Lista de obras - Frank Heppner - Dominio Público Uruguay

A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance

artículo científico

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

artículo científico publicado en 2005

A paucisymptomatic neuromuscular disease mimicking type III 5q-SMA with complex rearrangements in the SMN gene.

artículo científico publicado en 2013

Abdominal seeding of an atypical teratoid/rhabdoid tumor of the pineal gland along a ventriculoperitoneal shunt catheter

scientific article published on 23 November 2005

An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

artículo científico publicado en 2014

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.

artículo científico publicado en 2012

Architectural B-cell organization in skeletal muscle identifies subtypes of dermatomyositis.

artículo científico publicado en 2018

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS.

artículo científico publicado en 2015

Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus

artículo científico publicado en 2018

Automated vs. manual cerebrospinal fluid cell counts: a work and cost analysis comparing the Sysmex XE-5000 and the Fuchs-Rosenthal manual counting chamber.

artículo científico publicado en 2011

Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3

artículo científico publicado en 2019

Breaking up (amyloid) is hard to do.

artículo científico publicado en 2005

CNS myeloid cells critically regulate heat hyperalgesia

artículo científico publicado en 2018

Calcified myocardial necrosis in pediatric patients after cardiopulmonary resuscitation.

artículo científico publicado en 2012

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

artículo científico publicado en 2017

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

artículo científico publicado en 2008

Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP.

artículo científico publicado en 2005

Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas ⬇️

artículo científico publicado el 14 de marzo de 2013

Conserved size and periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex.

scientific article published on 30 July 2015

Current concepts and controversies in prion immunopathology

artículo científico publicado en 2004

DNA methylation-based classification of central nervous system tumours

artículo científico publicado en 2018

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

artículo científico publicado en 2005

Detection of kappa and delta opioid receptors in skin--outside the nervous system.

artículo científico publicado en 2005

Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19

artículo científico publicado en 2023

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Early and rapid engraftment of bone marrow-derived microglia in scrapie.

artículo científico publicado en 2006

Enhanced acute immune response in IL-12p35-/- mice is followed by accelerated distinct repair mechanisms in Staphylococcus aureus-induced murine brain abscess.

artículo científico publicado en 2013

Erratum to: MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and

article

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

artículo científico publicado en 2005

Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases ⬇️

artículo científico publicado el 8 de noviembre de 2011

Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation.

artículo científico publicado en 2010

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology

artículo científico publicado en 2013

Genome wide DNA copy number analysis in cholangiocarcinoma using high resolution molecular inversion probe single nucleotide polymorphism assay.

artículo científico publicado en 2015

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

artículo científico publicado en 2014

High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia

artículo científico publicado en 2016

Immune attack: the role of inflammation in Alzheimer disease.

artículo científico

Immune system and peripheral nerves in propagation of prions to CNS.

artículo científico publicado en 2003

Immune-Mediated Necrotizing Myopathy Is Characterized by a Specific Th1-M1 Polarized Immune Profile ⬇️

artículo científico publicado el 8 de octubre de 2012

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice.

artículo científico publicado en 2017

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice

artículo científico publicado en 2015

Impaired Pten expression in human malignant peripheral nerve sheath tumours

artículo científico publicado en 2012

Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain

scientific article published on 04 August 2018

Inflammatory myopathy with abundant macrophages (IMAM): the immunology revisited.

artículo científico publicado en 2013

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo

artículo científico publicado en 2016

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

artículo científico publicado en 2012

Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice

scientific article published on 30 January 2020

Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.

artículo científico publicado en 2019

Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH).

artículo científico publicado en 2016

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).

artículo científico publicado en 2018

Juvenile autophagic vacuolar myopathy - a new entity or variant?

artículo científico publicado en 2013

Loss of USP18 in microglia induces white matter pathology

artículo científico publicado en 2019

Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies

artículo científico publicado en 2013

MGMT Promoter Methylation and BRAF V600E Mutations Are Helpful Markers to Discriminate Pleomorphic Xanthoastrocytoma from Giant Cell Glioblastoma

artículo científico publicado en 2016

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.

artículo científico publicado en 2013

Microglia actions in Alzheimer’s disease.

artículo científico publicado en 2013

Microglia as dynamic and essential components of the amyloid hypothesis

artículo científico publicado en 2013

Microglia inflict delayed brain injury after subarachnoid hemorrhage.

artículo científico publicado en 2015

Microglia/macrophages promote glioma progression ⬇️

artículo científico publicado el 29 de diciembre de 2010

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice.

artículo científico publicado en 2010

Modeling multiple sclerosis in laboratory animals.

scientific article published on 03 October 2009

Nuclear actin aggregation is a hallmark of anti-synthetase syndrome-induced dysimmune myopathy.

artículo científico publicado en 2015

Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

artículo científico publicado en 2014

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

artículo científico publicado en 2020

Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies

artículo científico publicado en 2005

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib—A Phase II Trial ⬇️

artículo científico publicado el 6 de abril de 2011

Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project

artículo científico publicado en 2018

Phospho-AXL is widely expressed in glioblastoma and associated with significant shorter overall survival.

artículo científico publicado en 2017

Pipestem capillaries in necrotizing myopathy revisited ⬇️

artículo científico publicado el 25 de octubre de 2012

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients ⬇️

artículo científico publicado en 2019

Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance ⬇️

artículo científico publicado el 15 de marzo de 2013

Proposal for a New Grading of Moyamoya Disease in Adult Patients ⬇️

artículo científico publicado el 11 de mayo de 2011

Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress

artículo científico publicado en 2007

Proximal weakness in a patient with MALT lymphoma: a case report and discussion of possible pathogenesis.

artículo científico publicado en 2015

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

artículo científico publicado en 2011

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors.

artículo científico publicado en 2015

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma

artículo científico publicado en 2021

Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis.

artículo científico publicado en 2015

The 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatment

artículo científico publicado en 2010

The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin

scientific article published on 28 April 2020

The evolution of the anaplastic cerebellar liponeurocytoma: case report and review of the literature

artículo científico

The most fulminant course of the Marburg variant of multiple sclerosis-autopsy findings

artículo científico publicado en 2014

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

artículo científico publicado en 2024

[CORRECTION] High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

artículo científico publicado en 2018

Lista de obras de Frank Heppner

A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

A paucisymptomatic neuromuscular disease mimicking type III 5q-SMA with complex rearrangements in the SMN gene.

Abdominal seeding of an atypical teratoid/rhabdoid tumor of the pineal gland along a ventriculoperitoneal shunt catheter

An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.

Architectural B-cell organization in skeletal muscle identifies subtypes of dermatomyositis.

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS.

Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus

Automated vs. manual cerebrospinal fluid cell counts: a work and cost analysis comparing the Sysmex XE-5000 and the Fuchs-Rosenthal manual counting chamber.

Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3

Breaking up (amyloid) is hard to do.

CNS myeloid cells critically regulate heat hyperalgesia

Calcified myocardial necrosis in pediatric patients after cardiopulmonary resuscitation.

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP.

Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas ⬇️

Conserved size and periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex.

Current concepts and controversies in prion immunopathology

DNA methylation-based classification of central nervous system tumours

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

Detection of kappa and delta opioid receptors in skin--outside the nervous system.

Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Early and rapid engraftment of bone marrow-derived microglia in scrapie.

Enhanced acute immune response in IL-12p35-/- mice is followed by accelerated distinct repair mechanisms in Staphylococcus aureus-induced murine brain abscess.

Erratum to: MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases ⬇️

Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation.

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology

Genome wide DNA copy number analysis in cholangiocarcinoma using high resolution molecular inversion probe single nucleotide polymorphism assay.

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia

Immune attack: the role of inflammation in Alzheimer disease.

Immune system and peripheral nerves in propagation of prions to CNS.

Immune-Mediated Necrotizing Myopathy Is Characterized by a Specific Th1-M1 Polarized Immune Profile ⬇️

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice.

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice

Impaired Pten expression in human malignant peripheral nerve sheath tumours

Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain

Inflammatory myopathy with abundant macrophages (IMAM): the immunology revisited.

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice

Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.

Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH).

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).

Juvenile autophagic vacuolar myopathy - a new entity or variant?

Loss of USP18 in microglia induces white matter pathology

Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies

MGMT Promoter Methylation and BRAF V600E Mutations Are Helpful Markers to Discriminate Pleomorphic Xanthoastrocytoma from Giant Cell Glioblastoma

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.

Microglia actions in Alzheimer’s disease.

Microglia as dynamic and essential components of the amyloid hypothesis

Microglia inflict delayed brain injury after subarachnoid hemorrhage.

Microglia/macrophages promote glioma progression ⬇️

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice.

Modeling multiple sclerosis in laboratory animals.

Nuclear actin aggregation is a hallmark of anti-synthetase syndrome-induced dysimmune myopathy.

Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib—A Phase II Trial ⬇️

Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project

Phospho-AXL is widely expressed in glioblastoma and associated with significant shorter overall survival.

Pipestem capillaries in necrotizing myopathy revisited ⬇️

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients ⬇️

Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance ⬇️

Proposal for a New Grading of Moyamoya Disease in Adult Patients ⬇️

Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress

Proximal weakness in a patient with MALT lymphoma: a case report and discussion of possible pathogenesis.

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors.

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma

Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis.

The 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatment

The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin