Lista de obras - Jeanette H Leusen - Dominio Público Uruguay

A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA.

artículo científico publicado en 2015

A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling.

artículo científico publicado en 2014

A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice.

artículo científico publicado en 2005

A novel polymorphism in the coding region of CYBB, the human gp91-phox gene

artículo científico publicado en 1996

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

artículo científico publicado en 2015

Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice.

artículo científico publicado en 2014

Anti–GM1 IgG antibodies induce leukocyte effector functions via Fcγ receptors ⬇️

artículo científico publicado el 1 de mayo de 2003

Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

artículo científico publicado en 2020

Boosting antibody therapy with complement

artículo científico publicado en 2012

Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice ⬇️

artículo científico publicado el 23 de enero de 2012

Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness

artículo científico publicado en 2019

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

scientific article published on 18 November 2018

CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma

artículo científico publicado en 2019

Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice

scientific article published on 01 June 2003

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

artículo científico publicado en 2012

Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease ⬇️

artículo científico publicado el 1 de agosto de 1997

Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain".

artículo científico publicado en 2016

Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells"

artículo científico publicado en 2018

CpG oligodeoxynucleotides enhance FcgammaRI-mediated cross presentation by dendritic cells.

artículo científico publicado en 2004

Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.

artículo científico publicado en 2012

Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG.

artículo científico publicado en 2010

Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.

artículo científico publicado en 2000

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

artículo científico publicado en 2017

Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity

artículo científico publicado en 2004

Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity.

artículo científico publicado en 2006

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease

artículo científico publicado en 1996

Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2m(1) antibody.

artículo científico publicado en 2013

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

artículo científico publicado en 2017

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.

artículo científico publicado en 2018

Expression of CD64 (FcγRI) in skin of patients with acute GVHD

artículo científico publicado en 2011

Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents

scientific article published on 15 December 2020

Fc receptor inside-out signaling and possible impact on antibody therapy.

artículo científico publicado en 2015

Fc receptor-mediated immunity against Bordetella pertussis

artículo científico publicado en 2001

FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells

artículo científico publicado en 2014

FcgammaRI (CD64) resides constitutively in lipid rafts.

artículo científico publicado en 2008

FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

artículo científico publicado en 2018

Fcγ receptor IIIA genotype is associated with rituximab response in antimyelin-associated glycoprotein neuropathy

artículo científico publicado en 2014

Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing

artículo científico publicado en 2008

Flow cytometric determination of FcgammaRIIa (CD32) polymorphism.

artículo científico publicado en 2004

Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly

artículo científico publicado en 2000

Functional characteristics of the high affinity IgG receptor, FcγRI.

artículo científico publicado en 2011

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

scholarly article

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

scientific article published on 28 August 2019

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

artículo científico publicado en 2019

Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab

artículo científico publicado en 2013

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

artículo científico publicado en 2016

Human amniotic fluid antibodies protect the neonate against respiratory syncytial virus infection

artículo científico publicado en 2016

Identification of a tumor-specific allo-HLA-restricted γδTCR

scientific article published on 01 October 2019

IgA as therapeutic antibody

artículo científico publicado en 2015

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRPα Checkpoint Inhibition

artículo científico publicado en 2019

IgG antibodies in food allergy influence allergen-antibody complex formation and binding to B cells: a role for complement receptors.

artículo científico publicado en 2013

Immune effector functions of human IgG2 antibodies against EGFR

scientific article published on 03 October 2018

Immunoreceptors: evolution, structure and therapeutic applications ⬇️

artículo científico publicado el 13 de noviembre de 2012

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

artículo científico publicado en 2015

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

artículo científico publicado en 2010

Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C

scientific article published on 01 September 1993

Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2.

artículo científico publicado en 2013

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

artículo científico publicado en 2014

Inside-out regulation of Fc alpha RI (CD89) depends on PP2A.

artículo científico publicado en 2008

Interactions between the components of the human NADPH oxidase: a review about the intrigues in the phox family.

artículo científico publicado en 1996

Interactions between the cytosolic components p47phox and p67phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system.

artículo científico publicado en 1995

Intravenous immune globulin suppresses angiogenesis in mice and humans

artículo científico publicado en 2016

Isolation from purulent sputum of an antigen reactive with antibodies in serum of patients with Wegener's granulomatosis.

artículo científico publicado en 1990

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

artículo científico publicado en 2016

Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgA.

artículo científico publicado en 2002

Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation.

artículo científico publicado en 2001

Mechanisms of action of CD20 antibodies ⬇️

artículo científico publicado el 20 de noviembre de 2012

Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI

scientific article published on 24 July 2018

Meeting report on immunoreceptors 2014.

artículo científico publicado en 2015

Modulation of FcgammaRI (CD64) ligand binding by blocking peptides of periplakin.

artículo científico publicado en 2004

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

artículo científico publicado en 2018

New insights in Type I and II CD20 antibody mechanisms-of-action with a panel of novel CD20 antibodies.

artículo científico publicado en 2018

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies

artículo científico publicado en 2020

OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation.

artículo científico publicado en 2008

Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells.

artículo científico publicado en 2006

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

artículo científico publicado en 2019

Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail.

artículo científico publicado en 2007

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

artículo científico publicado en 2015

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

artículo científico publicado en 2011

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo.

artículo científico publicado en 2018

Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer

artículo científico publicado en 2014

Serum antibodies critically affect virus-specific CD4+/CD8+ T cell balance during respiratory syncytial virus infections.

artículo científico publicado en 2010

Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.

artículo científico publicado en 2006

Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing

artículo científico publicado en 2015

Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions

artículo científico publicado en 2017

Specificity and Effector Functions of Human RSV-Specific IgG from Bovine Milk

artículo científico publicado en 2014

Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions.

artículo científico publicado en 2013

Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread

artículo científico publicado en 2015

The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain.

artículo científico publicado en 1999

The Fcγ receptor IIA R131H gene polymorphism is associated with endothelial function in patients with hypercholesterolaemia.

artículo científico publicado en 2011

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking

artículo científico publicado en 2016

The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma

scientific article published on 01 February 2006

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden.

artículo científico publicado en 2011

The latest developments with anti-CD20 monoclonal antibodies in chronic lymphocytic leukemia

scientific article published on 10 August 2018

c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcalphaRI and FcRgamma-chain.

artículo científico publicado en 2010

Association of the leukocyte immunoglobulin G (Fcgamma) receptor IIIa-158V/F polymorphism with inflammatory myopathies in Dutch patients

artículo científico publicado en 2009

Lista de obras de Jeanette H Leusen

A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA.

A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling.

A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice.

A novel polymorphism in the coding region of CYBB, the human gp91-phox gene

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice.

Anti–GM1 IgG antibodies induce leukocyte effector functions via Fcγ receptors ⬇️

Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

Boosting antibody therapy with complement

Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice ⬇️

Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma

Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease ⬇️

Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain".

Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells"

CpG oligodeoxynucleotides enhance FcgammaRI-mediated cross presentation by dendritic cells.

Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.

Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG.

Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity

Direct targeting of genetically modified tumour cells to Fc gammaRI triggers potent tumour cytotoxicity.

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease

Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2m(1) antibody.

Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.

Expression of CD64 (FcγRI) in skin of patients with acute GVHD

Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents

Fc receptor inside-out signaling and possible impact on antibody therapy.

Fc receptor-mediated immunity against Bordetella pertussis

FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells

FcgammaRI (CD64) resides constitutively in lipid rafts.

FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

Fcγ receptor IIIA genotype is associated with rituximab response in antimyelin-associated glycoprotein neuropathy

Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing

Flow cytometric determination of FcgammaRIIa (CD32) polymorphism.

Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly

Functional characteristics of the high affinity IgG receptor, FcγRI.

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

Human amniotic fluid antibodies protect the neonate against respiratory syncytial virus infection

Identification of a tumor-specific allo-HLA-restricted γδTCR

IgA as therapeutic antibody

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRPα Checkpoint Inhibition

IgG antibodies in food allergy influence allergen-antibody complex formation and binding to B cells: a role for complement receptors.

Immune effector functions of human IgG2 antibodies against EGFR

Immunoreceptors: evolution, structure and therapeutic applications ⬇️

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C

Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2.

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

Inside-out regulation of Fc alpha RI (CD89) depends on PP2A.

Interactions between the components of the human NADPH oxidase: a review about the intrigues in the phox family.

Interactions between the cytosolic components p47phox and p67phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system.

Intravenous immune globulin suppresses angiogenesis in mice and humans

Isolation from purulent sputum of an antigen reactive with antibodies in serum of patients with Wegener's granulomatosis.

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgA.

Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation.

Mechanisms of action of CD20 antibodies ⬇️

Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI

Meeting report on immunoreceptors 2014.

Modulation of FcgammaRI (CD64) ligand binding by blocking peptides of periplakin.

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

New insights in Type I and II CD20 antibody mechanisms-of-action with a panel of novel CD20 antibodies.

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies

OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation.

Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells.

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail.

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.