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Lista de obras de Patrick J Sinko

A Biofunctional Molecular Beacon for Detecting Single Base Mutations in Cancer Cells

artículo científico publicado en 2016

A Novel Bivalent Mannosylated Targeting Ligand Displayed on Nanoparticles Selectively Targets Anti-Inflammatory M2 Macrophages

artículo científico publicado en 2020

A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: a new biomaterial for protein drug delivery

artículo científico publicado en 2003

Active efflux kinetics of etoposide from rabbit small intestine and colon

scientific article published on 01 April 2000

Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres. I. In vitro characterization.

artículo científico publicado en 2000

Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres. II. In vivo investigation

scientific article published on 01 October 2000

An investigation of the intradermal route as an effective means of immunization for microparticulate vaccine delivery systems

scientific article published on 01 May 2000

Analysis of intestinal perfusion data for highly permeable drugs using a numerical aqueous resistance--nonlinear regression method.

artículo científico publicado en 1996

Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin

artículo científico publicado en 2014

Antitubercular Nanocarrier Combination Therapy: Formulation Strategies and in Vitro Efficacy for Rifampicin and SQ641.

artículo científico publicado en 2015

Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates

scientific article published on 03 October 2012

Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir: 1. Interactions with peptides, organic anions and organic cations in rats

artículo científico publicado en 1998

Characterization of the oral absorption of beta-lactam antibiotics. II. Competitive absorption and peptide carrier specificity.

artículo científico publicado en 1989

Characterization of the oral absorption of several aminopenicillins: determination of intrinsic membrane absorption parameters in the rat intestine in situ

scientific article published on 01 September 1992

Characterization of the oral absorption of some beta-lactams: effect of the alpha-amino side chain group

artículo científico publicado en 1993

China and the United States--Global partners, competitors and collaborators in nanotechnology development.

artículo científico publicado en 2015

Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates--proof of concept for HIV mucosal pre-exposure prophylaxis.

artículo científico publicado en 2015

Computation of log BB values for compounds transported through carrier-mediated mechanisms using in vitro permeability data from brain microvessel endothelial cell (BMEC) monolayers.

artículo científico publicado en 2003

Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic

artículo científico publicado en 2002

Delineation of human peptide transporter 1 (hPepT1)-mediated uptake and transport of substrates with varying transporter affinities utilizing stably transfected hPepT1/Madin-Darby canine kidney clones and Caco-2 cells.

artículo científico publicado en 2005

Design and evaluation of a CXCR4 targeting peptide 4DV3 as an HIV entry inhibitor and a ligand for targeted drug delivery

article

Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response

artículo científico publicado en 2009

Determination intestinal metabolism and permeability for several compounds in rats. Implications on regional bioavailability in humans

scientific article published on 01 January 1996

Development of predictive pharmacokinetic simulation models for drug discovery

artículo científico publicado en 2000

Differentiation of gut and hepatic first-pass effect of drugs: 1. Studies of verapamil in ported dogs.

artículo científico publicado en 2001

Differentiation of gut and hepatic first-pass loss of verapamil in intestinal and vascular access-ported (IVAP) rabbits.

artículo científico publicado en 2004

Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2).

artículo científico publicado en 2002

Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries ⬇️

artículo científico publicado el 14 de octubre de 2010

Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds.

artículo científico publicado en 2009

Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment

artículo científico publicado en 2015

Endocytosis and membrane potential are required for HeLa cell uptake of R.I.-CKTat9, a retro-inverso Tat cell penetrating peptide.

artículo científico publicado en 2009

Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats

artículo científico publicado en 2010

Erratum to: Safety, Formulation and In Vitro Antiviral Activity of the Antimicrobial Peptide Subtilosin Against Herpes Simplex Virus Type 1.

artículo científico publicado en 2013

Estimating human drug oral absorption kinetics from Caco-2 permeability using an absorption-disposition model: model development and evaluation and derivation of analytical solutions for k(a) and F(a).

artículo científico publicado en 2005

Evaluation of intraductal delivery of poly(ethylene glycol)-doxorubicin conjugate nanocarriers for the treatment of ductal carcinoma in situ (DCIS)-like lesions in rats

artículo científico publicado en 2018

Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages.

artículo científico publicado en 1997

Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials

artículo científico publicado en 2015

Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial

artículo científico publicado en 2015

Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide ⬇️

artículo científico publicado el 16 de septiembre de 2010

Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery

artículo científico publicado en 2013

Impact of regional intestinal pH modulation on absorption of peptide drugs: oral absorption studies of salmon calcitonin in beagle dogs

artículo científico publicado en 1999

Influence of molecular size on the retention of polymeric nanocarrier diagnostic agents in breast ducts.

artículo científico publicado en 2012

Influence of the Microporous Substratum and Hydrodynamics on Resistances to Drug Transport in Cell Culture Systems: Calculation of Intrinsic Transport Parameters ⬇️

artículo científico publicado el 1 de diciembre de 1997

Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: evidence for multifactorial multidrug resistance.

artículo científico publicado en 2006

Intestinal absorption of peptides and peptide analogues: implications of fasting pancreatic serine protease levels and pH on the extent of oral absorption in dogs and humans

artículo científico publicado el 1 de marzo de 1992

Intestinal drug transporters: in vivo function and clinical importance.

artículo científico publicado en 2004

Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

artículo científico publicado en 2003

Involvement of multiple transporters in the oral absorption of nucleoside analogues

scientific article published on 01 October 1999

Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry

artículo científico publicado en 2015

Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach.

artículo científico publicado en 1988

Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

artículo científico publicado en 2004

Microfluidic generation of droplets with a high loading of nanoparticles

artículo científico publicado en 2012

Modulation of nonspecific binding in ultrafiltration protein binding studies.

artículo científico publicado en 2003

Multimeric peptide-based PEG nanocarriers with programmable elimination properties.

artículo científico publicado en 2009

Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells

artículo científico publicado en 2015

Nonenzymatic, self-elimination degradation mechanism of glutathione.

artículo científico publicado en 2009

Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors

artículo científico publicado en 2011

Novel monodisperse PEGtide dendrons: design, fabrication, and evaluation of mannose receptor-mediated macrophage targeting

artículo científico publicado en 2013

Optimal structural design of mannosylated nanocarriers for macrophage targeting.

artículo científico publicado en 2014

Optimizing size and copy number for PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarrier uptake by macrophages.

scientific article published on 20 December 2007

Oral absorption of anti-AIDS nucleoside analogues. 1. Intestinal transport of didanosine in rat and rabbit preparations

artículo científico publicado en 1995

Oral absorption of anti-acquired immune deficiency syndrome nucleoside analogues. 2. Carrier-mediated intestinal transport of stavudine in rat and rabbit preparations

artículo científico publicado en 1996

Oral absorption of anti-aids nucleoside analogues: 3. Regional absorption and in vivo permeability of 2',3'-dideoxyinosine in an intestinal-vascular access port (IVAP) dog model.

artículo científico publicado en 1997

Oral absorption of the HIV protease inhibitors: a current update

scientific article published on 01 October 1999

Oxidants and antioxidants in sulfur mustard-induced injury

artículo científico publicado en 2010

Peritoneal macrophage uptake, pharmacokinetics and biodistribution of macrophage-targeted PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarriers for improving HIV drug delivery.

artículo científico publicado en 2007

Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery

artículo científico publicado en 2014

Physiologically-based pharmacokinetic simulation modelling.

artículo científico publicado en 2002

Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment

artículo científico publicado en 2014

Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis.

scientific article published on 24 February 2014

Predicting fraction dose absorbed in humans using a macroscopic mass balance approach

artículo científico publicado en 1991

Preface

Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy.

artículo científico publicado en 2009

Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model

artículo científico publicado en 2010

Recent trends in targeted anticancer prodrug and conjugate design

artículo científico publicado en 2008

Regional differences in intestinal spreading and pH recovery and the impact on salmon calcitonin absorption in dogs

scientific article published on 01 March 2000

Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs

artículo científico publicado en 2000

Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide ⬇️

artículo científico publicado el 30 de marzo de 2011

Responsive foams for nanoparticle delivery

artículo científico publicado en 2015

Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide.

artículo científico publicado en 2010

Safety, formulation, and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1.

artículo científico publicado en 2013

Selective cytotoxicity and combined effects of camptothecin or paclitaxel with sodium-R-alpha lipoate on A549 human non-small cell lung cancer cells

scientific article published on 24 September 2013

Single-Step Assembly of Multimodal Imaging Nanocarriers: MRI and Long-Wavelength Fluorescence Imaging.

artículo científico publicado en 2015

Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard

artículo científico publicado en 2014

Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.

artículo científico publicado en 2011

Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity.

artículo científico publicado en 2010

Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs.

artículo científico publicado en 2009

Synthesis, characterization, and in vitro assay of folic acid conjugates of 3'-azido-3'-deoxythymidine (AZT): toward targeted AZT based anticancer therapeutics.

artículo científico publicado en 2008

Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex.

artículo científico publicado en 2015

The Architecture and Function of Monoclonal Antibody-Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention.

artículo científico publicado en 2016

The blood-brain barrier sodium-dependent multivitamin transporter: a molecular functional in vitro-in situ correlation.

artículo científico publicado en 2005

The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hMDR1.

artículo científico publicado en 2003

The effect of physical barriers and properties on the oral absorption of particulates.

artículo científico publicado en 1998

The effect of size and polymer architecture of doxorubicin-poly(ethylene) glycol conjugate nanocarriers on breast duct retention, potency and toxicity

artículo científico publicado en 2018

The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard.

artículo científico publicado en 2013

The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and ε-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli.

artículo científico publicado en 2012

The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.

artículo científico publicado en 2004

Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard.

artículo científico publicado en 2014

Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: implications for microemboli-based drug delivery systems

artículo científico publicado en 2012

Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide.

artículo científico publicado en 2005

Tumor-targeted and activated bioconjugates for improved camptothecin delivery.

artículo científico publicado en 2005

Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation.

artículo científico publicado en 2004

Two sorting motifs, a ubiquitination motif and a tyrosine motif, are involved in HIV-1 and simian immunodeficiency virus Nef-mediated receptor endocytosis.

artículo científico publicado en 2011

Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon calcitonin in rats

scientific article published on 01 November 1995

siRNA--getting the message out.

artículo científico publicado en 2006

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