Lista de obras - Roberto Perrone - Dominio Público Uruguay

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity

artículo científico publicado en 2011

1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3

artículo científico publicado en 1996

11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors.

artículo científico publicado en 2005

2-Aminopyridine derivatives as potential σ(2) receptor antagonists

artículo científico publicado en 2012

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

artículo científico publicado en 2008

A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder

artículo científico publicado en 2003

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

artículo científico publicado en 2013

Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers

artículo científico publicado en 2011

Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers

artículo científico publicado en 2011

Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.

artículo científico publicado en 2015

Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins

artículo científico publicado en 2008

Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.

artículo científico publicado en 2005

EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives

artículo científico publicado en 2011

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum

artículo científico publicado en 2008

Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

artículo científico publicado en 2009

Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells

artículo científico publicado en 2011

Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay

artículo científico publicado en 2007

Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer

artículo científico publicado en 2010

Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines

artículo científico publicado en 2013

Is the sigma2 receptor a histone binding protein?

artículo científico publicado en 2006

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor

artículo científico publicado en 2010

Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

artículo científico publicado en 2009

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

artículo científico publicado en 2012

Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.

artículo científico publicado en 2013

PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD.

artículo científico

Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials

scientific article published on March 2010

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp

artículo científico publicado en 2013

Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein

artículo científico publicado en 2011

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity

artículo científico publicado en 2013

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

artículo científico publicado en 2007

Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands

artículo científico publicado en 2011

Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor

artículo científico publicado en 2014

The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells

artículo científico publicado en 2006

Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters

artículo científico publicado en 2013

Lista de obras de Roberto Perrone

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity

1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3

11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors.

2-Aminopyridine derivatives as potential σ(2) receptor antagonists

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers

Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers

Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.

Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins

Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.

EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum

Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells

Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay

Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer

Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines

Is the sigma2 receptor a histone binding protein?

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor

Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.

PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD.

Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp

Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands

Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor

The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells

Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters