Lista de obras - Adriano Mollica - Dominio Público Uruguay

(Acyloxy)alkoxy moiety as amino acids protecting group for the synthesis of (R,R)-2,7 diaminosuberic acid via RCM

artículo científico publicado en 2012

2,5-diketopiperazines as neuroprotective agents.

artículo científico publicado en 2012

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

artículo científico publicado en 2017

A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.

artículo científico publicado en 2016

An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats

artículo científico publicado en 2017

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

artículo científico publicado en 2017

Anorexigenic effects induced by RVD-hemopressin(α) administration.

artículo científico publicado en 2017

Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives

artículo científico publicado en 2015

Anti-Oxidant and Tyrosinase Inhibitory In Vitro Activity of Amino Acids and Small Peptides: New Hints for the Multifaceted Treatment of Neurologic and Metabolic Disfunctions

artículo científico publicado en 2018

Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker

artículo científico publicado en 2012

Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents

artículo científico publicado en 2015

Bioactive isoflavones from Pueraria lobata root and starch: Different extraction techniques and carbonic anhydrase inhibition

artículo científico publicado en 2017

Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches

artículo científico publicado en 2017

Biological Active Analogues of the Opioid Peptide Biphalin: Mixed α/β3-Peptides ⬇️

artículo científico publicado el 12 de abril de 2013

Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents

artículo científico publicado en 2017

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

scientific article published on 17 November 2010

Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications.

artículo científico publicado en 2016

Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan

scientific article published on 06 December 2019

Chemical, biological and molecular modelling analyses to probe into the pharmacological potential of Antidesma madagascariense Lam.: A multifunctional agent for developing novel therapeutic formulations

scientific article published on 04 September 2018

Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea.

artículo científico publicado en 2017

Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control. ⬇️

artículo científico publicado en 2011

Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile.

artículo científico publicado en 2017

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

scientific article published on 26 May 2018

Cyclotides: a natural combinatorial peptide library or a bioactive sequence player?

artículo científico

Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P. speciosa L. and P. reptans Willd.) and Their Chemical Composition

artículo científico publicado en 2017

DPP-4 inhibitors: a patent review (2012 - 2014).

artículo científico publicado en 2014

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands

artículo científico publicado en 2014

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

artículo científico publicado en 2019

Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity

scientific article published on 16 September 2019

Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats.

artículo científico publicado en 2017

Enzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts

artículo científico publicado en 2016

Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations

artículo científico publicado en 2016

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

artículo científico publicado en 2016

Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies

scientific article published on 01 August 2015

Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine

article

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

artículo científico publicado en 2017

Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers.

artículo científico

Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies

artículo científico publicado en 2017

GPE and GPE Analogues as Promising Neuroprotective Agents ⬇️

artículo científico publicado el 1 de enero de 2012

Geographical characterization by MAE-HPLC and NIR methodologies and carbonic anhydrase inhibition of Saffron components.

artículo científico publicado en 2016

HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts

scientific article published on 29 July 2018

Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools

artículo científico publicado en 2016

Hybrid alpha/beta-peptides: for-Met-Leu-Phe-OMe analogues containing geminally disubstituted beta2,2- and beta 3,3-amino acids at the central position

artículo científico publicado en 2006

Hybrid alpha/beta3-peptides with proteinogenic side chains. Monosubstituted analogues of the chemotactic tripeptide For-Met-Leu-Phe-OMe.

artículo científico publicado en 2004

Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation.

artículo científico publicado en 2013

Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease.

artículo científico publicado en 2010

Identification of new anti-Candida compounds by ligand-based pharmacophore virtual screening.

artículo científico publicado en 2016

Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.)

scholarly article by Azzurra Stefanucci et al published August 2018 in Food and Chemical Toxicology

In vitro and in silico Studies of Mangiferin from Aphloia theiformis on Key Enzymes Linked to Diabetes Type 2 and Associated Complications.

artículo científico publicado en 2017

Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives

artículo científico publicado en 2018

Isopeptide bonds in chemotactic tripeptides. Synthesis and activity of lysine-containing fMLF analogs.

artículo científico publicado en 2002

Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies.

artículo científico publicado en 2017

Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars.

artículo científico publicado en 2016

Multifunctional approaches to provide potential pharmacophores for the pharmacy shelf: Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt

scientific article published on 20 November 2018

Nanoformulations of natural products for management of metabolic syndrome

artículo científico publicado en 2019

New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular modelling studies

artículo científico publicado en 2015

New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L

scientific article published on 06 May 2018

Nitric oxide donors and selective carbonic anhydrase inhibitors: a dual pharmacological approach for the treatment of glaucoma, cancer and osteoporosis.

artículo científico

Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione

artículo científico publicado en 2015

Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties

artículo científico publicado en 2016

Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators

scientific article published on 25 August 2018

Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on met residue replacement by 4-amino-proline scaffold: synthesis and bioactivity.

artículo científico publicado en 2008

Novel cyclic biphalin analogue with improved antinociceptive properties.

artículo científico publicado en 2014

Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

artículo científico publicado en 2017

Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

artículo científico publicado en 2016

Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.

artículo científico publicado en 2017

Orexigenic effects of endomorphin-2 (EM-2) related to decreased CRH gene expression and increased dopamine and norepinephrine activity in the hypothalamus.

artículo científico publicado en 2013

Pecan nuts: A review of reported bioactivities and health effects

article

Peptides containing 4-amino-1,2-dithiolane-4-carboxylic acid (Adt): conformation of Boc-Adt-Adt-NHMe and NH...S interactions.

artículo científico publicado en 2005

Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products

artículo científico publicado en 2017

Phenolic profile and pharmacological propensities of Gynandriris sisyrinchium through in vitro and in silico perspectives

scholarly article by Gokhan Zengin et al published October 2018 in Industrial Crops and Products

Polyphenolic composition, enzyme inhibitory effects ex-vivo and in-vivo studies on two Brassicaceae of north-central Italy

artículo científico publicado en 2018

Potent biphalin analogs with µ/δ mixed opioid activity: in vivo and in vitro biological evaluation

artículo científico publicado en 2014

Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration

scientific article published on 27 December 2019

Preparation of Constrained Unnatural Aromatic Amino AcidsviaUnsaturated Diketopiperazine Intermediate

article by Adriano Mollica et al published 7 September 2015 in Journal of Heterocyclic Chemistry

Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors

scientific article published on 21 May 2019

Prodrug approach for increasing cellular glutathione levels

artículo científico publicado en 2010

Pyroglutamic Acid Derivatives: Building Blocks for Drug Discovery

article published in 2014

Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems ⬇️

artículo científico publicado el 3 de junio de 2012

Recent application of analytical methods to phase I and phase II drugs development: a review ⬇️

artículo científico publicado el 19 de agosto de 2011

Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC

artículo científico publicado en 2015

Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles

artículo científico publicado en 2019

Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils

artículo científico publicado en 2006

Strategies for Developing Tuberculosis Vaccines: Emerging Approaches ⬇️

artículo científico publicado el 1 de agosto de 2013

Study of synthetic peptides derived from the PKI55 protein, a protein kinase C modulator, in human neutrophils stimulated by the methyl ester derivative of the hydrophobic N-formyl tripeptide for-Met-Leu-Phe-OH.

artículo científico publicado en 2007

Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 ⬇️

artículo científico publicado el 21 de julio de 2010

Synthesis and anti-cancer activity of naturally occurring 2,5-diketopiperazines.

artículo científico publicado en 2014

Synthesis and bioactivity of secondary metabolites from marine sponges containing dibrominated indolic systems.

artículo científico

Synthesis and biological activity of the first cyclic biphalin analogues.

artículo científico publicado en 2005

Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues

artículo científico publicado en 2012

Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.

scientific article published on 06 June 2009

Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.

artículo científico publicado en 2010

Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma.

artículo científico publicado en 2015

Synthesis, Characterization, and DNA Binding Profile of a Macrocyclic β-Sheet Analogue of ARC Protein

artículo científico publicado en 2015

The Positive Regulation of eNOS Signaling by PPAR Agonists in Cardiovascular Diseases.

artículo científico publicado en 2017

The analgesic activity of biphalin and its analog AM 94 in rats.

artículo científico publicado en 2012

The design of multitarget ligands for chronic and neuropathic pain

artículo científico publicado en 2015

Traditionally Used Lathyrus Species: Phytochemical Composition, Antioxidant Activity, Enzyme Inhibitory Properties, Cytotoxic Effects, and in silico Studies of L. czeczottianus and L. nissolia

scientific article published on 27 February 2017

Twisted nanoribbons from a RGD-bearing cholic acid derivative

artículo científico

cis-4-Amino-l-proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2 ⬇️

artículo científico publicado el 25 de septiembre de 2012

Lista de obras de Adriano Mollica

(Acyloxy)alkoxy moiety as amino acids protecting group for the synthesis of (R,R)-2,7 diaminosuberic acid via RCM

2,5-diketopiperazines as neuroprotective agents.

A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica

A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.

An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

Anorexigenic effects induced by RVD-hemopressin(α) administration.

Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives

Anti-Oxidant and Tyrosinase Inhibitory In Vitro Activity of Amino Acids and Small Peptides: New Hints for the Multifaceted Treatment of Neurologic and Metabolic Disfunctions

Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker

Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents

Bioactive isoflavones from Pueraria lobata root and starch: Different extraction techniques and carbonic anhydrase inhibition

Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches

Biological Active Analogues of the Opioid Peptide Biphalin: Mixed α/β3-Peptides ⬇️

Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications.

Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan

Chemical, biological and molecular modelling analyses to probe into the pharmacological potential of Antidesma madagascariense Lam.: A multifunctional agent for developing novel therapeutic formulations

Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea.

Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control. ⬇️

Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile.

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

Cyclotides: a natural combinatorial peptide library or a bioactive sequence player?

Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P. speciosa L. and P. reptans Willd.) and Their Chemical Composition

DPP-4 inhibitors: a patent review (2012 - 2014).

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity

Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats.

Enzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts

Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies

Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers.

Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies

GPE and GPE Analogues as Promising Neuroprotective Agents ⬇️

Geographical characterization by MAE-HPLC and NIR methodologies and carbonic anhydrase inhibition of Saffron components.

HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts

Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools

Hybrid alpha/beta-peptides: for-Met-Leu-Phe-OMe analogues containing geminally disubstituted beta2,2- and beta 3,3-amino acids at the central position

Hybrid alpha/beta3-peptides with proteinogenic side chains. Monosubstituted analogues of the chemotactic tripeptide For-Met-Leu-Phe-OMe.

Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation.

Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease.

Identification of new anti-Candida compounds by ligand-based pharmacophore virtual screening.

Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.)

In vitro and in silico Studies of Mangiferin from Aphloia theiformis on Key Enzymes Linked to Diabetes Type 2 and Associated Complications.

Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives

Isopeptide bonds in chemotactic tripeptides. Synthesis and activity of lysine-containing fMLF analogs.

Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies.

Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars.

Multifunctional approaches to provide potential pharmacophores for the pharmacy shelf: Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt

Nanoformulations of natural products for management of metabolic syndrome

New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular modelling studies

New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L

Nitric oxide donors and selective carbonic anhydrase inhibitors: a dual pharmacological approach for the treatment of glaucoma, cancer and osteoporosis.

Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione

Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties

Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators

Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on met residue replacement by 4-amino-proline scaffold: synthesis and bioactivity.

Novel cyclic biphalin analogue with improved antinociceptive properties.

Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.

Orexigenic effects of endomorphin-2 (EM-2) related to decreased CRH gene expression and increased dopamine and norepinephrine activity in the hypothalamus.

Pecan nuts: A review of reported bioactivities and health effects

Peptides containing 4-amino-1,2-dithiolane-4-carboxylic acid (Adt): conformation of Boc-Adt-Adt-NHMe and NH...S interactions.

Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products

Phenolic profile and pharmacological propensities of Gynandriris sisyrinchium through in vitro and in silico perspectives

Polyphenolic composition, enzyme inhibitory effects ex-vivo and in-vivo studies on two Brassicaceae of north-central Italy

Potent biphalin analogs with µ/δ mixed opioid activity: in vivo and in vitro biological evaluation

Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration

Preparation of Constrained Unnatural Aromatic Amino AcidsviaUnsaturated Diketopiperazine Intermediate

Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors

Prodrug approach for increasing cellular glutathione levels

Pyroglutamic Acid Derivatives: Building Blocks for Drug Discovery

Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems ⬇️