Lista de obras - Koh Takeuchi - Dominio Público Uruguay

1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins

scientific article published on 28 March 2007

15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins

artículo científico publicado en 2018

A BRET-based assay reveals collagen-Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction

scientific article published on 06 September 2019

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation

artículo científico publicado en 2013

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis

artículo científico publicado en 2017

Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions.

artículo científico publicado en 2014

Alternate 13C-12C labeling for complete mainchain resonance assignments using C alpha direct-detection with applicability toward fast relaxing protein systems

artículo científico publicado en 2008

Amino acid selective cross-saturation method for identification of proximal residue pairs in a protein-protein complex

artículo científico publicado en 2008

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

artículo científico publicado en 2019

Application of C-terminal 7-azabicyclo[2.2.1]heptane to stabilize β-strand-like extended conformation of a neighboring α-amino acid

artículo científico publicado en 2018

Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics

scientific article published on 11 March 2019

Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity.

artículo científico publicado en 2010

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).

artículo científico publicado en 2009

Bead-linked proteoliposomes: a reconstitution method for nmr analyses of membrane protein-ligand interactions

artículo científico publicado en 2005

Channel-forming membrane permeabilization by an antibacterial protein, sapecin: determination of membrane-buried and oligomerization surfaces by NMR.

artículo científico publicado en 2003

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

artículo científico publicado en 2018

Conformational equilibrium defines the variable induction of the multidrug-binding transcriptional repressor QacR

artículo científico publicado en 2019

Cross-saturation and transferred cross-saturation experiments

artículo científico

Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis

artículo científico publicado en 2013

Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data

artículo científico publicado en 2015

Direct determination of a membrane-peptide interface using the nuclear magnetic resonance cross-saturation method

artículo científico publicado en 2005

Dynamic equilibrium on DNA defines transcriptional regulation of a multidrug binding transcriptional repressor, LmrR.

artículo científico publicado en 2017

Dynamic multidrug recognition by multidrug transcriptional repressor LmrR.

artículo científico publicado en 2014

Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins

scientific article published on 19 July 2019

Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR.

artículo científico publicado en 2017

Forbidden Coherence Transfer of 19F Nuclei to Quantitatively Measure the Dynamics of a CF₃-Containing Ligand in Receptor-Bound States

artículo científico publicado en 2017

Functional Equilibrium of the KcsA Structure Revealed by NMR ⬇️

artículo científico publicado el 28 de septiembre de 2012

Functional dynamics of cell surface membrane proteins

artículo científico publicado en 2013

Functional dynamics of proteins revealed by solution NMR.

artículo científico

HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment ⬇️

artículo científico publicado el 26 de noviembre de 2010

Identification and characterization of the slowly exchanging pH-dependent conformational rearrangement in KcsA

scientific article published on 14 March 2007

Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State

scientific article published on 20 October 2016

Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY.

artículo científico publicado en 2015

Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment.

artículo científico publicado en 2018

Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A ⬇️

artículo científico publicado el 15 de enero de 2004

NMR Analyses of the Gβγ Binding and Conformational Rearrangements of the Cytoplasmic Pore of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) ⬇️

artículo científico publicado el 12 de noviembre de 2010

NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states

artículo científico publicado en 2014

NMR studies of protein interactions.

artículo científico publicado en 2006

Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR

artículo científico publicado en 2015

Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments.

artículo científico publicado en 2010

Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions.

artículo científico publicado en 2016

Perdeuteration and methyl-selective (1)H, (13)C-labeling by using a Kluyveromyces lactis expression system.

artículo científico publicado en 2013

Perspective: revisiting the field dependence of TROSY sensitivity.

artículo científico publicado en 2016

Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif

artículo científico publicado en 2018

Poisson-gap sampling and forward maximum entropy reconstruction for enhancing the resolution and sensitivity of protein NMR data

artículo científico publicado en 2010

Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR.

artículo científico publicado en 2011

Quantitative Structure-activity Relationship (QSAR) Models for Docking Score Correction.

artículo científico publicado en 2016

Rapid identification of ligand-binding sites by using an assignment-free NMR approach

artículo científico publicado en 2013

Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies

artículo científico publicado en 2020

Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor

artículo científico publicado en 2019

Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel

artículo científico publicado en 2002

Solution structure of the first SRC homology 3 domain of human Nck2

scientific article published on 01 March 2006

Speeding up direct (15)N detection: hCaN 2D NMR experiment.

artículo científico publicado en 2011

Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR

artículo científico publicado en 2020

Structural Basis for the Golgi Association by the Pleckstrin Homology Domain of the Ceramide Trafficking Protein (CERT)

artículo científico publicado en 2012

Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity

artículo científico publicado en 2008

Structural basis of the KcsA K(+) channel and agitoxin2 pore-blocking toxin interaction by using the transferred cross-saturation method

artículo científico publicado en 2003

Structural basis underlying the dual gate properties of KcsA

artículo científico publicado en 2010

Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells

artículo científico publicado en 2016

Structure determination using solution NMR: Is it worth the effort?

scientific article published on 13 July 2019

Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates

artículo científico publicado en 2007

Structure of the VP16 transactivator target in the Mediator

artículo científico publicado en 2011

Structure-Based Development of a Protein-Protein Interaction Inhibitor Targeting Tumor Necrosis Factor Receptor-Associated Factor 6.

artículo científico publicado en 2015

Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand.

artículo científico publicado en 2014

Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines

artículo científico publicado en 2015

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

scientific article published on 30 September 2020

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

artículo científico publicado en 2016

The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.

artículo científico publicado en 2014

The alphabeta T cell receptor is an anisotropic mechanosensor.

artículo científico publicado en 2009

The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6.

artículo científico publicado en 2017

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

artículo científico publicado en 2011

Lista de obras de Koh Takeuchi

1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins

15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins

A BRET-based assay reveals collagen-Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis

Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions.

Alternate 13C-12C labeling for complete mainchain resonance assignments using C alpha direct-detection with applicability toward fast relaxing protein systems

Amino acid selective cross-saturation method for identification of proximal residue pairs in a protein-protein complex

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

Application of C-terminal 7-azabicyclo[2.2.1]heptane to stabilize β-strand-like extended conformation of a neighboring α-amino acid

Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics

Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity.

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).

Bead-linked proteoliposomes: a reconstitution method for nmr analyses of membrane protein-ligand interactions

Channel-forming membrane permeabilization by an antibacterial protein, sapecin: determination of membrane-buried and oligomerization surfaces by NMR.

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Conformational equilibrium defines the variable induction of the multidrug-binding transcriptional repressor QacR

Cross-saturation and transferred cross-saturation experiments

Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis

Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data

Direct determination of a membrane-peptide interface using the nuclear magnetic resonance cross-saturation method

Dynamic equilibrium on DNA defines transcriptional regulation of a multidrug binding transcriptional repressor, LmrR.

Dynamic multidrug recognition by multidrug transcriptional repressor LmrR.

Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins

Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR.

Forbidden Coherence Transfer of 19F Nuclei to Quantitatively Measure the Dynamics of a CF₃-Containing Ligand in Receptor-Bound States

Functional Equilibrium of the KcsA Structure Revealed by NMR ⬇️

Functional dynamics of cell surface membrane proteins

Functional dynamics of proteins revealed by solution NMR.

HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment ⬇️

Identification and characterization of the slowly exchanging pH-dependent conformational rearrangement in KcsA

Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State

Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY.

Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment.

Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A ⬇️

NMR Analyses of the Gβγ Binding and Conformational Rearrangements of the Cytoplasmic Pore of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) ⬇️

NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states

NMR studies of protein interactions.

Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR

Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments.

Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions.

Perdeuteration and methyl-selective (1)H, (13)C-labeling by using a Kluyveromyces lactis expression system.

Perspective: revisiting the field dependence of TROSY sensitivity.

Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif

Poisson-gap sampling and forward maximum entropy reconstruction for enhancing the resolution and sensitivity of protein NMR data

Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR.

Quantitative Structure-activity Relationship (QSAR) Models for Docking Score Correction.

Rapid identification of ligand-binding sites by using an assignment-free NMR approach

Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies

Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor

Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel

Solution structure of the first SRC homology 3 domain of human Nck2

Speeding up direct (15)N detection: hCaN 2D NMR experiment.

Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR

Structural Basis for the Golgi Association by the Pleckstrin Homology Domain of the Ceramide Trafficking Protein (CERT)

Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity

Structural basis of the KcsA K(+) channel and agitoxin2 pore-blocking toxin interaction by using the transferred cross-saturation method

Structural basis underlying the dual gate properties of KcsA

Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells

Structure determination using solution NMR: Is it worth the effort?

Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates

Structure of the VP16 transactivator target in the Mediator

Structure-Based Development of a Protein-Protein Interaction Inhibitor Targeting Tumor Necrosis Factor Receptor-Associated Factor 6.

Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand.

Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.

The alphabeta T cell receptor is an anisotropic mechanosensor.

The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6.

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.