Lista de obras - Thierry Besson - Dominio Público Uruguay

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

scientific article published on 16 May 2019

A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.

artículo científico publicado en 2015

An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases

artículo científico publicado en 2016

Binaphthyl platform as starting materials for the preparation of electron rich benzo[g,h,i]perylenes. Application to molecular architectures based on amino benzo[g,h,i]perylenes and carborane combinations

artículo científico publicado en 2011

Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A

artículo científico publicado en 2019

Biophysical and biological properties of newly synthesized dioxinocoumarin derivatives. II. Dark and photoinduced effects on T7 phage, yeast and HeLa cells.

artículo científico publicado en 1994

Cytotoxic evaluation of sarcodifurines A and B, two novel dihydrofuroquinolines from Sarcomelicope follicularis (Rutaceae)

artículo científico publicado en 2008

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

artículo científico publicado en 2015

Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling

scientific article published in 2021

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I.

artículo científico publicado en 2014

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.

artículo científico publicado en 2014

Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-]-quinazolin-9-ones Designed by Fragment-Growing Studies

article

Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality

artículo científico publicado en 2013

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole.

artículo científico publicado en 2013

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

artículo científico publicado en 2017

Gas-phase structure of a pi-allyl-palladium complex: efficient infrared spectroscopy in a 7 T Fourier transform mass spectrometer.

artículo científico publicado en 2007

Influence of microwave irradiation on enzymatic properties: applications in enzyme chemistry.

artículo científico publicado en 2007

Influence of microwave radiation on free Candida antarctica lipase B activity and stability

article

Ligand-free Pd-catalyzed and copper-assisted C-H arylation of quinazolin-4-ones with aryl iodides under microwave heating

artículo científico publicado en 2015

Microwave-Assisted Synthesis of Potential Bioactive Benzo-, Pyrido- or Pyrazino-thieno[3,2-d]pyrimidin-4-amine Analogs of MPC-6827

artículo científico publicado en 2020

Microwave-assisted solid-phase synthesis of 5-carboxamido-N-acetyltryptamine derivatives

scientific article published on 01 August 2002

Microwave-assisted synthesis of bioactive quinazolines and quinazolinones.

artículo científico publicado en 2007

Microwave-assisted synthesis of galacto-oligosaccharides from lactose with immobilized beta-galactosidase from Kluyveromyces lactis.

artículo científico publicado en 2003

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.

artículo científico publicado en 2007

Pd-Catalyzed and Copper Assisted Regioselective Sequential C2 and C7 Arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one with Aryl Halides.

artículo científico publicado en 2016

Relieving Dyrk1a repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

artículo científico publicado en 2022

Room-Temperature Infrared Spectroscopy Combined with Mass Spectrometry Distinguishes Gas-Phase Protein Isomers

artículo científico publicado en 2009

Stability improvement of immobilized Candida antarctica lipase B in an organic medium under microwave radiation

artículo científico publicado en 2004

Study of N1-alkylation of indoles from the reaction of 2(or 3)-aminoindole-3-(or 2)carbonitriles with DMF-dialkylacetals

artículo científico publicado en 2012

Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives.

artículo científico publicado en 2000

Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.

artículo científico publicado en 2009

Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.

artículo científico publicado en 2012

Synthesis and cytotoxic evaluation of novel thiazolocarbazoles

Synthesis and cytotoxic evaluation of novel thiazolocarbazoles. Part III

Synthesis and kinase inhibitory activity of novel substituted indigoids.

artículo científico publicado en 2009

Synthesis of 2-Mercapto-(2-Oxoindolin-3-Ylidene)Acetonitriles from 3-(4-Chloro-5H-1,2,3-Dithiazol-5-Ylidene)Indolin-2-ones

artículo científico publicado en 2018

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

artículo científico publicado en 2016

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.

artículo científico publicado en 2016

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.

artículo científico publicado en 2006

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

artículo científico publicado en 2012

Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.

artículo científico publicado en 2013

Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3

scientific article published on 27 April 2006

Lista de obras de Thierry Besson

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.

An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases

Binaphthyl platform as starting materials for the preparation of electron rich benzo[g,h,i]perylenes. Application to molecular architectures based on amino benzo[g,h,i]perylenes and carborane combinations

Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A

Biophysical and biological properties of newly synthesized dioxinocoumarin derivatives. II. Dark and photoinduced effects on T7 phage, yeast and HeLa cells.

Cytotoxic evaluation of sarcodifurines A and B, two novel dihydrofuroquinolines from Sarcomelicope follicularis (Rutaceae)

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I.

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.

Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-]-quinazolin-9-ones Designed by Fragment-Growing Studies

Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole.

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

Gas-phase structure of a pi-allyl-palladium complex: efficient infrared spectroscopy in a 7 T Fourier transform mass spectrometer.

Influence of microwave irradiation on enzymatic properties: applications in enzyme chemistry.

Influence of microwave radiation on free Candida antarctica lipase B activity and stability

Ligand-free Pd-catalyzed and copper-assisted C-H arylation of quinazolin-4-ones with aryl iodides under microwave heating

Microwave-Assisted Synthesis of Potential Bioactive Benzo-, Pyrido- or Pyrazino-thieno[3,2-d]pyrimidin-4-amine Analogs of MPC-6827

Microwave-assisted solid-phase synthesis of 5-carboxamido-N-acetyltryptamine derivatives

Microwave-assisted synthesis of bioactive quinazolines and quinazolinones.

Microwave-assisted synthesis of galacto-oligosaccharides from lactose with immobilized beta-galactosidase from Kluyveromyces lactis.

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.

Pd-Catalyzed and Copper Assisted Regioselective Sequential C2 and C7 Arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one with Aryl Halides.

Relieving Dyrk1a repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

Room-Temperature Infrared Spectroscopy Combined with Mass Spectrometry Distinguishes Gas-Phase Protein Isomers

Stability improvement of immobilized Candida antarctica lipase B in an organic medium under microwave radiation

Study of N1-alkylation of indoles from the reaction of 2(or 3)-aminoindole-3-(or 2)carbonitriles with DMF-dialkylacetals

Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives.

Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.

Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.

Synthesis and cytotoxic evaluation of novel thiazolocarbazoles

Synthesis and cytotoxic evaluation of novel thiazolocarbazoles. Part III

Synthesis and kinase inhibitory activity of novel substituted indigoids.

Synthesis of 2-Mercapto-(2-Oxoindolin-3-Ylidene)Acetonitriles from 3-(4-Chloro-5H-1,2,3-Dithiazol-5-Ylidene)Indolin-2-ones

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.

Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3