científico publicado en 2013

Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy

artículo científico publicado en 2021

Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats

scientific journal article

Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass.

artículo científico publicado en 2012

Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy

artículo científico publicado en 2013

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

artículo científico publicado en 2016

Lista de obras de Fatima Bosch

AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance

AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice.

AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease.

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.

Activation by vanadate of glycolysis in hepatocytes from diabetic rats.

Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity

Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance.

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism

Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

BMP7 overexpression in adipose tissue induces white adipogenesis and improves insulin sensitivity in ob/ob mice

Beta cell expression of IGF-I leads to recovery from type 1 diabetes.

Biochemical, histological and functional correction of mucopolysaccharidosis type IIIB by intra-cerebrospinal fluid gene therapy

CDK4 is an essential insulin effector in adipocytes

CNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome)

Calcium-mobilizing effectors inhibit P-enolpyruvate carboxykinase gene expression in cultured rat hepatocytes.

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material

Contribution of Intronic miR-338-3p and Its Hosting Gene AATK to Compensatory β-Cell Mass Expansion

Control of glycogen synthase and phosphorylase in hepatocytes from diabetic rats. Effects of glucagon, vasopressin, and vanadate.

Correction of diabetic alterations by glucokinase.

Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer

Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice.

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.

Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice

Diabetic neuropathy: electrophysiological and morphological study of peripheral nerve degeneration and regeneration in transgenic mice that express IFNbeta in beta cells.

Different effects of glucagon and epinephrine on the kinetic properties of liver glycogen synthase

Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID.

Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes

Effects of vanadate on protein kinases in rat hepatocytes.

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

Erratum to: Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes Mellitus

Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver

Evidence from transgenic mice that myc regulates hepatic glycolysis

Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes

Expression of Glucokinase in Skeletal Muscle: A New Approach to Counteract Diabetic Hyperglycemia

Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes

Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.

FGF21 gene therapy as treatment for obesity and insulin resistance

Gene and cellular therapy in Spain: moving forward

Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone gene

Glucose-regulated glucose uptake by transplanted muscle cells expressing glucokinase counteracts diabetic hyperglycemia

Glycogen synthase activation by sugars in isolated hepatocytes

Good news on the clinical gene transfer front

HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance.

Hormonal effects on the phosphorylation of glycogen synthase in rat hepatocytes

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

In vivo adeno-associated viral vector-mediated genetic engineering of white and brown adipose tissue in adult mice

In vivo gene transfer to healthy and diabetic canine pancreas.

In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9.

Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

Increased Atherosclerotic Lesion Calcification in a Novel Mouse Model Combining Insulin Resistance, Hyperglycemia, and Hypercholesterolemia

Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance

Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown

Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

Insulin activation of basal hepatic glycogen synthase

Insulin inhibits liver expression of the CCAAT/enhancer-binding protein beta

Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage

Insulin-like growth factor I (IGF-I)-induced chronic gliosis and retinal stress lead to neurodegeneration in a mouse model of retinopathy

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression.

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression ⬇️

Lithium restores glycogen synthesis from glucose in hepatocytes from diabetic rats

Liver production of sulfamidase reverses peripheral and ameliorates CNS pathology in mucopolysaccharidosis IIIA mice

Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs

Long-Term Retinal PEDF Overexpression Prevents Neovascularization in a Murine Adult Model of Retinopathy ⬇️

Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.

Molecular signature of the immune and tissue response to non-coding plasmid DNA in skeletal muscle after electrotransfer ⬇️

Morphofunctional changes underlying intestinal dysmotility in diabetic RIP-I/hIFNβ transgenic mice.

New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance.

Nonviral-mediated hepatic expression of IGF-I increases Treg levels and suppresses autoimmune diabetes in mice