Lista de obras - Nunilo Cremades - Dominio Público Uruguay

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

artículo científico publicado en 2017

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

artículo científico publicado en 2015

Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni

artículo científico publicado en 2006

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

artículo científico publicado en 2015

Common conformational changes in flavodoxins induced by FMN and anion binding: the structure of Helicobacter pylori apoflavodoxin

artículo científico publicado en 2007

Conformational stability of Helicobacter pylori flavodoxin: fit to function at pH 5.

artículo científico publicado en 2007

Direct observation of the interconversion of normal and toxic forms of α-synuclein

artículo científico publicado en 2012

Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection

artículo científico publicado en 2009

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers

artículo científico publicado en 2015

Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni

artículo científico publicado en 2007

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

artículo científico publicado en 2013

Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

artículo científico publicado en 2008

Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution

artículo científico publicado en 2010

Molten globule and native state ensemble of Helicobacter pylori flavodoxin: can crowding, osmolytes or cofactors stabilize the native conformation relative to the molten globule?

artículo científico publicado en 2008

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease

scientific article published on 28 October 2020

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

scientific article published on 18 November 2019

On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid

artículo científico publicado en 2009

Population of nonnative states of lysozyme variants drives amyloid fibril formation

artículo científico publicado en 2011

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants

artículo científico publicado en 2015

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

artículo científico publicado en 2017

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

artículo científico publicado en 2015

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

artículo científico publicado en 2010

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

artículo científico publicado en 2014

The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.

artículo científico publicado en 2007

The native-state ensemble of proteins provides clues for folding, misfolding and function

artículo científico publicado en 2006

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

artículo científico publicado en 2021

Towards a new therapeutic target: Helicobacter pylori flavodoxin.

artículo científico publicado en 2005

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Lista de obras de Nunilo Cremades

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

Common conformational changes in flavodoxins induced by FMN and anion binding: the structure of Helicobacter pylori apoflavodoxin

Conformational stability of Helicobacter pylori flavodoxin: fit to function at pH 5.

Direct observation of the interconversion of normal and toxic forms of α-synuclein

Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers

Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution

Molten globule and native state ensemble of Helicobacter pylori flavodoxin: can crowding, osmolytes or cofactors stabilize the native conformation relative to the molten globule?

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid

Population of nonnative states of lysozyme variants drives amyloid fibril formation

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.

The native-state ensemble of proteins provides clues for folding, misfolding and function

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Towards a new therapeutic target: Helicobacter pylori flavodoxin.

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism