Lista de obras - Marc Nazaré - Dominio Público Uruguay

5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors

artículo científico publicado en 2016

A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus-Silane System.

artículo científico publicado en 2018

A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles

scientific article published on 01 September 2020

A flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones.

artículo científico publicado en 2004

A general and mild domino approach to substituted 1-aminoindoles

scientific article published on 12 November 2010

A general and mild palladium-catalyzed domino reaction for the synthesis of 2H-indazoles

artículo científico publicado en 2009

A new highly thyrotropin receptor-selective small molecule antagonist with potential for the treatment of Graves' orbitopathy

article

A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.

artículo científico publicado en 2017

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels ⬇️

scientific article published on 01 February 2019

Allosteric inhibition of a mammalian lectin

scientific article published on 24 October 2018

CellFy: A Cell-Based Fragment Screen against C-Type Lectins

scientific article published on 03 December 2018

Chemical fragment arrays for rapid druggability assessment.

artículo científico publicado en 2016

DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.

artículo científico publicado en 2015

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

artículo científico publicado en 2020

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

artículo científico publicado en 2021

Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances.

artículo científico publicado en 2017

Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors

artículo científico publicado en 2014

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach

artículo científico publicado en 2017

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

artículo científico publicado en 2019

Efficient enantioselective synthesis of a β-hydroxyepoxide building block for the construction of macrocyclic natural products

Enantiospecific synthesis of the (9S,18R)-diastereomer of the leukocyte adhesion inhibitor cyclamenol A.

artículo científico publicado en 2001

Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity.

artículo científico publicado en 2009

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

artículo científico publicado en 2004

Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes

artículo científico publicado en 2012

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

artículo científico publicado en 2020

Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin

artículo científico publicado en 2017

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells

artículo científico publicado en 2017

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone

artículo científico publicado en 2012

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

artículo científico publicado en 2017

Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5.

artículo científico publicado en 2016

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.

artículo científico publicado en 2018

N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist

artículo científico publicado en 2014

Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles

artículo científico publicado en 2016

Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

artículo científico publicado en 2019

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.

artículo científico publicado en 2005

Rapid Synthesis of γ-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen

artículo científico publicado en 2019

Revealing cytotoxic substructures in molecules using deep learning

artículo científico publicado en 2020

Selective non-lipid modulator of LPA5 activity in human platelets.

artículo científico publicado en 2012

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

artículo científico publicado en 2019

Synthesis of the (9S,18R) Diastereomer of Cyclamenol A This research was supported by the Bayer AG and the Fonds der chemischen Industrie

artículo científico publicado en 2000

Synthesis of the (9S,18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol A

Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures

artículo científico publicado en 2016

Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform

artículo científico publicado en 2014

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

artículo científico publicado en 2018

Weizhouochrones: Gorgonian-Derived Symmetric Dimers and Their Structure Elucidation Using Anisotropic NMR Combined with DP4+ Probability and CASE-3D

scientific article published in 2022

visualization of osteoarthritic hypertrophic lesions

artículo científico publicado en 2015

Lista de obras de Marc Nazaré

5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors

A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus-Silane System.

A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles

A flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones.

A general and mild domino approach to substituted 1-aminoindoles

A general and mild palladium-catalyzed domino reaction for the synthesis of 2H-indazoles

A new highly thyrotropin receptor-selective small molecule antagonist with potential for the treatment of Graves' orbitopathy

A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels ⬇️

Allosteric inhibition of a mammalian lectin

CellFy: A Cell-Based Fragment Screen against C-Type Lectins

Chemical fragment arrays for rapid druggability assessment.

DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances.

Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

Efficient enantioselective synthesis of a β-hydroxyepoxide building block for the construction of macrocyclic natural products

Enantiospecific synthesis of the (9S,18R)-diastereomer of the leukocyte adhesion inhibitor cyclamenol A.

Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity.

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5.

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.

N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist

Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles

Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.

Rapid Synthesis of γ-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen

Revealing cytotoxic substructures in molecules using deep learning

Selective non-lipid modulator of LPA5 activity in human platelets.

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

Synthesis of the (9S,18R) Diastereomer of Cyclamenol A This research was supported by the Bayer AG and the Fonds der chemischen Industrie

Synthesis of the (9S,18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol A

Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures

Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

Weizhouochrones: Gorgonian-Derived Symmetric Dimers and Their Structure Elucidation Using Anisotropic NMR Combined with DP4+ Probability and CASE-3D

visualization of osteoarthritic hypertrophic lesions