Lista de obras - Bernard Ducommun - Dominio Público Uruguay

3D imaging of the response to CDC25 inhibition in multicellular spheroids.

artículo científico publicado en 2009

3D print customized sample holders for live light sheet microscopy

artículo científico publicado en 2015

5-Substituted [1]pyrindine derivatives with antiproliferative activity.

artículo científico publicado en 2009

A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis.

artículo científico publicado en 2008

A checkpoint-oriented cell cycle simulation model

scientific article published on 04 April 2019

A new mitotic-cell specific monoclonal antibody

scientific article published on 07 November 2007

A novel synthetic inhibitor of CDC25 phosphatases: BN82002.

artículo científico publicado en 2004

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

artículo científico publicado en 2010

A versatile microtiter assay for the universal cdc2 cell cycle regulator.

artículo científico publicado en 1990

A versatile sample holder for single plane illumination microscopy.

artículo científico publicado en 2013

Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?

artículo científico

Asymmetric localization of the CDC25B phosphatase to the mother centrosome during interphase.

artículo científico publicado en 2007

CDC25 phosphatases in cancer cells: key players? Good targets?

artículo científico publicado en 2007

CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.

artículo científico publicado en 2011

CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci

artículo científico publicado en 2013

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis

artículo científico publicado en 2005

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.

artículo científico publicado en 2005

CDC25B phosphorylation by p38 and MK-2

artículo científico publicado en 2006

Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.

artículo científico publicado en 2011

Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia

artículo científico publicado en 2006

Cell cycle control by the CDC25 phosphatases

scientific journal article

Cell cycle regulation of p34cdc2 kinase activity in Physarum polycephalum

artículo científico publicado en 1990

Cell-Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation

scientific article published on 08 April 2015

Characterisation of human cdc2 lysine 33 mutations expressed in the fission yeast Schizosaccharomyces pombe

artículo científico publicado en 1996

Characterization of an active GST-human Cdc2 fusion protein kinase expressed in the fission yeast Schizosaccharomyces pombe: a new approach to the study of cell cycle control proteins

artículo científico publicado en 1994

Characterization of the antiproliferative activity of Xylopia aethiopica

artículo científico publicado en 2012

Characterization of the physical properties of tumor-derived spheroids reveals critical insights for pre-clinical studies

scientific article published on 29 April 2019

Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

artículo científico publicado en 2016

Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.

artículo científico publicado en 2009

Cyclin E-cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells

scientific article published on 01 August 2000

Deep and clear optical imaging of thick inhomogeneous samples

artículo científico publicado en 2012

Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity.

artículo científico publicado en 2005

Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors

artículo científico publicado en 2009

Direct activation of cdc2 with phosphatase: identification of p13suc1-sensitive and insensitive steps

artículo científico publicado en 1990

Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells

scientific article published on 01 May 2000

Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast

artículo científico publicado en 1990

Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

artículo científico publicado en 2004

Doxorubicin promotes transcriptional upregulation of Cdc25B in cancer cells by releasing Sp1 from the promoter.

artículo científico publicado en 2012

Effect of phenylarsine oxide on the fission yeast Schizosaccharomyces pombe cell cycle

scientific article published on 01 January 1995

Effects of TGF-beta 1 (transforming growth factor-beta 1) on the cell cycle regulation of human breast adenocarcinoma (MCF-7) cells.

artículo científico publicado en 1995

Effects of phleomycin-induced DNA damage on the fission yeast Schizosaccharomyces pombe cell cycle

scientific article published on 01 March 1995

Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation ⬇️

artículo científico publicado el 1 de diciembre de 1997

Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR.

artículo científico publicado en 2001

Evaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matrices

artículo científico publicado en 2016

Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia.

artículo científico publicado en 2008

Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype

artículo científico publicado en 2012

Evidence for a mammalian Nim1-like kinase pathway acting at the G0-1/S transition

scientific article published on 01 July 1997

Evolutionary conservation of a novel splice variant of the Cds1/CHK2 checkpoint kinase restricted to its regulatory domain.

artículo científico publicado en 2004

Fission yeast Msp1 is a mitochondrial dynamin-related protein

scientific article published on 01 November 1999

Fission yeast cdc25 is a cell-cycle regulated protein.

artículo científico publicado en 1990

G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.

artículo científico publicado en 2008

Gap junctions contribute to anchorage-independent clustering of breast cancer cells.

artículo científico publicado en 2018

Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression

artículo científico publicado en 2006

High-resolution in-depth imaging of optically cleared thick samples using an adaptive SPIM

artículo científico publicado en 2015

Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A.

artículo científico publicado en 1998

Human CDC25B and CDC25C differ by their ability to restore a functional checkpoint response after gene replacement in fission yeast.

artículo científico publicado en 2002

Identification of N-Terminally Truncated Stable Nuclear Isoforms of CDC25B That Are Specifically Involved in G2/M Checkpoint Recovery ⬇️

artículo científico publicado el 1 de marzo de 2011

Identification of a fission yeast dynamin-related protein involved in mitochondrial DNA maintenance.

artículo científico publicado en 1998

Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B

artículo científico publicado en 2006

Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor

scientific article published on 01 June 1995

Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids.

artículo científico publicado en 2018

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.

artículo científico publicado en 2005

Inhibitors of the CDC25 phosphatases

artículo científico publicado el 1 de enero de 2003

Interaction between the fission yeast nim1/cdr1 protein kinase and a dynamin-related protein

artículo científico publicado en 1999

Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair

artículo científico publicado en 2008

Interaction studies between the p21Cip1/Waf1 cyclin-dependent kinase inhibitor and proliferating cell nuclear antigen (PCNA) by surface plasmon resonance

scientific article published on 01 August 1996

Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

artículo científico publicado en 1998

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

artículo científico publicado en 2001

Linking PCNA-dependent replication and ATR by human Claspin

scientific article published on 25 January 2007

Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy

artículo científico publicado en 2011

Measure and characterization of the forces exerted by growing multicellular spheroids using microdevice arrays

artículo científico publicado en 2019

Mechanical stress impairs mitosis progression in multi-cellular tumor spheroids

artículo científico publicado en 2013

Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.

artículo científico publicado en 1995

Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

artículo científico publicado en 2009

Microdevice arrays of high aspect ratio poly(dimethylsiloxane) pillars for the investigation of multicellular tumour spheroid mechanical properties

artículo científico publicado en 2014

Microtubule cytoskeleton and morphogenesis in the amoebae of the myxomycete Physarum polycephalum.

artículo científico publicado en 1988

Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site

artículo científico publicado en 2010

Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model

artículo científico publicado en 2015

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer ⬇️

artículo científico publicado el 13 de enero de 2012

Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D. ⬇️

artículo científico publicado en 2013

Mutations at sites involved in Suc1 binding inactivate Cdc2.

artículo científico publicado en 1991

NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo: full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro.

artículo científico publicado en 2008

Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.

artículo científico publicado en 2008

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

artículo científico publicado en 2000

OPA1 functions in mitochondria and dysfunctions in optic nerve.

artículo científico publicado en 2009

Oxygen Partial Pressure Is a Rate-Limiting Parameter for Cell Proliferation in 3D Spheroids Grown in Physioxic Culture Condition

artículo científico publicado en 2016

PKB/Akt phosphorylates the CDC25B phosphatase and regulates its intracellular localisation.

artículo científico publicado en 2003

Pharmacologic inhibition of CDC25 phosphatases impairs interphase microtubule dynamics and mitotic spindle assembly

artículo científico publicado en 2007

Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics

artículo científico publicado en 2009

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

artículo científico publicado en 2004

Phosphorylation of Human CDC25B Phosphatase by CDK1-Cyclin A Triggers Its Proteasome-dependent Degradation ⬇️

artículo científico publicado el 26 de diciembre de 1997

Phosphorylation of the myristoylated protein kinase C substrate MARCKS by the cyclin E-cyclin-dependent kinase 2 complex in vitro.

artículo científico publicado en 1999

Protein kinase CK2 regulates CDC25B phosphatase activity

artículo científico publicado en 2003

Regulation of CDC25B phosphatases subcellular localization

artículo científico publicado en 2000

Regulation of tubulin synthesis during the cell cycle in the synchronous plasmodia of Physarum polycephalum

artículo científico publicado en 1990

Reversible growth arrest of 3D tumor spheroids stored in oxygen absorber-induced anoxia.

artículo científico publicado en 2017

Role of CDC25 phosphatases in the control of proliferation

scientific article published on 01 April 2000

Role of the fission yeast nim 1 protein kinase in the cell cycle response to nutritional signals.

artículo científico publicado en 1997

Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids.

artículo científico

Structure Tensor Based Analysis of Cells and Nuclei Organization in Tissues.

artículo científico publicado en 2015

Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase.

artículo científico publicado en 2001

Study of the cytolethal distending toxin-induced cell cycle arrest in HeLa cells: involvement of the CDC25 phosphatase

scientific article published on 01 May 2000

Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.

artículo científico publicado en 2011

Subcellular localisation of human wee1 kinase is regulated during the cell cycle.

artículo científico publicado en 1995

Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.

artículo científico publicado en 2005

The "starter" and "gas pedal" of mitosis reside at the centrosome. Commentary on "characterization of centrosomal localization and dynamics of CDC25C phosphatase in mitosis" by Bonnet et al

artículo científico publicado en 2008

The CDC25B phosphatase shortens the G2 phase of neural progenitors and promotes efficient neuron production ⬇️

artículo científico publicado el 8 de febrero de 2012

The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.

artículo científico publicado en 1999

The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

artículo científico publicado en 2011

The fission yeast Nim1/Cdr1 kinase: a link between nutritional state and cell cycle control.

artículo científico publicado en 1995

The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space

artículo científico publicado en 2002

The polo-like kinase 1 regulates CDC25B-dependent mitosis entry

artículo científico publicado en 2009

Use of CDC2 from etoposide-treated cells as substrate to assay CDC25 phosphatase activity

artículo científico publicado en 1999

Use of the two-hybrid system to identify protein-protein interaction temperature-sensitive mutants: application to the CDK2/p21Cip1 interaction ⬇️

artículo científico publicado el 15 de septiembre de 1997

Variation of tubulin half-life during the cell cycle in the synchronous plasmodia of Physarum polycephalum

scientific article published on 01 October 1989

What similarity between human and fission yeast proteins is required for orthology?

artículo científico publicado en 2002

[Bacterial cyclostatin, or how do bacteria manipulate the eukaryotic cell cycle]

scientific article published on 01 November 2003

[The cell cycle and its regulation]

scientific article published on 01 January 2000

cdc2 phosphorylation is required for its interaction with cyclin.

artículo científico publicado en 1991

cdc2 protein kinase: interactions with cyclins and suc1

artículo científico publicado en 1991

p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

scientific article published on 01 January 1998

p21CDKN1A does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent binding of DNA polymerase delta at the G1/S phase transition

artículo científico publicado en 2003

Lista de obras de Bernard Ducommun

3D imaging of the response to CDC25 inhibition in multicellular spheroids.

3D print customized sample holders for live light sheet microscopy

5-Substituted [1]pyrindine derivatives with antiproliferative activity.

A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis.

A checkpoint-oriented cell cycle simulation model

A new mitotic-cell specific monoclonal antibody

A novel synthetic inhibitor of CDC25 phosphatases: BN82002.

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

A versatile microtiter assay for the universal cdc2 cell cycle regulator.

A versatile sample holder for single plane illumination microscopy.

Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?

Asymmetric localization of the CDC25B phosphatase to the mother centrosome during interphase.

CDC25 phosphatases in cancer cells: key players? Good targets?

CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.

CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.

CDC25B phosphorylation by p38 and MK-2

Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.

Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia

Cell cycle control by the CDC25 phosphatases

Cell cycle regulation of p34cdc2 kinase activity in Physarum polycephalum

Cell-Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation

Characterisation of human cdc2 lysine 33 mutations expressed in the fission yeast Schizosaccharomyces pombe

Characterization of an active GST-human Cdc2 fusion protein kinase expressed in the fission yeast Schizosaccharomyces pombe: a new approach to the study of cell cycle control proteins

Characterization of the antiproliferative activity of Xylopia aethiopica

Characterization of the physical properties of tumor-derived spheroids reveals critical insights for pre-clinical studies

Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.

Cyclin E-cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells

Deep and clear optical imaging of thick inhomogeneous samples

Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity.

Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors

Direct activation of cdc2 with phosphatase: identification of p13suc1-sensitive and insensitive steps

Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells

Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast

Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

Doxorubicin promotes transcriptional upregulation of Cdc25B in cancer cells by releasing Sp1 from the promoter.

Effect of phenylarsine oxide on the fission yeast Schizosaccharomyces pombe cell cycle

Effects of TGF-beta 1 (transforming growth factor-beta 1) on the cell cycle regulation of human breast adenocarcinoma (MCF-7) cells.

Effects of phleomycin-induced DNA damage on the fission yeast Schizosaccharomyces pombe cell cycle

Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation ⬇️

Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR.

Evaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matrices

Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia.

Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype

Evidence for a mammalian Nim1-like kinase pathway acting at the G0-1/S transition

Evolutionary conservation of a novel splice variant of the Cds1/CHK2 checkpoint kinase restricted to its regulatory domain.

Fission yeast Msp1 is a mitochondrial dynamin-related protein

Fission yeast cdc25 is a cell-cycle regulated protein.

G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.

Gap junctions contribute to anchorage-independent clustering of breast cancer cells.

Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression

High-resolution in-depth imaging of optically cleared thick samples using an adaptive SPIM

Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A.

Human CDC25B and CDC25C differ by their ability to restore a functional checkpoint response after gene replacement in fission yeast.

Identification of N-Terminally Truncated Stable Nuclear Isoforms of CDC25B That Are Specifically Involved in G2/M Checkpoint Recovery ⬇️

Identification of a fission yeast dynamin-related protein involved in mitochondrial DNA maintenance.

Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B

Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor

Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids.

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.

Inhibitors of the CDC25 phosphatases

Interaction between the fission yeast nim1/cdr1 protein kinase and a dynamin-related protein

Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair

Interaction studies between the p21Cip1/Waf1 cyclin-dependent kinase inhibitor and proliferating cell nuclear antigen (PCNA) by surface plasmon resonance

Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

Linking PCNA-dependent replication and ATR by human Claspin

Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy

Measure and characterization of the forces exerted by growing multicellular spheroids using microdevice arrays

Mechanical stress impairs mitosis progression in multi-cellular tumor spheroids

Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.

Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

Microdevice arrays of high aspect ratio poly(dimethylsiloxane) pillars for the investigation of multicellular tumour spheroid mechanical properties

Microtubule cytoskeleton and morphogenesis in the amoebae of the myxomycete Physarum polycephalum.

Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site

Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer ⬇️