Lista de obras - Justin Guinney - Dominio Público Uruguay

A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma.

artículo científico publicado en 2011

A DREAM Challenge to Build Prediction Models for Short-Term Discontinuation of Docetaxel in Metastatic Castration-Resistant Prostate Cancer

scientific article published on 01 November 2017

A Machine-Learning Tool Concurrently Models Single Omics and Phenome Data for Functional Subtyping and Personalized Cancer Medicine

scientific article published on 30 September 2020

A cancer pharmacogenomic screen powering crowd-sourced advancement of drug combination prediction

A clinically and genomically annotated nerve sheath tumor biospecimen repository

scientific article published on 19 June 2020

A high-throughput molecular data resource for cutaneous neurofibromas.

artículo científico publicado en 2017

Alternative models for sharing confidential biomedical data

article by Justin Guinney et al published 9 May 2018 in Nature Biotechnology

American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond—Lessons Learned and Member Institutions’ Perspectives

artículo científico publicado en 2018

Analysis of sample set enrichment scores: assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles

artículo científico publicado en 2006

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

artículo científico publicado en 2016

CRI iAtlas: an interactive portal for immuno-oncology research

scientific article published on 24 August 2020

CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer

artículo científico publicado en 2014

Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies

artículo científico publicado en 2017

Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2

artículo científico publicado en 2018

Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection

scientific article published on 06 November 2018

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.

artículo científico publicado en 2019

Community mining of open clinical trial data.

artículo científico publicado en 2017

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

artículo científico publicado en 2017

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

artículo científico publicado en 2017

Correlation set analysis: detecting active regulators in disease populations using prior causal knowledge

artículo científico publicado en 2012

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge

artículo científico publicado en 2021

Cutaneous neurofibromas in the genomics era: current understanding and open questions

artículo científico publicado en 2018

Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors

artículo científico publicado en 2015

Engaging a community to enable disease-centric data sharing with the NF Data Portal

scientific article published on 13 December 2019

Estimating variable structure and dependence in multitask learning via gradients

article

Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms

artículo científico publicado en 2020

Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma

artículo científico publicado en 2012

F-Seq: a feature density estimator for high-throughput sequence tags

artículo científico publicado en 2008

Functional precision medicine identifies novel druggable targets and therapeutic options in head and neck cancer.

artículo científico publicado en 2018

GSVA: gene set variation analysis for microarray and RNA-seq data.

artículo científico publicado en 2013

Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data

scientific article published on 24 September 2020

Genome-wide methylation profiles reveal quantitative views of human aging rates

artículo científico publicado en 2012

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

artículo científico

Genomic determinants of protein abundance variation in colorectal cancer cells

Genomic strategy for targeting therapy in castration-resistant prostate cancer

artículo científico publicado en 2009

Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in oncology.

artículo científico publicado en 2013

Impact of centralization on aCGH-based genomic profiles for precision medicine in oncology

artículo científico publicado en 2014

Improving breast cancer survival analysis through competition-based multidimensional modeling

artículo científico publicado en 2013

Inferring causal molecular networks: empirical assessment through a community-based effort

artículo científico publicado en 2016

Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus

artículo científico publicado en 2012

Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1

artículo científico publicado en 2020

KRAS mutation and Consensus Molecular Subtypes 2 and 3 are independently associated with reduced immune infiltration and reactivity in colorectal cancer.

artículo científico publicado en 2017

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

artículo científico publicado en 2020

Knowledge-based classification of fine-grained immune cell types in single-cell RNA-Seq data

artículo científico publicado en 2021

Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients

artículo científico publicado en 2013

Modeling cancer progression via pathway dependencies

artículo científico publicado en 2008

Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes

artículo científico publicado en 2014

Multi-targeting Drug Community Challenge

artículo científico publicado en 2017

Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease

artículo científico publicado en 2020

PERSONALIZED HYPOTHESIS TESTS FOR DETECTING MEDICATION RESPONSE IN PARKINSON DISEASE PATIENTS USING iPHONE SENSOR DATA.

artículo científico publicado en 2016

Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells.

artículo científico publicado en 2018

Piloting a model-to-data approach to enable predictive analytics in health care through patient mortality prediction

artículo científico publicado en 2020

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

artículo científico publicado en 2016

Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study

artículo científico publicado en 2017

Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting

artículo científico publicado en 2011

Probing the chemical-biological relationship space with the Drug Target Explorer

Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer

artículo científico publicado en 2019

Reply to the letter to the editor 'Including lynch syndrome in personalized prognostication and follow-up of stage II and III colon cancer' by Sciallero et al.

artículo científico publicado en 2017

Reproducible biomedical benchmarking in the cloud: lessons from crowd-sourced data challenges

artículo científico publicado en 2019

Social interactomes for enabling research communities

artículo científico publicado en 2014

Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges

scientific article published on 01 October 2020

Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges

scientific article published on 01 December 2020

Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the Hippo pathway

article

Stepwise group sparse regression (SGSR): gene-set-based pharmacogenomic predictive models with stepwise selection of functional priors

artículo científico publicado en 2015

Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer

artículo científico publicado en 2013

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

scientific article published on 01 April 2020

The Immune Landscape of Cancer

artículo científico publicado en 2018

The Immune Landscape of Cancer

scientific article published on 01 August 2019

The NIH BD2K center for big data in translational genomics

artículo científico publicado en 2015

The consensus molecular subtypes of colorectal cancer

artículo científico publicado en 2015

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin

scientific article published on 20 May 2019

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.

artículo científico publicado en 2018

rCGH: a comprehensive array-based genomic profile platform for precision medicine

artículo científico publicado en 2015

Lista de obras de Justin Guinney

A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma.

A DREAM Challenge to Build Prediction Models for Short-Term Discontinuation of Docetaxel in Metastatic Castration-Resistant Prostate Cancer

A Machine-Learning Tool Concurrently Models Single Omics and Phenome Data for Functional Subtyping and Personalized Cancer Medicine

A cancer pharmacogenomic screen powering crowd-sourced advancement of drug combination prediction

A clinically and genomically annotated nerve sheath tumor biospecimen repository

A high-throughput molecular data resource for cutaneous neurofibromas.

Alternative models for sharing confidential biomedical data

American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond—Lessons Learned and Member Institutions’ Perspectives

Analysis of sample set enrichment scores: assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

CRI iAtlas: an interactive portal for immuno-oncology research

CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer

Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies

Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2

Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.

Community mining of open clinical trial data.

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

Correlation set analysis: detecting active regulators in disease populations using prior causal knowledge

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge

Cutaneous neurofibromas in the genomics era: current understanding and open questions

Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors

Engaging a community to enable disease-centric data sharing with the NF Data Portal

Estimating variable structure and dependence in multitask learning via gradients

Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms

Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma

F-Seq: a feature density estimator for high-throughput sequence tags

Functional precision medicine identifies novel druggable targets and therapeutic options in head and neck cancer.

GSVA: gene set variation analysis for microarray and RNA-seq data.

Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data

Genome-wide methylation profiles reveal quantitative views of human aging rates

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

Genomic determinants of protein abundance variation in colorectal cancer cells

Genomic strategy for targeting therapy in castration-resistant prostate cancer

Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in oncology.

Impact of centralization on aCGH-based genomic profiles for precision medicine in oncology

Improving breast cancer survival analysis through competition-based multidimensional modeling

Inferring causal molecular networks: empirical assessment through a community-based effort

Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus

Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1

KRAS mutation and Consensus Molecular Subtypes 2 and 3 are independently associated with reduced immune infiltration and reactivity in colorectal cancer.

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Knowledge-based classification of fine-grained immune cell types in single-cell RNA-Seq data

Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients

Modeling cancer progression via pathway dependencies

Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes

Multi-targeting Drug Community Challenge

Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease

PERSONALIZED HYPOTHESIS TESTS FOR DETECTING MEDICATION RESPONSE IN PARKINSON DISEASE PATIENTS USING iPHONE SENSOR DATA.

Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells.

Piloting a model-to-data approach to enable predictive analytics in health care through patient mortality prediction

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study

Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting

Probing the chemical-biological relationship space with the Drug Target Explorer

Probing the chemical-biological relationship space with the Drug Target Explorer

Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer

Reply to the letter to the editor 'Including lynch syndrome in personalized prognostication and follow-up of stage II and III colon cancer' by Sciallero et al.

Reproducible biomedical benchmarking in the cloud: lessons from crowd-sourced data challenges

Social interactomes for enabling research communities

Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges

Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges

Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the Hippo pathway

Stepwise group sparse regression (SGSR): gene-set-based pharmacogenomic predictive models with stepwise selection of functional priors

Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

The Immune Landscape of Cancer

The Immune Landscape of Cancer

The NIH BD2K center for big data in translational genomics

The consensus molecular subtypes of colorectal cancer

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.

rCGH: a comprehensive array-based genomic profile platform for precision medicine