Lista de obras - Antonio Di Stefano - Dominio Público Uruguay

(R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.

artículo científico publicado en 2017

(R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities

artículo científico publicado en 2012

A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation

artículo científico publicado en 2013

Advances in prodrug design for Parkinson's disease

artículo científico publicado en 2018

Antiparkinson prodrugs

artículo científico publicado en 2008

Biodegradable microspheres loaded with an anti-Parkinson prodrug: an in vivo pharmacokinetic study

artículo científico publicado el 5 de diciembre de 2011

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

scientific article published on 17 November 2010

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

artículo científico publicado en 2020

Carvacrol codrugs: a new approach in the antimicrobial plan

artículo científico publicado en 2015

Carvacrol prodrugs as novel antimicrobial agents

scientific article published on 10 June 2019

Characterization of alkanoyl-10-O-minocyclines in micellar dispersions as potential agents for treatment of human neurodegenerative disorders

artículo científico publicado en 2008

Chelating and antioxidant properties of l-Dopa containing tetrapeptide for the treatment of neurodegenerative diseases

artículo científico publicado en 2018

Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease.

artículo científico publicado en 2009

Design, synthesis, and preliminary pharmacological evaluation of new imidazolinones as L-DOPA prodrugs.

artículo científico publicado en 2010

Designing prodrugs for the treatment of Parkinson's disease.

artículo científico publicado en 2012

Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC.

artículo científico publicado en 2005

Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties

artículo científico publicado en 2015

Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids

artículo científico publicado en 2006

Drug delivery strategies for Alzheimer's disease treatment.

artículo científico publicado en 2011

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

scientific article published on 19 June 2019

Editorial: Neurodegenerative Disorders: Synthesis, Drug Delivery Strategies and Biological Evaluation of New Therapeutic Agents.

artículo científico publicado en 2017

Effect of 17β-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats

artículo científico publicado en 2014

Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration

artículo científico publicado en 2016

Effect of choline-containing phospholipids on brain cholinergic transporters in the rat

artículo científico publicado en 2010

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

artículo científico publicado en 2012

Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound

artículo científico publicado en 2016

Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring

scientific article published on 19 February 2019

Evaluation of rat striatal L-dopa and DA concentration after intraperitoneal administration of L-dopa prodrugs in liposomal formulations

artículo científico publicado en 2004

Evidence for a dopamine intrinsic direct role in the regulation of the ovary reproductive function: in vitro study on rabbit corpora lutea

artículo científico publicado en 2014

Glycosyl and polyalcoholic prodrugs of lonidamine.

artículo científico publicado en 2008

Graphene Oxide increases mammalian spermatozoa fertilizing ability by extracting cholesterol from their membranes and promoting capacitation.

artículo científico publicado en 2019

HPLC-FLD and spectrofluorometer apparatus: How to best detect fluorescent probe-loaded niosomes in biological samples

artículo científico publicado en 2015

Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.

artículo científico publicado en 2014

Health risk assessments of lithium titanate nanoparticles in rat liver cell model for its safe applications in nanopharmacology and nanomedicine

artículo científico publicado en 2016

Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates

scientific article published on 09 May 2020

Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease.

artículo científico publicado en 2010

Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.

artículo científico publicado en 2011

Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.

artículo científico publicado en 2013

Ibuprofen and lipoic acid diamide as co-drug with neuroprotective activity: pharmacological properties and effects in beta-amyloid (1-40) infused Alzheimer's disease rat model.

artículo científico publicado en 2010

Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.

artículo científico publicado en 2010

L-Dopa prodrugs: an overview of trends for improving Parkinson's disease treatment.

artículo científico

L-dopa co-drugs in nanostructured lipid carriers: A comparative study.

artículo científico publicado en 2016

L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

artículo científico publicado en 2006

Lipid nanocarriers containing a levodopa prodrug with potential antiparkinsonian activity.

artículo científico publicado en 2014

Maleic- and fumaric-diamides of (O,O-diacetyl)-L-Dopa-methylester as anti-Parkinson prodrugs in liposomal formulation.

artículo científico publicado en 2006

Memantine-derived drugs as potential antitumor agents for the treatment of glioblastoma

artículo científico publicado en 2017

Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease

artículo científico publicado en 2013

Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione-L-Dopa Codrug Against H2O2-Induced Cellular Toxicity

artículo científico publicado en 2019

Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain.

artículo científico publicado en 2013

NOS-mediated morphological and molecular modifications in rats infused with Aβ (1-40), as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1.

artículo científico publicado en 2010

Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.

artículo científico publicado en 2017

Natural oxyprenylated coumarins are modulators of melanogenesis

scientific article published on 27 April 2018

Neuroprotective effects of farnesene against hydrogen peroxide-induced neurotoxicity in vitro

artículo científico publicado en 2013

New L-dopa codrugs as potential antiparkinson agents

artículo científico publicado en 2008

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

artículo científico publicado en 2016

New drug delivery strategies for improved Parkinson's disease therapy

artículo científico publicado en 2009

New flurbiprofen derivatives: synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels

artículo científico publicado en 2013

Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease

artículo científico publicado en 2016

Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: Development, characterization and interaction with leuprolide

article

Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation

artículo científico publicado en 2019

Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI.

artículo científico publicado en 2010

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease

scientific article published on 10 October 2019

Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate.

artículo científico publicado en 2005

Potential antibacterial activity of carvacrol-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles against microbial biofilm

artículo científico

Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug.

artículo científico publicado en 2011

Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug

Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists

artículo científico publicado en 2005

Prodrug approach for increasing cellular glutathione levels

artículo científico publicado en 2010

Protective effects of cyclosativene on H2O 2-induced injury in cultured rat primary cerebral cortex cells.

artículo científico publicado en 2014

RNAIII Inhibiting Peptide (RIP) and Derivatives as Potential Tools for the Treatment of S. aureus Biofilm Infections

article

Role of Dietary Supplements in the Management of Parkinson's Disease

scientific article published on 10 July 2019

Single-Walled Carbon Nanotubes in Highly Viscous Media: A Comparison between the Dispersive Agents [BMIM][BF4 ], L121, and Triton X-100.

artículo científico publicado en 2015

Solid lipid nanoparticles as a drug delivery system for the treatment of neurodegenerative diseases.

artículo científico publicado en 2016

Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization.

artículo científico publicado en 2015

Surfactant hydrogels for the dispersion of carbon-nanotube-based catalysts

artículo científico publicado en 2013

Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson's Disease Agents

scientific article published on 18 June 2019

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage.

artículo científico publicado en 2003

Synthesis and biological evaluation of GABA derivatives able to cross the blood–Brain barrier in rats ⬇️

artículo científico publicado el 3 de noviembre de 2003

Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents

artículo científico publicado en 2018

Synthesis and preliminary pharmacological evaluation of 5-hydroxy- and 5,6-dihydroxy-1,2,3,7,12,12a-hexahydrobenzo[5,6]cyclohepta[1,2,3-ij]isoquinoline derivatives as dopamine receptor ligands.

artículo científico publicado en 2001

Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands

artículo científico publicado en 2002

Synthesis of L-(+)-3-(3-hydroxy-4-pivaloyloxybenzyl)-2,5-diketomorpholine as potential prodrug of L-dopa.

artículo científico publicado en 2000

Synthesis of a novel cyclic prodrug of S-allyl-glutathione able to attenuate LPS-induced ROS production through the inhibition of MAPK pathways in U937 cells

artículo científico publicado en 2014

Synthesis of novel 4-aryl-1,2,3,4-tetrahydroisoquinolines as probes for dopamine receptor ligands

artículo científico publicado en 2012

Synthesis, resolution, and preliminary evaluation of trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes and related derivatives as dopamine receptors ligands

artículo científico publicado en 1996

Temporal expression ofagrB,cidA, andalsSin the early development ofStaphylococcus aureusUAMS-1 biofilm formation and the structural role of extracellular DNA and carbohydrates

article

The effect of lauryl capping group on protein release and degradation of poly(d,l-lactic-co-glycolic acid) particles ⬇️

artículo científico publicado el 7 de junio de 2013

Toll-like receptor-2 agonist functionalized biopolymer for mucosal vaccination.

artículo científico publicado en 2009

Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione.

artículo científico publicado en 2004

psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine

artículo científico publicado en 1999

Lista de obras de Antonio Di Stefano

(R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.

(R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities

A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation

Advances in prodrug design for Parkinson's disease

Antiparkinson prodrugs

Biodegradable microspheres loaded with an anti-Parkinson prodrug: an in vivo pharmacokinetic study

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

Carvacrol codrugs: a new approach in the antimicrobial plan

Carvacrol prodrugs as novel antimicrobial agents

Characterization of alkanoyl-10-O-minocyclines in micellar dispersions as potential agents for treatment of human neurodegenerative disorders

Chelating and antioxidant properties of l-Dopa containing tetrapeptide for the treatment of neurodegenerative diseases

Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease.

Design, synthesis, and preliminary pharmacological evaluation of new imidazolinones as L-DOPA prodrugs.

Designing prodrugs for the treatment of Parkinson's disease.

Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC.

Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties

Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids

Drug delivery strategies for Alzheimer's disease treatment.

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

Editorial: Neurodegenerative Disorders: Synthesis, Drug Delivery Strategies and Biological Evaluation of New Therapeutic Agents.

Effect of 17β-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats

Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration

Effect of choline-containing phospholipids on brain cholinergic transporters in the rat

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound

Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring

Evaluation of rat striatal L-dopa and DA concentration after intraperitoneal administration of L-dopa prodrugs in liposomal formulations

Evidence for a dopamine intrinsic direct role in the regulation of the ovary reproductive function: in vitro study on rabbit corpora lutea

Glycosyl and polyalcoholic prodrugs of lonidamine.

Graphene Oxide increases mammalian spermatozoa fertilizing ability by extracting cholesterol from their membranes and promoting capacitation.

HPLC-FLD and spectrofluorometer apparatus: How to best detect fluorescent probe-loaded niosomes in biological samples

Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.

Health risk assessments of lithium titanate nanoparticles in rat liver cell model for its safe applications in nanopharmacology and nanomedicine

Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates

Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease.

Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.

Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.

Ibuprofen and lipoic acid diamide as co-drug with neuroprotective activity: pharmacological properties and effects in beta-amyloid (1-40) infused Alzheimer's disease rat model.

Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.

L-Dopa prodrugs: an overview of trends for improving Parkinson's disease treatment.

L-dopa co-drugs in nanostructured lipid carriers: A comparative study.

L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

Lipid nanocarriers containing a levodopa prodrug with potential antiparkinsonian activity.

Maleic- and fumaric-diamides of (O,O-diacetyl)-L-Dopa-methylester as anti-Parkinson prodrugs in liposomal formulation.

Memantine-derived drugs as potential antitumor agents for the treatment of glioblastoma

Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease

Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione-L-Dopa Codrug Against H2O2-Induced Cellular Toxicity

Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain.

NOS-mediated morphological and molecular modifications in rats infused with Aβ (1-40), as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1.

Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.

Natural oxyprenylated coumarins are modulators of melanogenesis

Neuroprotective effects of farnesene against hydrogen peroxide-induced neurotoxicity in vitro

New L-dopa codrugs as potential antiparkinson agents

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

New drug delivery strategies for improved Parkinson's disease therapy

New flurbiprofen derivatives: synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels

Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease

Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: Development, characterization and interaction with leuprolide

Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation

Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI.

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease

Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate.

Potential antibacterial activity of carvacrol-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles against microbial biofilm

Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug.

Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug

Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists

Prodrug approach for increasing cellular glutathione levels

Protective effects of cyclosativene on H2O 2-induced injury in cultured rat primary cerebral cortex cells.

RNAIII Inhibiting Peptide (RIP) and Derivatives as Potential Tools for the Treatment of S. aureus Biofilm Infections

Role of Dietary Supplements in the Management of Parkinson's Disease

Single-Walled Carbon Nanotubes in Highly Viscous Media: A Comparison between the Dispersive Agents [BMIM][BF4 ], L121, and Triton X-100.

Solid lipid nanoparticles as a drug delivery system for the treatment of neurodegenerative diseases.

Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization.

Surfactant hydrogels for the dispersion of carbon-nanotube-based catalysts

Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson's Disease Agents

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage.

Synthesis and biological evaluation of GABA derivatives able to cross the blood–Brain barrier in rats ⬇️

Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents