Lista de obras - Philippe Clézardin - Dominio Público Uruguay

A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden.

artículo científico publicado en 2007

A convenient clinically relevant model of human breast cancer bone metastasis.

artículo científico publicado en 2007

A new murine model of osteoblastic/osteolytic lesions from human androgen-resistant prostate cancer

artículo científico publicado en 2013

A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, beta-thromboglobulin and platelet factor 4 in healthy volunteers.

artículo científico publicado en 1983

A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis

artículo científico publicado en 2013

Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone

scientific article published on 01 October 1999

Adjuvant bisphosphonates in early breast cancer: consensus guidance for clinical practice from a European Panel

artículo científico

Adjuvant bisphosphonates in patients with breast cancer: does the potency matter?

artículo científico publicado en 2015

Advances in optical imaging and novel model systems for cancer metastasis research.

artículo científico publicado en 2007

Anti-tumour activity of zoledronic acid.

artículo científico publicado en 2005

Bioluminescence imaging of prenylation inhibition--letter

artículo científico publicado en 2012

Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity

artículo científico publicado en 2005

Bisphosphonates in cancer therapy

artículo científico publicado en 2007

Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class.

artículo científico publicado en 2010

Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma

artículo científico publicado en 2015

Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers

artículo científico publicado en 2018

Bone-Targeted Therapies in Cancer-Induced Bone Disease

artículo científico publicado en 2017

Cancer Cell Colonisation in the Bone Microenvironment

artículo científico publicado en 2016

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

artículo científico publicado en 2010

Cathepsin K inhibitors as treatment of bone metastasis.

artículo científico publicado en 2008

Cell attachment and fibrinogen binding properties of platelet and endothelial cell thrombospondin are not affected by structural differences in the 70 and 18 kDa protease-resistant domains

artículo científico publicado en 1988

Characterization of two murine monoclonal antibodies (P10, P12) directed against different determinants on human blood platelet thrombospondin

artículo científico publicado en 1986

Combination of anti-angiogenic therapies reduces osteolysis and tumor burden in experimental breast cancer bone metastasis

artículo científico publicado en 2014

Complex formation of human thrombospondin with osteonectin ⬇️

artículo científico publicado el 1 de agosto de 1988

Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.

artículo científico publicado en 2010

Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo.

artículo científico publicado en 2008

Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis.

artículo científico publicado en 2012

Direct and indirect anticancer activity of bisphosphonates: a brief review of published literature

artículo científico

Dual Function of ERRα in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin ⬇️

artículo científico publicado el 6 de julio de 2011

ERRα expression in bone metastases leads to an exacerbated anti-tumor immune response

scientific article published on 04 May 2020

Effect of intra-tibial injection on mechanical properties of mouse bone

artículo científico publicado en 2017

Effects of bone-targeted agents on cancer progression and mortality.

artículo científico publicado en 2012

Emerging therapies in bone metastasis

artículo científico

Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone

artículo científico publicado en 2016

Expression and localisation of alphav integrins in human odontoblasts.

artículo científico publicado en 2005

Frequent low-dose bisphosphonate therapy

scientific article published on 15 August 2007

High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo.

artículo científico publicado en 2011

How do bisphosphonates inhibit bone metastasis in vivo?

artículo científico publicado en 2010

Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo

scientific article published on 01 September 2005

Identification and characterization of fragments of major glycoproteins from platelet membrane after chymotrypsin treatment

artículo científico publicado en 1985

Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers

artículo científico publicado en 2014

In vivo phosphoantigen levels in bisphosphonate-treated human breast tumors trigger Vγ9Vδ2 T-cell antitumor cytotoxicity through ICAM-1 engagement.

artículo científico publicado en 2012

Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.

artículo científico publicado en 2010

Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression

artículo científico publicado en 2013

Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone

artículo científico publicado en 2002

Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone

artículo científico publicado en 2014

International Society of Geriatric Oncology (SIOG) clinical practice recommendations for the use of bisphosphonates in elderly patients.

artículo científico publicado en 2007

Isolation of thrombospondin released from thrombin-stimulated human platelets by fast protein liquid chromatography on an anion-exchange Mono-Q column

scientific article published on 01 July 1984

Localization of thrombospondin, CD36 and CD51 during prenatal development of the human mammary gland

scientific article published on 01 August 1994

Low-Intensity Ultrasound Promotes Clathrin-Dependent Endocytosis for Drug Penetration into Tumor Cells

artículo científico publicado en 2015

Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer

artículo científico publicado en 2015

Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

artículo científico publicado en 2008

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.

artículo científico publicado en 2014

Lysophosphatidic acid: a new link between blood platelets and bone metastasis

artículo científico publicado en 2005

Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone

artículo científico publicado en 2016

Mechanisms of action of bisphosphonates in oncology: a scientific concept evolving from antiresorptive to anticancer activities

artículo científico publicado en 2013

Metastasis and bone loss: advancing treatment and prevention.

artículo científico publicado en 2010

MiRNAs and snoRNAs in Bone Metastasis: Functional Roles and Clinical Potential

artículo científico publicado en 2022

Molecularly targeted therapies in breast cancer bone metastases

artículo científico publicado en 2010

Mutational profiling of bone metastases from lung adenocarcinoma: results of a prospective study (POUMOS-TEC)

artículo científico publicado en 2014

Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention.

artículo científico publicado en 2009

Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase

artículo científico publicado en 2010

Non-coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance

scientific article published on 18 August 2019

Oligometastatic bone disease. Can limited metastatic bone disease be cured? Is there room for local ablative treatments?

artículo científico publicado en 2012

One-step procedure for the rapid isolation of mouse monoclonal antibodies and their antigen binding fragments by fast protein liquid chromatography on a mono Q anion-exchange column

artículo científico publicado en 1985

Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation

artículo científico publicado en 2017

Pathophysiology of bone metastases from solid malignancies

artículo científico publicado en 2017

Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs

artículo científico publicado en 2012

Platelet membrane glycoprotein abnormalities in patients with myeloproliferative disorders and secondary thrombocytosis

Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.

artículo científico publicado en 2004

Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1

scientific article published on 01 February 2000

Production, characterization, and use of monoclonal antibodies directed against human blood platelet thrombospondin: immunologic comparison with human endothelial and fibroblast thrombospondins

scientific article published on 01 July 1987

RANK/RANKL pathway in cancer: Biological activity beyond bone?

artículo científico publicado en 2012

Recent insights into the role of integrins in cancer metastasis.

artículo científico publicado en 1998

Structural and immunological comparison of human thrombospondins isolated from platelets and from culture supernatants of endothelial cells and fibroblasts. Evidence for a thrombospondin polymorphism

scientific article published on 01 September 1986

Structural and immunological differences between human platelet and endothelial thrombospondins

scientific article published on 01 February 1986

TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival

artículo científico publicado en 2014

TWIST1 expression in breast cancer cells facilitates bone metastasis formation.

artículo científico publicado en 2014

Tandem purification of IgM monoclonal antibodies from mouse ascites fluids by anion-exchange and gel fast protein liquid chromatography

scientific article published on 01 February 1986

Tandem purification of mouse IgM monoclonal antibodies produced in vitro using anion-exchange and gel fast protein liquid chromatography

artículo científico publicado en 1986

Tandem separation of labelled human blood platelet membrane glycoproteins by anion-exchange and gel fast protein liquid chromatography

artículo científico publicado en 1985

Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

artículo científico publicado en 2011

The C-Terminal Intact Forms of Periostin (iPTN) Are Surrogate Markers for Osteolytic Lesions in Experimental Breast Cancer Bone Metastasis

artículo científico publicado en 2018

The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth

artículo científico publicado en 2011

The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer ⬇️

artículo científico publicado en 2015

The Molecular Basis of Bisphosphonate Activity: A Preclinical Perspective ⬇️

artículo científico publicado el 1 de junio de 2010

The role of osteoclasts in breast cancer bone metastasis.

artículo científico publicado en 2016

Therapeutic targets for bone metastases in breast cancer ⬇️

artículo científico publicado el 6 de abril de 2011

Thrombospondin (TSP1) mediates in vitro proliferation of human MG-63 osteoblastic cells induced by alpha-thrombin

artículo científico publicado en 1993

Thrombospondin in milk, other breast secretions, and breast tissue.

artículo científico publicado en 1987

Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells. A model to study the different effects of thrombospondin in cell adhesion

artículo científico publicado en 1989

Tryptic peptide map analysis of the major human blood platelet membrane glycoproteins separated by two-dimensional polyacrylamide gel electrophoresis

artículo científico publicado en 1982

Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases.

artículo científico publicado en 2007

Tumour-derived miRNAs and bone metastasis

artículo científico publicado en 2015

Unseeded Inertial Cavitation for Enhancing the Delivery of Chemotherapies: A Safety Study

artículo científico publicado en 2015

Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells

artículo científico publicado en 2014

[Pathophysiology of bone metastases and new molecular targets involved in bone remodelling].

artículo científico publicado en 2013

[The role of RANK/RANKL/osteoprotegerin (OPG) triad in cancer-induced bone diseases: physiopathology and clinical implications]

scientific article published on 01 July 2011

Lista de obras de Philippe Clézardin

A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden.

A convenient clinically relevant model of human breast cancer bone metastasis.

A new murine model of osteoblastic/osteolytic lesions from human androgen-resistant prostate cancer

A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, beta-thromboglobulin and platelet factor 4 in healthy volunteers.

A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis

Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone

Adjuvant bisphosphonates in early breast cancer: consensus guidance for clinical practice from a European Panel

Adjuvant bisphosphonates in patients with breast cancer: does the potency matter?

Advances in optical imaging and novel model systems for cancer metastasis research.

Anti-tumour activity of zoledronic acid.

Bioluminescence imaging of prenylation inhibition--letter

Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity

Bisphosphonates in cancer therapy

Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class.

Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma

Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers

Bone-Targeted Therapies in Cancer-Induced Bone Disease

Cancer Cell Colonisation in the Bone Microenvironment

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

Cathepsin K inhibitors as treatment of bone metastasis.

Cell attachment and fibrinogen binding properties of platelet and endothelial cell thrombospondin are not affected by structural differences in the 70 and 18 kDa protease-resistant domains

Characterization of two murine monoclonal antibodies (P10, P12) directed against different determinants on human blood platelet thrombospondin

Combination of anti-angiogenic therapies reduces osteolysis and tumor burden in experimental breast cancer bone metastasis

Complex formation of human thrombospondin with osteonectin ⬇️

Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.

Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo.

Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis.

Direct and indirect anticancer activity of bisphosphonates: a brief review of published literature

Dual Function of ERRα in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin ⬇️

ERRα expression in bone metastases leads to an exacerbated anti-tumor immune response

Effect of intra-tibial injection on mechanical properties of mouse bone

Effects of bone-targeted agents on cancer progression and mortality.

Emerging therapies in bone metastasis

Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone

Expression and localisation of alphav integrins in human odontoblasts.

Frequent low-dose bisphosphonate therapy

High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo.

How do bisphosphonates inhibit bone metastasis in vivo?

Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo

Identification and characterization of fragments of major glycoproteins from platelet membrane after chymotrypsin treatment

Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers

In vivo phosphoantigen levels in bisphosphonate-treated human breast tumors trigger Vγ9Vδ2 T-cell antitumor cytotoxicity through ICAM-1 engagement.

Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.

Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression

Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone

Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone

International Society of Geriatric Oncology (SIOG) clinical practice recommendations for the use of bisphosphonates in elderly patients.

Isolation of thrombospondin released from thrombin-stimulated human platelets by fast protein liquid chromatography on an anion-exchange Mono-Q column

Localization of thrombospondin, CD36 and CD51 during prenatal development of the human mammary gland

Low-Intensity Ultrasound Promotes Clathrin-Dependent Endocytosis for Drug Penetration into Tumor Cells

Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer

Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.

Lysophosphatidic acid: a new link between blood platelets and bone metastasis

Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone

Mechanisms of action of bisphosphonates in oncology: a scientific concept evolving from antiresorptive to anticancer activities

Metastasis and bone loss: advancing treatment and prevention.

MiRNAs and snoRNAs in Bone Metastasis: Functional Roles and Clinical Potential

Molecularly targeted therapies in breast cancer bone metastases

Mutational profiling of bone metastases from lung adenocarcinoma: results of a prospective study (POUMOS-TEC)

Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention.

Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase

Non-coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance

Oligometastatic bone disease. Can limited metastatic bone disease be cured? Is there room for local ablative treatments?

One-step procedure for the rapid isolation of mouse monoclonal antibodies and their antigen binding fragments by fast protein liquid chromatography on a mono Q anion-exchange column

Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation

Pathophysiology of bone metastases from solid malignancies

Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs

Platelet membrane glycoprotein abnormalities in patients with myeloproliferative disorders and secondary thrombocytosis

Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.

Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1

Production, characterization, and use of monoclonal antibodies directed against human blood platelet thrombospondin: immunologic comparison with human endothelial and fibroblast thrombospondins

RANK/RANKL pathway in cancer: Biological activity beyond bone?

Recent insights into the role of integrins in cancer metastasis.

Structural and immunological comparison of human thrombospondins isolated from platelets and from culture supernatants of endothelial cells and fibroblasts. Evidence for a thrombospondin polymorphism

Structural and immunological differences between human platelet and endothelial thrombospondins

TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival

TWIST1 expression in breast cancer cells facilitates bone metastasis formation.

Tandem purification of IgM monoclonal antibodies from mouse ascites fluids by anion-exchange and gel fast protein liquid chromatography