Lista de obras - Ulrike Garscha - Dominio Público Uruguay

4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)

scholarly article by Erden Banoglu et al published May 2016 in European Journal of Medicinal Chemistry

5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

artículo científico publicado en 2016

A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein

artículo científico publicado en 2018

A lipoxygenase with dual positional specificity is expressed in olives (Olea europaea L.) during ripening.

artículo científico publicado en 2009

A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection

artículo científico publicado en 2015

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis

artículo científico publicado en 2014

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

artículo científico publicado en 2016

Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP

artículo científico publicado en 2015

Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]

scholarly article by Daniela de Lucia et al published October 2015 in European Journal of Medicinal Chemistry

Critical amino acids for the 8(R)-dioxygenase activity of linoleate diol synthase. A comparison with cyclooxygenases

artículo científico publicado en 2008

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

artículo científico publicado en 2015

Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors

artículo científico publicado en 2016

Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening

artículo científico publicado en 2016

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

artículo científico publicado en 2015

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

artículo científico publicado en 2017

Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells

artículo científico publicado en 2011

Enantiomeric separation and analysis of unsaturated hydroperoxy fatty acids by chiral column chromatography-mass spectrometry

artículo científico publicado en 2008

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

artículo científico publicado en 2018

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones

artículo científico publicado en 2017

Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis

artículo científico publicado en 2019

Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase.

artículo científico publicado en 2010

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

artículo científico publicado en 2020

Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.

artículo científico publicado en 2007

Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7.

artículo científico publicado en 2018

Impact of food polyphenols on oxylipin biosynthesis in human neutrophils

artículo científico publicado en 2019

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase

artículo científico publicado en 2014

Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity

artículo científico publicado en 2009

Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acids

scientific article published on 16 July 2019

Manganese lipoxygenase oxidizes bis-allylic hydroperoxides and octadecenoic acids by different mechanisms

artículo científico publicado en 2010

Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159

scientific article published on 08 November 2018

Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents

artículo científico publicado en 2016

Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry

artículo científico publicado en 2006

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

artículo científico publicado en 2017

Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase

artículo científico publicado en 2008

Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.

artículo científico publicado en 2010

Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases

artículo científico publicado en 2011

Steric analysis of 8-hydroxy- and 10-hydroxyoctadecadienoic acids and dihydroxyoctadecadienoic acids formed from 8R-hydroperoxyoctadecadienoic acid by hydroperoxide isomerases

artículo científico publicado en 2007

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

scientific article published on 11 May 2020

Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.

artículo científico publicado en 2016

Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

scientific article published on 08 February 2019

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

artículo científico publicado en 2016

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes

artículo científico publicado en 2015

Lista de obras de Ulrike Garscha

4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)

5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein

A lipoxygenase with dual positional specificity is expressed in olives (Olea europaea L.) during ripening.

A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP

Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]

Critical amino acids for the 8(R)-dioxygenase activity of linoleate diol synthase. A comparison with cyclooxygenases

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors

Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells

Enantiomeric separation and analysis of unsaturated hydroperoxy fatty acids by chiral column chromatography-mass spectrometry

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones

Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis

Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase.

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.

Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7.

Impact of food polyphenols on oxylipin biosynthesis in human neutrophils

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase

Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity

Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acids

Manganese lipoxygenase oxidizes bis-allylic hydroperoxides and octadecenoic acids by different mechanisms

Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159

Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents

Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase

Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.

Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases

Steric analysis of 8-hydroxy- and 10-hydroxyoctadecadienoic acids and dihydroxyoctadecadienoic acids formed from 8R-hydroperoxyoctadecadienoic acid by hydroperoxide isomerases

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.

Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes