Lista de obras - Valentina Gandin - Dominio Público Uruguay

(99m)Tc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study.

artículo científico publicado en 2013

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

artículo científico publicado en 2016

A Pt(IV) Prodrug Combining Chlorambucil and Cisplatin: a Dual-Acting Weapon for Targeting DNA in Cancer Cells

artículo científico publicado en 2018

A Quadruple-Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines.

artículo científico publicado en 2017

A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation.

artículo científico publicado en 2010

A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling

artículo científico publicado en 2012

A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

artículo científico publicado en 2014

Advances in copper complexes as anticancer agents

artículo científico

An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties

artículo científico publicado en 2017

An unsymmetric cisplatin-based Pt(iv) derivative containing 2-(2-propynyl)octanoate: a very efficient multi-action antitumor prodrug candidate

artículo científico publicado en 2017

Anticancer activity of a series of copper(II) complexes with tripodal ligands.

artículo científico publicado en 2017

Antiproliferative Homoleptic and Heteroleptic Phosphino Silver(I) Complexes: Effect of Ligand Combination on Their Biological Mechanism of Action

artículo científico publicado en 2020

Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid

artículo científico publicado en 2017

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

artículo científico publicado en 2015

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase

artículo científico publicado en 2009

Cell biology. Trans-HSF1 express

artículo científico publicado en 2013

Chemistry and biological activity of platinum amidine complexes

artículo científico publicado en 2011

Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy

artículo científico publicado en 2007

Co-translational mechanisms of quality control of newly synthesized polypeptides

artículo científico publicado en 2014

Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines.

artículo científico publicado en 2010

Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity.

artículo científico publicado en 2009

Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands.

artículo científico publicado en 2015

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

artículo científico publicado en 2015

DNA binding ellipticine analogues: synthesis, biological evaluation, and structure-activity relationships.

artículo científico publicado en 2009

DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex

artículo científico publicado en 2015

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex

artículo científico publicado en 2013

Distinct translational control in CD4+ T cell subsets

artículo científico publicado en 2013

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

artículo científico publicado en 2018

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands

scientific article published on 01 May 2018

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression.

artículo científico publicado en 2012

Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.

artículo científico publicado en 2008

Encapsulation of lipophilic kiteplatin Pt(iv) prodrugs in PLGA-PEG micelles.

artículo científico publicado en 2016

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates

artículo científico publicado en 2017

Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila

artículo científico publicado en 2012

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

artículo científico publicado en 2008

Evaluation of the Profile and Mechanism of Neurotoxicity of Water-Soluble [Cu(P)4]PF6 and [Au(P)4]PF6 (P = thp or PTA) Anticancer Complexes.

artículo científico publicado en 2018

Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

scientific article published on 28 October 2019

FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.

artículo científico publicado en 2014

Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways

artículo científico publicado en 2005

Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapour synthesis are electively internalized in a pancreatic adenocarcinoma cell line expressing GLUT1 transporter

artículo científico publicado en 2015

Homoleptic phosphino copper(I) complexes with in vitro and in vivo dual cytotoxic and anti-angiogenic activity

artículo científico publicado en 2015

Hydroxyapatite nanocrystals as a smart, pH sensitive, delivery system for kiteplatin.

artículo científico publicado en 2016

In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxiliary monodentate phosphine ligands.

artículo científico publicado en 2014

In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand.

artículo científico publicado en 2008

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands.

artículo científico publicado en 2010

Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase

artículo científico publicado en 2014

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.

artículo científico publicado en 2006

Insights into the cytotoxic activity of the phosphane copper(I) complex [Cu(thp)4][PF6].

artículo científico publicado en 2016

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications.

artículo científico publicado en 2011

JNK inhibition arrests cotranslational degradation

artículo científico publicado en 2010

Largen: a molecular regulator of mammalian cell size control

artículo científico publicado en 2014

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

artículo científico publicado en 2015

Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems

artículo científico publicado en 2012

Monofunctional platinum(II) complexes with potent tumor cell growth inhibitory activity: the effect of a hydrogen-bond donor/acceptor N-heterocyclic ligand.

artículo científico publicado en 2014

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

scientific article published on 14 July 2018

Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates

artículo científico publicado en 2011

Neutral and charged phosphine/scorpionate copper(I) complexes: effects of ligand assembly on their antiproliferative activity.

artículo científico publicado en 2012

Nitroimidazole and glucosamine conjugated heteroscorpionate ligands and related copper(II) complexes. Syntheses, biological activity and XAS studies

artículo científico publicado en 2011

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

scientific article published on 17 July 2014

Novel Kiteplatin Pyrophosphate Derivatives with Improved Efficacy

artículo científico publicado en 2017

Novel imino thioether complexes of platinum(II): synthesis, structural investigation, and biological activity

artículo científico publicado en 2013

Novel mixed-ligand copper(I) complexes: role of diimine ligands on cytotoxicity and genotoxicity

artículo científico publicado en 2013

Novel triazolium based 11(th) group NHCs: synthesis, characterization and cellular response mechanisms.

artículo científico publicado en 2015

Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

scientific article published on 08 May 2018

Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position

artículo científico publicado en 2016

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

artículo científico publicado en 2014

Photoreactivity of 5-fluorouracil under UVB light: photolysis and cytotoxicity studies.

artículo científico publicado en 2011

Phthalates and heavy metals as endocrine disruptors in food: A study on pre-packed coffee products

artículo científico publicado en 2017

Phytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal

scientific article published on 05 December 2019

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.

artículo científico publicado en 2017

Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance

scientific article published on 27 March 2020

Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale

artículo científico publicado en 2014

Psoralenquinones as a novel class of proteasome inhibitors: design, synthesis and biological evaluation.

artículo científico publicado en 2011

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

artículo científico publicado en 2016

RACK1 Function in Cell Motility and Protein Synthesis.

scientific article published on September 2013

Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.

artículo científico publicado en 2012

Role of zinc trafficking in male fertility: from germ to sperm

artículo científico publicado en 2014

S6K1 plays a critical role in early adipocyte differentiation

artículo científico publicado en 2010

Selenium compounds as therapeutic agents in cancer.

artículo científico

Selenium induces a multi-targeted cell death process in addition to ROS formation

artículo científico publicado en 2014

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.

artículo científico publicado en 2015

Sesquiterpene rich essential oil from Nepalese Bael tree (Aegle marmelos (L.) Correa) as potential antiproliferative agent

scientific article published on 11 July 2019

Syntheses and Biological Studies of Cu(II) Complexes Bearing Bis(pyrazol-1-yl)- and Bis(triazol-1-yl)-acetato Heteroscorpionate Ligands.

artículo científico publicado en 2019

Syntheses and biological studies of nitroimidazole conjugated heteroscorpionate ligands and related Cu(I) and Cu(II) complexes

artículo científico publicado en 2018

Synthesis and Cytotoxic Activity Evaluation of New Cu(I) Complexes of Bis(pyrazol-1-yl) Acetate Ligands Functionalized with an NMDA Receptor Antagonist

artículo científico publicado en 2020

Synthesis and biological activity of ester- and amide-functionalized imidazolium salts and related water-soluble coinage metal N-heterocyclic carbene complexes

artículo científico publicado en 2012

Synthesis and characterization of azolate gold(I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents

artículo científico publicado en 2012

Synthesis and in vitro antitumor activity of water soluble sulfonate- and ester-functionalized silver(I) N-heterocyclic carbene complexes

artículo científico publicado en 2013

Synthesis and structural characterization of copper(I) complexes bearing N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA): cytotoxic activity evaluation of a series of water soluble Cu(I) derivatives containing PTA, PTAH and mPTA ligands

artículo científico publicado en 2009

Synthesis, Characterization and Biological Activity of Novel Cu(II) Complexes of 6-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde-4n-Substituted Thiosemicarbazones

artículo científico publicado en 2020

Synthesis, characterization and cytotoxic activity of novel copper(II) complexes with aroylhydrazone derivatives of 2-Oxo-1,2-dihydrobenzo[h]quinoline-3-carbaldehyde.

artículo científico publicado en 2018

Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine.

artículo científico publicado en 2011

Synthesis, characterization and in vitro and in vivo anticancer activity of Pt(iv) derivatives of [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)]

artículo científico publicado en 2017

Synthesis, characterization, and biological activity of platinum II, III, and IV pivaloamidine complexes

artículo científico publicado en 2014

Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours

artículo científico publicado en 2009

Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand

artículo científico publicado en 2006

Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily.

artículo científico publicado en 2015

The relationship between the electrospray ionization behaviour and biological activity of some phosphino Cu(I) complexes

artículo científico publicado en 2010

Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors.

artículo científico publicado en 2017

Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift

artículo científico publicado en 2009

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance.

artículo científico publicado en 2018

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

artículo científico publicado en 2012

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

artículo científico publicado en 2016

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

artículo científico publicado en 2016

trans,cis,cis-bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a prodrug candidate for the treatment of oxaliplatin-refractory colorectal cancer

artículo científico publicado en 2014

Lista de obras de Valentina Gandin

(99m)Tc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study.

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

A Pt(IV) Prodrug Combining Chlorambucil and Cisplatin: a Dual-Acting Weapon for Targeting DNA in Cancer Cells

A Quadruple-Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines.

A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation.

A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling

A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

Advances in copper complexes as anticancer agents

An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties

An unsymmetric cisplatin-based Pt(iv) derivative containing 2-(2-propynyl)octanoate: a very efficient multi-action antitumor prodrug candidate

Anticancer activity of a series of copper(II) complexes with tripodal ligands.

Antiproliferative Homoleptic and Heteroleptic Phosphino Silver(I) Complexes: Effect of Ligand Combination on Their Biological Mechanism of Action

Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase

Cell biology. Trans-HSF1 express

Chemistry and biological activity of platinum amidine complexes

Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy

Co-translational mechanisms of quality control of newly synthesized polypeptides

Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines.

Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity.

Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands.

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

DNA binding ellipticine analogues: synthesis, biological evaluation, and structure-activity relationships.

DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex

Distinct translational control in CD4+ T cell subsets

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression.

Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.

Encapsulation of lipophilic kiteplatin Pt(iv) prodrugs in PLGA-PEG micelles.

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates

Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

Evaluation of the Profile and Mechanism of Neurotoxicity of Water-Soluble [Cu(P)4]PF6 and [Au(P)4]PF6 (P = thp or PTA) Anticancer Complexes.

Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.

Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways

Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapour synthesis are electively internalized in a pancreatic adenocarcinoma cell line expressing GLUT1 transporter

Homoleptic phosphino copper(I) complexes with in vitro and in vivo dual cytotoxic and anti-angiogenic activity

Hydroxyapatite nanocrystals as a smart, pH sensitive, delivery system for kiteplatin.

In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxiliary monodentate phosphine ligands.

In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand.

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands.

Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.

Insights into the cytotoxic activity of the phosphane copper(I) complex [Cu(thp)4][PF6].

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications.

JNK inhibition arrests cotranslational degradation

Largen: a molecular regulator of mammalian cell size control

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems

Monofunctional platinum(II) complexes with potent tumor cell growth inhibitory activity: the effect of a hydrogen-bond donor/acceptor N-heterocyclic ligand.

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates

Neutral and charged phosphine/scorpionate copper(I) complexes: effects of ligand assembly on their antiproliferative activity.

Nitroimidazole and glucosamine conjugated heteroscorpionate ligands and related copper(II) complexes. Syntheses, biological activity and XAS studies

Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

Novel Kiteplatin Pyrophosphate Derivatives with Improved Efficacy

Novel imino thioether complexes of platinum(II): synthesis, structural investigation, and biological activity

Novel mixed-ligand copper(I) complexes: role of diimine ligands on cytotoxicity and genotoxicity

Novel triazolium based 11(th) group NHCs: synthesis, characterization and cellular response mechanisms.

Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

Photoreactivity of 5-fluorouracil under UVB light: photolysis and cytotoxicity studies.

Phthalates and heavy metals as endocrine disruptors in food: A study on pre-packed coffee products

Phytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.

Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance

Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale

Psoralenquinones as a novel class of proteasome inhibitors: design, synthesis and biological evaluation.

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

RACK1 Function in Cell Motility and Protein Synthesis.

Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.

Role of zinc trafficking in male fertility: from germ to sperm

S6K1 plays a critical role in early adipocyte differentiation

Selenium compounds as therapeutic agents in cancer.