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Lista de obras de C Negrier

A French multicenter randomised trial comparing two dose-regimens of prothrombin complex concentrates in urgent anticoagulation reversal.

artículo científico publicado en 2013

A case of Glanzmann's thrombasthenia successfully treated with recombinant factor viia during a surgical procedure: observations on the monitoring and the mechanism of action of this drug

artículo científico publicado en 2006

A comparison of the 12s rule and Bayesian approach for quality control: application to one-stage clotting factor VIII assay

artículo científico publicado en 2014

A cross-over pharmacokinetic study of a double viral inactivated factor IX concentrate (15 nm filtration and SD) compared to a SD factor IX concentrate

scientific article published on 01 December 1998

A factor VIII minigene comprising the truncated intron I of factor IX highly improves the in vitro production of factor VIII

scientific article published on 01 August 2001

A nonsense mutation in the GPIIb heavy chain (Ser 870-->stop) impairs platelet GPIIb-IIIa expression

artículo científico publicado en 1996

A novel protocol for accurate and reliable postoperative bolus administration of recombinant factor VIIa using an automated mini-pump system

scientific article published on 01 November 2019

A retrospective postlicensure survey of FEIBA efficacy and safety.

artículo científico publicado en 2006

A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective study

artículo científico publicado en 2009

Achievements, challenges and unmet needs for haemophilia patients with inhibitors: Report from a symposium in Paris, France on 20 November 2014.

artículo científico publicado en 2016

Alpha cyano-4-hydroxy-3-methoxycinnamic acid inhibits proliferation and induces apoptosis in human breast cancer cells

artículo científico publicado en 2013

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

artículo científico publicado en 2015

An unusual clinical presentation of factor XIII deficiency and issues relating to the monitoring of factor XIII replacement therapy

scientific article published on 01 July 2008

An unusual haemarthrosis in an HIV-seronegative haemophilia A patient.

artículo científico publicado en 1998

Analytic variability due to change of deficient plasma vials: application to one-stage clotting factor VIII assay.

artículo científico publicado en 2011

Assessment of the interest of using confirmatory test in ELISA with use of high concentration of heparin-induced thrombocytopenia

artículo científico publicado en 2010

B-domain deleted factor VIII is aggregated and degraded through proteasomal and lysosomal pathways.

artículo científico publicado en 2005

BAY 94-9027 prophylaxis is efficacious and well tolerated for up to >5 years with extended dosing intervals: PROTECT VIII extension interim results

scientific article published on 17 October 2019

Basic aspects of bypassing agents.

artículo científico publicado en 2006

Bayesian logic in statistical test control: application to coagulation factor VIII assay.

artículo científico publicado en 2010

Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels.

artículo científico publicado en 2013

Characterisation of 96 mutations in 128 unrelated severe haemophilia A patients from France. Description of 62 novel mutations

artículo científico publicado en 2006

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

artículo científico publicado en 2015

Characterization of five associations of F8 missense mutations containing FVIII B domain mutations.

artículo científico publicado en 2016

Characterization of four novel molecular changes in the promoter region of the factor VIII gene

artículo científico publicado en 2013

Chromogenic analysis of FIX activity in haemophilia B patients treated with nonacog beta pegol.

artículo científico publicado en 2017

Clinical and biological features of 3 cases of hypofibrinogenemia associated with three different mutations (gamma Ala341Thr, Bbeta Tyr326Cys and Aalpha Asp496Asn)

scientific article published on 01 September 2007

Clinical management of patients with von Willebrand's disease with a VHP vWF concentrate: the French experience.

artículo científico publicado en 1998

Coagulation factor concentrates: past, present, and future.

artículo científico publicado en 2007

Combined factor IX and protein C deficiency in a child: thrombogenic effects of two factor IX concentrates.

artículo científico publicado en 1995

Combined hereditary disorders of haemophilia B Leyden (-6 G-->A) and type 1 von Willebrand disease

artículo científico publicado en 1996

Comparison of an automated chemiluminescent assay to a manual ELISA assay for determination of von Willebrand Factor collagen binding activity on VWD plasma patients previously diagnosed through molecular analysis of VWF.

artículo científico publicado en 2017

Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response. A review of the literature.

artículo científico publicado en 2016

Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study.

artículo científico publicado en 2008

Consensus perspectives on surgery in haemophilia patients with inhibitors: summary statement.

artículo científico publicado en 2004

Consensus recommendations for the use of FEIBA(®) in haemophilia A patients with inhibitors undergoing elective orthopaedic and non-orthopaedic surgery

artículo científico

Continuous intravenous infusion of a plasma-derived factor IX concentrate (Mononine) in haemophilia B.

artículo científico publicado en 2003

Contribution of genetical analysis for diagnosis of von Willebrand's disease type 2B.

artículo científico publicado en 2009

Decreased factor XII activity in a child with nephrotic syndrome and thromboembolic complications

scientific article published on 01 October 1991

Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development.

artículo científico publicado en 2003

Description of 10 new mutations in platelet glycoprotein IIb (alphaIIb) and glycoprotein IIIa (beta3) genes

artículo científico publicado en 2001

Determinants of adherence and consequences of the transition from adolescence to adulthood among young people with severe haemophilia (TRANSHEMO): study protocol for a multicentric French national observational cross-sectional study

article

Determining the adequate number of internal quality control levels: the example of coagulation factor VIII assay

artículo científico publicado en 2008

Diagnosis and management challenges in patients with mild haemophilia A and discrepant FVIII measurements

artículo científico publicado en 2014

Dosing regimens, FVIII levels and estimated haemostatic protection with special focus on rFVIIIFc.

artículo científico publicado en 2016

Early coagulopathy in trauma patients: an on-scene and hospital admission study.

artículo científico publicado en 2010

Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria.

artículo científico publicado en 2014

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.

artículo científico publicado en 2015

Effect of pre-analytical conditions on the thrombodynamics assay.

artículo científico publicado en 2013

Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study.

artículo científico publicado en 2007

Efficacy and safety of continuous infusion of Mononine during five surgical procedures in three hemophilic patients.

artículo científico publicado en 1998

Efficacy and safety of long-acting recombinant fusion protein linking factor IX with albumin in haemophilia B patients undergoing surgery.

artículo científico publicado en 2016

Emicizumab Prophylaxis in Hemophilia A with Inhibitors

artículo científico publicado en 2017

Emicizumab Prophylaxis in Patients Who Have Hemophilia A without Inhibitors

artículo científico publicado en 2018

Emicizumab should be prescribed independent of immune tolerance induction

article

Endogenous thrombin potential, prothrombin fragment 1+2 and D-dimers during pregnancy

artículo científico publicado en 2009

Entering new areas in known fields: recombinant fusion protein linking recombinant factor VIIa with recombinant albumin (rVIIa-FP) - advancing the journey

artículo científico publicado en 2016

European curriculum for thrombosis and haemostasis.

artículo científico publicado en 2009

Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study

artículo científico publicado en 2012

Evaluation of early musculoskeletal disease in patients with haemophilia: results from an expert consensus

scholarly article by Axel Seuser et al published September 2018 in Blood Coagulation and Fibrinolysis

Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients

artículo científico publicado en 2008

Evaluation of the impact of information about treatment-related risks in patients receiving blood-derived or recombinant medications.

artículo científico publicado en 2004

Evaluation of the overall haemostatic effect of recombinant factor VIIa by measuring thrombin generation and stability of fibrin clots.

artículo científico publicado en 2011

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

artículo científico publicado en 2005

Evaluation of thromboelastography for monitoring recombinant activated factor VII ex vivo in haemophilia A and B patients with inhibitors: a multicentre trial.

artículo científico publicado en 2008

Expanding the Mutation Spectrum Affecting αIIbβ3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort

artículo científico publicado en 2015

Experiences with continuous infusion of recombinant activated factor VII.

artículo científico publicado en 1998

Expression and characterization of a novel human recombinant factor IX molecule with enhanced in vitro and in vivo clotting activity.

artículo científico publicado en 2015

Expression of coagulation factor IX in a haematopoietic cell line

scientific article published on 01 March 2002

FEIBA in the treatment of acquired haemophilia A: results from the prospective multicentre French 'FEIBA dans l'hémophilie A acquise' (FEIBHAC) registry.

artículo científico publicado en 2014

Factor IX gene analysis in 70 unrelated patients with haemophilia B: description of 13 new mutations

scientific article published on 01 November 1999

Factor VIII gene inversions in severe hemophilia A: results of an international consortium study.

artículo científico publicado en 1995

Factor VIII recovery after a single infusion of recalibrated ReFacto in 14 severe haemophilia A patients.

artículo científico publicado en 2007

Factor XI and traveling waves: the key to understanding coagulation in hemophilia?

artículo científico publicado en 2013

Feasibility of an easy-to-use risk score in the prevention of venous thromboembolism and placental vascular complications in pregnant women. A rebuttal

artículo científico publicado en 2008

First report on the safety and efficacy of an extended half-life glycoPEGylated recombinant FVIII for major surgery in severe haemophilia A.

artículo científico publicado en 2017

Functional mapping of factor VIII C2 domain

artículo científico publicado en 2011

Functional mapping of the A2 domain from human factor VIII.

artículo científico publicado en 2012

Global Post-Authorization Safety Surveillance Study: real-world data on prophylaxis and on-demand treatment using FEIBA (an activated prothrombin complex concentrate).

artículo científico publicado en 2016

Global haemostasis and point of care testing.

artículo científico publicado en 2012

Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: are these results really discordant?

artículo científico publicado en 2007

Health-related quality of life in patients with haemophilia and inhibitors on prophylaxis with anti-inhibitor complex concentrate: results from the Pro-FEIBA study.

artículo científico publicado en 2013

Hemophilia therapy innovation: development of an advanced category recombinant factor VIII by a plasma/albumin-free method. Proceedings of a Special Symposium at the XIXth Congress of the International Society on Thrombosis and Haemostasis, July 12-

artículo científico publicado en 2004

Hepatitis A in French hemophiliacs.

artículo científico publicado en 1994

Human herpesvirus 6 infection and transient acquired myelodysplasia in children.

artículo científico publicado en 2006

Human plasma fibrinogen measurement derived from activated partial thromboplastin time clot formation.

artículo científico publicado en 2002

Identification of new F8 deep intronic variations in patients with haemophilia A

artículo científico publicado en 2020

Identification of new and known polymorphisms in glycoprotein IIb and IIIa genes by denaturing gradient gel electrophoresis.

artículo científico publicado en 1998

Illegitimate transcription: its use for studying genetic abnormalities in lymphoblastoid cells from patients with Glanzmann thrombasthenia.

artículo científico publicado en 1998

Impact of quality control matrix effect: application to the calculation of uncertainty of measurement in one-stage clotting factor VIII assay.

artículo científico publicado en 2010

In vitro tests for assessing heparin-induced thrombocytopenia in patients after elective hip replacement. A medico-economical evaluation.

artículo científico publicado en 2002

In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH-7.

artículo científico publicado en 2015

Incidence of factor VIII inhibitor development in severe hemophilia A patients treated only with one brand of highly purified plasma-derived concentrate

artículo científico publicado en 1995

Increased thrombin generation in a child with a combined factor IX and protein C deficiency.

artículo científico publicado en 1993

Increased thrombosis incidence in a family with an inherited protein S deficiency and a high oxygen affinity hemoglobin variant

scientific article published on 01 July 1994

Individual thrombin generation and spontaneous bleeding rate during personalized prophylaxis with Nuwiq® (human-cl rhFVIII) in previously treated patients with severe haemophilia A

artículo científico publicado en 2018

Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiency

artículo científico publicado en 2005

Intraindividual thrombin generation measurement variability in healthy adults over a one year period

scientific article published on 24 September 2008

MDA-9/syntenin is essential for factor VIIa-induced signaling, migration, and metastasis in melanoma cells

artículo científico publicado en 2014

Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision.

artículo científico publicado en 2005

Management of an anti-factor VIII inhibitor occurring during surgical procedure with continuous infusion of Novoseven.

artículo científico publicado en 1998

Management of bleeding and invasive procedures in haemophilia A patients with inhibitor treated with emicizumab (Hemlibra® ): Proposals from the French network on inherited bleeding disorders (MHEMO), the French Reference Centre on Haemophilia, in c

artículo científico publicado en 2019

Management of intracranial haemorrhage in a newborn with inherited factor VII deficiency with the use of rFVIIa aliquots

scientific article published on 20 November 2020

Management of pregnant women with increased risk of venous thrombosis

artículo científico publicado en 2005

Molecular cytogenetic characterization of five F8 complex rearrangements: utility for haemophilia A genetic counselling.

artículo científico publicado en 2017

Molecular study of Glanzmann thrombasthenia in 3 patients issued from 2 different families

artículo científico publicado en 1995

Monitoring the bioavailability of FEIBA with a thrombin generation assay.

artículo científico publicado en 2003

Multicenter retrospective study on the utilization of FEIBA in France in patients with factor VIII and factor IX inhibitors. French FEIBA Study Group. Factor Eight Bypassing Activity

artículo científico publicado en 1997

Multiple arterial thromboses in a patient with primary antiphospholipid syndrome receiving a bromocriptine therapy.

artículo científico publicado en 2004

New approaches to using FEIBA in the treatment of inhibitor patients.

artículo científico publicado en 2006

New developments in laboratory diagnosis and monitoring.

artículo científico publicado en 2010

Nonacog beta pegol (N9-GP) in haemophilia B: A multinational phase III safety and efficacy extension trial (paradigm™4).

artículo científico publicado en 2016

Optimizing on-demand treatment with NovoSeven room temperature stable.

scientific article published on May 2010

Pharmacokinetics of a novel extended half-life glycoPEGylated factor IX, nonacog beta pegol (N9-GP) in previously treated patients with haemophilia B: results from two phase 3 clinical trials.

artículo científico publicado en 2017

Phase I study of interleukin-6 in children with solid tumours in relapse

artículo científico publicado en 1997

Pioneering therapeutic proteins in hemophilia care through innovative technologies.

artículo científico publicado en 2016

Post-authorization safety study of Clottafact® , a triply secured fibrinogen concentrate in congenital afibrinogenemia. A prospective observational study

artículo científico publicado en 2016

Postauthorization safety study of Clottafact® , a triply secured fibrinogen concentrate in acquired fibrinogen deficiency: a prospective observational study

artículo científico publicado en 2017

Pre-analytical effects of pneumatic tube system transport on routine haematology and coagulation tests, global coagulation assays and platelet function assays

artículo científico publicado en 2016

Preventing and treating bleeding complications: new insights into therapeutic options

scientific article published on 01 January 2008

Prophylactic and therapeutic recombinant factor VIIa administration to patients with Glanzmann's thrombasthenia: results of an international survey.

artículo científico publicado en 2004

Prophylactic versus on-demand treatment strategies for severe haemophilia: a comparison of costs and long-term outcome.

artículo científico publicado en 2002

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH.

artículo científico publicado en 2017

Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery.

artículo científico publicado en 2010

Prospective evaluation of automatized PF4/heparin immunoassays HemosIL HIT-ab (PF4-H) for the diagnosis of heparin-induced thrombocytopenia.

artículo científico publicado en 2014

Protein S: A multifunctional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer.

artículo científico

Reccurrent F8 Intronic Deletion Found in Mild Hemophilia A Causes Alu Exonization.

artículo científico publicado en 2018

Recombinant activated factor VII in approved indications: Update on safety

scientific article published on 13 July 2018

Recombinant long-acting glycoPEGylated factor IX (nonacog beta pegol) in haemophilia B: assessment of target joints in multinational phase 3 clinical trials

artículo científico publicado en 2016

Recombinant long-acting glycoPEGylated factor IX in hemophilia B: a multinational randomized phase 3 trial

artículo científico publicado en 2014

Recurrent spontaneous intracerebral hematoma in a patient with afibrinogenemia

artículo científico publicado en 1998

Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC.

artículo científico publicado en 2008

Safety and efficacy of three arthroscopic procedures using Holmium: Yag laser in two high-responder haemophiliacs.

artículo científico publicado en 1999

Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients.

artículo científico publicado en 2012

Safety and pharmacokinetics of subcutaneously administered recombinant activated factor VII (rFVIIa).

artículo científico publicado en 2011

Safety update on the use of recombinant activated factor VII in approved indications.

artículo científico

Skewed X-chromosome inactivation in monochorionic diamniotic twin sisters results in severe and mild hemophilia A.

artículo científico publicado en 2002

Spectrum of the mutations in Bernard-Soulier syndrome

artículo científico publicado en 2014

Spontaneous proximal deep vein thrombosis in a patient with severe haemophilia A.

artículo científico publicado en 2003

Spotlight on the human factor: building a foundation for the future of haemophilia A management: report from a symposium on human recombinant FVIII at the World Federation of Hemophilia World Congress, Melbourne, Australia on 12 May 2014.

artículo científico publicado en 2015

Standardisation of thrombin generation test--which reference plasma for TGT? An international multicentre study.

artículo científico publicado en 2009

Study of six patients with complete F9 deletion characterized by cytogenetic microarray: role of the SOX3 gene in intellectual disability.

artículo científico publicado en 2016

Successful systemic thrombolysis of hepatic vein thrombosis in a patient with promyelocytic leukemia treated with all-trans retinoic acid

scientific article published on 01 April 1995

Successful treatment of acquired factor VIII antibody by extracorporeal immunoadsorption

artículo científico publicado en 1991

Successive bleeding and thrombotic complications in a patient with afibrinogenemia: a case report

artículo científico publicado en 2011

Surgical evaluation of a recombinant factor VIII prepared using a plasma/albumin-free method: efficacy and safety of Advate in previously treated patients

artículo científico publicado en 2008

Switching to recombinant factor IX Fc fusion protein prophylaxis results in fewer infusions, decreased factor IX consumption and lower bleeding rates.

artículo científico publicado en 2014

Target plasma factor levels for personalized treatment in haemophilia: a Delphi consensus statement.

artículo científico publicado en 2017

The application of bypassing-agent prophylaxis in haemophilia A patients with inhibitors: a meeting report.

artículo científico publicado en 2009

The benefits of exercise for patients with haemophilia and recommendations for safe and effective physical activity.

artículo científico

The concept of recombinant factor VIIa megadose for treating bleeding episodes in high-titer inhibitor patients with hemophilia: toward an expanding indication?

artículo científico publicado en 2003

The first recombinant FVIII produced in human cells--an update on its clinical development programme.

artículo científico

The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B.

artículo científico publicado en 2004

The three in-frame ATG, clustered in the translation initiation sequence of human factor IX gene, are required for an optimal protein production

artículo científico publicado en 1999

The treatment of bleeding in acquired haemophilia with recombinant factor VIIa: a multicentre study

artículo científico publicado en 1997

The treatment of bleeding in hemophilic patients with inhibitors with recombinant factor VIIa.

artículo científico publicado en 2000

The use of porcine factor VIII in France.

artículo científico publicado en 1994

Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives.

artículo científico publicado en 2013

Thrombin-generating capacity in patients with von Willebrand's disease

artículo científico publicado en 2007

Two novel factor V null mutations associated with activated protein C resistance phenotype/genotype discrepancy.

artículo científico publicado en 2003

Use of Haemate(®) P as immune tolerance induction in patients with severe haemophilia A who failed previous induction attempts: a multicentre observational study

artículo científico publicado en 2012

Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotype

artículo científico publicado en 2006

Use of prior manufacturer specifications with Bayesian logic eludes preliminary phase issues in quality control: an example in a hemostasis laboratory.

artículo científico publicado en 2015

Use of recombinant factor VIIa (NovoSeven) in patients with Glanzmann thrombasthenia.

artículo científico publicado en 2001

Use of the thrombin generation test to evaluate response to treatment with recombinant activated factor VII.

artículo científico publicado en 2008

Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab.

artículo científico publicado en 2018

Usefulness of an in vitro cellular expression model for haemophilia A carrier diagnosis: illustration with five novel mutations in the F8 gene in women with isolated factor VIII:C deficiency.

artículo científico publicado en 2015

Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?

artículo científico publicado en 2017

[Contribution of genetic analysis in management of hemophilie patients]

artículo científico publicado en 2010

[Hemophilia. Diagnosis, genetics, complications]

artículo científico publicado en 1998

[Portal vein thrombosis associated with protein S type 1 deficiency]

artículo científico publicado en 1992

[Reference center for platelet diseases]

artículo científico publicado en 2007

[The current therapeutic bases for hemophilia]

artículo científico publicado en 2000

[Thrombosis of superior longitudinal sinus and pulmonary embolism in nephrotic syndrome]

artículo científico publicado en 1992

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