Lista de obras - Joanna Kowalska - Dominio Público Uruguay

2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion

2’- O -methylation of the second transcribed nucleotide within mRNA 5’ cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion

artículo científico publicado en 2022

5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.

artículo científico publicado en 2018

5'-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

artículo científico publicado en 2020

7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase.

artículo científico publicado en 2017

A fluorescent HTS assay for phosphohydrolases based on nucleoside 5'-fluorophosphates: its application in screening for inhibitors of mRNA decapping scavenger and PDE-I.

artículo científico publicado en 2016

A novel route for preparing 5' cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry

artículo científico publicado en 2016

A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain

artículo científico publicado en 2007

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

artículo científico publicado en 2016

Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor.

artículo científico publicado en 2008

Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA.

artículo científico publicado en 2017

Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.

artículo científico publicado en 2013

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues

artículo científico publicado en 2017

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

artículo científico publicado en 2017

Assignment of the absolute configuration of P-chiral 5' mRNA cap analogues containing phosphorothioate moiety

artículo científico publicado en 2007

Azido-Functionalized 5' Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

artículo científico publicado en 2017

Azido-Functionalized 5′ Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

artículo científico publicado en 2017

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

artículo científico publicado en 2021

Biomolecular condensates amplify mRNA decapping by coupling protein interactions with conformational changes in Dcp1/Dcp2

artículo científico publicado en 2020

Cap analogs containing 6-thioguanosine--reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules.

artículo científico publicado en 2014

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

artículo científico publicado en 2016

Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

artículo científico publicado en 2016

Cover Feature: Fluorescent Turn‐On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap‐Recognizing Proteins (Chem. Eur. J. 27/2019)

artículo científico publicado en 2019

DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs

scientific article published on 06 May 2020

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity

artículo científico publicado en 2020

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

artículo científico publicado en 2009

Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP).

artículo científico publicado en 2010

Efficient and Rapid Synthesis of Nucleoside Diphosphate Sugars from Nucleoside Phosphorimidazolides

Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation

artículo científico publicado en 2021

Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC.

artículo científico publicado en 2015

Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy

artículo científico publicado en 2021

ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions

artículo científico publicado en 2018

Exploring the potential of phosphotriazole 5' mRNA cap analogues as efficient translation initiators

artículo científico publicado en 2018

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

artículo científico publicado en 2014

Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9

artículo científico publicado en 2022

Fluorescent Turn-On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap-Recognizing Proteins

artículo científico publicado en 2019

Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by 19 F NMR Spectroscopy

Functional and LC-MS/MS analysis ofin vitrotranscribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression

artículo científico publicado en 2020

Gold-decorated polymer vessel structures as carriers of mRNA cap analogs

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

artículo científico publicado en 2021

Interaction of human decapping scavenger with 5′ mRNA cap analogues: structural requirements for catalytic activity

Introducing SuFNucs: Sulfamoyl-Fluoride-Functionalized Nucleosides That Undergo Sulfur Fluoride Exchange Reaction

scientific article published in 2022

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

scientific article published on 28 October 2019

Magnetic-nanoparticle-decorated polypyrrole microvessels: toward encapsulation of mRNA cap analogues.

artículo científico publicado en 2013

Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases.

artículo científico publicado en 2006

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins.

artículo científico publicado en 2019

NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry

artículo científico publicado en 2019

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

scientific article published on 27 November 2018

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation

artículo científico

Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties

artículo científico

Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression

artículo científico publicado en 2020

Phosphoroselenoate dinucleotides for modification of mRNA 5' end

artículo científico publicado en 2009

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

artículo científico publicado en 2009

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

artículo científico publicado en 2010

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

artículo científico publicado en 2007

Potential therapeutic applications of RNA cap analogs.

artículo científico publicado en 2013

Preparation of synthetically challenging nucleotides using cyanoethyl P-imidazolides and microwaves

artículo científico publicado en 2012

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks

RNA Ligation for Mono and Dually Labeled RNAs

artículo científico publicado en 2021

Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins

Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation

artículo científico publicado en 2018

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

artículo científico publicado en 2021

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

scientific article published on 29 April 2022

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

artículo científico publicado en 2008

Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A).

artículo científico publicado en 2005

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

artículo científico publicado en 2012

Synthesis and properties of mRNA cap analogs containing phosphorothioate moiety in 5',5'-triphosphate chain

artículo científico publicado en 2005

Synthesis of RNA 5'-Azides from 2'-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide-Alkyne Cycloaddition Reactions

artículo científico publicado en 2017

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes

scientific article published on 13 February 2020

Synthesis of biotin labelled cap analogue--incorporable into mRNA transcripts and promoting cap-dependent translation

scientific article published on 01 November 2012

Synthesis of nucleoside phosphosulfates

artículo científico publicado en 2012

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

artículo científico publicado en 2014

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5',5' bridge containing methylenebis(phosphonate) modification

artículo científico publicado en 2009

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

Synthetic mRNAs with superior translation and stability properties.

artículo científico

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells

artículo científico publicado en 2020

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5’ cap modulates protein expression in living cells

artículo científico publicado en 2019

The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation.

artículo científico publicado en 2013

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

artículo científico publicado en 2010

Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5′,5′-triphosphate bridge

artículo científico publicado en 2014

Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog

Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

artículo científico publicado en 2011

Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.

artículo científico publicado en 2016

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

artículo científico publicado en 2014

mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation

artículo científico publicado en 2015

mRNAs biotinylated within the 5' cap and protected against decapping: new tools to capture RNA-protein complexes

scientific article published on 05 November 2018

mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end.

artículo científico publicado en 2012

Lista de obras de Joanna Kowalska

2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion

2’- O -methylation of the second transcribed nucleotide within mRNA 5’ cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion

5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.

5'-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase.

A fluorescent HTS assay for phosphohydrolases based on nucleoside 5'-fluorophosphates: its application in screening for inhibitors of mRNA decapping scavenger and PDE-I.

A novel route for preparing 5' cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry

A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor.

Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA.

Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

Assignment of the absolute configuration of P-chiral 5' mRNA cap analogues containing phosphorothioate moiety

Azido-Functionalized 5' Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

Azido-Functionalized 5′ Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

Biomolecular condensates amplify mRNA decapping by coupling protein interactions with conformational changes in Dcp1/Dcp2

Cap analogs containing 6-thioguanosine--reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules.

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

Cover Feature: Fluorescent Turn‐On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap‐Recognizing Proteins (Chem. Eur. J. 27/2019)

DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP).

Efficient and Rapid Synthesis of Nucleoside Diphosphate Sugars from Nucleoside Phosphorimidazolides

Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation

Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC.

Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy

ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions

Exploring the potential of phosphotriazole 5' mRNA cap analogues as efficient translation initiators

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9

Fluorescent Turn-On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap-Recognizing Proteins

Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by 19 F NMR Spectroscopy

Functional and LC-MS/MS analysis ofin vitrotranscribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression

Gold-decorated polymer vessel structures as carriers of mRNA cap analogs

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase

Interaction of human decapping scavenger with 5′ mRNA cap analogues: structural requirements for catalytic activity

Introducing SuFNucs: Sulfamoyl-Fluoride-Functionalized Nucleosides That Undergo Sulfur Fluoride Exchange Reaction

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

Magnetic-nanoparticle-decorated polypyrrole microvessels: toward encapsulation of mRNA cap analogues.

Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases.

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins.

NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation

Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties

Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression

Phosphoroselenoate dinucleotides for modification of mRNA 5' end

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

Potential therapeutic applications of RNA cap analogs.

Preparation of synthetically challenging nucleotides using cyanoethyl P-imidazolides and microwaves

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks

RNA Ligation for Mono and Dually Labeled RNAs

Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins

Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A).

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

Synthesis and properties of mRNA cap analogs containing phosphorothioate moiety in 5',5'-triphosphate chain

Synthesis of RNA 5'-Azides from 2'-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide-Alkyne Cycloaddition Reactions

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes

Synthesis of biotin labelled cap analogue--incorporable into mRNA transcripts and promoting cap-dependent translation

Synthesis of nucleoside phosphosulfates

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5',5' bridge containing methylenebis(phosphonate) modification

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

Synthetic mRNAs with superior translation and stability properties.

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5’ cap modulates protein expression in living cells

The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation.