Lista de obras - Giulio Poli - Dominio Público Uruguay

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

scientific article published on 04 February 2020

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

artículo científico publicado en 2016

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

scientific article published on 21 October 2020

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells.

artículo científico publicado en 2018

Application of MM-PBSA Methods in Virtual Screening

artículo científico publicado en 2020

Application of a FLAP-consensus docking mixed strategy for the identification of new fatty acid amide hydrolase inhibitors.

artículo científico publicado en 2015

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

artículo científico publicado en 2018

Computational approaches for the identification and optimization of Src family kinases inhibitors

artículo científico

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

artículo científico publicado en 2019

Conformational Sampling of Small Molecules With iCon: Performance Assessment in Comparison With OMEGA.

artículo científico publicado en 2018

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

scientific article published on 21 December 2018

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles

scientific article published on 29 January 2019

Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors.

artículo científico publicado en 2018

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

artículo científico publicado en 2017

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

scientific article published on 18 June 2018

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

artículo científico publicado en 2020

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

artículo científico publicado en 2020

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 16 August 2018

Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator

artículo científico publicado en 2016

Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies ⬇️

artículo científico publicado en 2019

Extensive consensus docking evaluation for ligand pose prediction and virtual screening studies

artículo científico publicado en 2014

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

scientific article published on 20 February 2019

Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

artículo científico publicado en 2015

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

artículo científico publicado en 2013

Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.

artículo científico publicado en 2015

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.

artículo científico publicado en 2017

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

scientific article published on 06 June 2019

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

artículo científico publicado en 2018

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

artículo científico publicado en 2018

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

scientific article published on 01 December 2019

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII ⬇️

artículo científico

Novel broad spectrum virucidal molecules against enveloped viruses

scientific article published in PLoS ONE

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

artículo científico publicado en 2019

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

artículo científico publicado en 2018

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines

scientific article published on 15 February 2019

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

artículo científico publicado en 2014

Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies.

artículo científico publicado en 2016

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.

artículo científico publicado en 2018

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

artículo científico publicado en 2019

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists

artículo científico publicado en 2016

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel

artículo científico publicado en 2019

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

artículo científico publicado en 2017

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

scientific article published on 29 January 2019

Lista de obras de Giulio Poli

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells.

Application of MM-PBSA Methods in Virtual Screening

Application of a FLAP-consensus docking mixed strategy for the identification of new fatty acid amide hydrolase inhibitors.

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

Computational approaches for the identification and optimization of Src family kinases inhibitors

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Conformational Sampling of Small Molecules With iCon: Performance Assessment in Comparison With OMEGA.

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles

Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors.

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator

Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies ⬇️

Extensive consensus docking evaluation for ligand pose prediction and virtual screening studies

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII ⬇️

Novel broad spectrum virucidal molecules against enveloped viruses

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies.

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects