Lista de obras - John Hadcock - Dominio Público Uruguay

AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin

artículo científico publicado en 2011

Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.

artículo científico publicado en 2009

Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys

scientific article published on 13 July 2007

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue

artículo científico publicado en 2010

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

artículo científico publicado en 2013

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

artículo científico publicado en 2012

Discovery and biological characterization of capromorelin analogues with extended half-lives.

artículo científico publicado en 2002

Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity

artículo científico publicado en 2009

Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists ⬇️

artículo científico publicado el 23 de febrero de 2012

Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity

scientific article published on 30 June 2007

Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs

artículo científico publicado en 1998

Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: II. Nitrogen balance responses

scientific article published on 01 July 1998

Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway.

artículo científico publicado en 1995

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

scientific journal article

Glucocorticoids down-regulate beta 1-adrenergic-receptor expression by suppressing transcription of the receptor gene

artículo científico publicado en 1994

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

artículo científico publicado en 2012

Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2

artículo científico publicado en 1995

New bicyclic cannabinoid receptor-1 (CB1-R) antagonists.

artículo científico publicado en 2005

Photoaffinity labeling of the guinea pig pulmonary mast cell beta-adrenergic receptor.

artículo científico publicado en 1989

Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.

artículo científico publicado en 2003

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.