Lista de obras - Laurence Vico - Dominio Público Uruguay

3D Analysis of Cortical and Trabecular Bone From Hip DXA:Precision and Trend Assessment Interval in PostmenopausalWomen

artículo científico publicado en 2018

Absence of bone sialoprotein (BSP) alters profoundly hematopoiesis and upregulates osteopontin.

artículo científico publicado en 2015

Absence of bone sialoprotein (BSP) impairs cortical defect repair in mouse long bone.

artículo científico publicado en 2009

Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge

artículo científico publicado en 2012

Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice.

artículo científico publicado en 2007

Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.

artículo científico publicado en 2011

Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix.

artículo científico publicado en 2010

Assessment of bone structure and acoustic impedance in C3H and BL6 mice using high resolution scanning acoustic microscopy.

artículo científico publicado en 2006

Assessment of bone vascularization and its role in bone remodeling.

artículo científico publicado en 2015

Bisphosphonate effects in rat unloaded hindlimb bone loss model: three-dimensional microcomputed tomographic, histomorphometric, and densitometric analyses

artículo científico publicado en 1999

Blocking the expression of both bone sialoprotein (BSP) and osteopontin (OPN) impairs the anabolic action of PTH in mouse calvaria bone

artículo científico publicado en 2015

Bone Shaft Revascularization After Marrow Ablation Is Dramatically Accelerated in BSP-/- Mice, Along With Faster Hematopoietic Recolonization.

artículo científico publicado en 2016

Bone mass and bone cellular variations after five months of physical training in rhesus monkeys: histomorphometric study

artículo científico publicado el 1 de mayo de 1992

Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro ⬇️

artículo científico publicado el 1 de diciembre de 2010

Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis

artículo científico publicado en 2008

Bone vascularization and remodeling

scientific article published on 25 October 2010

Cancellous bone structure of iliac crest biopsies following 370 days of head-down bed rest.

artículo científico publicado en 2005

Combined effects of exercise and propranolol on bone tissue in ovariectomized rats.

artículo científico publicado en 2007

Constitutional thinness: unusual human phenotype of low bone quality.

artículo científico publicado en 2007

Cortical and Trabecular Bone Microstructure Did Not Recover at Weight-Bearing Skeletal Sites and Progressively Deteriorated at Non-Weight-Bearing Sites During the Year Following International Space Station Missions

artículo científico publicado en 2017

Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells.

artículo científico publicado en 2006

Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover

scientific article published on 05 December 2018

Differences in osteocyte density and bone histomorphometry between men and women and between healthy and osteoporotic subjects.

artículo científico publicado en 2005

Divergent Anabolic Signalling responses of Murine Soleus and Tibialis Anterior Muscles to Chronic 2G Hypergravity

artículo científico publicado en 2017

Doping dose of salbutamol and exercise training: impact on the skeleton of ovariectomized rats.

artículo científico publicado en 2007

Doping dose of salbutamol and exercise: deleterious effect on cancellous and cortical bones in adult rats.

artículo científico publicado en 2006

Dose effects of propranolol on cancellous and cortical bone in ovariectomized adult rats.

artículo científico publicado en 2006

Dramatic decrease of innervation density in bone after ovariectomy.

artículo científico publicado en 2004

Dual-energy X-ray absorptiometry underestimates in vivo lumbar spine bone mineral density in overweight rats.

artículo científico publicado en 2017

Early Subchondral Bone Loss at Arthritis Onset Predicted Late Arthritis Severity in a Rat Arthritis Model.

artículo científico publicado en 2016

Early sclerostin expression explains bone formation inhibition before arthritis onset in the rat adjuvant-induced arthritis model.

artículo científico publicado en 2018

Effect of a five-week swimming program on rat bone: a histomorphometric study

artículo científico publicado el 1 de agosto de 1992

Effects of centrifugation and whole-body vibrations on blood-brain barrier permeability in mice

artículo científico publicado en 2020

Effects of centrifuging at 2g on rat long bone metaphyses

artículo científico publicado en 1999

Effects of chronic hypergravity: from adaptive to deleterious responses in growing mouse skeleton

artículo científico publicado en 2015

Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cells

scientific article published on 01 October 1997

Effects of phospholipase D during cultured osteoblast mineralization and bone formation

artículo científico publicado en 2018

Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines.

artículo científico

Eight Days of Earth Reambulation Worsen Bone Loss Induced by 1-Month Spaceflight in the Major Weight-Bearing Ankle Bones of Mature Mice.

artículo científico publicado en 2018

Energy and substrate metabolism during a 42-day bed-rest in a head-down tilt position in humans

artículo científico publicado en 1998

Energy and water metabolism, body composition, and hormonal changes induced by 42 days of enforced inactivity and simulated weightlessness

artículo científico publicado en 1998

Erratum: One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons.

artículo científico publicado en 2017

Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain.

artículo científico publicado en 2008

Excised bone structures in mice: imaging at three-dimensional synchrotron radiation micro CT.

artículo científico publicado en 2003

Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation.

artículo científico publicado en 2005

Extracellular matrix produced by osteoblasts cultured under low-magnitude, high-frequency stimulation is favourable to osteogenic differentiation of mesenchymal stem cells.

artículo científico publicado en 2010

Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats

artículo científico publicado en 2015

Femtosecond laser nano/micro patterning of titanium influences mesenchymal stem cell adhesion and commitment.

artículo científico publicado en 2015

Focal contacts organization in osteoblastic cells under microgravity and cyclic deformation conditions.

artículo científico publicado en 2003

Functional hypoparathyroidism in postmenopausal women with fragility fracture

artículo científico publicado en 2011

Functionalization of matrices by cyclically stretched osteoblasts through matrix targeting of VEGF.

artículo científico publicado en 2010

High-acceleration whole body vibration stimulates cortical bone accrual and increases bone mineral content in growing mice.

artículo científico publicado en 2016

High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures

scientific article published on 01 November 2008

High-resolution three-dimensional micro-computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis.

artículo científico publicado en 2002

Hindlimb unloading in rat decreases preosteoblast proliferation assessed in vivo with BrdU incorporation

artículo científico publicado en 1998

Histomorphometric analyses of cancellous bone from COSMOS 2044 rats

artículo científico publicado en 1993

Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model

scientific article published on 09 December 2020

Imaging and quantitative assessment of long bone vascularization in the adult rat using microcomputed tomography

scientific article published on 01 February 2010

Impaired energetic metabolism after central leptin signaling leads to massive appendicular bone loss in hindlimb-suspended rats.

artículo científico publicado en 2008

In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment.

artículo científico

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study.

artículo científico publicado en 2017

Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites

artículo científico publicado en 2011

Leptin modulates both resorption and formation while preventing disuse-induced bone loss in tail-suspended female rats.

artículo científico publicado en 2005

Long-duration bed rest as an analog to microgravity.

artículo científico

Long-term soccer practice increases bone mineral content gain in prepubescent boys.

artículo científico publicado en 2007

Lower bone cellular activities in male and female mature C3H/HeJ mice are associated with higher bone mass and different pyridinium crosslink profiles compared to C57BL/6J mice.

artículo científico publicado en 2003

MAPK and SRC-Kinases Control EGR-1 and NF-κB Inductions by Changes in Mechanical Environment in Osteoblasts

artículo científico publicado en 2001

Macrotopographic closure promotes tissue growth and osteogenesis in vitro.

artículo científico publicado en 2017

Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation.

artículo científico publicado en 2008

Mice lacking bone sialoprotein (BSP) lose bone after ovariectomy and display skeletal site-specific response to intermittent PTH treatment.

artículo científico publicado en 2010

Microgravity and bone adaptation at the tissue level

artículo científico publicado el 1 de diciembre de 1992

Modifications of bone and connective tissue after orthostatic bedrest

scientific article published on 01 January 2000

Modulation of the responses of human osteoblast-like cells to physiologic mechanical strains by biomaterial surfaces.

artículo científico publicado en 2005

Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing system.

artículo científico publicado en 2009

Multiscale grooved titanium processed with femtosecond laser influences mesenchymal stem cell morphology, adhesion, and matrix organization.

artículo científico publicado en 2012

Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography.

artículo científico publicado en 2003

One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons.

artículo científico publicado en 2017

Osteobiology, strain, and microgravity: part I. Studies at the cellular level.

artículo científico publicado en 2000

Osteoblast and osteoclast differentiation in an in vitro three-dimensional model of bone.

artículo científico publicado en 2009

Parathyroid Hormone Remodels Bone Transitional Vessels and the Leptin Receptor-Positive Pericyte Network in Mice

artículo científico publicado en 2019

Parathyroid hormone 1-84 targets bone vascular structure and perfusion in mice: impacts of its administration regimen and of ovariectomy

artículo científico publicado en 2014

Pathophysiology of bone loss in disuse osteoporosis ⬇️

artículo científico publicado el 12 de junio de 2011

Periostin expression contributes to cortical bone loss during unloading

artículo científico publicado en 2014

Physiological strains remodel extracellular matrix and cell-cell adhesion in osteoblastic cells cultured on alumina-coated titanium alloy.

artículo científico publicado en 2004

Plasticity of osteoprogenitor cells.

artículo científico publicado en 2007

Porphyromonas gingivalis experimentally induces periodontis and an anti-CCP2-associated arthritis in the rat

scientific article published on 30 January 2019

Positive Association of Obesity and Insulin Resistance With Bone Mineral Density in Tunisian Postmenopausal Women.

artículo científico publicado en 2017

Protein quality affects bone status during moderate protein restriction in growing mice

artículo científico publicado en 2013

Quantification of focal contacts in osteoblastic cells--effects of intermittent and continuous gravitational stresses

scientific article published on 01 September 1996

Quantitation of cell-matrix adhesion using confocal image analysis of focal contact associated proteins and interference reflection microscopy

scientific article published on 01 August 1997

Rac1 GTPase silencing counteracts microgravity-induced effects on osteoblastic cells

artículo científico publicado en 2014

Rat Hindlimb Unloading by Tail Suspension Reduces Osteoblast Differentiation, Induces IL-6 Secretion, and Increases Bone Resorption in Ex Vivo Cultures

article

Recurrence of vertebral fracture with cyclical etidronate therapy in osteoporosis: histomorphometry and X-Ray microanalysis evaluation

artículo científico publicado en 1999

Reduction by strontium of the bone marrow adiposity in mice and repression of the adipogenic commitment of multipotent C3H10T1/2 cells.

artículo científico publicado en 2011

Regulation of ubiquitin–proteasome system, caspase enzyme activities, and extracellular proteinases in rat soleus muscle in response to unloading

artículo científico publicado en 2007

RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment.

artículo científico publicado en 2017

RhoGTPases as key players in mammalian cell adaptation to microgravity

artículo científico publicado en 2015

Skeletal changes during and after spaceflight.

artículo científico publicado en 2018

Skeletal development of mice lacking bone sialoprotein (BSP)--impairment of long bone growth and progressive establishment of high trabecular bone mass

artículo científico publicado en 2014

Skeletal site-specific effects of whole body vibration in mature rats: from deleterious to beneficial frequency-dependent effects.

artículo científico publicado en 2013

Soccer increases bone mass in prepubescent boys during growth: a 3-yr longitudinal study.

artículo científico publicado en 2015

Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: observations in two cosmonauts

artículo científico publicado en 2000

Space-related bone mineral redistribution and lack of bone mass recovery after reambulation in young rats.

artículo científico publicado en 1998

Stimulation of Bone Repair with Ultrasound.

artículo científico publicado en 2016

Stimulation of bone repair with ultrasound: a review of the possible mechanic effects.

artículo científico publicado en 2014

Structure and quantification of microvascularisation within mouse long bones: what and how should we measure?

artículo científico publicado en 2011

Structure of the cortical cytoskeleton in fibers of postural muscles and cardiomyocytes of mice after 30-day 2-g centrifugation.

artículo científico publicado en 2014

Summary of research issues in biomechanics and mechanical sensing

artículo científico publicado el 1 de mayo de 1998

Synchrotron radiation micro-CT at the micrometer scale for the analysis of the three-dimensional morphology of microcracks in human trabecular bone ⬇️

artículo científico publicado en 2011

Tail suspension induces bone loss in skeletally mature mice in the C57BL/6J strain but not in the C3H/HeJ strain

scientific article published on 01 March 2003

The effect of dual frequency cyclic compression on matrix deposition by osteoblast-like cells grown in 3D scaffolds and on modulation of VEGF variant expression.

artículo científico publicado en 2009

The impairment of osteogenesis in bone sialoprotein (BSP) knockout calvaria cell cultures is cell density dependent.

artículo científico publicado en 2015

The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics.

artículo científico publicado en 2016

Third harmonic generation imaging and analysis of the effect of low gravity on the lacuno-canalicular network of mouse bone

artículo científico publicado en 2019

Thyroid hormone receptor β mediates thyroid hormone effects on bone remodeling and bone mass.

artículo científico publicado en 2011

Towards human exploration of space: the THESEUS review series on muscle and bone research priorities.

artículo científico publicado en 2017

Tumor Necrosis Factor Alpha Overexpression Induces Mainly Osteoclastogenesis at the Vertebral Site.

artículo científico publicado en 2017

Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences.

artículo científico publicado en 2006

Ultrafast Laser Processing of Nanostructured Patterns for the Control of Cell Adhesion and Migration on Titanium Alloy

scientific article published on 30 April 2020

Unloading-Induced Cortical Bone Loss is Exacerbated by Low-Dose Irradiation During a Simulated Deep Space Exploration Mission

scientific article published on 25 May 2020

Validation of an in vitro 3D bone culture model with perfused and mechanically stressed ceramic scaffold.

artículo científico publicado en 2015

Variations of microstructure, mineral density and tissue elasticity in B6/C3H mice.

artículo científico publicado en 2007

Volleyball and Basketball Enhanced Bone Mass in Prepubescent Boys.

artículo científico publicado en 2015

What do we know about alteration in the osteoblast phenotype with microgravity?

scientific article published on 01 October 2006

[Adaptation of the skeleton to microgravity]

scientific article published on 01 December 1994

Lista de obras de Laurence Vico

3D Analysis of Cortical and Trabecular Bone From Hip DXA:Precision and Trend Assessment Interval in PostmenopausalWomen

Absence of bone sialoprotein (BSP) alters profoundly hematopoiesis and upregulates osteopontin.

Absence of bone sialoprotein (BSP) impairs cortical defect repair in mouse long bone.

Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge

Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice.

Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.

Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix.

Assessment of bone structure and acoustic impedance in C3H and BL6 mice using high resolution scanning acoustic microscopy.

Assessment of bone vascularization and its role in bone remodeling.

Bisphosphonate effects in rat unloaded hindlimb bone loss model: three-dimensional microcomputed tomographic, histomorphometric, and densitometric analyses

Blocking the expression of both bone sialoprotein (BSP) and osteopontin (OPN) impairs the anabolic action of PTH in mouse calvaria bone

Bone Shaft Revascularization After Marrow Ablation Is Dramatically Accelerated in BSP-/- Mice, Along With Faster Hematopoietic Recolonization.

Bone mass and bone cellular variations after five months of physical training in rhesus monkeys: histomorphometric study

Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro ⬇️

Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis

Bone vascularization and remodeling

Cancellous bone structure of iliac crest biopsies following 370 days of head-down bed rest.

Combined effects of exercise and propranolol on bone tissue in ovariectomized rats.

Constitutional thinness: unusual human phenotype of low bone quality.

Cortical and Trabecular Bone Microstructure Did Not Recover at Weight-Bearing Skeletal Sites and Progressively Deteriorated at Non-Weight-Bearing Sites During the Year Following International Space Station Missions

Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells.

Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover

Differences in osteocyte density and bone histomorphometry between men and women and between healthy and osteoporotic subjects.

Divergent Anabolic Signalling responses of Murine Soleus and Tibialis Anterior Muscles to Chronic 2G Hypergravity

Doping dose of salbutamol and exercise training: impact on the skeleton of ovariectomized rats.

Doping dose of salbutamol and exercise: deleterious effect on cancellous and cortical bones in adult rats.

Dose effects of propranolol on cancellous and cortical bone in ovariectomized adult rats.

Dramatic decrease of innervation density in bone after ovariectomy.

Dual-energy X-ray absorptiometry underestimates in vivo lumbar spine bone mineral density in overweight rats.

Early Subchondral Bone Loss at Arthritis Onset Predicted Late Arthritis Severity in a Rat Arthritis Model.

Early sclerostin expression explains bone formation inhibition before arthritis onset in the rat adjuvant-induced arthritis model.

Effect of a five-week swimming program on rat bone: a histomorphometric study

Effects of centrifugation and whole-body vibrations on blood-brain barrier permeability in mice

Effects of centrifuging at 2g on rat long bone metaphyses

Effects of chronic hypergravity: from adaptive to deleterious responses in growing mouse skeleton

Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cells

Effects of phospholipase D during cultured osteoblast mineralization and bone formation

Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines.

Eight Days of Earth Reambulation Worsen Bone Loss Induced by 1-Month Spaceflight in the Major Weight-Bearing Ankle Bones of Mature Mice.

Energy and substrate metabolism during a 42-day bed-rest in a head-down tilt position in humans

Energy and water metabolism, body composition, and hormonal changes induced by 42 days of enforced inactivity and simulated weightlessness

Erratum: One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons.

Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain.

Excised bone structures in mice: imaging at three-dimensional synchrotron radiation micro CT.

Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation.

Extracellular matrix produced by osteoblasts cultured under low-magnitude, high-frequency stimulation is favourable to osteogenic differentiation of mesenchymal stem cells.

Fat and Sucrose Intake Induces Obesity-Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats

Femtosecond laser nano/micro patterning of titanium influences mesenchymal stem cell adhesion and commitment.

Focal contacts organization in osteoblastic cells under microgravity and cyclic deformation conditions.

Functional hypoparathyroidism in postmenopausal women with fragility fracture

Functionalization of matrices by cyclically stretched osteoblasts through matrix targeting of VEGF.

High-acceleration whole body vibration stimulates cortical bone accrual and increases bone mineral content in growing mice.

High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures

High-resolution three-dimensional micro-computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis.

Hindlimb unloading in rat decreases preosteoblast proliferation assessed in vivo with BrdU incorporation

Histomorphometric analyses of cancellous bone from COSMOS 2044 rats

Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model

Imaging and quantitative assessment of long bone vascularization in the adult rat using microcomputed tomography

Impaired energetic metabolism after central leptin signaling leads to massive appendicular bone loss in hindlimb-suspended rats.

In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment.

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study.

Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites

Leptin modulates both resorption and formation while preventing disuse-induced bone loss in tail-suspended female rats.

Long-duration bed rest as an analog to microgravity.

Long-term soccer practice increases bone mineral content gain in prepubescent boys.

Lower bone cellular activities in male and female mature C3H/HeJ mice are associated with higher bone mass and different pyridinium crosslink profiles compared to C57BL/6J mice.

MAPK and SRC-Kinases Control EGR-1 and NF-κB Inductions by Changes in Mechanical Environment in Osteoblasts

Macrotopographic closure promotes tissue growth and osteogenesis in vitro.

Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation.

Mice lacking bone sialoprotein (BSP) lose bone after ovariectomy and display skeletal site-specific response to intermittent PTH treatment.

Microgravity and bone adaptation at the tissue level

Modifications of bone and connective tissue after orthostatic bedrest

Modulation of the responses of human osteoblast-like cells to physiologic mechanical strains by biomaterial surfaces.

Morphological, physiological and behavioural evaluation of a 'Mice in Space' housing system.

Multiscale grooved titanium processed with femtosecond laser influences mesenchymal stem cell morphology, adhesion, and matrix organization.

Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography.

One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons.

Osteobiology, strain, and microgravity: part I. Studies at the cellular level.

Osteoblast and osteoclast differentiation in an in vitro three-dimensional model of bone.