Lista de obras - Pawel Dokurno - Dominio Público Uruguay

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

artículo científico publicado en 2009

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

artículo científico publicado en 2011

Conformation of cyclodipeptides. factor analysis: a convenient tool for simplifying conformational studies of condensed poly-ring systems: prolyltype cyclopeptides

article published in 1990

Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody

artículo científico publicado en 1998

Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition

artículo científico publicado en 1998

Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion ⬇️

artículo científico publicado en 2001

Crystallization of an antitumour antibody SM3 complexed with a peptide epitope

artículo científico publicado en 1997

Crystallization of the Fab fragment of the tumour-specific antibody PR1A3.

artículo científico publicado en 1997

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

artículo científico publicado en 2017

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

artículo científico publicado en 2020

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

artículo científico publicado en 2007

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

artículo científico publicado en 2010

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

scientific article published on 23 May 2019

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

artículo científico publicado en 2009

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

Molecular basis of AKAP specificity for PKA regulatory subunits

artículo científico publicado en 2006

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

artículo científico publicado en 2009

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

artículo científico publicado en 2018

Structure of (±)-egenine

Structure of the AAA ATPase p97

artículo científico publicado en 2000

Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity

scientific article published on 24 July 2019

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

artículo científico publicado en 2010

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

artículo científico publicado en 2005

Synthesis, X-ray structure and high-resolution NMR spectroscopy of methyl 3-azido-2,3-dideoxy-alpha-D-arabino-hexopyranoside

artículo científico publicado en 2000

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

artículo científico publicado en 2016

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

artículo científico publicado en 2005

Lista de obras de Pawel Dokurno

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

Conformation of cyclodipeptides. factor analysis: a convenient tool for simplifying conformational studies of condensed poly-ring systems: prolyltype cyclopeptides

Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody

Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition

Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion ⬇️

Crystallization of an antitumour antibody SM3 complexed with a peptide epitope

Crystallization of the Fab fragment of the tumour-specific antibody PR1A3.

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

Molecular basis of AKAP specificity for PKA regulatory subunits

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

Structure of (±)-egenine

Structure of the AAA ATPase p97

Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Synthesis, X-ray structure and high-resolution NMR spectroscopy of methyl 3-azido-2,3-dideoxy-alpha-D-arabino-hexopyranoside

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.