Lista de obras - Kristian Bowles - Dominio Público Uruguay

"Haemorrhagic disease of the newborn" 89 years later than expected: vitamin K deficiency bleeding

artículo científico publicado en 2014

A 35-year-old with swollen knees who had recurrent fever and pericarditis, then diarrhoea before getting better.

artículo científico publicado en 1996

A 6-Point TACS Score Predicts In-Hospital Mortality Following Total Anterior Circulation Stroke.

artículo científico publicado en 2016

A History of Falls is Associated with a Significant Increase in Acute Mortality in Women after Stroke

artículo científico publicado en 2017

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

artículo científico publicado en 2015

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

artículo científico publicado en 2018

Addition of sodium criterion to SOAR stroke score.

artículo científico publicado en 2016

Anthracycline-based chemotherapy as first-line treatment in adults with malignant posttransplant lymphoproliferative disorder after solid organ transplantation

artículo científico publicado en 2006

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

artículo científico publicado en 2013

Bonding in women with postnatal anaemia: a pilot case control study looking at postnatal bonding in women who have been diagnosed with anaemia at a University Hospital in the East of England ⬇️

artículo científico publicado el 30 de noviembre de 2011

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

artículo científico publicado el 15 de junio de 2012

Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia

artículo científico publicado en 2017

CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma

scientific article published on 08 January 2019

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

scientific article published on 29 June 2016

Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines.

scientific article published on 16 April 2010

Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura

artículo científico publicado en 2006

Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke

scientific article published on 30 July 2018

Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

scientific article published on 24 April 2019

Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study.

artículo científico publicado en 2018

Estimated glomerular filtration rate and risk of poor outcomes after stroke

scientific article published on 17 July 2019

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism ⬇️

artículo científico publicado el 1 de septiembre de 2010

Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

artículo científico publicado en 2021

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

artículo científico publicado en 2018

HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells.

artículo científico publicado en 2006

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

artículo científico publicado el 6 de enero de 2011

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

artículo científico publicado en 2017

Hyperglycaemia and the SOAR stroke score in predicting mortality.

artículo científico publicado en 2017

Hyponatremia predicts mortality after stroke.

artículo científico publicado en 2015

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

artículo científico publicado en 2015

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

artículo científico publicado en 2014

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

artículo científico publicado en 2013

Impact of Hemoglobin Levels and Anemia on Mortality in Acute Stroke: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis

artículo científico publicado en 2016

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

artículo científico publicado en 2017

Impact of stroke-associated pneumonia on mortality, length of hospitalization, and functional outcome

artículo científico publicado en 2018

Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction

artículo científico publicado en 2017

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

artículo científico publicado en 2017

Long-Term Factors Associated With Falls and Fractures Poststroke.

artículo científico publicado en 2018

Low estimated glomerular filtration rate and pneumonia in stroke patients: findings from a prospective stroke registry in the East of England

article

MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

artículo científico publicado en 2016

Management of post-transplant lymphoproliferative disorder in adult solid organ transplant recipients - BCSH and BTS Guidelines.

scientific article published on 16 April 2010

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.

artículo científico publicado en 2018

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

artículo científico publicado en 2017

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

artículo científico publicado en 2014

Necrotizing cervical lymphadenopathy caused by Kikuchi-Fujimoto disease

scientific article published on 01 September 2003

Nodular Lymphocyte Predominant Hodgkin Lymphoma: A Real-world Case Series of Consecutive Patients Treated by a Single Multidisciplinary Team in the East of England From 1999 to 2015.

artículo científico publicado en 2017

Overcoming bortezomib resistance in multiple myeloma.

artículo científico publicado en 2014

Oxidative stress responses and NRF2 in human leukaemia

artículo científico publicado en 2015

PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

artículo científico publicado en 2018

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

artículo científico publicado en 2017

Platelet mass has prognostic value in patients with myelodysplastic syndromes

scientific article published on 25 August 2006

Platelet size has diagnostic predictive value in patients with thrombocytopenia.

artículo científico publicado en 2005

Predicting response to recombinant factor VIIa in non-haemophiliac patients with severe haemorrhage.

artículo científico publicado en 2006

Prediction of acute myeloid leukaemia risk in healthy individuals

scientific article published in Nature

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

artículo científico publicado el 1 de septiembre de 2011

ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

scientific article published on 14 November 2019

Resolution of Roth spots in chronic myeloid leukaemia after treatment with imatinib.

artículo científico publicado en 2015

Resolution of chronic severe refractory thrombocytopenia after treatment of hypothyroidism.

artículo científico publicado en 2004

Results of a multicentre UK-wide compassionate use programme evaluating the efficacy of idelalisib monotherapy in relapsed, refractory follicular lymphoma

artículo científico publicado en 2017

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

artículo científico publicado en 2015

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.

artículo científico publicado en 2016

Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia.

artículo científico publicado en 2018

The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

artículo científico publicado en 2017

The bone marrow microenvironment - Home of the leukemic blasts

artículo científico publicado en 2017

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

artículo científico publicado en 2012

Understanding the role of NRF2-regulated miRNAs in human malignancies.

scientific article published on August 2013

You can't have your cake and eat it too

artículo científico publicado en 2010

p16INK4A dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors

artículo científico publicado en 2022

Lista de obras de Kristian Bowles

"Haemorrhagic disease of the newborn" 89 years later than expected: vitamin K deficiency bleeding

A 35-year-old with swollen knees who had recurrent fever and pericarditis, then diarrhoea before getting better.

A 6-Point TACS Score Predicts In-Hospital Mortality Following Total Anterior Circulation Stroke.

A History of Falls is Associated with a Significant Increase in Acute Mortality in Women after Stroke

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

Addition of sodium criterion to SOAR stroke score.

Anthracycline-based chemotherapy as first-line treatment in adults with malignant posttransplant lymphoproliferative disorder after solid organ transplantation

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

Bonding in women with postnatal anaemia: a pilot case control study looking at postnatal bonding in women who have been diagnosed with anaemia at a University Hospital in the East of England ⬇️

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia

CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines.

Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura

Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke

Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study.

Estimated glomerular filtration rate and risk of poor outcomes after stroke

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism ⬇️

Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells.

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

Hyperglycaemia and the SOAR stroke score in predicting mortality.

Hyponatremia predicts mortality after stroke.

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

Impact of Hemoglobin Levels and Anemia on Mortality in Acute Stroke: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

Impact of stroke-associated pneumonia on mortality, length of hospitalization, and functional outcome

Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

Long-Term Factors Associated With Falls and Fractures Poststroke.

Low estimated glomerular filtration rate and pneumonia in stroke patients: findings from a prospective stroke registry in the East of England

MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

Management of post-transplant lymphoproliferative disorder in adult solid organ transplant recipients - BCSH and BTS Guidelines.

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

Necrotizing cervical lymphadenopathy caused by Kikuchi-Fujimoto disease

Nodular Lymphocyte Predominant Hodgkin Lymphoma: A Real-world Case Series of Consecutive Patients Treated by a Single Multidisciplinary Team in the East of England From 1999 to 2015.

Overcoming bortezomib resistance in multiple myeloma.

Oxidative stress responses and NRF2 in human leukaemia

PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

Platelet mass has prognostic value in patients with myelodysplastic syndromes

Platelet size has diagnostic predictive value in patients with thrombocytopenia.

Predicting response to recombinant factor VIIa in non-haemophiliac patients with severe haemorrhage.

Prediction of acute myeloid leukaemia risk in healthy individuals

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

Resolution of Roth spots in chronic myeloid leukaemia after treatment with imatinib.

Resolution of chronic severe refractory thrombocytopenia after treatment of hypothyroidism.

Results of a multicentre UK-wide compassionate use programme evaluating the efficacy of idelalisib monotherapy in relapsed, refractory follicular lymphoma

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.

Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia.

The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

The bone marrow microenvironment - Home of the leukemic blasts

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

Understanding the role of NRF2-regulated miRNAs in human malignancies.

You can't have your cake and eat it too

p16INK4A dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors

Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke