Lista de obras - Paul M Janssen - Dominio Público Uruguay

A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular Dystrophy ⬇️

artículo científico publicado el 28 de julio de 2010

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

artículo científico publicado en 2010

A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium.

artículo científico publicado en 2009

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice

artículo científico publicado en 2013

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

artículo científico publicado en 2015

Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium

artículo científico publicado en 2004

Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart

artículo científico publicado en 2016

Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium

scientific article published on 03 November 2018

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes

artículo científico publicado en 2019

Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts.

artículo científico publicado en 2015

Atrial glutathione content, calcium current, and contractility

artículo científico publicado en 2007

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

artículo científico publicado en 2014

Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship

scientific article published on 01 December 1995

Challenges in cardiac muscle physiology ⬇️

artículo científico publicado el 13 de abril de 2010

Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1.

artículo científico publicado en 2014

Claudin-5 levels are reduced in human end-stage cardiomyopathy

artículo científico publicado en 2008

Comparison of telephone and face-to-face assessment of the modified Rankin Scale

artículo científico publicado en 2009

Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency

scientific article published on 30 March 2012

Correction: Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch.

artículo científico publicado en 2015

Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae.

artículo científico publicado en 2014

Deletion of Galgt2 (B4Galnt2) reduces muscle growth in response to acute injury and increases muscle inflammation and pathology in dystrophin-deficient mice

artículo científico publicado en 2015

Designing proteins to combat disease: Cardiac troponin C as an example.

artículo científico publicado en 2016

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.

artículo científico publicado en 2007

Differential involvement of various sources of reactive oxygen species in thyroxin-induced hemodynamic changes and contractile dysfunction of the heart and diaphragm muscles.

artículo científico publicado en 2015

Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium

artículo científico publicado en 2015

Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium

artículo científico publicado en 2007

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia

artículo científico publicado en 2015

Dysfunction of the β2-spectrin-based pathway in human heart failure

artículo científico publicado en 2016

Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.

artículo científico publicado en 2011

Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium

artículo científico publicado en 2016

Effect of muscle dimensions on trabecular contractile performance under physiological conditions

scientific article published on 05 August 2005

Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions ⬇️

artículo científico publicado el 21 de julio de 2011

Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit

artículo científico publicado en 2010

Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.

artículo científico publicado en 2011

Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase

artículo científico publicado en 2013

Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch

artículo científico publicado en 2015

FK506 does not affect cardiac contractility and adrenergic response in vitro.

artículo científico publicado en 2001

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates

artículo científico publicado en 2009

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

artículo científico publicado en 2004

Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity

scientific article published on 05 January 2007

Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase

scientific article published on 25 January 2007

Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy.

artículo científico publicado en 2015

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways.

artículo científico publicado en 2015

Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium

artículo científico publicado en 2019

Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.

artículo científico publicado en 2012

Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy ⬇️

artículo científico publicado el 17 de mayo de 2011

In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae

artículo científico publicado en 2015

Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.

artículo científico publicado en 2010

Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium

scientific article published on 12 October 2007

Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure

artículo científico publicado en 2016

Influence of pyruvate on economy of contraction in isolated rabbit myocardium.

artículo científico publicado en 2007

Insights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium.

artículo científico publicado en 2016

Integration of High-Resolution Optical Mapping and 3-Dimensional Micro-Computed Tomographic Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart.

artículo científico publicado en 2015

Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles

artículo científico publicado en 2007

Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.

artículo científico publicado en 2010

Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy ⬇️

artículo científico publicado el 2 de diciembre de 2010

Levosimendan improves diastolic and systolic function in failing human myocardium.

artículo científico publicado en 2000

Load-induced cardiomyocyte apoptosis in cultured multicellular myocardial preparations is unaltered in presence of the beta-adrenoceptor antagonist nebivolol.

artículo científico publicado en 2008

Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA.

artículo científico publicado en 2015

Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae

scientific article published on 01 May 2006

Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.

artículo científico publicado en 2004

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

artículo científico publicado en 2015

Molecular basis of diastolic dysfunction.

artículo científico publicado en 2008

Murine strain differences in contractile function are temperature- and frequency-dependent

scientific article published on 06 January 2006

Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles

artículo científico publicado en 2013

Myocardial contraction-relaxation coupling ⬇️

artículo científico publicado el 17 de septiembre de 2010

N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice

artículo científico publicado en 2013

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release

artículo científico publicado en 2014

Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.

artículo científico publicado en 2008

Overexpression of sarcolipin decreases myocyte contractility and calcium transient

artículo científico publicado en 2005

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.

artículo científico publicado en 2011

Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium

artículo científico publicado en 2012

Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy.

artículo científico publicado en 2014

Preservation of contractile characteristics of human myocardium in multi-day cell culture.

artículo científico publicado en 1999

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

artículo científico publicado en 2016

Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice.

artículo científico publicado en 2017

Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story

artículo científico publicado en 2015

Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening

artículo científico publicado en 2004

S100A1: a regulator of myocardial contractility

artículo científico publicado en 2001

SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia

scientific journal article

SERCA overexpression reduces hydroxyl radical injury in murine myocardium

scientific article published on 23 June 2006

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

artículo científico publicado en 2020

Small and large animal models in cardiac contraction research: advantages and disadvantages

artículo científico publicado en 2014

Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.

artículo científico publicado en 2012

Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model.

artículo científico publicado en 2012

Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.

artículo científico publicado en 2005

Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro.

artículo científico publicado en 2009

The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities

artículo científico publicado en 2016

The Frank-Starling mechanism involves deceleration of cross-bridge kinetics and is preserved in failing human right ventricular myocardium

artículo científico publicado en 2015

The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve

artículo científico publicado en 2016

The effect of applied mechanical vibration on two different phases of rat papillary muscle relaxation

scientific article published on 01 November 1997

The effect of diastolic vibration on the relaxation of rat papillary muscle

artículo científico publicado en 1996

The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts

artículo científico publicado en 2003

The force-temperature relationship in healthy and dystrophic mouse diaphragm; implications for translational study design.

artículo científico publicado en 2012

The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity.

artículo científico publicado en 2013

The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.

artículo científico publicado en 2012

Tissue triage and freezing for models of skeletal muscle disease.

artículo científico publicado en 2014

Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol

artículo científico publicado en 1999

Truncated CASK does not alter skeletal muscle or protein interactors.

artículo científico publicado en 2008

UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway

Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.

artículo científico publicado en 2012

Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice

artículo científico publicado en 2005

Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice

scientific article published on 01 December 2012

mdx Mice Manifest More Severe Muscle Dysfunction and Diaphragm Force Deficits than Do mdx Mice ⬇️

artículo científico publicado el 3 de septiembre de 2011

Lista de obras de Paul M Janssen

A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular Dystrophy ⬇️

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium.

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium

Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart

Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes

Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts.

Atrial glutathione content, calcium current, and contractility

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship

Challenges in cardiac muscle physiology ⬇️

Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1.

Claudin-5 levels are reduced in human end-stage cardiomyopathy

Comparison of telephone and face-to-face assessment of the modified Rankin Scale

Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency

Correction: Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch.

Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae.

Deletion of Galgt2 (B4Galnt2) reduces muscle growth in response to acute injury and increases muscle inflammation and pathology in dystrophin-deficient mice

Designing proteins to combat disease: Cardiac troponin C as an example.

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.

Differential involvement of various sources of reactive oxygen species in thyroxin-induced hemodynamic changes and contractile dysfunction of the heart and diaphragm muscles.

Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium

Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia

Dysfunction of the β2-spectrin-based pathway in human heart failure

Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.

Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium

Effect of muscle dimensions on trabecular contractile performance under physiological conditions

Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions ⬇️

Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit

Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.

Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase

Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch

FK506 does not affect cardiac contractility and adrenergic response in vitro.

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity

Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase

Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy.

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways.

Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium

Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.

Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy ⬇️

In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae

Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.

Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium

Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure

Influence of pyruvate on economy of contraction in isolated rabbit myocardium.

Insights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium.

Integration of High-Resolution Optical Mapping and 3-Dimensional Micro-Computed Tomographic Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart.

Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles

Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.

Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy ⬇️

Levosimendan improves diastolic and systolic function in failing human myocardium.

Load-induced cardiomyocyte apoptosis in cultured multicellular myocardial preparations is unaltered in presence of the beta-adrenoceptor antagonist nebivolol.

Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA.

Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae

Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

Molecular basis of diastolic dysfunction.

Murine strain differences in contractile function are temperature- and frequency-dependent

Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles

Myocardial contraction-relaxation coupling ⬇️

N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release

Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.

Overexpression of sarcolipin decreases myocyte contractility and calcium transient

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.

Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium

Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy.

Preservation of contractile characteristics of human myocardium in multi-day cell culture.

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice.

Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story

Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening

S100A1: a regulator of myocardial contractility