Lista de obras - Gary A Piazza - Dominio Público Uruguay

6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

artículo científico publicado en 2013

A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.

artículo científico publicado en 1997

A Novel Sulindac Derivative Inhibits Lung Adenocarcinoma Cell Growth through Suppression of Akt/mTOR Signaling and Induction of Autophagy ⬇️

artículo científico publicado el 26 de febrero de 2013

A high-throughput screen for chemical inhibitors of exocytic transport in yeast

artículo científico publicado en 2010

A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors.

artículo científico publicado en 2010

A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model.

artículo científico publicado en 2010

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

artículo científico publicado en 2009

A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity

artículo científico publicado en 2012

Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation.

artículo científico publicado en 2015

Aquaporins mediate the chemoresistance of human melanoma cells to arsenite.

artículo científico publicado en 2011

Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells.

artículo científico publicado en 2014

COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs ⬇️

artículo científico publicado el 11 de julio de 2013

Calmodulin and actin polymerization

scientific article published on 01 January 1987

Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention

artículo científico publicado en 2015

CoMFA and CoMSIA Studies of 1,2-dihydropyridine Derivatives as Anticancer Agents ⬇️

artículo científico publicado el 1 de mayo de 2012

Colon Tumor Cell Growth–Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition ⬇️

artículo científico publicado el 28 de septiembre de 2010

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors

artículo científico publicado en 2015

Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.

artículo científico publicado en 2013

Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

artículo científico publicado en 2010

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.

artículo científico publicado en 2009

Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.

artículo científico publicado en 2017

Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines ⬇️

artículo científico publicado el 1 de abril de 1998

Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix.

artículo científico publicado en 1989

Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis

artículo científico publicado en 1999

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

artículo científico publicado en 2012

Expression of enzymatically active rat dipeptidyl peptidase IV in Chinese hamster ovary cells after transfection

artículo científico publicado en 1989

First International Conference on Chemoprevention of Prostate Cancer. Overview consensus statement

artículo científico publicado en 2004

Honokiol: A Novel Natural Agent for Cancer Prevention and Therapy ⬇️

artículo científico publicado el 1 de diciembre de 2012

Hypoxia-regulated microRNAs in human cancer ⬇️

artículo científico publicado el 4 de febrero de 2013

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

artículo científico publicado en 2016

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

artículo científico publicado en 2016

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone)

artículo científico publicado en 1998

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/β-Catenin–Mediated Transcription in Human Breast Tumor Cells ⬇️

artículo científico publicado el 19 de abril de 2011

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

artículo científico publicado en 2017

Lysophosphatidic acid induction of transforming growth factors alpha and beta: modulation of proliferation and differentiation in cultured human keratinocytes and mouse skin

artículo científico publicado en 1995

Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs

artículo científico

Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells. ⬇️

artículo científico publicado en 2016

MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit.

artículo científico publicado en 2012

MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells

artículo científico publicado en 2013

Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.

artículo científico publicado en 2013

NSAIDs inhibit tumorigenesis, but how?

artículo científico

NSAIDs: Old Drugs Reveal New Anticancer Targets.

artículo científico publicado en 2010

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

artículo científico publicado en 2017

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway

artículo científico publicado en 2011

Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention.

artículo científico publicado en 2004

Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases ⬇️

artículo científico publicado el 1 de diciembre de 2012

Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention

artículo científico publicado en 2014

Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies

artículo científico publicado en 2014

Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer

artículo científico publicado en 2014

Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity

artículo científico publicado en 2020

Pharmacokinetics and pharmacodynamics of Phor21-betaCG(ala), a lytic peptide conjugate.

artículo científico publicado en 2008

Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer

artículo científico publicado en 2002

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors.

artículo científico publicado en 2015

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.

artículo científico publicado en 1999

Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs

artículo científico publicado en 2012

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion

artículo científico publicado en 2015

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

artículo científico publicado en 2009

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation

artículo científico publicado en 2008

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.

artículo científico publicado en 2015

Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex

artículo científico publicado en 2016

Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents ⬇️

artículo científico publicado el 16 de marzo de 2013

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

artículo científico publicado en 2010

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.

artículo científico publicado en 2013

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

artículo científico publicado en 2010

The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment

scientific article published on 26 February 2014

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

artículo científico publicado en 2013

Validation of PDE5 as a Chemoprevention Target

artículo científico publicado en 2017

Lista de obras de Gary A Piazza

6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.

A Novel Sulindac Derivative Inhibits Lung Adenocarcinoma Cell Growth through Suppression of Akt/mTOR Signaling and Induction of Autophagy ⬇️

A high-throughput screen for chemical inhibitors of exocytic transport in yeast

A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors.

A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model.

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity

Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation.

Aquaporins mediate the chemoresistance of human melanoma cells to arsenite.

Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells.

COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs ⬇️

Calmodulin and actin polymerization

Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention

CoMFA and CoMSIA Studies of 1,2-dihydropyridine Derivatives as Anticancer Agents ⬇️

Colon Tumor Cell Growth–Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition ⬇️

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors

Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.

Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.

Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.

Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines ⬇️

Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix.

Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

Expression of enzymatically active rat dipeptidyl peptidase IV in Chinese hamster ovary cells after transfection

First International Conference on Chemoprevention of Prostate Cancer. Overview consensus statement

Honokiol: A Novel Natural Agent for Cancer Prevention and Therapy ⬇️

Hypoxia-regulated microRNAs in human cancer ⬇️

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone)

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/β-Catenin–Mediated Transcription in Human Breast Tumor Cells ⬇️

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

Lysophosphatidic acid induction of transforming growth factors alpha and beta: modulation of proliferation and differentiation in cultured human keratinocytes and mouse skin

Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs

Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells. ⬇️

MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit.

MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells

Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.

NSAIDs inhibit tumorigenesis, but how?

NSAIDs: Old Drugs Reveal New Anticancer Targets.

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway

Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention.

Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases ⬇️

Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention

Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies

Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer

Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity

Pharmacokinetics and pharmacodynamics of Phor21-betaCG(ala), a lytic peptide conjugate.

Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors.

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.

Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.

Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex

Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents ⬇️

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Validation of PDE5 as a Chemoprevention Target