Lista de obras - Joan Wither - Dominio Público Uruguay

A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis

artículo científico publicado en 2016

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

artículo científico publicado en 2010

A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells

artículo científico publicado en 2018

Aberrant IgM signaling promotes survival of transitional T1 B cells and prevents tolerance induction in lupus-prone New Zealand black mice

scientific article published on 01 December 2005

Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice

artículo científico publicado en 2011

Activated B cells express increased levels of costimulatory molecules in young autoimmune NZB and (NZB x NZW)F(1) mice

scientific article published on 01 January 2000

Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus

artículo científico publicado en 2010

An epitaph for sulfated insulin: immunologic profile of the last patients as they are switched from sulfated beef to human insulin

artículo científico publicado en 1998

An intrinsic B-cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice

scientific article published on 29 December 2010

Anti-dsDNA and Antichromatin Antibody Isotypes in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

artículo científico publicado en 2015

Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus

artículo científico publicado en 2014

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

scientific article published on 14 May 2018

Association of LY9 in UK and Canadian SLE families

artículo científico publicado en 2008

Association of systemic lupus erythematosus (SLE) genetic susceptibility loci with lupus nephritis in childhood-onset and adult-onset SLE

scientific article published on 01 January 2020

Autoreactive B cells in lupus-prone New Zealand black mice exhibit aberrant survival and proliferation in the presence of self-antigen in vivo

scientific article published on 01 February 2004

B cell activating factor (BAFF) and T cells cooperate to breach B cell tolerance in lupus-prone New Zealand Black (NZB) mice

artículo científico publicado en 2010

Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint

artículo científico publicado en 2010

Both MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response

artículo científico publicado en 1995

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways

artículo científico publicado en 2015

Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval.

artículo científico publicado en 2005

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

artículo científico publicado en 2008

Development, Sensibility, and Validity of a Systemic Autoimmune Rheumatic Disease Case Ascertainment Tool

artículo científico publicado en 2016

Dissociation of the genetic loci leading to b1a and NKT cell expansions from autoantibody production and renal disease in B6 mice with an introgressed New Zealand Black chromosome 4 interval

artículo científico publicado en 2007

Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice.

artículo científico publicado en 2011

Evaluation of clinical outcomes and renal vascular pathology among patients with lupus

artículo científico publicado en 2012

Experimental evidence that mutated-self peptides derived from mitochondrial DNA somatic mutations have the potential to trigger autoimmunity.

artículo científico publicado en 2014

Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease

scientific article published on 04 November 2019

Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.

artículo científico publicado en 2003

Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice

scientific article published on 01 December 2005

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

artículo científico publicado en 2015

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins

artículo científico publicado en 2018

Healthcare cost and loss of productivity in a Canadian population of patients with and without lupus nephritis.

artículo científico publicado en 2010

IL-10 Production Is Critical for Sustaining the Expansion of CD5+ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice

artículo científico publicado en 2016

Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.

scientific article published on 17 January 2013

Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms.

artículo científico publicado en 2018

Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.

artículo científico publicado en 2015

Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice

scientific article published on 01 September 2007

Immunoglobulin G subclass analysis in psoriatic arthritis

scientific article published on 15 October 2014

Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in Vκ8/3H9 lupus-prone mice

artículo científico publicado en 2020

Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.

artículo científico publicado en 2017

Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

artículo científico publicado en 2015

Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus

artículo científico publicado en 2008

Molecular basis of antigen recognition by insulin specific T cell receptor.

artículo científico publicado en 2004

Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis

artículo científico

Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice

artículo científico publicado en 2017

Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents

artículo científico publicado en 2010

Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus

artículo científico publicado en 2011

Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis

artículo científico publicado en 2017

Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis

scientific article published on 28 June 2019

Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity

artículo científico publicado en 2008

Rethinking Lupus Nephritis Classification on a Molecular Level

scientific article published on 23 September 2019

Suppression of autoimmunity by CD5(+) IL-10-producing B cells in lupus-prone mice.

artículo científico publicado en 2015

T cell and dendritic cell abnormalities synergize to expand pro-inflammatory T cell subsets leading to fatal autoimmunity in B6.NZBc1 lupus-prone mice

artículo científico publicado en 2013

T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus

scientific article published on 01 March 2000

TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice

artículo científico publicado en 2012

The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.

artículo científico publicado en 1998

The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus

artículo científico publicado en 2011

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease

artículo científico publicado en 2018

Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells

artículo científico publicado en 1996

Transancestral mapping and genetic load in systemic lupus erythematosus

artículo científico

Lista de obras de Joan Wither

A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells

Aberrant IgM signaling promotes survival of transitional T1 B cells and prevents tolerance induction in lupus-prone New Zealand black mice

Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice

Activated B cells express increased levels of costimulatory molecules in young autoimmune NZB and (NZB x NZW)F(1) mice

Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus

An epitaph for sulfated insulin: immunologic profile of the last patients as they are switched from sulfated beef to human insulin

An intrinsic B-cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice

Anti-dsDNA and Antichromatin Antibody Isotypes in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

Association of LY9 in UK and Canadian SLE families

Association of systemic lupus erythematosus (SLE) genetic susceptibility loci with lupus nephritis in childhood-onset and adult-onset SLE

Autoreactive B cells in lupus-prone New Zealand black mice exhibit aberrant survival and proliferation in the presence of self-antigen in vivo

B cell activating factor (BAFF) and T cells cooperate to breach B cell tolerance in lupus-prone New Zealand Black (NZB) mice

Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint

Both MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways

Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval.

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

Development, Sensibility, and Validity of a Systemic Autoimmune Rheumatic Disease Case Ascertainment Tool

Dissociation of the genetic loci leading to b1a and NKT cell expansions from autoantibody production and renal disease in B6 mice with an introgressed New Zealand Black chromosome 4 interval

Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice.

Evaluation of clinical outcomes and renal vascular pathology among patients with lupus

Experimental evidence that mutated-self peptides derived from mitochondrial DNA somatic mutations have the potential to trigger autoimmunity.

Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease

Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.

Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins

Healthcare cost and loss of productivity in a Canadian population of patients with and without lupus nephritis.

IL-10 Production Is Critical for Sustaining the Expansion of CD5+ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice

Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.

Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms.

Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.

Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice

Immunoglobulin G subclass analysis in psoriatic arthritis

Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in Vκ8/3H9 lupus-prone mice

Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.

Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus

Molecular basis of antigen recognition by insulin specific T cell receptor.

Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis

Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice

Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents

Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus

Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis

Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis

Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity

Rethinking Lupus Nephritis Classification on a Molecular Level

Suppression of autoimmunity by CD5(+) IL-10-producing B cells in lupus-prone mice.

T cell and dendritic cell abnormalities synergize to expand pro-inflammatory T cell subsets leading to fatal autoimmunity in B6.NZBc1 lupus-prone mice

T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus

TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice

The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.

The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease

Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells

Transancestral mapping and genetic load in systemic lupus erythematosus