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Lista de obras de Yusaku Nakabeppu

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

artículo científico publicado en 2017

8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog

artículo científico publicado en 2002

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction

artículo científico publicado en 2022

8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction

artículo científico publicado en 2012

8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.

artículo científico publicado en 2016

8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis

artículo científico publicado en 2005

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

artículo científico

8-oxoguanine causes spontaneous de novo germline mutations in mice.

artículo científico publicado en 2014

A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas.

artículo científico publicado en 2003

A comprehensive screening system for damaged nucleotide-binding proteins.

artículo científico publicado en 2010

A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

artículo científico publicado en 2005

A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1

scientific journal article

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

artículo científico publicado en 1991

A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae.

artículo científico publicado en 2004

A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration

artículo científico publicado en 2008

A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.

artículo científico publicado en 1997

A unique structural feature of rabbit DNA repair methyltransferase as revealed by cDNA cloning.

artículo científico publicado en 1994

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

artículo científico publicado en 2007

Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion

artículo científico publicado en 1985

Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice.

artículo científico publicado en 2014

Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage.

artículo científico publicado en 2013

Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney.

artículo científico publicado en 2003

Accumulation of adenine DNA glycosylase-sensitive sites in human mitochondrial DNA

scientific article published on 01 April 2000

Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer

scientific journal article

Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.

artículo científico publicado en 2008

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

scientific article published on 13 September 2018

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

artículo científico publicado en 2003

Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: the Hisayama Study

artículo científico publicado en 2006

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

artículo científico publicado en 2009

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.

artículo científico publicado en 2011

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.

artículo científico publicado en 2014

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

artículo científico publicado en 2017

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

artículo científico publicado en 2016

Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.

artículo científico publicado en 1997

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues.

artículo científico publicado en 2011

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

artículo científico publicado en 2016

Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells

artículo científico publicado en 2014

Changes in expression of delta FosB and the Fos family proteins following NMDA receptor activation in the rat striatum.

artículo científico publicado en 1997

Characterization of galectin-1-positive cells in the mouse hippocampus

artículo científico publicado en 2014

Characterization of human polymorphic DNA repair methyltransferase.

artículo científico publicado en 2000

Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome.

artículo científico publicado en 2005

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse.

artículo científico publicado en 2017

Cisplatin-mediated upregulation of APE2 binding to MYH9 provokes mitochondrial fragmentation and acute kidney injury

artículo científico publicado en 2020

Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors.

artículo científico publicado en 2004

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

artículo científico publicado en 2016

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

artículo científico publicado en 2017

Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson's Disease Model Mice.

artículo científico publicado en 2017

Constitutive expression of zif268 in neocortex is regulated by synaptic activity ⬇️

artículo científico publicado el 15 de junio de 1991

Contribution of estrogen receptor alpha to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 pathway.

artículo científico publicado en 2002

Corrigendum: 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions

artículo científico publicado en 2016

Corrigendum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

artículo científico publicado en 2016

CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection.

artículo científico publicado en 2003

Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus.

artículo científico publicado en 2012

D1-Receptor-related priming is attenuated by antisense-meditated 'knockdown' of fosB expression.

artículo científico publicado en 1998

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

artículo científico publicado en 2014

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.

artículo científico publicado en 2011

DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1

artículo científico publicado en 2010

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

artículo científico publicado en 2016

DeltaFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line.

artículo científico publicado en 2003

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

artículo científico publicado en 2016

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

artículo científico publicado en 2014

Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus

artículo científico publicado en 2000

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

artículo científico

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

artículo científico publicado en 2015

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains.

artículo científico publicado en 2014

Enhancement of laminar FosB expression in frontal cortex of rats receiving long chronic clozapine administration.

artículo científico publicado en 2001

Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1-/- mice

scientific article published on 24 April 2020

Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

artículo científico publicado en 1999

Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders

artículo científico publicado en 2004

Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain.

artículo científico publicado en 2002

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.

artículo científico publicado en 2018

Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages.

artículo científico publicado en 2005

Expression of the ada gene of Escherichia coli in response to alkylating agents. Identification of transcriptional regulatory elements.

artículo científico publicado en 1988

FER-1, an enhancer of the ferritin H gene and a target of E1A-mediated transcriptional repression.

artículo científico publicado en 1995

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

artículo científico publicado en 2017

FosB Is Essential for the Enhancement of Stress Tolerance and Antagonizes Locomotor Sensitization by ΔFosB ⬇️

artículo científico publicado el 15 de junio de 2011

FosB gene products trigger cell proliferation and morphological alteration with an increased expression of a novel processed form of galectin-1 in the rat 3Y1 embryo cell line.

artículo científico publicado en 2002

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

artículo científico publicado en 2014

Functional sites of the Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions.

artículo científico publicado en 1988

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons.

artículo científico publicado en 2013

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1(G93A) transgenic mice

artículo científico publicado en 2015

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

artículo científico publicado en 2006

Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus.

artículo científico publicado en 2008

Galectin-1beta, a natural monomeric form of galectin-1 lacking its six amino-terminal residues promotes axonal regeneration but not cell death.

artículo científico publicado en 2004

Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis.

artículo científico publicado en 2008

Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion

artículo científico publicado en 1994

Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein

scientific journal article

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

artículo científico publicado en 2016

Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

artículo científico publicado en 2009

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells. ⬇️

artículo científico publicado en 2010

ITPase-deficient mice show growth retardation and die before weaning.

artículo científico publicado en 2009

Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice

artículo científico publicado en 2008

Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1.

artículo científico publicado en 2005

Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis.

artículo científico publicado en 2002

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis.

artículo científico publicado en 2011

Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.

artículo científico publicado en 1994

Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.

artículo científico publicado en 2014

International Symposium on "Germline mutagenesis and biodiversification"

artículo científico publicado en 2014

Intracellular localization and function of DNA repair methyltransferase in human cells

artículo científico publicado en 1994

Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

artículo científico publicado en 1995

Ischemia-induced CA1 neuronal death is preceded by elevated FosB and Jun expression and reduced NGFI-A and JunB levels.

artículo científico publicado en 1998

Isoforms of JSAP1 scaffold protein generated through alternative splicing.

artículo científico publicado en 2000

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

artículo científico publicado en 2016

MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

artículo científico publicado en 2006

MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity.

artículo científico publicado en 2006

MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis in a Bleomycin-Induced Model

artículo científico publicado en 2020

MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model

artículo científico publicado en 2021

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death.

artículo científico publicado en 2014

MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis

artículo científico publicado en 2007

Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression.

artículo científico publicado en 2003

Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

scientific article published on 01 March 1999

Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes

artículo científico publicado en 2013

Molecular cloning of AtMMH, an Arabidopsis thaliana ortholog of the Escherichia coli mutM gene, and analysis of functional domains of its product.

artículo científico publicado en 1998

MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration

artículo científico publicado en 2012

Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.

artículo científico publicado en 2006

Mutagenic target for hydroxyl radicals generated in Escherichia coli mutant deficient in Mn- and Fe- superoxide dismutases and Fur, a repressor for iron-uptake systems.

artículo científico publicado en 2002

Mutator phenotype of MUTYH-null mouse embryonic stem cells.

artículo científico publicado en 2003

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

scientific journal article

Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer

artículo científico publicado en 2007

Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus.

artículo científico publicado en 2013

Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons.

artículo científico publicado en 2006

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine

artículo científico publicado en 2016

Nucleotides function as endogenous chemical sensors for oxidative stress signaling.

artículo científico publicado en 2010

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

artículo científico publicado en 2020

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.

artículo científico publicado en 2013

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.

artículo científico publicado en 2007

Oxidative Stress and Microglial Response in Retinitis Pigmentosa

scientific article published on 28 September 2020

Oxidative damage in nucleic acids and Parkinson's disease.

artículo científico publicado en 2007

PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions

artículo científico publicado en 2020

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.

artículo científico publicado en 2016

Physical association of pyrimidine dimer DNA glycosylase and apurinic/apyrimidinic DNA endonuclease essential for repair of ultraviolet-damaged DNA ⬇️

artículo científico publicado el 1 de mayo de 1981

Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs

artículo científico publicado en 2004

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma.

artículo científico publicado en 2016

Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method.

artículo científico publicado en 2009

RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.

artículo científico publicado en 2007

Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein

artículo científico publicado en 2006

Regulation of expression of the cloned ada gene in Escherichia coli.

artículo científico publicado en 1985

Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator

scientific article published on September 1986

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.

artículo científico

Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein

artículo científico publicado en 2002

Selective increase in cellular A beta 42 is related to apoptosis but not necrosis.

artículo científico publicado en 2000

Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II).

artículo científico publicado en 1997

Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation.

artículo científico publicado en 2017

Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.

artículo científico publicado en 2007

Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines.

artículo científico publicado en 2012

Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype

artículo científico publicado en 2012

Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant.

artículo científico publicado en 2004

Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

scientific journal article

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

artículo científico publicado en 2016

Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer

artículo científico publicado en 2021

Synaptic Regulation of Immediate Early Gene Expression in Primary Cultures of Cortical Neurons ⬇️

artículo científico publicado el 1 de diciembre de 1991

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

artículo científico publicado en 2015

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.

artículo científico publicado en 2018

The conjunctive stimuli that cause long-term desensitization also predominantly induce c-Fos and Jun-B in cerebellar Purkinje cells

artículo científico publicado en 1993

The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression

scientific journal article

The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice

artículo científico publicado en 2006

The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells

artículo científico publicado en 2004

Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes.

artículo científico

Therapeutic effects of hydrogen in animal models of Parkinson's disease.

artículo científico publicado en 2011

Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli.

artículo científico publicado en 1996

Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin

artículo científico publicado en 2022

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.

artículo científico publicado en 2008

Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease

artículo científico publicado en 2006

XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair.

artículo científico publicado en 2005

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