Lista de obras - Alexandre Wohlkonig - Dominio Público Uruguay

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2

scientific article published on 10 February 2019

A general protocol for the generation of Nanobodies for structural biology

artículo científico publicado en 2014

A novel expression system for production of soluble prion proteins in E. coli

artículo científico publicado en 2012

An improved yeast surface display platform for the screening of nanobody immune libraries

scientific article published in Scientific Reports

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes

artículo científico publicado en 2007

Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission

artículo científico publicado en 2013

Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes

artículo científico publicado en 2011

Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

artículo científico publicado en 2015

Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein

artículo científico publicado en 2010

Crystallization and preliminary X-ray diffraction analysis of kanamycin-binding β-lactamase in complex with its ligand

artículo científico publicado en 2011

Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis

artículo científico publicado en 2008

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

artículo científico publicado en 2012

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

artículo científico publicado en 2017

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors

artículo científico publicado en 2012

Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase

artículo científico publicado en 2007

Expression, purification, characterization, and solution nuclear magnetic resonance study of highly deuterated yeast cytochrome C peroxidase with enhanced solubility

artículo científico publicado en 2013

High-resolution structure of a papaya plant-defense barwin-like protein solved by in-house sulfur-SAD phasing

artículo científico publicado en 2013

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches

artículo científico publicado en 2014

Multiple post-translational modifications implied in the gene expression regulation: example of the sumoylation of Ets factors

artículo científico publicado en 2007

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody

artículo científico publicado en 2014

Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody

artículo científico publicado en 2014

Purification of ArcR, an oxidation-sensitive regulatory protein from Bacillus licheniformis.

artículo científico publicado en 2004

Quiescin-sulfhydryl oxidase inhibits prion formation in vitro

artículo científico publicado en 2016

Recombinant human prion protein inhibits prion propagation in vitro

artículo científico publicado en 2013

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

artículo científico publicado en 2017

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

artículo científico publicado en 2017

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

artículo científico publicado en 2012

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.

artículo científico publicado en 2017

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

artículo científico publicado en 2010

Structural relationships in the lysozyme superfamily: significant evidence for glycoside hydrolase signature motifs

artículo científico publicado en 2010

Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering.

artículo científico publicado en 2009

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation

artículo científico publicado en 2014

The Peptidyl–Prolyl Isomerase and Chaperone Par27 of Bordetella pertussis as the Prototype for a New Group of Parvulins

scientific article published on 09 November 2007

The mannose-specific lectin domains of Flo1p from Saccharomyces cerevisiae and Lg-Flo1p from S. pastorianus: crystallization and preliminary X-ray diffraction analysis of the adhesin-carbohydrate complexes.

artículo científico publicado en 2013

Type IIA topoisomerase inhibition by a new class of antibacterial agents

artículo científico publicado en 2010

Lista de obras de Alexandre Wohlkonig

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2

A general protocol for the generation of Nanobodies for structural biology

A novel expression system for production of soluble prion proteins in E. coli

An improved yeast surface display platform for the screening of nanobody immune libraries

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes

Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission

Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes

Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein

Crystallization and preliminary X-ray diffraction analysis of kanamycin-binding β-lactamase in complex with its ligand

Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors

Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase

Expression, purification, characterization, and solution nuclear magnetic resonance study of highly deuterated yeast cytochrome C peroxidase with enhanced solubility

High-resolution structure of a papaya plant-defense barwin-like protein solved by in-house sulfur-SAD phasing

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches

Multiple post-translational modifications implied in the gene expression regulation: example of the sumoylation of Ets factors

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody

Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody

Purification of ArcR, an oxidation-sensitive regulatory protein from Bacillus licheniformis.

Quiescin-sulfhydryl oxidase inhibits prion formation in vitro

Recombinant human prion protein inhibits prion propagation in vitro

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

Structural relationships in the lysozyme superfamily: significant evidence for glycoside hydrolase signature motifs

Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering.

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation

The Peptidyl–Prolyl Isomerase and Chaperone Par27 of Bordetella pertussis as the Prototype for a New Group of Parvulins

The mannose-specific lectin domains of Flo1p from Saccharomyces cerevisiae and Lg-Flo1p from S. pastorianus: crystallization and preliminary X-ray diffraction analysis of the adhesin-carbohydrate complexes.

Type IIA topoisomerase inhibition by a new class of antibacterial agents