Lista de obras - Yves P Auberson - Dominio Público Uruguay

5-Aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists

scientific article published on 01 March 1998

5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists

scientific article published on 01 January 1998

5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists

artículo científico publicado en 1998

A Comparative Study of in vitro Assays for Predicting the Nonspecific Binding of PET Imaging Agents in vivo

scientific article published on 13 December 2019

ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies

artículo científico publicado en 2006

AMPA receptor antagonists: potential therapeutic applications.

artículo científico publicado en 2006

BZM055, an iodinated radiotracer candidate for PET and SPECT imaging of myelin and FTY720 brain distribution

artículo científico publicado en 2011

Blockade of NMDA receptors 2A subunit in the dorsal striatum impairs the learning of a complex motor skill.

artículo científico publicado en 2011

EFMC, Medicinal Chemistry and Chemical Biology in Europe

scientific article published on 03 September 2020

Ergoline-derived inverse agonists of the human h3 receptor for the treatment of narcolepsy.

artículo científico publicado en 2014

Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras.

artículo científico publicado en 2005

From ergolines to indoles: improved inhibitors of the human H3 receptor for the treatment of narcolepsy.

artículo científico publicado en 2014

GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats

artículo científico publicado en 2013

Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para-Phenyl Bioisosteres

artículo científico publicado en 2017

In vivo molecular imaging tools facilitate drug discovery.

artículo científico publicado en 2017

Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum.

artículo científico publicado en 2017

Ligand Specific Efficiency (LSE) Index for PET Tracer Optimization.

artículo científico publicado en 2016

Ligand-biased and probe-dependent modulation of chemokine receptor CXCR3 signaling by negative allosteric modulators.

artículo científico

MS565: A SPECT Tracer for Evaluating the Brain Penetration of BAF312 (Siponimod).

artículo científico publicado en 2015

Medicinal Chemistry and Chemical Biology Highlights

scientific article published on 01 February 2019

Medicinal Chemists Don't Just Make Drugs - The Art of Developing Low Molecular Weight Imaging Agents in Switzerland.

artículo científico publicado en 2016

N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists

artículo científico publicado en 1999

PET imaging of T cells: Target identification and feasibility assessment.

artículo científico publicado en 2018

Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor-Targeted PET Imaging

artículo científico publicado en 2019

Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5).

artículo científico publicado en 2014

Rap2-JNK removes synaptic AMPA receptors during depotentiation

artículo científico publicado en 2005

Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study

artículo científico publicado en 2011

Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis.

artículo científico publicado en 2009

Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices

artículo científico publicado en 2004

Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist.

artículo científico publicado en 2018

The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders

scientific article published on 21 May 2019

The Partnership of DMCCB and LS²

The Young Scientists Network: How the European Federation for Medicinal Chemistry (EFMC) Became Young Again

artículo científico publicado en 2020

The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression

artículo científico publicado en 2014

The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdala.

artículo científico publicado en 2009

Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.

artículo científico publicado en 2005

Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.

artículo científico publicado en 2006

[18 F]PRIMATX, a New Positron Emission Tomography Tracer for Imaging of Autotaxin in Lung Tissue and Tumor-Bearing Mice

artículo científico publicado en 2019

Lista de obras de Yves P Auberson

5-Aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists

5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists

5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists

A Comparative Study of in vitro Assays for Predicting the Nonspecific Binding of PET Imaging Agents in vivo

ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies

AMPA receptor antagonists: potential therapeutic applications.

BZM055, an iodinated radiotracer candidate for PET and SPECT imaging of myelin and FTY720 brain distribution

Blockade of NMDA receptors 2A subunit in the dorsal striatum impairs the learning of a complex motor skill.

EFMC, Medicinal Chemistry and Chemical Biology in Europe

Ergoline-derived inverse agonists of the human h3 receptor for the treatment of narcolepsy.

Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras.

From ergolines to indoles: improved inhibitors of the human H3 receptor for the treatment of narcolepsy.

GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats

Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para-Phenyl Bioisosteres

In vivo molecular imaging tools facilitate drug discovery.

Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum.

Ligand Specific Efficiency (LSE) Index for PET Tracer Optimization.

Ligand-biased and probe-dependent modulation of chemokine receptor CXCR3 signaling by negative allosteric modulators.

MS565: A SPECT Tracer for Evaluating the Brain Penetration of BAF312 (Siponimod).

Medicinal Chemistry and Chemical Biology Highlights

Medicinal Chemists Don't Just Make Drugs - The Art of Developing Low Molecular Weight Imaging Agents in Switzerland.

N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists

PET imaging of T cells: Target identification and feasibility assessment.

Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor-Targeted PET Imaging

Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5).

Rap2-JNK removes synaptic AMPA receptors during depotentiation

Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study

Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis.

Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices

Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist.

The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders

The Partnership of DMCCB and LS²

The Young Scientists Network: How the European Federation for Medicinal Chemistry (EFMC) Became Young Again

The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression

The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdala.

Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.

Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.

[18 F]PRIMATX, a New Positron Emission Tomography Tracer for Imaging of Autotaxin in Lung Tissue and Tumor-Bearing Mice