Lista de obras - Giovanni Capranico - Dominio Público Uruguay

10th Conference on DNA Topoisomerases in therapy

artículo científico publicado en 1999

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons.

artículo científico publicado en 1997

A rational selection of drug targets needs deeper insights into general regulation mechanisms

artículo científico publicado en 2004

A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors

artículo científico

A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin.

artículo científico publicado en 1993

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta

scientific article published on 01 December 1996

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives ⬇️

artículo científico publicado en 2018

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

artículo científico publicado en 2013

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

artículo científico publicado en 2004

Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.

artículo científico publicado en 1995

Characterization of a topoisomerase II gene rearrangement in a human small-cell lung cancer cell line

artículo científico publicado el 18 de noviembre de 1992

Characterization of novel antisense HIF-1α transcripts in human cancers

artículo científico publicado en 2011

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

artículo científico publicado en 1999

Conformational drug determinants of the sequence specificity of drug-stimulated topoisomerase II DNA cleavage

scientific article published on 01 January 1994

Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage

scientific article published on 01 September 1994

Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation.

artículo científico publicado en 2013

DNA Topoisomerase I differentially modulates R-loops across the human genome

artículo científico publicado en 2018

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

scientific article published on 27 December 2018

DNA sequence selectivity of topoisomerases and topoisomerase poisons.

artículo científico publicado en 1998

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus

artículo científico publicado en 2009

DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.

artículo científico publicado en 2007

DNA topoisomerase-trapping antitumour drugs

artículo científico publicado el 1 de enero de 1992

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

artículo científico publicado en 2015

DROPA: DRIP-seq optimized peak annotator ⬇️

artículo científico publicado en 2019

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent

artículo científico publicado en 2009

Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges

artículo científico publicado en 2004

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

artículo científico publicado el 17 de agosto de 1992

Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung

artículo científico publicado en 1995

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

artículo científico publicado en 2016

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity

artículo científico publicado en 2010

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs ⬇️

artículo científico publicado el 20 de diciembre de 1991

Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line.

artículo científico publicado en 1988

Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo.

artículo científico publicado en 1997

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

artículo científico publicado en 2019

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

artículo científico publicado en 2016

Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells

artículo científico publicado en 2006

Effects of common buffer systems on drug activity: the case of clerocidin.

artículo científico publicado en 2004

Electron paramagnetic resonance (EPR) study of spin-labeled camptothecin derivatives: a different look of the ternary complex.

artículo científico publicado en 2011

Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins

artículo científico publicado en 2004

Formation, resealing and persistence of DNA breaks produced by 4-demethoxydaunorubicin in P388 leukemia cells

scientific article published on 01 January 1989

G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells

artículo científico publicado en 2021

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent

artículo científico publicado en 2006

Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma

artículo científico publicado en 1996

Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion

artículo científico publicado en 2008

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2.

artículo científico publicado en 2012

Interaction model for anthracycline activity against DNA topoisomerase II.

artículo científico publicado en 2004

Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation.

artículo científico publicado en 2007

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

artículo científico publicado en 1991

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

artículo científico publicado en 1990

MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.

artículo científico publicado en 1995

Mapping DNA Breaks by Next-Generation Sequencing

artículo científico publicado en 2018

Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.

artículo científico publicado en 1998

Mechanism of action of DNA topoisomerase inhibitors.

artículo científico publicado en 1995

Metallothionein cDNA cloning, metallothionein expression and heavy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy

artículo científico publicado en 2011

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

scientific article published on 18 March 2020

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism

artículo científico publicado en 2013

Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.

artículo científico publicado en 2012

New developments in antitumor anthracyclines.

artículo científico publicado en 1997

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

scientific article published on 17 July 2014

Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening

artículo científico publicado en 2014

Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.

artículo científico publicado en 2005

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin.

artículo científico publicado en 1990

Peptidyl Anthraquinones as Potential Antineoplastic Drugs: Synthesis, DNA Binding, Redox Cycling, and Biological Activity

artículo científico publicado en 1996

Physicochemical properties, cytotoxic activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones

scientific article published on 01 January 1997

Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity.

artículo científico publicado en 1996

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

artículo científico publicado en 2017

Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene

artículo científico publicado en 2004

Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents.

artículo científico publicado en 2016

Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues

scientific article published on 01 January 1998

The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I.

artículo científico publicado en 2007

The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells

artículo científico publicado en 2013

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives

article

Type I DNA Topoisomerases

artículo científico publicado en 2017

Lista de obras de Giovanni Capranico

10th Conference on DNA Topoisomerases in therapy

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons.

A rational selection of drug targets needs deeper insights into general regulation mechanisms

A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors

A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin.

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives ⬇️

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.

Characterization of a topoisomerase II gene rearrangement in a human small-cell lung cancer cell line

Characterization of novel antisense HIF-1α transcripts in human cancers

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

Conformational drug determinants of the sequence specificity of drug-stimulated topoisomerase II DNA cleavage

Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage

Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation.

DNA Topoisomerase I differentially modulates R-loops across the human genome

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

DNA sequence selectivity of topoisomerases and topoisomerase poisons.

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus

DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.

DNA topoisomerase-trapping antitumour drugs

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

DROPA: DRIP-seq optimized peak annotator ⬇️

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent

Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs ⬇️

Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line.

Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo.

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells

Effects of common buffer systems on drug activity: the case of clerocidin.

Electron paramagnetic resonance (EPR) study of spin-labeled camptothecin derivatives: a different look of the ternary complex.

Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins

Formation, resealing and persistence of DNA breaks produced by 4-demethoxydaunorubicin in P388 leukemia cells

G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent

Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma

Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2.

Interaction model for anthracycline activity against DNA topoisomerase II.

Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation.

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.

Mapping DNA Breaks by Next-Generation Sequencing

Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.

Mechanism of action of DNA topoisomerase inhibitors.

Metallothionein cDNA cloning, metallothionein expression and heavy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy

Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism

Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.

New developments in antitumor anthracyclines.

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening

Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin.

Peptidyl Anthraquinones as Potential Antineoplastic Drugs: Synthesis, DNA Binding, Redox Cycling, and Biological Activity

Physicochemical properties, cytotoxic activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones

Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity.

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene

Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents.

Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues

The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I.

The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives

Type I DNA Topoisomerases