Lista de obras - Albert Hagege - Dominio Público Uruguay

"Crochetage" (notch) on R wave in inferior limb leads: a new independent electrocardiographic sign of atrial septal defect

scientific article published on 01 March 1996

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).

artículo científico publicado en 2014

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates.

artículo científico publicado en 2010

A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure

artículo científico publicado en 2015

Accuracy of European diagnostic criteria for familial hypertrophic cardiomyopathy in a genotyped population

scientific article published on 01 July 2003

Acute catecholamine cardiomyopathy in patients with phaeochromocytoma or functional paraganglioma.

artículo científico publicado en 2013

Adenoviral cardiotrophin-1 gene transfer protects pmn mice from progressive motor neuronopathy.

artículo científico publicado en 1999

Adult patients with Fabry disease: what does the cardiologist need to know?

artículo científico publicado en 2015

Ambulatory treatment of chronic cardiac insufficiency

artículo científico publicado en 1995

Amylose cardiaque : à propos d’une série de 14 patients, description et facteurs pronostiques

artículo científico publicado en 2013

An egg-shaped cyst of the right interventricular septum.

artículo científico publicado en 2013

Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice.

artículo científico publicado en 2013

Angiotensin-converting enzyme inhibitor therapy improves respiratory muscle strength in patients with heart failure.

artículo científico publicado en 2001

Assessment of diastolic function from velocity-encoded cardiac magnetic resonance data in patients with hypertrophic cardiomyopathy

Atrioventricular valve development: new perspectives on an old theme.

artículo científico publicado en 2012

Autologous Myoblast Transplantation for Chronic Ischemic Mitral Regurgitation

article

Can erythropoietin improve skeletal myoblast engraftment in infarcted myocardium?

artículo científico publicado en 2007

Can magnetic targeting of magnetically labeled circulating cells optimize intramyocardial cell retention?

artículo científico publicado en 2011

Can mesenchymal stem cells induce tolerance to cotransplanted human embryonic stem cells?

artículo científico publicado en 2008

Cardiogenic shock, asthma, and hypereosinophilia

scientific article published on 08 August 2014

Cardiotoxicity of 5-fluorouracil: coronary spasm? Apropos of 2 cases with normal coronarography

artículo científico publicado en 1989

Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice

scientific journal article

Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure.

artículo científico publicado en 2016

Characterization of the paracrine effects of human skeletal myoblasts transplanted in infarcted myocardium.

artículo científico publicado en 2008

Chordal cutting does not adversely affect left ventricle contractile function

artículo científico publicado en 2006

Clinical study of the effects of latissimus dorsi muscle flap stimulation after cardiomyoplasty

scientific article published on 01 November 1995

Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy

artículo científico publicado en 1996

Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency

artículo científico publicado en 2016

Comparison of human skeletal myoblasts and bone marrow-derived CD133+progenitors for the repair of infarcted myocardium

artículo científico publicado en 2004

Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function

scientific article published on 01 June 2000

Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells.

artículo científico publicado en 2010

Consequences of mitral valve prolapse on chordal tension: ex vivo and in vivo studies in large animal models

artículo científico publicado en 2011

Detection of pathologic or physiologic left ventricular remodeling in athletes

scientific article published on 01 May 2005

Determination of left ventricular mass with electron beam computed tomography in deformed, hypertrophic human hearts

scientific article published on 01 June 1994

Diagnostic Value of Electrocardiography and Echocardiography for Familial Hypertrophic Cardiomyopathy in a Genotyped Adult Population ⬇️

artículo científico publicado el 1 de julio de 1997

Diagnostic value of electrocardiography and echocardiography for familial hypertrophic cardiomyopathy in genotyped children

artículo científico publicado en 1998

Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats.

artículo científico publicado en 2007

Does karate injure blood vessels of the hand?

artículo científico publicado en 1984

Does ketanserin relieve frostbite?

artículo científico publicado en 1986

Does transplantation of cardiomyocytes improve function of infarcted myocardium?

scientific article published on 01 November 1997

Dynamic changes of the mitral valve annulus: new look at mitral valve diseases

artículo científico publicado en 2015

Efficacy of chordal cutting to relieve chronic persistent ischemic mitral regurgitation

artículo científico publicado en 2003

Efficacy of epicardially delivered adipose stroma cell sheets in dilated cardiomyopathy.

artículo científico publicado en 2013

Enhancement of the functional benefits of skeletal myoblast transplantation by means of coadministration of hypoxia-inducible factor 1alpha

artículo científico publicado en 2005

Epicardial adipose stem cell sheets results in greater post-infarction survival than intramyocardial injections.

artículo científico publicado en 2011

Evaluation of a specific French scale of activity in chronic heart failure. A national multicenter study. Group for Cardiac Insufficiency and Cardiomyopathy of the French Society of Cardiology

artículo científico publicado en 1999

Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis.

artículo científico publicado en 2010

Factors affecting functional outcome after autologous skeletal myoblast transplantation

scientific article published on 01 March 2001

First clinical use of a bioprosthetic total artificial heart: report of two cases

artículo científico publicado en 2015

First evaluation using a validated scale of the risk of congestive heart failure among hypertensive patients treated by general practitioners (O-PREDICT survey).

artículo científico publicado en 2010

First hospitalization for heart failure in France in 2009: patient characteristics and 30-day follow-up.

artículo científico publicado en 2013

GLA-Ring Opportunities and Challenges for Fabry Disease

artículo científico publicado en 2016

Gene delivery to the myocardium by intrapericardial injection.

artículo científico publicado en 1999

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

artículo científico publicado en 2015

Genotype-phenotype analysis in four families with mutations in β-myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy

article

Genotype–phenotype correlations in familial hypertrophic cardiomyopathy A comparison between mutations in the cardiac protein-C and the beta-myosin heavy chain genes

article

Geographic variations in the PARADIGM-HF heart failure trial.

artículo científico publicado en 2016

Global circumferential left ventricular strain impairment in hypertrophic cardiomyopathy: comparison to left ventricular hypertrophy and late gadolinium enhancement.

artículo científico publicado en 2013

Head-to-head comparison of the diagnostic performance of coronary computed tomography angiography and dobutamine-stress echocardiography in the evaluation of acute chest pain with normal ECG findings and negative troponin tests: A prospective multic

artículo científico publicado en 2017

Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report: Figure 1

artículo científico publicado en 2015

In Vitro System for Measuring Chordal Force Changes Following Mitral Valve Patch Repair.

artículo científico publicado en 2012

In vivo quantitative mapping of myocardial stiffening and transmural anisotropy during the cardiac cycle

artículo científico publicado en 2010

Influence of Vagus Nerve Stimulation parameters on chronotropism and inotropism in heart failure.

artículo científico publicado en 2014

Intramyocardial transplantation of autologous myoblasts: can tissue processing be optimized?

artículo científico publicado en 2000

Is skeletal myoblast transplantation clinically relevant in the era of angiotensin-converting enzyme inhibitors?

artículo científico publicado en 2001

Is xenotransplantation of embryonic stem cells a realistic option?

artículo científico publicado en 2007

Kinetic index combining native and postcontrast myocardial T1 in hypertrophic cardiomyopathy

artículo científico

Letter by Messas et al regarding article, "Initial results of posterior leaflet extension for severe type IIIb ischemic mitral regurgitation"

artículo científico publicado en 2010

Long-term (1 year) functional and histological results of autologous skeletal muscle cells transplantation in rat

scientific article published on 01 April 2003

Long-term efficacy of dynamic cardiomyoplasty. Clinical, ultrasonic and haemodynamic evidence in one case

artículo científico publicado en 1990

Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction

artículo científico publicado en 2002

Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold

artículo científico publicado en 2014

Management of the patient with chronic coronary artery disease

artículo científico publicado en 2008

Mapping myocardial fiber orientation using echocardiography-based shear wave imaging.

artículo científico publicado en 2011

Mediastinitis due to Mycobacterium tuberculosis after a redo open heart surgery

scientific article published on 01 February 2005

Mice chronically fed a westernized experimental diet as a model of obesity, metabolic syndrome and osteoporosis.

artículo científico publicado en 2006

Mitral valve disease--morphology and mechanisms

artículo científico publicado en 2015

Model-Based Design and Experimental Validation of Control Modules for Neuromodulation Devices

artículo científico publicado en 2015

Mutations in DCHS1 cause mitral valve prolapse

scientific journal article

Myoblast transplantation for heart failure

scientific article published in The Lancet

Myoblast transplantation for heart failure: where are we heading?

artículo científico publicado en 2005

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.

artículo científico publicado en 2016

Myocardial contractile reserve under low doses of dobutamine and improvement of left ventricular ejection fraction with treatment by carvedilol.

artículo científico publicado en 2002

New trends in treatment of hypertrophic cardiomyopathy.

artículo científico publicado en 2009

Non-vitamin K antagonist oral anticoagulants and heart failure

artículo científico publicado en 2016

Patient journey in decompensated heart failure: An analysis in departments of cardiology and geriatrics in the Greater Paris University Hospitals

artículo científico

Percutaneous transluminal septal coil embolisation as an alternative to alcohol septal ablation for hypertrophic obstructive cardiomyopathy.

artículo científico publicado en 2005

Pericardial effusion causing echocardiographic mimicking of left intra-atrial thrombus

artículo científico publicado en 2008

Pocket-sized focused cardiac ultrasound: strengths and limitations

artículo científico publicado en 2015

Population movement and sudden cardiac arrest location.

artículo científico publicado en 2015

Prognostic factors in dilated cardiomyopathies

artículo científico publicado en 1988

Regeneration of the myocardium: a new role in the treatment of ischemic heart disease?

artículo científico publicado en 2001

Relation between QT duration and maximal wall thickness in familial hypertrophic cardiomyopathy

artículo científico publicado en 2002

Relief of mitral leaflet tethering following chronic myocardial infarction by chordal cutting diminishes left ventricular remodeling.

artículo científico publicado en 2010

Renin-angiotensin system contribution to cardiac hypertrophy in experimental hyperthyroidism: an echocardiographic study.

artículo científico publicado en 2001

Routine delivery of myoblasts during coronary artery bypass surgery: why not?

artículo científico publicado en 2006

Rupture of mitral valve chordae in hypertrophic cardiomyopathy

artículo científico publicado en 2015

Screening for rheumatic heart disease: evaluation of a focused cardiac ultrasound approach.

artículo científico publicado en 2015

Serial left ventricular adaptations in world-class professional cyclists: implications for disease screening and follow-up.

artículo científico publicado en 2004

Skeletal myoblast transplantation through a catheter-based coronary sinus approach: an effective means of improving function of infarcted myocardium

artículo científico publicado en 2005

Stress ultrasonography under low doses of dobutamine, contractile reserve and dilated cardiomyopathy

artículo científico publicado en 2002

Survival from sports-related sudden cardiac arrest: In sports facilities versus outside of sports facilities.

artículo científico publicado en 2015

Survival, haemodynamics and cardiac remodelling follow up in mice after myocardial infarction

artículo científico publicado en 2003

Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities

artículo científico publicado en 2015

The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation.

artículo científico publicado en 2008

The mitral valve in hypertrophic cardiomyopathy: old versus new concepts.

artículo científico

The unsaddled annulus: biomechanical culprit in mitral valve prolapse?

artículo científico publicado en 2013

Tissue kallikrein deficiency aggravates cardiac remodelling and decreases survival after myocardial infarction in mice

scientific article published on 14 March 2008

Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience

artículo científico publicado en 2014

Translational research on the mitral valve: from developmental mechanisms to new therapies

artículo científico publicado en 2011

Transplantation of cardiac-committed mouse embryonic stem cells to infarcted sheep myocardium: a preclinical study

artículo científico publicado en 2005

Two-year outcome of patients after a first hospitalization for heart failure: A national observational study

artículo científico publicado en 2014

Vagus nerve stimulation: state of the art of stimulation and recording strategies to address autonomic function neuromodulation

artículo científico publicado en 2016

Value and limitations of methods for measuring left ventricular mass

artículo científico publicado en 1995

Wytyczne ESC dotyczące rozpoznawania i postępowania w kardiomiopatii przerostowej w 2014 roku

artículo científico publicado en 2014

X-chromosome inactivation in female patients with Fabry disease

artículo científico publicado en 2015

[2 cases of agenesis of the left coronary trunk in adults]

scientific article published on 01 April 1989

[Autologous skeletal myoblast transplantation for cardiac insufficiency. First clinical case]

artículo científico publicado en 2001

[Cardiac cellular therapy: from cells to the first clinical uses]

scientific article published on 01 June 2005

[Cardiac manifestations of Anderson-Fabry disease and efficacy of enzyme replacement therapy]

artículo científico publicado en 2010

[Cardiomyopathy and sport]

artículo científico publicado en 2006

[Cellular cardiomyoplasty: state of the art, evaluation, and future possibilities]

artículo científico publicado en 1998

[Clinico-pathological polymorphism of hypertrophic cardiomyopathy in echocardiography]

scientific article published on 01 April 1995

[Coronary angioplasty combining rotational atherectomy and balloon dilatation. Results in 67 complex stenoses]

scientific article published on 01 November 1993

[Demonstration of a fifth locus implicated in familial hypertrophic cardiomyopathies]

scientific article published on 01 December 1994

[Dynamic cardiomyoplasty: models of action and indications]

scientific article published on 01 November 1996

[Exertion doppler echocardiography and hypertrophic cardiomyopathy]

scientific article published on 01 June 2000

[French familial multicenter survey of hypertrophic cardiomyopathy. Initial Doppler echocardiographic results]

artículo científico publicado en 1993

[Giant negative T waves in idiopathic apical diverticulum of the left ventricle in adults]

scientific article published on 01 October 1995

[How to evaluate a patient with heart failure? Round table]

artículo científico publicado en 1995

[Hypertrophic cardiomyopathy: place and limitations of medical therapy]

scientific article published on 01 April 1995

[Inherited metabolic cardiomyopathies]

scientific article published on 01 March 2007

[Late effect of intracoronary urokinase. Apropos of a case of recurrent coronary thrombosis after angioplasty]

scientific article published on 01 March 1988

[Management of arterial hypertension]

[Mitral valve insufficiency]

artículo científico publicado en 2002

[Myoblast transplantation for heart failure: where are we heading?]

scientific article published on 01 June 2005

[New methods of measurement of left ventricular hypertrophy]

scientific article published on 01 May 1994

[Physical reproduction of cardiac sutures. A new field of investigation in cardiology]

scientific article published on 01 October 2000

[Physiopathology of mitral mechanics in hypertrophic cardiomyopathy. Groupe de travail "Cardiomyopathies et insuffisance cardiaque" de la Société Française de Cardiologie]

artículo científico publicado en 1994

[Raynaud's phenomenon]

scientific article published on 01 April 1986

[Recommendations of the French Society of Cardiology concerning indications for doppler echocardiography]

scientific article published on 01 March 2003

[Sarcoidosis disclosed by renal insufficiency (3 cases)]

[Spasm of the left main coronary artery resistant to intracoronary vasodilators. Apropos of a case]

scientific article published on 01 February 1992

[The natural history of 270 cases of Wolff-Parkinson-White syndrome in a survey of the general population]

scientific article published on 01 March 1989

[Three-dimensional echocardiography. Principles and applications]

scientific article published on 01 November 1996

[Three-dimensional echocardiography: methodology trial]

artículo científico publicado en 2000

[Transplantation of autologous skeletal myoblasts in ischemic cardiac insufficiency]

artículo científico publicado en 2001

Lista de obras de Albert Hagege

"Crochetage" (notch) on R wave in inferior limb leads: a new independent electrocardiographic sign of atrial septal defect

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates.

A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure

Accuracy of European diagnostic criteria for familial hypertrophic cardiomyopathy in a genotyped population

Acute catecholamine cardiomyopathy in patients with phaeochromocytoma or functional paraganglioma.

Adenoviral cardiotrophin-1 gene transfer protects pmn mice from progressive motor neuronopathy.

Adult patients with Fabry disease: what does the cardiologist need to know?

Ambulatory treatment of chronic cardiac insufficiency

Amylose cardiaque : à propos d’une série de 14 patients, description et facteurs pronostiques

An egg-shaped cyst of the right interventricular septum.

Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice.

Angiotensin-converting enzyme inhibitor therapy improves respiratory muscle strength in patients with heart failure.

Assessment of diastolic function from velocity-encoded cardiac magnetic resonance data in patients with hypertrophic cardiomyopathy

Atrioventricular valve development: new perspectives on an old theme.

Autologous Myoblast Transplantation for Chronic Ischemic Mitral Regurgitation

Can erythropoietin improve skeletal myoblast engraftment in infarcted myocardium?

Can magnetic targeting of magnetically labeled circulating cells optimize intramyocardial cell retention?

Can mesenchymal stem cells induce tolerance to cotransplanted human embryonic stem cells?

Cardiogenic shock, asthma, and hypereosinophilia

Cardiotoxicity of 5-fluorouracil: coronary spasm? Apropos of 2 cases with normal coronarography

Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice

Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure.

Characterization of the paracrine effects of human skeletal myoblasts transplanted in infarcted myocardium.

Chordal cutting does not adversely affect left ventricle contractile function

Clinical study of the effects of latissimus dorsi muscle flap stimulation after cardiomyoplasty

Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy

Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency

Comparison of human skeletal myoblasts and bone marrow-derived CD133+progenitors for the repair of infarcted myocardium

Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function

Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells.

Consequences of mitral valve prolapse on chordal tension: ex vivo and in vivo studies in large animal models

Detection of pathologic or physiologic left ventricular remodeling in athletes

Determination of left ventricular mass with electron beam computed tomography in deformed, hypertrophic human hearts

Diagnostic Value of Electrocardiography and Echocardiography for Familial Hypertrophic Cardiomyopathy in a Genotyped Adult Population ⬇️

Diagnostic value of electrocardiography and echocardiography for familial hypertrophic cardiomyopathy in genotyped children

Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats.

Does karate injure blood vessels of the hand?

Does ketanserin relieve frostbite?

Does transplantation of cardiomyocytes improve function of infarcted myocardium?

Dynamic changes of the mitral valve annulus: new look at mitral valve diseases

Efficacy of chordal cutting to relieve chronic persistent ischemic mitral regurgitation

Efficacy of epicardially delivered adipose stroma cell sheets in dilated cardiomyopathy.

Enhancement of the functional benefits of skeletal myoblast transplantation by means of coadministration of hypoxia-inducible factor 1alpha

Epicardial adipose stem cell sheets results in greater post-infarction survival than intramyocardial injections.

Evaluation of a specific French scale of activity in chronic heart failure. A national multicenter study. Group for Cardiac Insufficiency and Cardiomyopathy of the French Society of Cardiology

Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis.

Factors affecting functional outcome after autologous skeletal myoblast transplantation

First clinical use of a bioprosthetic total artificial heart: report of two cases

First evaluation using a validated scale of the risk of congestive heart failure among hypertensive patients treated by general practitioners (O-PREDICT survey).

First hospitalization for heart failure in France in 2009: patient characteristics and 30-day follow-up.

GLA-Ring Opportunities and Challenges for Fabry Disease

Gene delivery to the myocardium by intrapericardial injection.

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

Genotype-phenotype analysis in four families with mutations in β-myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy

Genotype–phenotype correlations in familial hypertrophic cardiomyopathy A comparison between mutations in the cardiac protein-C and the beta-myosin heavy chain genes

Geographic variations in the PARADIGM-HF heart failure trial.

Global circumferential left ventricular strain impairment in hypertrophic cardiomyopathy: comparison to left ventricular hypertrophy and late gadolinium enhancement.

Head-to-head comparison of the diagnostic performance of coronary computed tomography angiography and dobutamine-stress echocardiography in the evaluation of acute chest pain with normal ECG findings and negative troponin tests: A prospective multic

Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report: Figure 1

In Vitro System for Measuring Chordal Force Changes Following Mitral Valve Patch Repair.

In vivo quantitative mapping of myocardial stiffening and transmural anisotropy during the cardiac cycle

Influence of Vagus Nerve Stimulation parameters on chronotropism and inotropism in heart failure.

Intramyocardial transplantation of autologous myoblasts: can tissue processing be optimized?

Is skeletal myoblast transplantation clinically relevant in the era of angiotensin-converting enzyme inhibitors?

Is xenotransplantation of embryonic stem cells a realistic option?

Kinetic index combining native and postcontrast myocardial T1 in hypertrophic cardiomyopathy

Letter by Messas et al regarding article, "Initial results of posterior leaflet extension for severe type IIIb ischemic mitral regurgitation"

Long-term (1 year) functional and histological results of autologous skeletal muscle cells transplantation in rat

Long-term efficacy of dynamic cardiomyoplasty. Clinical, ultrasonic and haemodynamic evidence in one case

Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction

Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold

Management of the patient with chronic coronary artery disease

Mapping myocardial fiber orientation using echocardiography-based shear wave imaging.

Mediastinitis due to Mycobacterium tuberculosis after a redo open heart surgery

Mice chronically fed a westernized experimental diet as a model of obesity, metabolic syndrome and osteoporosis.

Mitral valve disease--morphology and mechanisms

Model-Based Design and Experimental Validation of Control Modules for Neuromodulation Devices

Mutations in DCHS1 cause mitral valve prolapse