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Lista de obras de Calixto JB

A Triterpene and Phenolic Compounds from Leaves and Stems of Phyllanthus sellowianus

artículo científico publicado en 1995

A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma

artículo científico publicado en 2019

A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.

artículo científico publicado en 2013

Action of Polygodial on Agonist-Induced Contractions of the Rat Portal Vein In Vitro

artículo científico publicado en 2000

Action of polygodial, a sesquiterpene isolated from Drymis winteri, in the guinea-pig ileum and trachea `in vitro' ⬇️

artículo científico publicado el 5 de marzo de 1998

Action of pregnane compounds from Mandevilla illustris against contractions induced by kinins and other oxytocics in the rat isolated uterus

scientific article published on 01 January 1991

Action of the extract of Drymis winteri on contraction induced by inflammatory mediators, compound 48/80 and ovalbumin of the guinea-pig trachea in vitro.

artículo científico publicado en 1997

Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice.

artículo científico publicado en 2011

Activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) reverses referred mechanical hyperalgesia induced by colonic inflammation in mice.

artículo científico publicado en 2012

Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection

artículo científico publicado en 2012

Additional evidence for the anti-inflammatory and anti-allergic properties of the sesquiterpene polygodial ⬇️

artículo científico publicado el 30 de noviembre de 2001

Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects.

artículo científico

Analgesic effects of callus culture extracts from selected species of Phyllanthus in mice

artículo científico publicado en 1994

Analysis of the inflammatory response induced by substance P in the mouse pleural cavity

artículo científico publicado en 1999

Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus.

artículo científico publicado en 1995

Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro

artículo científico publicado en 1995

Analysis of the vasorelaxant action of jatrophone in the isolated aorta of the rat: influence of potassium channel blockers

artículo científico publicado en 1992

Antagonism of kinin-induced contraction of isolated rat uterus by the crude hydroalcoholic extract from Mandevilla illustris

scientific article published on 01 January 1991

Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis ⬇️

artículo científico publicado el 21 de marzo de 2013

Antagonistic effect of Mandevilla velutina extract on kinin-induced contractions of guinea-pig and cat ileum longitudinal smooth muscle.

artículo científico publicado en 1988

Anti-allergic effects and oedema inhibition caused by the extract of Drymis winteri

artículo científico publicado en 1997

Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice.

artículo científico publicado en 2002

Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain ⬇️

artículo científico publicado el 8 de octubre de 2003

Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex

artículo científico publicado en 2007

Anti-edematogenic effects of velutinol A isolated from Mandevilla velutina: Evidence for a selective inhibition of kinin B1 receptor-mediated responses

article

Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae) ⬇️

artículo científico publicado el 1 de enero de 1998

Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice.

artículo científico publicado en 2007

Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB).

artículo científico publicado en 2003

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

artículo científico publicado en 2012

Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus.

artículo científico publicado en 2005

Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.

artículo científico publicado en 2017

Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms

artículo científico publicado en 2005

Antinociception caused by the extract of Hedyosmum brasiliense and its active principle, the sesquiterpene lactone 13-hydroxy-8,9-dehydroshizukanolide

artículo científico publicado en 1999

Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice

artículo científico publicado en 1999

Antinociceptive properties and nitric oxide synthase inhibitory action of new ruthenium complexes

scientific article published on 01 March 1999

Antinociceptive properties of steroids isolated from Phyllanthus corcovadensis in mice

scientific article published on 01 August 1995

Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias (Polygalaceae)

artículo científico publicado en 1997

Antinociceptive properties produced by the pregnane compound velutinol A isolated from Mandevilla velutina.

artículo científico publicado en 2006

Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist.

artículo científico publicado en 1996

Antispasmodic Activity of Xanthoxyline Derivatives: Structure–Activity Relationships ⬇️

artículo científico publicado el 1 de abril de 1995

Anti‐nociceptive effect of kinin B1 and B2 receptor antagonists on peripheral neuropathy induced by paclitaxel in mice ⬇️

artículo científico publicado el 1 de septiembre de 2011

Assessment of TNFalpha contribution to the functional up-regulation of kinin B(1) receptors in the mouse paw after treatment with LPS.

artículo científico publicado en 2005

Big-endothelin-1 contracts rat isolated uterus via a phosphoramidon-sensitive endothelin ETA receptor-mediated mechanism

scientific article published on 01 August 1993

Biological activity of plant extracts: novel analgesic drugs.

artículo científico publicado en 2001

Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats

artículo científico publicado en 2016

Blockade of kinin-induced responses of the guinea-pig isolated urinary bladder by the extract of Mandevilla velutina

artículo científico publicado en 1990

Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model

artículo científico publicado en 2020

Bradykinin induces a calcium-store- dependent calcium influx in mouse mesangial cells

artículo científico publicado en 2002

Bradykinin into amygdala induces thermal hyperalgesia in rats.

artículo científico publicado en 2007

Bradykinin-induced biphasic response in the rat isolated stomach fundus: functional evidence for a novel bradykinin receptor

scientific article published on 01 January 1992

B₂ receptor blockage prevents Aβ-induced cognitive impairment by neuroinflammation inhibition.

artículo científico publicado en 2014

C-fibers, but not the transient potential receptor vanilloid 1 (TRPV1), play a role in experimental allergic airway inflammation

artículo científico publicado en 2011

Changes in paw oedema triggered via bradykinin B(1) and B(2) receptors in streptozotocin-diabetic rats

artículo científico publicado en 2001

Characterization of des-Arg9-bradykinin-induced contraction in guinea-pig gallbladder in vitro ⬇️

artículo científico publicado el 16 de julio de 1997

Characterization of kinin receptors modulating neurogenic contractions of the mouse isolated vas deferens

artículo científico publicado en 1995

Characterization of the mechanism involved in the relaxant response of dopexamine in the guinea pig pulmonary artery in vitro.

artículo científico publicado en 1999

Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy.

artículo científico publicado en 1998

Chemical and preliminary analgesic evaluation of geraniin and furosin isolated from Phyllanthus sellowianus.

artículo científico publicado en 1996

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

artículo científico publicado en 2016

Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.

artículo científico publicado en 2003

Competitive and selective antagonistic action of NPC 17731 on bradykinin-induced relaxant and contractile responses of the guinea pig isolated ileum

scientific article published on 01 November 1995

Complexes trans-[RuCl(2)(nic)(4)] and trans-[RuCl(2)(i-nic)(4)] as free radical scavengers.

artículo científico publicado en 2001

Compounds extracted from Phyllantus and Jatropha elliptica inhibit the binding of [3H]glutamate and [3H]GMP-PNP in rat cerebral cortex membrane

scientific article published on 01 February 2000

Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein.

artículo científico publicado en 2007

Connective tissue reaction of rats to a new zinc-oxide-eugenol endodontic sealer

artículo científico publicado en 2013

Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder.

artículo científico publicado en 2006

Contribution and interaction of kinin receptors and dynorphin A in a model of trigeminal neuropathic pain in mice

artículo científico publicado en 2015

Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions.

artículo científico publicado en 2005

Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.

artículo científico publicado en 2006

Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice.

artículo científico publicado en 2004

Cytokines and neutrophils as important mediators of platelet-activating factor-induced kinin B1 receptor expression.

artículo científico publicado en 2005

Decreased gamma-aminobutyric acid (GABA) modulatory effect on rat vas deferens neurotransmission after chronic administration of imipramine

artículo científico publicado en 1989

Depressive-like behavior induced by tumor necrosis factor-α in mice.

artículo científico publicado en 2011

Diabetes-induced changes in responsiveness of rat bladder and vas deferens to peptides in vitro: susceptibility to reversal by insulin

artículo científico publicado en 2002

Diacerein reduces joint damage, pain behavior and inhibits transient receptor potential vanilloid 1, matrix metalloproteinase and glial cells in rat spinal cord

artículo científico publicado en 2015

Differential effects of Mandevilla velutina compounds on paw oedema induced by phospholipase A2 and phospholipase C

artículo científico publicado en 1993

Diphenyl diselenide decreases the prevalence of vacuous chewing movements induced by fluphenazine in rats

artículo científico publicado en 2007

EPA- and DHA-derived resolvins' actions in inflammatory bowel disease

artículo científico publicado en 2015

Effect of a kinin B2 receptor antagonist on LPS- and cytokine-induced neutrophil migration in rats.

artículo científico publicado en 2003

Effect of diphenylhydantoin on drug and calcium induced contractions of isolated rat uterus: a comparative study with nifedipine

artículo científico publicado en 1987

Effect of induced thyroid dysfunction upon uterine responsiveness in strips from pregnant and nonpregnant rats

artículo científico publicado en 1989

Effect of novel selective non-peptide kinin B1 receptor antagonists on mouse pleurisy induced by carrageenan

scientific article published on 17 August 2006

Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation.

artículo científico publicado en 2002

Effects and mechanisms of action of endothelins on non-vascular smooth muscle of the respiratory, gastrointestinal and urogenital tracts.

artículo científico publicado en 1995

Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan

scientific article published on 01 January 1999

Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice.

artículo científico publicado en 1996

Effects of compound D600 (methoxyverapamil) on drug-induced contractions of isolated dog uterine muscle

artículo científico publicado en 1986

Effects of endothelins on nerve-mediated contractions of the mouse vas deferens

artículo científico publicado en 1990

Effects of endothelins, Bay K 8644 and other oxytocics in non-pregnant and late pregnant rat isolated uterus ⬇️

artículo científico publicado el 3 de enero de 1991

Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats

scientific journal article

Effects of kinin B(1) and B(2) receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats

artículo científico publicado en 2012

Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse

artículo científico publicado en 2011

Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents).

artículo científico publicado en 2000

Endothelin-1 (ET)-induced mobilization of intracellular Ca2+ stores from the smooth muscle facilitates sympathetic cotransmission by potentiation of adenosine 5'-triphosphate (ATP) motor activity: studies in the rat vas deferens

artículo científico publicado en 1992

Endothelium dependent expression and underlying mechanisms of des-Arg⁹-bradykinin-induced B₁R-mediated vasoconstriction in rat portal vein.

artículo científico publicado en 2012

Essential oil from Pterodon emarginatus seeds ameliorates experimental autoimmune encephalomyelitis by modulating Th1/Treg cell balance.

artículo científico publicado en 2014

Euphol prevents experimental autoimmune encephalomyelitis in mice: evidence for the underlying mechanisms

artículo científico publicado en 2011

Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system

artículo científico publicado en 2012

Evaluation of chemical mediators and cellular response during acute and chronic gut inflammatory response induced by dextran sodium sulfate in mice ⬇️

artículo científico publicado el 19 de septiembre de 2012

Evaluation of the antinociceptive action caused by ether fraction and a triterpene isolated from resin of Protium kleinii.

artículo científico publicado en 2001

Evaluation of the effects of the herbal product Catuama® in inflammatory and neuropathic models of nociception in rats

Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse.

artículo científico publicado en 1993

Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.

artículo científico publicado en 2004

Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats.

artículo científico publicado en 2004

Evidence for the mechanism of the inhibitory action of jatrophone in the isolated rat uterine muscle

artículo científico publicado en 1990

Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice

artículo científico publicado en 2001

Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice.

artículo científico publicado en 2008

Extract and compounds obtained from Mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction

artículo científico publicado en 1991

Folic Acid Plus α-Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of Mitochondrial Complexes Activity

scientific article published on 01 January 2011

Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice.

artículo científico publicado en 1997

Further studies on analgesic activity of cyclic imides

scientific article published on 01 January 1998

Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease.

artículo científico publicado en 2007

Highlight: Kinin 2015 at São Paulo, Brazil

artículo científico publicado en 2016

Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors

artículo científico publicado en 2000

In vitro and in vivo anti-glioma activity of a chalcone-quinoxaline hybrid

artículo científico publicado en 2014

Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways

artículo científico publicado en 2012

Influence of calcium entry blockers and calmodulin inhibitors on 5-hydroxytryptamine-, potassium- and calcium-induced contractions in human umbilical artery in-vitro

artículo científico publicado en 1991

Inhibitor of PI3Kγ ameliorates TNBS‐induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells ⬇️

artículo científico publicado el 1 de mayo de 2011

Inhibitory effect of diphenylhydantoin on myometrium from pregnant women in vitro. A comparative study with nicardipine and trifluoperazine

artículo científico publicado en 1990

Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor.

artículo científico publicado en 2016

Interactions between forskolin, calcium and Bay K 8644 in K+-depolarized rat uterine muscle

artículo científico publicado en 1989

Interactions of calcium antagonists and the calcium channel agonist Bay K 8644 on neurotransmission of the mouse isolated vas deferens

artículo científico publicado en 1989

Involvement of NMDA receptors and L-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice.

artículo científico publicado en 2003

Isolation and identification of active compounds from Drimys winteri barks.

artículo científico publicado en 1998

Jatrophone and 12-O-tetradecanoyl phorbol-13-acetate antagonism of stimulation of natural killer activity and lymphocyte proliferation

scientific article published on 01 October 1996

Kinin B(1) and B(2) receptors contribute to orofacial heat hyperalgesia induced by infraorbital nerve constriction injury in mice and rats.

artículo científico publicado en 2009

Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide.

artículo científico publicado en 2010

Kinin Receptors Sensitize TRPV4 Channel and Induce Mechanical Hyperalgesia: Relevance to Paclitaxel-Induced Peripheral Neuropathy in Mice.

artículo científico publicado en 2017

Kinins in pain and inflammation.

artículo científico publicado en 2000

Long interpositional nerve graft consistently induces incomplete motor and sensory recovery in the rat. An experimental model to test nerve repair

scientific article published on 01 March 2004

Long-lasting neuropathic pain induced by brachial plexus injury in mice: Role triggered by the pro-inflammatory cytokine, tumour necrosis factor alpha.

artículo científico publicado en 2005

Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis.

artículo científico publicado en 2013

Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice.

artículo científico publicado en 2015

Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice.

artículo científico publicado en 2010

Mechanisms involved in the antinociception caused by agmatine in mice.

artículo científico publicado en 2005

Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.

artículo científico publicado en 2009

Mechanisms involved in the antinociception caused by melatonin in mice

artículo científico publicado en 2006

Mechanisms involved in the contractile responses induced by the hydroalcoholic extract of Phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of tachykinins and influx of extracellular Ca2+ sensitive to ruthenium red

scientific article published on 01 July 1996

Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.

artículo científico publicado en 2005

Mechanisms involved in the relaxant response of bradykinin in epithelium intact strips of the guinea-pig trachea

artículo científico publicado en 1995

Mechanisms of bradykinin-induced contraction of the guinea-pig gallbladder in vitro.

artículo científico publicado en 1995

Mechanisms underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in vitro.

artículo científico publicado en 2006

Mechanisms underlying the contraction induced by bradykinin in the guinea pig epithelium-denuded trachea.

artículo científico publicado en 2002

Mechanisms underlying the inhibitory actions of the pentacyclic triterpene α-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate

artículo científico publicado en 2006

Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw.

artículo científico publicado en 2003

Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw ⬇️

artículo científico publicado el 11 de enero de 2002

Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw

article

Mechanisms underlying the relaxation caused by the sesquiterpene polygodial in vessels from rabbit and guinea-pig.

artículo científico publicado en 1999

Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro.

artículo científico publicado en 2005

Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.

artículo científico publicado en 2016

Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-D-aspartate receptors and the L-arginine-nitric oxide pathway.

artículo científico publicado en 2003

Modulation of kinin B1 but not B2 receptors-mediated rat paw edema by IL-1β and TNFα

artículo científico publicado en 1998

Molecular mechanisms of topical anti-inflammatory effects of lipoxin A(4) in endotoxin-induced uveitis.

artículo científico publicado en 2008

Multidrug resistance related protein (ABCC1) and its role on nitrite production by the murine macrophage cell line RAW 264.7.

artículo científico publicado en 2006

Multiple mechanisms of bradykinin-induced contraction in rat and guinea pig smooth muscles in vitro

scientific article published on 01 August 1995

Naturally occurring compounds affect glutamatergic neurotransmission in rat brain.

artículo científico publicado en 2007

Neurokinin mediation of edema and inflammation.

artículo científico publicado en 2000

Neuromodulatory effect of creatine on extracellular action potentials in rat hippocampus: role of NMDA receptors.

artículo científico publicado en 2008

Neuropathic Pain-Like Behavior after Brachial Plexus Avulsion in Mice: The Relevance of Kinin B1 and B2 Receptors

artículo científico publicado en 2008

New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.

artículo científico publicado en 2003

Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies

scientific article published on 24 October 2016

Non-peptide antagonists for kinin B1 receptors: new insights into their therapeutic potential for the management of inflammation and pain.

artículo científico publicado en 2006

Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice.

artículo científico publicado en 2011

Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway.

artículo científico publicado en 2013

Oral anti-inflammatory action of NPC 18884, a novel bradykinin B2 receptor antagonist

artículo científico publicado en 1998

PAF-induced kinin B1 receptor in vivo up-regulation: involvement of distinct kinase pathways

Peripheral kinin B(1) and B(2) receptor-operated mechanisms are implicated in neuropathic nociception induced by spinal nerve ligation in rats

scientific article published on 03 May 2007

Pharmacokinetics and tissue distribution of the sesquiterpene alpha-humulene in mice.

artículo científico publicado en 2008

Pharmacological Activities and Hydrolysis by Peptidases of [Phospho-Ser(6)]-Bradykinin (pS(6)-BK).

artículo científico publicado en 2015

Pharmacological analysis of paregoric elixir and its constituents: in vitro and in vivo studies

artículo científico publicado en 2007

Pharmacological analysis of the methanolic extract and sorocein A, a new Diels-Alder compound isolated from the roots of Sorocea bonplandii Bailon in the isolated rat uterus and guinea pig ileum

artículo científico publicado en 1993

Pharmacological and biochemical characterization of bradykinin B2 receptors in the mouse colon: Influence of the TNBS-induced colitis

artículo científico publicado en 2007

Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema

scientific article published on 27 April 2006

Pharmacological and neurochemical evidence for antidepressant-like effects of the herbal product Catuama.

artículo científico publicado en 2004

Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain.

artículo científico publicado en 2004

Pharmacological evaluation of rat paw oedema induced by Bothrops jararaca venom

scientific article published on 01 March 1989

Phyllanthimide, a new alkaloid from Phyllanthus sellowianus

scientific article published on 01 May 1988

Physical Exercise Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Peripheral Immune Response and Blood-Brain Barrier Disruption

artículo científico publicado en 2016

Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil

artículo científico publicado en 2001

Phα1β, a peptide from the venom of the spider Phoneutria nigriventer shows antinociceptive effects after continuous infusion in a neuropathic pain model in rats

scientific article published on 01 July 2014

Plant derived alkaloid (−)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models

article

Potent antinociceptive activity of a hydroalcoholic extract of Phyllanthus corcovadensis

scientific article published on 01 December 1993

Potential role for ET-2 acting through ETA receptors in experimental colitis in mice.

artículo científico publicado en 2016

Preclinical safety evaluation of IQG-607 in rats: Acute and repeated dose toxicity studies.

artículo científico publicado en 2017

Preventive and therapeutic anti-inflammatory effects of systemic and topical thalidomide on endotoxin-induced uveitis in rats

scientific article published on 12 January 2007

Preventive and therapeutic euphol treatment attenuates experimental colitis in mice

artículo científico publicado en 2011

Preventive and therapeutic oral administration of the pentacyclic triterpene α,β-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: the relevance of cannabinoid system.

artículo científico publicado en 2013

Pro-inflammatory effects induced by bradykinin in a murine model of pleurisy

scientific article published on 01 July 1997

Pronociceptive response elicited by TRPA1 receptor activation in mice

scientific journal article

Prostaglandin E2 modulates Na+,K+-ATPase activity in rat hippocampus: implications for neurological diseases.

artículo científico publicado en 2009

Protective effects of indomethacin-loaded nanocapsules against oxygen-glucose deprivation in organotypic hippocampal slice cultures: involvement of neuroinflammation.

artículo científico publicado en 2010

Receptor subtypes involved in tachykinin-mediated edema formation☆

artículo científico publicado en 1999

Reduced Nerve Injury-Induced Neuropathic Pain in Kinin B1 Receptor Knock-Out Mice

scientific article published on 01 March 2005

Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw

artículo científico publicado en 2006

Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis.

artículo científico publicado en 2014

Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide

artículo científico publicado en 2009

Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice ⬇️

artículo científico publicado el 10 de octubre de 1997

Selective restoration of sensation by peripheral nerve grafts directly implanted into the contralateral C7 dorsal root ganglion: an experimental study in rat brachial plexus

artículo científico publicado en 1998

Spatial reference memory deficits precede motor dysfunction in an experimental autoimmune encephalomyelitis model: the role of kallikrein-kinin system.

artículo científico publicado en 2013

Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action

artículo científico publicado en 1998

Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro.

artículo científico publicado en 2003

Synergistic effects of celecoxib and bupropion in a model of chronic inflammation-related depression in mice.

artículo científico publicado en 2013

Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: quantitative structure-activity relationships.

artículo científico publicado en 2007

Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors.

artículo científico publicado en 2007

Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells

artículo científico publicado en 2015

Systemic IL-12 burst expands intestinal T-lymphocyte subsets bearing the α₄ β₇ integrin in mice

artículo científico publicado en 2015

Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice

artículo científico publicado en 1998

TRP modulation by natural compounds.

artículo científico publicado en 2014

TRPA1 antagonists as potential analgesic drugs.

artículo científico publicado en 2011

TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury

scientific journal article

TRPV1 channel inhibition contributes to the antinociceptive effects of Croton macrostachyus extract in mice

artículo científico publicado en 2015

Tachykinin NK(3)receptor involvement in anxiety.

artículo científico publicado en 1999

Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats

artículo científico publicado en 2015

The "in vivo" and "ex vivo" roles of cylcooxygenase-2, nuclear factor-kappaB and protein kinases pathways in the up-regulation of B1 receptor-mediated contraction of the rabbit aorta

artículo científico publicado en 2001

The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε.

artículo científico publicado en 2015

The effects of IL-6 and IL-10 and their specific antibodies in the acute inflammatory responses induced by carrageenan in the mouse model of pleurisy

artículo científico publicado en 2002

The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.

artículo científico publicado en 2005

The effects of the selective and non-peptide CXCR2 receptor antagonist SB225002 on acute and long-lasting models of nociception in mice.

artículo científico publicado en 2009

The inhibition of paw oedema formation caused by the oil of Copaifera multijuga Hayne and its fractions

scientific article published on 01 October 2006

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation.

artículo científico publicado en 2009

The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy

scientific article published on 01 February 2001

The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats ⬇️

artículo científico publicado el 1 de septiembre de 2011

The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors

scientific article published on 01 January 1995

The role of B1 and B2 kinin receptors in oedema formation after long-term treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG).

artículo científico publicado en 1997

The role of CXCR2 chemokine receptors in the oral squamous cell carcinoma.

artículo científico publicado en 2011

The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice

scientific article published on 16 March 2008

The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice

scientific article published on 01 November 2013

The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: evidence for the involvement of astrocytes.

artículo científico publicado en 2013

The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice

artículo científico publicado en 2010

The role of kinin receptors in preventing neuroinflammation and its clinical severity during experimental autoimmune encephalomyelitis in mice

artículo científico publicado en 2011

The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.

artículo científico publicado en 2003

The role of neurotrophic factors in genesis and maintenance of mechanical hypernociception after brachial plexus avulsion in mice.

artículo científico publicado en 2007

The role of sensorial neuropeptides in the edematogenic responses mediated by B1 agonist des-Arg9-BK in rats pre-treated with LPS

article

The role of systemic, spinal and supraspinal L-arginine-nitric oxide-cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice

artículo científico publicado en 1999

The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice.

artículo científico publicado en 2008

The sesquiterpenes polygodial and drimanial in vitro affect glutamatergic transport in rat brain.

artículo científico publicado en 2006

The structure of velutinol A, an anti-inflammatory compound with a novel pregnane skeleton

The transient receptor potential ankyrin-1 mediates mechanical hyperalgesia induced by the activation of B1 receptor in mice

artículo científico publicado en 2016

The use of kinin B1 and B2 receptor knockout mice and selective antagonists to characterize the nociceptive responses caused by kinins at the spinal level

article

Tormentic acid reduces vascular smooth muscle cell proliferation and survival

scientific article published on 20 May 2009

Transient Receptor Potential Ankyrin 1 Channel Expression on Peripheral Blood Leukocytes from Rheumatoid Arthritic Patients and Correlation with Pain and Disability.

scientific article published on 10 February 2017

Triterpenes from Sebastiania schottiana

artículo científico publicado en 1990

Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines

artículo científico publicado en 2015

β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway ⬇️

artículo científico publicado el 1 de marzo de 2011

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