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Lista de obras de Gareth J Veal

13-cis retinoic acid and isomerisation in paediatric oncology--is changing shape the key to success?

artículo científico publicado en 2005

A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells

artículo científico publicado en 2019

A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia

artículo científico publicado en 2004

A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin

artículo científico publicado en 2001

A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.

artículo científico publicado en 2016

Adaptive dosing and platinum-DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours.

artículo científico publicado en 2007

Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma.

artículo científico publicado en 2012

Adaptive dosing of anticancer drugs in neonates: facilitating evidence-based dosing regimens.

artículo científico publicado en 2016

Biliary excretion of etoposide in children with cancer.

artículo científico publicado en 2006

Busulfan pharmacokinetics following intravenous and oral dosing regimens in children receiving high-dose myeloablative chemotherapy for high-risk neuroblastoma as part of the HR-NBL-1/SIOPEN trial.

artículo científico publicado en 2012

Carboplatin dosing in infants with retinoblastoma: a case for therapeutic drug monitoring.

artículo científico publicado en 2012

Carboplatin therapeutic monitoring in preterm and full-term neonates.

artículo científico publicado en 2015

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

artículo científico publicado en 2009

Characterisation of the clinical pharmacokinetics of actinomycin D and the influence of ABCB1 pharmacogenetic variation on actinomycin D disposition in children with cancer

artículo científico publicado en 2014

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

artículo científico publicado en 2012

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP‐glucuronosyltransferases

artículo científico publicado el 1 de febrero de 2011

Chemotherapy in newborns and preterm babies.

artículo científico

Chemotherapy individualization.

artículo científico publicado en 2003

Clinical pharmacology in the adolescent oncology patient

artículo científico publicado en 2010

Cyclophosphamide pharmacokinetics and pharmacogenetics in children with B-cell non-Hodgkin's lymphoma

artículo científico publicado en 2016

Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography-mass spectrometry.

artículo científico publicado en 2003

Development and validation of LC-MS/MS with in-source collision-induced dissociation for the quantification of pegcantratinib in human skin tumors

artículo científico publicado en 2017

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

artículo científico publicado en 2016

Diverse assays from a single skin punch biopsy to assess topical drug intervention

artículo científico publicado en 2019

Dosing of cancer patients with low or absent renal function

scientific article published on 01 March 2007

Drug interactions with zidovudine phosphorylation in vitro.

artículo científico publicado en 1995

Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells.

artículo científico publicado en 1994

Estimation of glomerular filtration rate in paediatric cancer patients using 51CR-EDTA population pharmacokinetics

artículo científico publicado en 2004

Estimation of renal function and its potential impact on carboplatin dosing in children with cancer

artículo científico publicado en 2008

Fundamental problems with pediatric adaptive dosing of carboplatin using nuclear-medicine-based estimates of renal function

scientific article published on 15 February 2019

Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial

artículo científico publicado en 2017

Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

scientific article published on 17 January 2019

Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia-a report from the UKALL 2011 trial

artículo científico publicado en 2019

In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

scientific article published on 12 August 2019

In vitro screening of nucleoside analog combinations for potential use in anti-HIV therapy

scientific article published on 01 April 1997

Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells

artículo científico publicado en 2005

Influence of cellular factors and pharmacokinetics on the formation of platinum-DNA adducts in leukocytes of children receiving cisplatin therapy

scientific article published on 01 August 2001

Institutional profile: pharmacogenomics research at Newcastle University.

artículo científico publicado en 2012

Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation

artículo científico publicado en 1996

Intracellular activation of 2',3'-dideoxyinosine and drug interactions in vitro

artículo científico publicado en 1999

Investigating current practices in renal function measurement and carboplatin dosing in children with cancer - a UK perspective

scientific article published on 16 January 2020

Investigating the Experiences of Childhood Cancer Patients and Parents Participating in Optional Nontherapeutic Clinical Research Studies in the UK.

artículo científico publicado en 2016

Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence.

artículo científico publicado en 2018

Investigating the roles and training of paediatric research nurses working across Europe: a questionnaire-based survey

artículo científico publicado en 2017

Lamivudine (3TC) phosphorylation and drug interactions in vitro

artículo científico publicado el 1 de septiembre de 1997

Malnourished Malawian patients presenting with large Wilms tumours have a decreased vincristine clearance rate

artículo científico publicado en 2010

Metabolism of Zidovudine.

artículo científico publicado en 1995

Modulation of signaling enhances the efficacy of the combination of satraplatin and erlotinib

artículo científico publicado en 2014

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

artículo científico publicado en 2007

Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells

artículo científico publicado en 2007

Novel micelles based on amphiphilic branched PEG as carriers for fenretinide

artículo científico publicado en 2011

Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold

artículo científico publicado en 2012

OP27ETOPOSIDE PHARMACOKINETICS FOLLOWING INTRA-CEREBROSPINAL FLUID ADMINISTRATION IN PATIENTS WITH LEPTOMENINGEAL METASTASES

Over a decade of experience with carboplatin therapeutic drug monitoring in a childhood cancer setting in the United Kingdom

artículo científico publicado en 2020

Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste

artículo científico publicado en 2019

Oxazaphosphorines: new therapeutic strategies for an old class of drugs

artículo científico publicado en 2010

P67DEFINING A TARGET INTRA-CEREBROSPINAL FLUID STEADY STATE ETOPOSIDE CONCENTRATION [CSF ETOPOSIDE] FOR PHASE I STUDY IN CHILDREN WITH LEPTOMENINGEAL METASTASIS (LM): INTREPID, A FIRST IN MAN STUDY

Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia

artículo científico

Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities

scientific article published on 01 April 2019

Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy

artículo científico publicado en 2004

Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma - a study of the United Kingdom Children's Cancer Study Group.

artículo científico publicado en 2007

Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2

artículo científico publicado en 2016

Pharmacokinetics and pharmacogenetics of 13-cis retinoic acid in Indian high-risk neuroblastoma patients

artículo científico publicado en 2016

Pharmacokinetics and pharmacogenetics of 13-cis-retinoic acid in the treatment of neuroblastoma

scientific article published on 01 March 2007

Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients

artículo científico publicado en 2009

Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition

artículo científico publicado en 2019

Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function

scientific article published on 04 November 2018

Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma

scientific article published on 09 January 2019

Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells

artículo científico publicado en 2009

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

artículo científico publicado en 2010

Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics

artículo científico publicado en 2014

Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies

artículo científico publicado en 2014

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

artículo científico publicado en 2010

Sequence-specific RNase H cleavage of gag mRNA from HIV-1 infected cells by an antisense oligonucleotide in vitro.

artículo científico publicado en 1998

Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates

artículo científico publicado en 2011

Synergistic inhibition of HIV-1 by an antisense oligonucleotide and nucleoside analog reverse transcriptase inhibitors

artículo científico publicado el 1 de abril de 1998

Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.

artículo científico publicado en 2012

Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).

artículo científico publicado en 2011

Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts.

artículo científico publicado en 2018

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

artículo científico publicado en 2018

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

artículo científico publicado en 2019

The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites

scientific article published on 01 October 1996

The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide

artículo científico publicado en 2011

The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients

artículo científico publicado en 2018

The use of pharmacokinetically guided carboplatin chemotherapy in a pre-term infant with neuroblastoma-associated spinal cord compression

artículo científico publicado en 2019

Therapeutic drug monitoring and dose adaptation of cisplatin in a newborn with hepatoblastoma: a case report

artículo científico publicado en 2018

Therapeutic drug monitoring in cancer--are we missing a trick?

artículo científico publicado en 2014

Therapeutic monitoring of carboplatin dosing in a premature infant with retinoblastoma.

artículo científico publicado en 2008

Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues.

artículo científico publicado en 2011

Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients

artículo científico publicado en 2021

Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers

scientific article published on 01 August 1994