Lista de obras - Francisca Vazquez - Dominio Público Uruguay

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

artículo científico publicado en 2017

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer

artículo científico publicado en 2022

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

artículo científico publicado en 2016

A first-generation pediatric cancer dependency map

artículo científico publicado en 2021

ARID1B is a specific vulnerability in ARID1A-mutant cancers. ⬇️

artículo científico publicado en 2014

Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

artículo científico publicado en 2019

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

artículo científico publicado en 2021

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

artículo científico publicado en 2013

Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

scientific article published on 26 September 2019

Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations

artículo científico publicado en 2020

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

artículo científico publicado en 2022

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

artículo científico publicado en 2017

BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

article

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

artículo científico publicado en 2017

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

scientific article published on 18 May 2020

Characterizing genomic alterations in cancer by complementary functional associations

artículo científico publicado en 2016

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

artículo científico publicado en 2017

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

artículo científico publicado en 2017

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

artículo científico publicado en 2017

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression

artículo científico publicado en 2014

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

artículo científico

Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle ⬇️

artículo científico publicado el 18 de junio de 2012

Defining a Cancer Dependency Map.

artículo científico publicado en 2017

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

artículo científico publicado en 2020

Functional Genomic Characterization of Cancer Genomes

artículo científico publicado en 2016

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

artículo científico publicado en 2021

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

artículo científico publicado en 2015

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

artículo científico publicado en 2021

Genetic and transcriptional evolution alters cancer cell line drug response

artículo científico publicado en 2018

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

scientific article published on 21 March 2019

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

scientific article published on 25 July 2018

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

artículo científico publicado en 2018

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

artículo científico publicado en 2016

Global computational alignment of tumor and cell line transcriptional profiles

artículo científico publicado en 2021

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

artículo científico publicado en 2018

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

artículo científico publicado en 2015

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

scientific article published in Nature Communications

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

artículo científico publicado en 2014

Integrated genetic and pharmacologic interrogation of rare cancers

artículo científico publicado en 2016

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

article published in 2018

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

artículo científico publicado en 2019

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

artículo científico publicado en 2016

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

artículo científico publicado en 2020

Mutational processes shape the landscape of TP53 mutations in human cancer.

artículo científico publicado en 2018

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

artículo científico publicado en 2019

Next-generation characterization of the Cancer Cell Line Encyclopedia

artículo científico publicado en 2019

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

artículo científico publicado en 2013

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

artículo científico publicado en 2011

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

artículo científico publicado en 2017

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

artículo científico publicado en 2017

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

artículo científico publicado en 2014

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

artículo científico publicado en 2015

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

publication published on 21 April 2021

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.

artículo científico publicado en 2017

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

artículo científico publicado en 2020

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

scientific article published on 01 October 2019

Systematic genomic and translational efficiency studies of uveal melanoma

artículo científico publicado en 2017

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

artículo científico publicado en 2013

TRTH-15. RESISTANCE MECHANISMS TO BET-BROMODOMAIN INHIBITION IN MYC-AMPLIFIED MEDULLOBLASTOMA.

artículo científico publicado en 2017

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

artículo científico publicado en 2018

Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization.

artículo científico publicado en 2014

The Cancer Dependency Map enables drug mechanism-of-action investigations

artículo científico publicado en 2020

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

artículo científico publicado en 2016

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

artículo científico publicado en 2015

The landscape of cancer cell line metabolism

scientific article published on 08 May 2019

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

scientific article published on 10 April 2019

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

artículo científico publicado en 2012

Lista de obras de Francisca Vazquez

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

A first-generation pediatric cancer dependency map

ARID1B is a specific vulnerability in ARID1A-mutant cancers. ⬇️

Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Characterizing genomic alterations in cancer by complementary functional associations

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle ⬇️

Defining a Cancer Dependency Map.

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

Functional Genomic Characterization of Cancer Genomes

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

Genetic and transcriptional evolution alters cancer cell line drug response

Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Global computational alignment of tumor and cell line transcriptional profiles

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

Integrated genetic and pharmacologic interrogation of rare cancers

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

Mutational processes shape the landscape of TP53 mutations in human cancer.

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Next-generation characterization of the Cancer Cell Line Encyclopedia

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

Small-molecule targeting of brachyury transcription factor addiction in chordoma

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Systematic genomic and translational efficiency studies of uveal melanoma

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

TRTH-15. RESISTANCE MECHANISMS TO BET-BROMODOMAIN INHIBITION IN MYC-AMPLIFIED MEDULLOBLASTOMA.

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization.

The Cancer Dependency Map enables drug mechanism-of-action investigations

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

The landscape of cancer cell line metabolism

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis