Lista de obras - Manfred Auer - Dominio Público Uruguay

A Wide-Field Fluorescence Microscope Extension for Ultrafast Screening of One-Bead One-Compound Libraries Using a Spectral Image Subtraction Approach

artículo científico publicado en 2016

A direct way of redox sensing ⬇️

artículo científico publicado el 1 de enero de 2011

A general synthetic route to isomerically pure functionalized rhodamine dyes.

artículo científico publicado en 2015

A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference

artículo científico publicado en 2014

A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery

artículo científico publicado en 2014

A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription.

artículo científico publicado en 1998

A two-channel detection method for autofluorescence correction and efficient on-bead screening of one-bead one-compound combinatorial libraries using the COPAS fluorescence activated bead sorting system.

artículo científico publicado en 2013

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection

artículo científico publicado en 2012

Analysis of Protein−Small Molecule Interactions by Microscale Equilibrium Dialysis and Its Application As a Secondary Confirmation Method for on-Bead Screening ⬇️

artículo científico publicado el 13 de septiembre de 2010

Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification

artículo científico

Beyond dimerization: a membrane-dependent activation model for interleukin-4 receptor-mediated signalling.

artículo científico publicado en 2006

Biochemical characterization of binding of multiple HIV-1 Rev monomeric proteins to the Rev responsive element.

artículo científico publicado en 1993

CSBB-ConeExclusion, adapting structure based solution virtual screening to libraries on solid support.

artículo científico publicado en 2013

Characterization of human immunodeficiency virus-1 (HIV-1) rev by (time-resolved) fluorescence spectroscopy

artículo científico publicado en 1994

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

artículo científico publicado en 2022

Complementary Benzophenone Cross-Linking/Mass Spectrometry Photochemistry.

artículo científico publicado en 2017

Confocal fluorescence detection expanded to UV excitation: the first continuous fluorimetric assay of human steroid sulfatase in nanoliter volume

artículo científico publicado en 2004

Confocal nanoscanning, bead picking (CONA): PickoScreen microscopes for automated and quantitative screening of one-bead one-compound libraries

artículo científico publicado en 2009

Crystallization and preliminary X-ray crystallographic study of interleukin-8.

artículo científico publicado en 1990

Detecting drug-target binding in cells using fluorescence-activated cell sorting coupled with mass spectrometry analysis

artículo científico publicado en 2017

Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques

artículo científico publicado en 2018

Diphenylhexatriene-phosphatidylcholine fluorescence in POPC vesicles: Comparison of the exponential-series and the maximum-entropy methods

artículo científico publicado en 1994

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin

artículo científico publicado en 2014

Effects of phosphatidylinositol-3-kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells.

artículo científico publicado en 1997

Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay

artículo científico publicado en 1996

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

scientific article published on 24 January 2020

Facile Synthesis of a Next Generation Safety-Catch Acid-Labile Linker, SCAL-2, Suitable for Solid-Phase Synthesis, On-Support Display and for Post-Synthesis Tagging.

artículo científico publicado en 2017

Fluorescent Fingerprinting of Molecular Recognition Landscapes J.J.L. thanks Wolfgang Rettig (Humboldt University) for his generosity during the preparation of this manuscript and the Uebbing Foundation for support. M.A. thanks Jan E. de Vries for c

artículo científico publicado en 2001

Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses

artículo científico publicado en 2017

HTS: understanding the physiology of life

scientific article published on 01 September 2001

Helix-loop-helix motif in HIV-1 Rev

artículo científico publicado en 1994

High Level Expression and Structural Characterisation of Herpes Simplex Virus Type I Transcriptional Activator VP16 (α-transInducing Factor) ⬇️

artículo científico publicado el 9 de octubre de 1998

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

artículo científico publicado en 2014

Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding

artículo científico publicado en 2014

Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.

artículo científico publicado en 2010

Intensity-independent fluorometric detection of cellular nitric oxide release

artículo científico publicado en 1997

Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.

artículo científico publicado en 1995

MRlogP: Transfer Learning Enables Accurate logP Prediction Using Small Experimental Training Datasets

artículo científico

Multi-photon excitation of intrinsic protein fluorescence and its application to pharmaceutical drug screening

scientific article published on 01 April 2005

New fluorogenic substrate for the first continuous steroid sulfatase assay

artículo científico publicado en 2000

Novel 1:1 labeling and purification process for C-terminal thioester and single cysteine recombinant proteins using generic peptidic toolbox reagents

artículo científico publicado en 2014

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

scientific article published on 29 November 2018

On-bead screens sample narrower affinity ranges of protein-ligand interactions compared to equivalent solution assays.

artículo científico publicado en 2012

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback

artículo científico publicado en 2016

Perturbation of the carboxy terminus of HIV-1 Rev affects multimerization on the Rev responsive element

artículo científico publicado en 1993

Proximity-dependent initiation of hybridization chain reaction

artículo científico publicado en 2015

PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries

artículo científico publicado en 2018

Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2).

artículo científico publicado en 1994

Quantitative Microdialysis: Experimental Protocol and Software for Small Molecule Protein Affinity Determination and for Exclusion of Compounds with Poor Physicochemical Properties

scientific article published on 30 July 2020

Rapid Synthesis of 2' and 3' Fluorinated Nucleotides and Their Use in 19F-NMR-Spectroscopy of Nucleotide-Binding Enzymes

Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods

artículo científico publicado en 2018

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

artículo científico publicado en 2018

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

Seamless Insert-Plasmid Assembly at High Efficiency and Low Cost.

artículo científico publicado en 2016

Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries

artículo científico publicado en 2009

Structural Dynamics of HIV-1 Rev and Its Complexes with RRE and 5S RNA ⬇️

artículo científico publicado el 17 de febrero de 1998

Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity

artículo científico publicado en 2006

Structure of the P-type ATPases

article

Synthesis and Biological Applications of 2',3'-Dideoxynucleoside-5'-O-(α-thio)Triphosphates

Temperature inducible beta-sheet structure in the transactivation domains of retroviral regulatory proteins of the Rev family

scientific article published on 01 November 1999

The amino terminal domain of HIV-1 Rev is required for discrimination of the RRE from nonspecific RNA.

artículo científico publicado en 1995

The polypeptide chain of eukaryotic initiation factor 5A occurs in two distinct conformations in the absence of the hypusine modification

artículo científico publicado en 1995

The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei

artículo científico publicado en 2017

Three-dimensional map of the plasma membrane H+-ATPase in the open conformation.

artículo científico publicado en 1998

Time-resolved fluorescence anisotropy of HIV-1 protease inhibitor complexes correlates with inhibitory activity

artículo científico publicado en 1998

Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening

artículo científico publicado en 2012

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

artículo científico publicado en 1997

UFSRAT: Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11βHSD1

artículo científico publicado en 2015

X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations

artículo científico publicado en 1999

mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure.

artículo científico publicado en 2004

α-Synuclein-Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation

artículo científico publicado en 2019

Lista de obras de Manfred Auer

A Wide-Field Fluorescence Microscope Extension for Ultrafast Screening of One-Bead One-Compound Libraries Using a Spectral Image Subtraction Approach

A direct way of redox sensing ⬇️

A general synthetic route to isomerically pure functionalized rhodamine dyes.

A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference

A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery

A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription.

A two-channel detection method for autofluorescence correction and efficient on-bead screening of one-bead one-compound combinatorial libraries using the COPAS fluorescence activated bead sorting system.

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection

Analysis of Protein−Small Molecule Interactions by Microscale Equilibrium Dialysis and Its Application As a Secondary Confirmation Method for on-Bead Screening ⬇️

Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification

Beyond dimerization: a membrane-dependent activation model for interleukin-4 receptor-mediated signalling.

Biochemical characterization of binding of multiple HIV-1 Rev monomeric proteins to the Rev responsive element.

CSBB-ConeExclusion, adapting structure based solution virtual screening to libraries on solid support.

Characterization of human immunodeficiency virus-1 (HIV-1) rev by (time-resolved) fluorescence spectroscopy

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

Complementary Benzophenone Cross-Linking/Mass Spectrometry Photochemistry.

Confocal fluorescence detection expanded to UV excitation: the first continuous fluorimetric assay of human steroid sulfatase in nanoliter volume

Confocal nanoscanning, bead picking (CONA): PickoScreen microscopes for automated and quantitative screening of one-bead one-compound libraries

Crystallization and preliminary X-ray crystallographic study of interleukin-8.

Detecting drug-target binding in cells using fluorescence-activated cell sorting coupled with mass spectrometry analysis

Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques

Diphenylhexatriene-phosphatidylcholine fluorescence in POPC vesicles: Comparison of the exponential-series and the maximum-entropy methods

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin

Effects of phosphatidylinositol-3-kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells.

Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Facile Synthesis of a Next Generation Safety-Catch Acid-Labile Linker, SCAL-2, Suitable for Solid-Phase Synthesis, On-Support Display and for Post-Synthesis Tagging.

Fluorescent Fingerprinting of Molecular Recognition Landscapes J.J.L. thanks Wolfgang Rettig (Humboldt University) for his generosity during the preparation of this manuscript and the Uebbing Foundation for support. M.A. thanks Jan E. de Vries for c

Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses

HTS: understanding the physiology of life

Helix-loop-helix motif in HIV-1 Rev

High Level Expression and Structural Characterisation of Herpes Simplex Virus Type I Transcriptional Activator VP16 (α-transInducing Factor) ⬇️

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding

Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.

Intensity-independent fluorometric detection of cellular nitric oxide release

Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.

MRlogP: Transfer Learning Enables Accurate logP Prediction Using Small Experimental Training Datasets

Multi-photon excitation of intrinsic protein fluorescence and its application to pharmaceutical drug screening

New fluorogenic substrate for the first continuous steroid sulfatase assay

Novel 1:1 labeling and purification process for C-terminal thioester and single cysteine recombinant proteins using generic peptidic toolbox reagents

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

On-bead screens sample narrower affinity ranges of protein-ligand interactions compared to equivalent solution assays.

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback

Perturbation of the carboxy terminus of HIV-1 Rev affects multimerization on the Rev responsive element

Proximity-dependent initiation of hybridization chain reaction

PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries

Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2).

Quantitative Microdialysis: Experimental Protocol and Software for Small Molecule Protein Affinity Determination and for Exclusion of Compounds with Poor Physicochemical Properties

Rapid Synthesis of 2' and 3' Fluorinated Nucleotides and Their Use in 19F-NMR-Spectroscopy of Nucleotide-Binding Enzymes

Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

Seamless Insert-Plasmid Assembly at High Efficiency and Low Cost.

Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries

Structural Dynamics of HIV-1 Rev and Its Complexes with RRE and 5S RNA ⬇️

Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity

Structure of the P-type ATPases

Synthesis and Biological Applications of 2',3'-Dideoxynucleoside-5'-O-(α-thio)Triphosphates

Temperature inducible beta-sheet structure in the transactivation domains of retroviral regulatory proteins of the Rev family

The amino terminal domain of HIV-1 Rev is required for discrimination of the RRE from nonspecific RNA.

The polypeptide chain of eukaryotic initiation factor 5A occurs in two distinct conformations in the absence of the hypusine modification

The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei

Three-dimensional map of the plasma membrane H+-ATPase in the open conformation.

Time-resolved fluorescence anisotropy of HIV-1 protease inhibitor complexes correlates with inhibitory activity

Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

UFSRAT: Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11βHSD1

X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations

mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure.

α-Synuclein-Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation