Lista de obras - Simona Collina - Dominio Público Uruguay

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

artículo científico publicado en 2018

An eco-friendly enantioselective access to (R)-naringenin as inhibitor of proinflammatory cytokine release.

artículo científico publicado en 2013

An efficient procedure based on a MW-assisted Horner-Wadsworth-Emmons reaction for the synthesis of (Z)-3,3-trisubstituted-alpha,beta-unsaturated esters.

artículo científico publicado en 2010

Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa

scientific article published on 09 July 2019

Binding studies and quantitative structure-activity relationship of 3-amino-1H-indazoles as inhibitors of GSK3β

artículo científico publicado en 2011

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

artículo científico publicado en 2017

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

scientific article published on 30 June 2018

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes.

artículo científico publicado en 2017

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

Chiral arylpyrrolidinols: preparation and biological profile

artículo científico publicado en 2005

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

artículo científico publicado en 2012

Chiral resolution and absolute configuration of the enantiomers of 5-acetyl-2-methyl-4-methylsulfinyl-6-phenyl-3(2H)-pyridazinone and evaluation of their platelet aggregation inhibitory activity

scientific article published on 01 January 1997

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

artículo científico publicado en 2017

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

artículo científico publicado en 2019

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

scientific article published on 04 March 2019

Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).

artículo científico publicado en 2009

Design, synthesis, and SAR analysis of novel selective sigma1 ligands.

artículo científico publicado en 2006

Development of a Mucoadhesive and an in Situ Gelling Formulation Based on κ-Carrageenan for Application on Oral Mucosa and Esophagus Walls. II. Loading of a Bioactive Hydroalcoholic Extract

scientific article published on 05 March 2019

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

artículo científico publicado en 2023

Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents

scientific article published on 08 July 2019

Discovery of small peptides derived from embryonic lethal abnormal vision proteins structure showing RNA-stabilizing properties.

artículo científico publicado en 2009

Dual-Functioning Scaffolds for the Treatment of Spinal Cord Injury: Alginate Nanofibers Loaded with the Sigma 1 Receptor (S1R) Agonist RC-33 in Chitosan Films

scientific article published on 26 December 2019

Enantiomeric Resolution and Absolute Configuration of a Chiral δ-Lactam, Useful Intermediate for the Synthesis of Bioactive Compounds

scientific article published on 19 December 2020

Enantiomers of 2-[(Acylamino)ethyl]-1,4-benzodiazepines, potent ligands of kappa-opioid receptor: chiral chromatographic resolution, configurational assignment and biological activity.

artículo científico publicado en 2001

Enantioselective Modulatory Effects of Naringenin Enantiomers on the Expression Levels of miR-17-3p Involved in Endogenous Antioxidant Defenses

artículo científico publicado en 2017

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

artículo científico publicado en 2018

Formulation of microspheres containing Crataegus monogyna Jacq. extract with free radical scavenging activity

scientific article published on 10 January 2013

Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines.

artículo científico publicado en 2016

Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties

scientific article published on 01 November 2006

Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-Scale synthesis, physicochemical characterization and in vitro metabolic stability

artículo científico publicado en 2013

Identification of a potent and selective σ₁ receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells

scientific article published on 14 September 2011

Influence of the extraction mode on the yield of hyperoside, vitexin and vitexin-2''-O-rhamnoside from Crataegus monogyna Jacq. (hawthorn).

artículo científico publicado en 2008

Lipid metabolites with free-radical scavenging activity from Euphorbia helioscopia L

artículo científico publicado en 2014

Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties.

artículo científico publicado en 2017

Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction.

artículo científico publicado en 2006

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

artículo científico publicado en 2013

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

scientific article published on 20 December 2019

Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment

artículo científico publicado en 2016

Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities

artículo científico publicado en 2002

PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discovering New Hit Compounds.

artículo científico publicado en 2018

PKC in Regenerative Therapy: New Insights for Old Targets

artículo científico publicado en 2017

Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In <i>In Vitro</i> Pancreatic Cancer Model

artículo científico publicado en 2020

Pistagremic acid, a glucosidase inhibitor from Pistacia integerrima

artículo científico publicado en 2012

Preparation and configuration of racemic and optically active analgesic cycloaminoalkylnaphthalenes

artículo científico publicado en 1999

Proteometric study of ghrelin receptor function variations upon mutations using amino acid sequence autocorrelation vectors and genetic algorithm-based least square support vector machines.

artículo científico publicado en 2006

Quantitative structure-activity relationship modeling of growth hormone secretagogues agonist activity of some tetrahydroisoquinoline 1-carboxamides.

artículo científico publicado en 2007

Quick development of an analytical enantioselective high performance liquid chromatography separation and preparative scale-up for the flavonoid Naringenin ⬇️

artículo científico publicado el 22 de febrero de 2011

Regulation of Aquaporin Functional Properties Mediated by the Antioxidant Effects of Natural Compounds.

artículo científico publicado en 2017

Scope and Limitations of Boron Fluorescent Complexes from Stable Nitrile Oxides in ABPP Assays

scientific article published on 29 April 2019

Sigma receptor modulators: a patent review

artículo científico publicado en 2013

Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A adenosine receptor

scientific article published on 09 November 2017

Studies on the enantiomers of RC-33 as neuroprotective agents: isolation, configurational assignment, and preliminary biological profile.

artículo científico publicado en 2013

Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site

artículo científico publicado en 2009

Substituted benzylaminoalkylindoles with preference for the sigma2 binding site.

artículo científico publicado en 2007

Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes

artículo científico publicado en 2000

Synthesis and pharmacological evaluation of new N-methyl-arylpyrrolidinols with analgesic activity

artículo científico publicado en 2003

Synthesis of pyrrolinylnaphthalenes and evaluation of their antinociceptive activity

artículo científico publicado en 2000

Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity

artículo científico publicado en 2003

TNF-α blocker effect of naringenin-loaded sericin microparticles that are potentially useful in the treatment of psoriasis

artículo científico publicado en 2014

Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities

scientific article published on 05 November 2020

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands

artículo científico publicado en 2018

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

artículo científico publicado en 2013

The sigma-1 receptor antagonists, promising players in fighting neuropathic pain

artículo científico publicado en 2020

The use of a microwave-assisted solvent extraction coupled with HPLC-UV/PAD to assess the quality of Marrubium vulgare L. (white horehound) herbal raw material

scientific article published on 27 January 2019

Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

artículo científico publicado en 2018

Lista de obras de Simona Collina

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

An eco-friendly enantioselective access to (R)-naringenin as inhibitor of proinflammatory cytokine release.

An efficient procedure based on a MW-assisted Horner-Wadsworth-Emmons reaction for the synthesis of (Z)-3,3-trisubstituted-alpha,beta-unsaturated esters.

Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa

Binding studies and quantitative structure-activity relationship of 3-amino-1H-indazoles as inhibitors of GSK3β

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

Chiral arylpyrrolidinols: preparation and biological profile

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

Chiral resolution and absolute configuration of the enantiomers of 5-acetyl-2-methyl-4-methylsulfinyl-6-phenyl-3(2H)-pyridazinone and evaluation of their platelet aggregation inhibitory activity

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).

Design, synthesis, and SAR analysis of novel selective sigma1 ligands.

Development of a Mucoadhesive and an in Situ Gelling Formulation Based on κ-Carrageenan for Application on Oral Mucosa and Esophagus Walls. II. Loading of a Bioactive Hydroalcoholic Extract

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents

Discovery of small peptides derived from embryonic lethal abnormal vision proteins structure showing RNA-stabilizing properties.

Dual-Functioning Scaffolds for the Treatment of Spinal Cord Injury: Alginate Nanofibers Loaded with the Sigma 1 Receptor (S1R) Agonist RC-33 in Chitosan Films

Enantiomeric Resolution and Absolute Configuration of a Chiral δ-Lactam, Useful Intermediate for the Synthesis of Bioactive Compounds

Enantiomers of 2-[(Acylamino)ethyl]-1,4-benzodiazepines, potent ligands of kappa-opioid receptor: chiral chromatographic resolution, configurational assignment and biological activity.

Enantioselective Modulatory Effects of Naringenin Enantiomers on the Expression Levels of miR-17-3p Involved in Endogenous Antioxidant Defenses

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

Formulation of microspheres containing Crataegus monogyna Jacq. extract with free radical scavenging activity

Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines.

Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties

Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-Scale synthesis, physicochemical characterization and in vitro metabolic stability

Identification of a potent and selective σ₁ receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells

Influence of the extraction mode on the yield of hyperoside, vitexin and vitexin-2''-O-rhamnoside from Crataegus monogyna Jacq. (hawthorn).

Lipid metabolites with free-radical scavenging activity from Euphorbia helioscopia L

Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties.

Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction.

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment

Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities

PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discovering New Hit Compounds.

PKC in Regenerative Therapy: New Insights for Old Targets

Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In <i>In Vitro</i> Pancreatic Cancer Model

Pistagremic acid, a glucosidase inhibitor from Pistacia integerrima

Preparation and configuration of racemic and optically active analgesic cycloaminoalkylnaphthalenes

Proteometric study of ghrelin receptor function variations upon mutations using amino acid sequence autocorrelation vectors and genetic algorithm-based least square support vector machines.

Quantitative structure-activity relationship modeling of growth hormone secretagogues agonist activity of some tetrahydroisoquinoline 1-carboxamides.

Quick development of an analytical enantioselective high performance liquid chromatography separation and preparative scale-up for the flavonoid Naringenin ⬇️

Regulation of Aquaporin Functional Properties Mediated by the Antioxidant Effects of Natural Compounds.

Scope and Limitations of Boron Fluorescent Complexes from Stable Nitrile Oxides in ABPP Assays

Sigma receptor modulators: a patent review

Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A adenosine receptor

Studies on the enantiomers of RC-33 as neuroprotective agents: isolation, configurational assignment, and preliminary biological profile.

Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site

Substituted benzylaminoalkylindoles with preference for the sigma2 binding site.

Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes

Synthesis and pharmacological evaluation of new N-methyl-arylpyrrolidinols with analgesic activity

Synthesis of pyrrolinylnaphthalenes and evaluation of their antinociceptive activity

Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity

TNF-α blocker effect of naringenin-loaded sericin microparticles that are potentially useful in the treatment of psoriasis

Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

The sigma-1 receptor antagonists, promising players in fighting neuropathic pain

The use of a microwave-assisted solvent extraction coupled with HPLC-UV/PAD to assess the quality of Marrubium vulgare L. (white horehound) herbal raw material

Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead