Lista de obras - Tetsuji Naka - Dominio Público Uruguay

A novel approach of optical biopsy using probe-based confocal laser endomicroscopy for peritoneal metastasis.

artículo científico publicado en 2015

A novel pathogenesis of inflammatory bowel disease from the perspective of glyco-immunology.

artículo científico publicado en 2017

Aberrant expression of glycosylation in juvenile gastrointestinal stromal tumors

artículo científico publicado en 2008

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner

artículo científico publicado en 2014

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers

artículo científico publicado en 2014

Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A.

artículo científico publicado en 2013

Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer

artículo científico publicado en 2017

Anti-glypican-1 antibody-drug conjugate is a potential therapy against pancreatic cancer

artículo científico publicado en 2020

Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells.

artículo científico publicado en 2011

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells.

artículo científico publicado en 2008

Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma

artículo científico publicado en 2011

Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses

scientific article published on 24 April 2010

Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis

artículo científico publicado en 2011

Brief Report: Leucine-Rich α2-Glycoprotein as a Potential Biomarker for Joint Inflammation During Anti-Interleukin-6 Biologic Therapy in Rheumatoid Arthritis

artículo científico publicado en 2015

CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma

artículo científico publicado en 2020

CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: Comparison with blockade of interleukin-6

artículo científico publicado en 2015

Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9.

artículo científico publicado en 2013

Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling

artículo científico publicado en 2016

Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer

artículo científico publicado en 2015

Cloning and Functional Analysis of New Members of STAT Induced STAT Inhibitor (SSI) Family: SSI-2 and SSI-3 ⬇️

artículo científico publicado el 8 de agosto de 1997

Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis

artículo científico publicado en 2011

Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration

artículo científico publicado en 2005

Copper ions are novel therapeutic agents for uterine leiomyosarcoma

scientific article published on 24 July 2019

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody

artículo científico publicado en 2015

Detecting Secondary C-KIT Mutations in the Peripheral Blood of Patients with Imatinib-Resistant Gastrointestinal Stromal Tumor.

artículo científico publicado en 2016

Development of anti-GPC-1 (glypican-1)-CAR-T cells for adoptive T cell immunotherapies for squamous cell carcinoma.

artículo científico publicado en 2015

Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris

scientific article published on 10 February 2012

Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.

artículo científico publicado en 2007

Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin

artículo científico publicado en 2009

Enhanced expression of suppressor of cytokine signalling-1 in the liver of chronic hepatitis C: possible involvement in resistance to interferon therapy.

artículo científico publicado en 2005

Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection

artículo científico publicado en 2020

Expression of MHC class I molecule in HHV-6B-infected cells.

artículo científico publicado en 2014

Functional disturbance of naive T lymphocytes in very high IgE producers: depletion of interleukin-4-induced interleukin-4-producing cells

artículo científico publicado en 1996

Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis.

artículo científico publicado en 2015

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors

artículo científico publicado en 2016

Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma

artículo científico publicado en 2017

Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression.

artículo científico publicado en 2010

Histamine contributes to tissue remodeling via periostin expression.

artículo científico publicado en 2014

Human herpesvirus 6 U11 protein is critical for virus infection.

artículo científico publicado en 2016

Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells.

artículo científico publicado en 2014

Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas

artículo científico publicado en 2003

Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.

artículo científico publicado en 2004

IL-18 gene polymorphisms affect IL-18 production capability by monocytes

artículo científico publicado en 2006

IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.

artículo científico publicado en 2007

Identification of sialylated glycoproteins in Doxorubicin-treated hepatoma cells with glycoproteomic analyses

artículo científico publicado en 2014

Implication of SOCS-1 gene methylation in acute myeloid leukaemia

artículo científico publicado en 2004

Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases

scientific article published on 01 February 2004

Increased serum CXCR2 ligand levels in livedo vasculopathy with winter ulcerations: Possible contribution of neutrophil recruitment to lesional skin.

artículo científico publicado en 2016

Infiltrating eosinophils and eotaxin: their association with idiopathic eosinophilic esophagitis

artículo científico publicado en 2002

Interleukin-6 Deficiency Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutation

artículo científico publicado en 2016

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

scientific article published on 01 December 2008

Intratumoral delivery of an adenoviral vector carrying the SOCS-1 gene enhances T cell-mediated anti-tumor immunity by suppressing PD-L1.

artículo científico publicado en 2018

Involvement of SIK3 in glucose and lipid homeostasis in mice

artículo científico publicado en 2012

Joint disease caused by defective gp130-mediated STAT signaling.

artículo científico publicado en 2002

Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes

artículo científico publicado en 2013

LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.

artículo científico publicado en 2017

Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease.

artículo científico publicado en 2013

Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury.

artículo científico publicado en 2018

Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.

artículo científico publicado en 2016

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells.

artículo científico publicado en 2017

Leucine-rich α-2 glycoprotein is an innovative biomarker for psoriasis.

artículo científico publicado en 2017

Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts

artículo científico publicado en 2017

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines

artículo científico publicado en 2015

Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer

MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment.

artículo científico publicado en 2014

Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells.

artículo científico publicado en 2013

Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.

artículo científico publicado en 2015

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation

artículo científico publicado en 2018

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: programmed endosomal escape and dissociation

artículo científico publicado en 2010

Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses.

artículo científico publicado en 2009

New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.

artículo científico publicado en 2013

Osteoblast differentiation is impaired in SOCS-1-deficient mice.

artículo científico publicado en 2006

Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

artículo científico publicado en 2010

Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.

artículo científico publicado en 2016

Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer.

artículo científico publicado en 2017

Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice

artículo científico publicado en 2007

Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment

artículo científico publicado en 2014

Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma.

artículo científico publicado en 2012

Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts.

artículo científico publicado en 2012

Peripheral blood T lymphocytes and basophils, freshly isolated from house-dust-mite-sensitive patients, produce interleukin-4 in response to allergen-specific stimulation.

artículo científico publicado en 1996

Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer.

artículo científico publicado en 2012

Proteomic analysis of autoantigens associated with systemic lupus erythematosus: Anti-aldolase A antibody as a potential marker of lupus nephritis

scientific article published on 22 January 2007

Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon.

artículo científico publicado en 2014

Proteomics-based identification of alpha-enolase as a tumor antigen in non-small lung cancer.

artículo científico publicado en 2007

Reprint of: Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation

scientific article published on 09 September 2010

SOCS-1 participates in negative regulation of LPS responses

artículo científico publicado en 2002

SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation

artículo científico publicado en 2004

SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.

artículo científico publicado en 2006

SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma

artículo científico publicado en 2017

SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling.

artículo científico publicado en 2018

Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice

artículo científico publicado en 2015

Screening for novel serum biomarker for monitoring disease activity in rheumatoid arthritis using iTRAQ technology-based quantitative proteomic approach

artículo científico publicado en 2014

Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas.

artículo científico publicado en 2016

Small Cell Carcinomas of the Uterine Cervix and Lung: Proteomics Reveals Similar Protein Expression Profiles

artículo científico publicado en 2018

Splicing factor proline/glutamine-rich is a novel autoantigen of dermatomyositis and associated with anti-melanoma differentiation-associated gene 5 antibody.

artículo científico publicado en 2016

Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma

artículo científico publicado en 2016

Structure and function of a new STAT-induced STAT inhibitor

scientific journal article

Substrate-attached materials are enriched with tetraspanins and are analogous to the structures associated with rear-end retraction in migrating cells.

artículo científico publicado en 2013

Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis

artículo científico publicado en 2012

Suppressor of cytokine signaling 1 suppresses muscle differentiation through modulation of IGF-I receptor signal transduction.

artículo científico publicado en 2005

Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice

scientific article published on 01 April 2008

Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice

artículo científico publicado en 2017

Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines

artículo científico publicado en 2004

Suppressor of cytokine signalling-1 induces significant preclinical antitumor effect in malignant melanoma cells.

artículo científico publicado en 2015

TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours

artículo científico publicado en 2019

Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary.

artículo científico publicado en 2010

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

scientific journal article

The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells

artículo científico publicado en 2010

The paradigm of IL-6: from basic science to medicine

artículo científico publicado en 2002

The translation elongation factor eEF2 is a novel tumor‑associated antigen overexpressed in various types of cancers.

artículo científico publicado en 2014

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression.

artículo científico publicado en 2008

Varicella-zoster virus ORF49 functions in the efficient production of progeny virus through its interaction with essential tegument protein ORF44

scientific article published on 23 October 2013

[Role of IL-6 in the development and pathogenesis of CIA and EAE]

scientific article published on 01 April 2008

iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases

artículo científico publicado en 2009

ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

artículo científico publicado en 2013

Lista de obras de Tetsuji Naka

A novel approach of optical biopsy using probe-based confocal laser endomicroscopy for peritoneal metastasis.

A novel pathogenesis of inflammatory bowel disease from the perspective of glyco-immunology.

Aberrant expression of glycosylation in juvenile gastrointestinal stromal tumors

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers

Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A.

Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer

Anti-glypican-1 antibody-drug conjugate is a potential therapy against pancreatic cancer

Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells.

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells.

Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma

Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses

Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis

Brief Report: Leucine-Rich α2-Glycoprotein as a Potential Biomarker for Joint Inflammation During Anti-Interleukin-6 Biologic Therapy in Rheumatoid Arthritis

CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma

CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: Comparison with blockade of interleukin-6

Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9.

Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling

Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer

Cloning and Functional Analysis of New Members of STAT Induced STAT Inhibitor (SSI) Family: SSI-2 and SSI-3 ⬇️

Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis

Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration

Copper ions are novel therapeutic agents for uterine leiomyosarcoma

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody

Detecting Secondary C-KIT Mutations in the Peripheral Blood of Patients with Imatinib-Resistant Gastrointestinal Stromal Tumor.

Development of anti-GPC-1 (glypican-1)-CAR-T cells for adoptive T cell immunotherapies for squamous cell carcinoma.

Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris

Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.

Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin

Enhanced expression of suppressor of cytokine signalling-1 in the liver of chronic hepatitis C: possible involvement in resistance to interferon therapy.

Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection

Expression of MHC class I molecule in HHV-6B-infected cells.

Functional disturbance of naive T lymphocytes in very high IgE producers: depletion of interleukin-4-induced interleukin-4-producing cells

Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis.

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors

Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma

Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression.

Histamine contributes to tissue remodeling via periostin expression.

Human herpesvirus 6 U11 protein is critical for virus infection.

Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells.

Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas

Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.

IL-18 gene polymorphisms affect IL-18 production capability by monocytes

IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.

Identification of sialylated glycoproteins in Doxorubicin-treated hepatoma cells with glycoproteomic analyses

Implication of SOCS-1 gene methylation in acute myeloid leukaemia

Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases

Increased serum CXCR2 ligand levels in livedo vasculopathy with winter ulcerations: Possible contribution of neutrophil recruitment to lesional skin.

Infiltrating eosinophils and eotaxin: their association with idiopathic eosinophilic esophagitis

Interleukin-6 Deficiency Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutation

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

Intratumoral delivery of an adenoviral vector carrying the SOCS-1 gene enhances T cell-mediated anti-tumor immunity by suppressing PD-L1.

Involvement of SIK3 in glucose and lipid homeostasis in mice

Joint disease caused by defective gp130-mediated STAT signaling.

Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes

LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.

Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease.

Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury.

Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells.

Leucine-rich α-2 glycoprotein is an innovative biomarker for psoriasis.

Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines

Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer

MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment.

Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells.

Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: programmed endosomal escape and dissociation

Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses.

New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.

Osteoblast differentiation is impaired in SOCS-1-deficient mice.

Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.

Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer.

Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice

Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment

Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma.

Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts.