Lista de obras - Donatella Boschi - Dominio Público Uruguay

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site

artículo científico publicado en 2018

4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade

scientific article published on 25 August 2017

6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity

artículo científico publicado en 2013

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

artículo científico publicado en 2019

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

artículo científico publicado en 2017

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.

artículo científico publicado en 2004

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

scientific article published on 12 September 2019

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

scientific article published on 27 June 2019

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

artículo científico publicado en 2019

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

artículo científico publicado en 2014

Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

artículo científico publicado en 2015

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

artículo científico publicado en 2017

Multitarget drugs: Focus on the NO-donor hybrid drugs

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities

artículo científico publicado en 2010

N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

artículo científico publicado en 2018

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

scientific article published on 01 May 2006

New potential uroselective NO-donor alpha1-antagonists

artículo científico publicado en 2003

Nicorandil analogues containing NO-donor furoxans and related furazans.

artículo científico publicado en 2000

Nitrooxymethyl-substituted analogues of celecoxib: synthesis and pharmacological characterization

artículo científico publicado en 2009

Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization

artículo científico publicado en 2010

Pyrazole analogues of prazosin

artículo científico publicado en 1998

Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.

artículo científico publicado en 2001

Structure-Property Relationships in the Basicity and Lipophilicity of Arylalkylamine Oxides

Studies on agents with mixed NO-dependent and calcium channel antagonistic vasodilating activities.

artículo científico publicado en 2001

Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives

scientific article published on 05 April 2011

Synthesis and voltage-clamp studies of methyl 1,4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl)pyridine-3-carboxylate racemates and enantiomers and of their benzofuroxanyl analogues.

artículo científico publicado en 1999

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

artículo científico publicado en 2018

The Furoxan System: Design of Selective Nitric Oxide (NO) Donor Inhibitors of COX-2 Endowed with Anti-Aggregatory and Vasodilating Activities

artículo científico publicado en 2005

Thermolysis of 4-(2-azido-3-nitrophenyl)-1,4-dihydropyridines as source of β-carboline derivatives and some related compounds

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

scientific article published on 18 April 2019

Validation of a GC/MS method for the detection of two quinolinone-derived selective androgen receptor modulators in doping control analysis

article

α1-Adrenoceptor Blocking Activity of Some Ring-open Analogues of Prazosin

scientific article published on 01 October 1994

Lista de obras de Donatella Boschi

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site

4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade

6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

Multitarget drugs: Focus on the NO-donor hybrid drugs

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities

N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

New potential uroselective NO-donor alpha1-antagonists

Nicorandil analogues containing NO-donor furoxans and related furazans.

Nitrooxymethyl-substituted analogues of celecoxib: synthesis and pharmacological characterization

Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization

Pyrazole analogues of prazosin

Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.

Structure-Property Relationships in the Basicity and Lipophilicity of Arylalkylamine Oxides

Studies on agents with mixed NO-dependent and calcium channel antagonistic vasodilating activities.

Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives

Synthesis and voltage-clamp studies of methyl 1,4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl)pyridine-3-carboxylate racemates and enantiomers and of their benzofuroxanyl analogues.

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

The Furoxan System: Design of Selective Nitric Oxide (NO) Donor Inhibitors of COX-2 Endowed with Anti-Aggregatory and Vasodilating Activities

Thermolysis of 4-(2-azido-3-nitrophenyl)-1,4-dihydropyridines as source of β-carboline derivatives and some related compounds

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

Validation of a GC/MS method for the detection of two quinolinone-derived selective androgen receptor modulators in doping control analysis

α1-Adrenoceptor Blocking Activity of Some Ring-open Analogues of Prazosin