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Lista de obras de Douglas R Spitz

2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress.

artículo científico publicado en 2007

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality

artículo científico publicado en 2018

A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11)

artículo científico publicado en 2013

A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats.

artículo científico publicado en 2000

A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media

artículo científico publicado en 2000

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.

artículo científico publicado en 2011

Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status.

artículo científico publicado en 2009

All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB.

artículo científico publicado en 2008

Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells.

artículo científico publicado en 2006

An inhibitor of K+ channels modulates human endometrial tumor-initiating cells.

artículo científico

Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide.

artículo científico publicado en 1995

Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats

scientific article published on 01 July 1998

Assay of superoxide dismutase activity in tumor tissue

artículo científico publicado en 1984

Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity.

artículo científico publicado en 2016

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

artículo científico publicado en 2017

Bcl-2 and Bcl-xL in peroxide-resistant A549 and U87MG cells

scientific article published on 01 April 1998

Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma.

artículo científico publicado en 2015

Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.

artículo científico publicado en 2012

Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair

artículo científico publicado en 2006

Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers

artículo científico publicado en 2013

Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation.

artículo científico publicado en 2000

Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung

artículo científico publicado en 2013

Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.

artículo científico publicado en 2008

Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism

artículo científico publicado en 2008

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

artículo científico publicado en 2014

Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials.

artículo científico publicado en 2017

Contribution of mitochondrial DNA repair to cell resistance from oxidative stress.

artículo científico publicado en 2005

Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87]

artículo científico publicado en 2018

D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress.

artículo científico publicado en 2017

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.

artículo científico publicado en 2012

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).

artículo científico publicado en 2008

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.

artículo científico publicado en 2018

Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis

artículo científico publicado en 2010

Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.

artículo científico publicado en 2010

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

artículo científico publicado en 2015

Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

artículo científico publicado en 2020

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge

artículo científico publicado en 2010

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

scientific article published on 31 August 2018

Enhanced γ-Glutamyl Transpeptidase Expression and Selective Loss of CuZn Superoxide Dismutase in Hepatic Iron Overload

artículo científico publicado en 1998

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism

artículo científico publicado en 2016

Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.

artículo científico publicado en 2011

Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.

artículo científico publicado en 2011

Essential Components of Cancer Education

artículo científico publicado en 2015

Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice.

artículo científico publicado en 2003

Evidence that hydrogen peroxide generated by 365-nm UVA radiation is not important in mammalian cell killing.

artículo científico publicado en 1990

Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent

artículo científico publicado en 1997

Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

artículo científico publicado en 2011

Glial cell type-specific responses to menadione-induced oxidative stress

artículo científico publicado en 2000

Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.

artículo científico publicado en 1998

Glutaminase inhibitors induce thiol-mediated oxidative stress and radio-sensitization in treatment resistant cervical cancers

artículo científico publicado en 2020

Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal ⬇️

artículo científico publicado el 1 de enero de 1991

Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts.

artículo científico publicado en 1997

High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide

scientific article published on 01 October 1996

Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells.

artículo científico publicado en 2008

Hyperbilirubinemia results in reduced oxidative injury in neonatal gunn rats exposed to hyperoxia

artículo científico publicado en 1995

Hypoxia and resistance to hydrogen peroxide confer resistance to tumor necrosis factor in murine L929 cells.

artículo científico publicado en 1992

In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine

artículo científico publicado en 1996

Inactivation of anthracyclines by cellular peroxidase.

artículo científico publicado en 2005

Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen.

artículo científico publicado en 2006

Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil

scientific article published on 01 May 1998

Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth

artículo científico publicado en 2007

Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress.

artículo científico publicado en 2006

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

artículo científico publicado en 2015

Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.

artículo científico publicado en 2006

Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.

artículo científico publicado en 2003

Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine

artículo científico publicado en 2014

James William Osborne, PhD 1928-2015.

artículo científico publicado en 2016

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

artículo científico publicado en 2014

Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways

artículo científico publicado en 2010

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

artículo científico publicado en 2015

Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender

artículo científico publicado en 2013

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.

artículo científico publicado en 2013

Mammalian resistance to oxidative stress: a comparative analysis.

artículo científico publicado en 2002

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.

artículo científico publicado en 2008

Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses

artículo científico publicado en 2003

Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives

artículo científico publicado en 1999

Mechanisms of H2O2-induced oxidative stress in endothelial cells.

artículo científico publicado en 2006

Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: The significance of increased catalase activity in H2O2-resistant fibroblasts ⬇️

artículo científico publicado el 1 de enero de 1992

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.

artículo científico publicado en 2004

Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells.

artículo científico publicado en 1999

Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation

scientific journal article

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

artículo científico publicado en 2004

Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.

artículo científico publicado en 2011

Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy.

artículo científico publicado en 2017

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival

artículo científico publicado en 2014

Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells.

artículo científico publicado en 2006

Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells

artículo científico publicado en 2016

Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction

artículo científico publicado en 2005

Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.

artículo científico publicado en 2005

Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells.

artículo científico publicado en 2007

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

artículo científico publicado en 2017

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

artículo científico publicado en 2017

Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth.

artículo científico publicado en 2006

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.

artículo científico publicado en 2011

Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.

artículo científico publicado en 2010

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

artículo científico publicado en 2015

Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma

artículo científico publicado en 2018

Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle.

artículo científico publicado en 2010

Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure.

artículo científico publicado en 2009

Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy

artículo científico publicado en 2007

Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells.

artículo científico publicado en 2004

Radio-resistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism

artículo científico publicado en 2018

Radiofrequency electromagnetic fields have no effect on the in vivo proliferation of the 9L brain tumor.

artículo científico publicado en 1999

Reactive oxygen species in normal and tumor stem cells.

artículo científico publicado en 2014

Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

artículo científico publicado en 2017

Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid

artículo científico publicado en 2015

Redox control of cell cycle-coupled topoisomerase II alpha gene expression

scientific article published on 01 January 2002

Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock.

artículo científico publicado en 1999

Redox signaling in cancer biology.

artículo científico publicado en 2006

Regulation of normal cell cycle progression by flavin-containing oxidases.

artículo científico publicado en 2007

Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population

artículo científico publicado en 2014

Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2.

artículo científico publicado en 2002

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

artículo científico publicado en 2010

Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes.

artículo científico publicado en 2013

Sensitivity to Low-Dose/Low-LET Ionizing Radiation in Mammalian Cells Harboring Mutations in Succinate Dehydrogenase Subunit C is Governed by Mitochondria-Derived Reactive Oxygen Species ⬇️

artículo científico publicado el 17 de noviembre de 2010

Serial changes in tumor oxygenation during the early phase of radiation therapy in cervical cancer—are we quantitating hypoxia change? re: Lyng et al., IJROBP 2000; 46:935–946

article

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.

artículo científico publicado en 2011

Sirt3, mitochondrial ROS, ageing, and carcinogenesis.

artículo científico publicado en 2011

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

artículo científico publicado en 2010

Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

artículo científico publicado en 2016

Stable H2O2-resistant variants of Chinese hamster fibroblasts demonstrate increases in catalase activity.

artículo científico publicado en 1988

Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats.

artículo científico publicado en 2009

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

artículo científico publicado en 2018

Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer.

artículo científico publicado en 2010

Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3.

artículo científico publicado en 2013

Superoxide mediates the actions of angiotensin II in the central nervous system.

artículo científico publicado en 2002

Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism

artículo científico publicado en 2012

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

artículo científico publicado en 2018

The Absence of CpG in Plasmid DNA–Chitosan Polyplexes Enhances Transfection Efficiencies and Reduces Inflammatory Responses in Murine Lungs

artículo científico publicado en 2014

The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells

artículo científico publicado el 1 de septiembre de 1992

The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency.

artículo científico publicado en 2011

The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion.

artículo científico publicado en 2005

Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress.

artículo científico publicado en 2005

Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.

artículo científico publicado en 2010

Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress.

artículo científico publicado en 2004

WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.

artículo científico publicado en 2008

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